GREMLIN Database
YRZL - UPF0297 protein YrzL
UniProt: Q7WY61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 88 (80)
Sequences: 591 (321)
Seq/√Len: 35.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T64_L3.9671.00
31_A59_R3.0081.00
53_A56_P2.9691.00
24_V68_L2.2610.99
43_I78_V2.2040.99
47_L53_A2.1980.99
10_F41_N2.0650.99
21_V73_L1.9310.98
48_L74_I1.9270.98
50_G69_E1.8330.97
50_G75_E1.8310.97
34_E59_R1.7830.97
60_D63_N1.7220.96
5_D47_L1.6590.95
21_V68_L1.5570.93
69_E75_E1.5510.93
31_A58_H1.5310.92
13_S63_N1.5080.92
24_V28_V1.4070.89
19_T23_E1.4000.88
80_S84_Q1.3820.88
30_D59_R1.3640.87
68_L73_L1.3500.86
53_A57_R1.3470.86
35_K56_P1.3420.86
69_E72_E1.3300.86
80_S83_E1.2900.84
35_K69_E1.2650.83
21_V75_E1.2370.81
20_N23_E1.1790.78
31_A61_A1.1400.75
48_L66_R1.1340.75
76_E80_S1.1340.75
27_T30_D1.0920.72
11_N57_R1.0870.72
12_F44_V1.0660.70
11_N19_T1.0370.68
14_D78_V1.0210.67
50_G57_R1.0050.66
10_F82_L1.0050.66
44_V64_L0.9790.64
25_L44_V0.9790.64
77_L80_S0.9610.62
37_Y51_D0.9540.62
53_A63_N0.9430.61
40_I79_K0.9240.59
4_F83_E0.9230.59
29_Y39_P0.9160.58
8_M66_R0.9150.58
56_P71_D0.9100.58
24_V63_N0.8910.56
50_G76_E0.8810.55
39_P58_H0.8760.55
59_R67_K0.8710.55
65_I71_D0.8700.55
56_P74_I0.8560.53
13_S19_T0.8520.53
32_L55_I0.8250.51
5_D8_M0.8180.50
21_V60_D0.8030.49
13_S79_K0.7780.47
6_K14_D0.7730.46
21_V69_E0.7730.46
47_L74_I0.7660.45
4_F67_K0.7620.45
25_L43_I0.7510.44
20_N67_K0.7430.44
9_K48_L0.7400.43
6_K9_K0.7320.43
11_N50_G0.7270.42
47_L78_V0.7240.42
4_F22_N0.7200.42
8_M80_S0.7180.41
45_G61_A0.7140.41
21_V50_G0.7060.40
24_V64_L0.6990.40
26_I57_R0.6950.39
18_E58_H0.6950.39
20_N47_L0.6940.39
12_F20_N0.6920.39
5_D77_L0.6910.39
79_K82_L0.6900.39
53_A71_D0.6760.38
27_T31_A0.6730.38
73_L77_L0.6660.37
17_A83_E0.6650.37
25_L55_I0.6570.36
18_E26_I0.6550.36
30_D33_Q0.6550.36
4_F8_M0.6490.36
17_A79_K0.6320.34
31_A35_K0.6290.34
19_T68_L0.6190.33
57_R83_E0.6070.32
8_M75_E0.6060.32
28_V61_A0.6030.32
15_D19_T0.6020.32
48_L82_L0.5960.32
37_Y41_N0.5850.31
53_A74_I0.5740.30
6_K13_S0.5700.30
9_K40_I0.5680.30
9_K63_N0.5660.29
21_V24_V0.5630.29
14_D25_L0.5560.29
44_V78_V0.5500.28
49_S84_Q0.5430.28
35_K39_P0.5400.28
30_D43_I0.5230.26
26_I30_D0.5220.26
35_K66_R0.5170.26
66_R82_L0.5160.26
17_A21_V0.5150.26
73_L76_E0.5150.26
5_D43_I0.5140.26
19_T27_T0.5140.26
76_E79_K0.5090.25
48_L51_D0.5020.25
47_L70_R0.5000.25
23_E27_T0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3va9A 2 0.7614 85.7 0.882 Contact Map
4r3zC 1 0 49.2 0.91 Contact Map
1ujpA 1 0.6705 33.8 0.918 Contact Map
1wmxA 2 0.5227 18.7 0.928 Contact Map
3ih6A 5 0.9545 16.7 0.929 Contact Map
2nrqA 1 0.9091 15 0.931 Contact Map
4jykA 2 0.7614 14.5 0.931 Contact Map
2y8uA 1 0.5682 13.4 0.932 Contact Map
2ekcA 1 0.6818 12.8 0.933 Contact Map
4lgyA 1 1 12.7 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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