GREMLIN Database
ACPK - Polyketide biosynthesis acyl-carrier-protein AcpK
UniProt: Q7PC63 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 82 (69)
Sequences: 22925 (18583)
Seq/√Len: 2237.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E69_G2.4281.00
13_N52_D2.4251.00
58_P61_E2.1171.00
61_E74_V2.0731.00
67_N70_E2.0551.00
65_V74_V2.0301.00
38_D41_D1.8221.00
11_I28_P1.8101.00
20_E48_M1.7991.00
31_Q66_K1.7781.00
32_L37_A1.7001.00
13_N16_E1.6801.00
18_L37_A1.6041.00
50_L56_K1.5331.00
27_E30_D1.5001.00
65_V70_E1.4351.00
31_Q34_E1.3921.00
15_C28_P1.3881.00
28_P69_G1.3861.00
15_C68_I1.3451.00
15_C19_P1.3391.00
13_N17_V1.2891.00
18_L68_I1.2531.00
48_M52_D1.2451.00
45_I62_L1.2391.00
46_I50_L1.2291.00
19_P25_R1.1981.00
60_I64_G1.1611.00
28_P68_I1.1431.00
17_V20_E1.1281.00
14_I72_A1.1131.00
16_E52_D1.1081.00
10_L76_Y1.1081.00
41_D44_E1.0981.00
9_V13_N1.0831.00
14_I68_I1.0801.00
42_R62_L1.0611.00
17_V48_M1.0561.00
42_R46_I1.0521.00
44_E48_M1.0401.00
18_L71_L1.0201.00
18_L45_I1.0081.00
11_I72_A0.9911.00
9_V12_T0.9611.00
17_V45_I0.9581.00
14_I49_V0.9471.00
21_L48_M0.9441.00
15_C26_F0.9431.00
10_L13_N0.9371.00
12_T16_E0.9211.00
39_S43_A0.9111.00
11_I69_G0.9091.00
61_E64_G0.8871.00
61_E65_V0.8851.00
16_E19_P0.8441.00
13_N53_L0.8381.00
48_M51_E0.8261.00
49_V57_I0.8051.00
50_L55_L0.7941.00
42_R59_R0.7811.00
17_V49_V0.7801.00
37_A41_D0.7731.00
57_I71_L0.7511.00
17_V52_D0.7461.00
47_T51_E0.7461.00
43_A47_T0.7441.00
21_L45_I0.7431.00
70_E73_E0.7391.00
45_I71_L0.7291.00
33_V37_A0.7151.00
30_D35_L0.6951.00
31_Q67_N0.6781.00
37_A42_R0.6751.00
46_I59_R0.6691.00
12_T15_C0.6451.00
74_V77_D0.6361.00
26_F35_L0.6311.00
18_L22_D0.6301.00
16_E20_E0.6231.00
22_D37_A0.6141.00
37_A45_I0.6111.00
73_E76_Y0.6071.00
33_V63_S0.6041.00
30_D34_E0.6041.00
55_L75_L0.5981.00
10_L75_L0.5981.00
43_A59_R0.5911.00
73_E77_D0.5851.00
20_E52_D0.5851.00
65_V73_E0.5811.00
68_I72_A0.5801.00
49_V55_L0.5721.00
21_L44_E0.5641.00
38_D59_R0.5581.00
66_K70_E0.5541.00
62_L71_L0.5531.00
11_I15_C0.5521.00
19_P24_H0.5471.00
39_S63_S0.5471.00
17_V21_L0.5361.00
11_I68_I0.5291.00
21_L41_D0.5261.00
10_L72_A0.5211.00
19_P26_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r0mB 1 0.9268 99.5 0.16 Contact Map
4oqjA 2 0 99.5 0.185 Contact Map
2vsqA 1 1 99.5 0.189 Contact Map
2jgpA 1 1 99.5 0.19 Contact Map
2cq8A 1 1 99.4 0.204 Contact Map
4pxhB 1 0.9024 99.4 0.225 Contact Map
4dg8A 1 0 99.4 0.231 Contact Map
3tejA 1 0.9756 99.4 0.239 Contact Map
1dnyA 1 0.9146 99.3 0.249 Contact Map
2mr7A 1 1 99.3 0.253 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.