GREMLIN Database
MRPE - Na(+)/H(+) antiporter subunit E
UniProt: Q7WY60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (153)
Sequences: 1916 (1478)
Seq/√Len: 119.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_L109_L5.1121.00
12_A34_G4.3021.00
96_E146_R3.7481.00
74_S78_S3.1531.00
139_E143_F2.8361.00
92_A127_I2.8211.00
89_G135_I2.6571.00
66_K70_L2.5441.00
77_K81_S2.3101.00
143_F147_E2.2531.00
81_S85_N2.2161.00
92_A129_Y2.2091.00
64_F68_L2.0431.00
93_F130_I1.9791.00
62_F66_K1.9571.00
16_M27_F1.9081.00
64_F109_L1.9031.00
96_E154_Q1.8671.00
106_L145_I1.8611.00
98_T126_T1.8161.00
78_S133_M1.8021.00
67_E70_L1.8011.00
58_I62_F1.7841.00
99_K102_E1.7541.00
8_N12_A1.7001.00
132_A135_I1.6371.00
75_V133_M1.5931.00
137_D140_K1.5871.00
97_L102_E1.5801.00
25_A29_T1.5741.00
22_P27_F1.5741.00
8_N38_L1.5551.00
59_K152_A1.5391.00
56_S59_K1.5171.00
142_I145_I1.4871.00
107_S118_V1.4871.00
55_I59_K1.4651.00
12_A31_Y1.4551.00
19_S26_G1.4101.00
77_K80_L1.4011.00
12_A27_F1.3781.00
8_N31_Y1.3661.00
93_F146_R1.3621.00
23_S26_G1.3481.00
81_S84_L1.3411.00
90_I129_Y1.3291.00
78_S134_D1.3291.00
97_L106_L1.3211.00
91_F132_A1.3151.00
138_A142_I1.3051.00
107_S111_T1.2640.99
76_M79_V1.2400.99
87_R136_E1.2220.99
110_I113_T1.2020.99
60_L64_F1.1800.99
73_V77_K1.1800.99
12_A30_G1.1720.99
87_R134_D1.1700.99
74_S77_K1.1690.99
82_P85_N1.1590.99
148_S152_A1.1480.99
118_V128_L1.1470.99
64_F104_T1.0830.98
76_M80_L1.0810.98
147_E151_K1.0700.98
15_W30_G1.0640.98
56_S152_A1.0610.98
26_G29_T1.0530.98
67_E149_F1.0410.98
110_I116_T1.0320.98
109_L153_I1.0250.98
139_E142_I1.0120.98
70_L74_S1.0050.97
142_I146_R0.9960.97
111_T118_V0.9850.97
106_L153_I0.9840.97
59_K63_I0.9740.97
8_N34_G0.9620.97
108_L113_T0.9590.97
35_M38_L0.9430.96
59_K155_E0.9330.96
13_F22_P0.9300.96
122_S125_R0.9280.96
108_L130_I0.9160.96
67_E148_S0.9100.95
151_K155_E0.9090.95
68_L109_L0.9070.95
64_F112_L0.9030.95
110_I118_V0.9020.95
31_Y35_M0.8850.95
61_C65_I0.8850.95
53_K56_S0.8760.94
57_I96_E0.8730.94
95_T103_I0.8640.94
16_M22_P0.8520.93
69_Y73_V0.8520.93
60_L156_V0.8490.93
30_G33_L0.8440.93
94_K142_I0.8390.93
12_A38_L0.8360.93
111_T116_T0.8330.93
90_I119_M0.8270.92
56_S155_E0.8250.92
120_D129_Y0.8200.92
36_L40_F0.8170.92
149_F153_I0.8130.92
146_R150_E0.8120.92
12_A16_M0.8060.91
63_I66_K0.8050.91
93_F106_L0.8040.91
31_Y50_Y0.8020.91
97_L154_Q0.7920.91
122_S126_T0.7890.91
103_I124_D0.7850.90
93_F110_I0.7820.90
108_L118_V0.7790.90
108_L112_L0.7740.90
140_K144_D0.7730.90
11_L30_G0.7670.89
34_G147_E0.7600.89
72_N76_M0.7580.89
98_T103_I0.7500.88
71_A74_S0.7460.88
29_T33_L0.7420.88
55_I58_I0.7400.88
14_C18_L0.7390.87
103_I121_I0.7360.87
33_L36_L0.7320.87
149_F155_E0.7320.87
65_I69_Y0.7300.87
27_F50_Y0.7260.87
59_K62_F0.7250.86
132_A141_A0.7230.86
30_G38_L0.7220.86
19_S22_P0.7180.86
68_L112_L0.7180.86
141_A144_D0.7180.86
103_I128_L0.7140.86
27_F31_Y0.7110.85
63_I152_A0.7110.85
11_L15_W0.7100.85
77_K85_N0.7020.85
94_K125_R0.6950.84
96_E150_E0.6940.84
77_K134_D0.6820.83
67_E113_T0.6730.82
88_P113_T0.6720.82
34_G38_L0.6720.82
29_T32_I0.6710.82
69_Y72_N0.6700.82
89_G92_A0.6670.82
92_A125_R0.6660.81
21_S26_G0.6650.81
54_L58_I0.6650.81
86_I134_D0.6630.81
61_C84_L0.6430.79
10_F14_C0.6410.79
52_W57_I0.6400.79
78_S85_N0.6390.79
31_Y62_F0.6380.79
113_T130_I0.6370.78
143_F146_R0.6350.78
32_I36_L0.6350.78
21_S105_M0.6330.78
113_T116_T0.6310.78
118_V121_I0.6240.77
101_W104_T0.6200.77
113_T121_I0.6170.76
107_S128_L0.6170.76
110_I145_I0.6100.75
41_F45_F0.6040.75
31_Y34_G0.6020.75
62_F65_I0.6000.74
79_V113_T0.5990.74
82_P131_H0.5980.74
36_L147_E0.5960.74
8_N35_M0.5940.74
28_I137_D0.5920.73
68_L129_Y0.5880.73
68_L79_V0.5870.73
93_F128_L0.5850.72
110_I130_I0.5820.72
148_S151_K0.5770.71
74_S133_M0.5770.71
153_I156_V0.5730.71
82_P88_P0.5710.71
108_L116_T0.5710.71
21_S27_F0.5700.70
8_N50_Y0.5680.70
59_K66_K0.5660.70
6_L11_L0.5660.70
71_A148_S0.5650.70
95_T106_L0.5630.70
5_I31_Y0.5590.69
137_D146_R0.5530.68
22_P144_D0.5530.68
71_A113_T0.5520.68
63_I67_E0.5510.68
39_F42_R0.5510.68
36_L39_F0.5480.67
20_N157_S0.5470.67
71_A108_L0.5460.67
18_L120_D0.5410.67
16_M19_S0.5410.67
66_K69_Y0.5400.66
16_M21_S0.5380.66
135_I138_A0.5360.66
52_W105_M0.5340.66
31_Y66_K0.5330.65
60_L71_A0.5320.65
71_A143_F0.5310.65
41_F44_F0.5310.65
79_V84_L0.5280.65
112_L141_A0.5270.65
15_W26_G0.5260.64
16_M26_G0.5260.64
20_N61_C0.5220.64
91_F141_A0.5180.63
9_V25_A0.5170.63
98_T102_E0.5160.63
49_F95_T0.5130.62
65_I139_E0.5090.62
40_F48_Q0.5090.62
109_L154_Q0.5080.62
63_I97_L0.5060.61
28_I45_F0.5050.61
140_K143_F0.5050.61
95_T107_S0.5050.61
47_R143_F0.5020.61
60_L110_I0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ookA 2 0.3038 11.3 0.94 Contact Map
4wxaA 1 0.4557 6 0.947 Contact Map
2rq6A 1 0.538 5.6 0.948 Contact Map
2werA 2 0.5063 4.5 0.95 Contact Map
4wnyA 2 0.4114 4 0.951 Contact Map
1ghhA 1 0.2152 4 0.951 Contact Map
4q4fA 1 0.3354 4 0.951 Contact Map
1vi7A 1 0.3228 2.7 0.955 Contact Map
2qe7H 1 0.5 2.3 0.957 Contact Map
4q2lA 1 0.3924 2.2 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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