GREMLIN Database
YLZA - UPF0296 protein YlzA
UniProt: Q7WY72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 89 (80)
Sequences: 409 (234)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_R59_D5.4771.00
25_P54_A2.7961.00
30_I55_V2.6460.99
18_R62_H2.2110.98
42_M61_D1.9930.95
19_M56_V1.8230.93
36_D43_L1.7960.92
18_R36_D1.7650.91
72_T76_R1.7060.90
18_R60_S1.6550.88
26_E35_Q1.5370.84
53_R72_T1.5230.84
19_M77_L1.5210.84
23_V30_I1.5100.83
61_D77_L1.5020.83
39_D58_M1.4920.83
69_Q72_T1.4720.82
12_N49_G1.4110.79
35_Q55_V1.3650.76
38_R45_D1.3550.76
58_M61_D1.3410.75
15_S67_A1.3410.75
31_K46_A1.3380.75
14_I66_S1.3090.73
43_L63_I1.2310.69
6_I77_L1.2120.67
27_S48_Y1.2110.67
53_R69_Q1.2000.67
27_S53_R1.1950.66
20_I40_R1.1840.66
37_A69_Q1.1630.64
16_A63_I1.1570.64
29_P49_G1.1490.63
13_I61_D1.1480.63
10_F68_V1.1380.62
14_I44_I1.1020.60
33_M38_R1.0810.58
34_I55_V1.0750.58
5_L21_S1.0660.57
20_I58_M1.0640.57
26_E30_I1.0470.56
24_S55_V1.0410.55
12_N44_I1.0110.53
57_V60_S1.0080.53
3_I17_N0.9870.51
50_R70_P0.9870.51
5_L77_L0.9850.51
7_N46_A0.9740.50
25_P30_I0.9430.48
26_E73_V0.9410.48
22_I54_A0.9350.48
19_M59_D0.9280.47
39_D43_L0.8930.44
56_V77_L0.8910.44
37_A63_I0.8850.44
13_I68_V0.8740.43
27_S75_H0.8730.43
50_R65_L0.8730.43
34_I54_A0.8600.42
30_I78_S0.8320.40
19_M80_K0.8250.40
32_R46_A0.8180.39
19_M47_T0.7980.38
17_N40_R0.7960.38
27_S62_H0.7940.37
67_A70_P0.7820.37
47_T77_L0.7810.36
7_N65_L0.7800.36
17_N81_E0.7780.36
7_N11_G0.7770.36
37_A53_R0.7760.36
23_V61_D0.7700.36
44_I60_S0.7500.34
58_M64_I0.7460.34
50_R71_E0.7440.34
48_Y77_L0.7340.33
63_I78_S0.7330.33
17_N51_R0.7180.32
15_S40_R0.7150.32
26_E39_D0.7120.32
23_V46_A0.7110.32
43_L71_E0.7000.31
59_D62_H0.6950.31
19_M79_V0.6940.31
33_M67_A0.6930.31
9_G12_N0.6870.30
13_I41_G0.6840.30
28_A31_K0.6640.29
26_E48_Y0.6580.29
57_V64_I0.6550.28
20_I42_M0.6340.27
8_I25_P0.6110.26
64_I80_K0.6070.26
18_R63_I0.6000.25
4_K21_S0.5960.25
10_F51_R0.5920.25
13_I82_E0.5880.24
19_M82_E0.5870.24
17_N78_S0.5840.24
35_Q43_L0.5790.24
4_K28_A0.5640.23
33_M40_R0.5630.23
33_M61_D0.5620.23
33_M82_E0.5610.23
46_A66_S0.5600.23
45_D65_L0.5550.23
70_P76_R0.5530.23
53_R57_V0.5510.22
34_I44_I0.5490.22
33_M44_I0.5460.22
51_R75_H0.5420.22
13_I20_I0.5390.22
17_N34_I0.5360.22
5_L15_S0.5350.22
42_M56_V0.5320.22
31_K48_Y0.5240.21
70_P74_A0.5240.21
19_M72_T0.5160.21
39_D70_P0.5140.21
4_K79_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjsK 4 0.8764 23.9 0.926 Contact Map
2etxA 2 0.3483 11.1 0.936 Contact Map
4r3oC 1 0.9888 10 0.938 Contact Map
1rypL 1 1 10 0.938 Contact Map
4nr2A 2 0.3483 8.9 0.939 Contact Map
2werA 2 0.9101 6 0.944 Contact Map
4l0nA 2 0.3483 5.8 0.944 Contact Map
1m4lA 1 0.4494 5.8 0.944 Contact Map
2k1eA 3 0.4494 5.3 0.945 Contact Map
4r3oD 1 0.9551 5.2 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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