GREMLIN Database
ESTB - Extracellular esterase EstB
UniProt: Q79F14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (175)
Sequences: 3785 (2759)
Seq/√Len: 208.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_G188_L3.6431.00
112_T128_V3.3041.00
130_T135_N3.2831.00
109_G133_G3.2641.00
113_L135_N3.0041.00
41_I107_M2.6311.00
102_I112_T2.5981.00
104_A112_T2.3951.00
33_N99_K2.3831.00
45_S69_D2.3461.00
38_V112_T2.3331.00
101_D126_Q2.2871.00
130_T133_G2.1751.00
58_Q199_K2.1501.00
54_Y195_N2.1071.00
155_T201_G2.0681.00
114_Y119_L2.0661.00
89_D124_K2.0261.00
99_K126_Q1.9941.00
33_N101_D1.9921.00
38_V84_L1.8511.00
110_A133_G1.8391.00
92_L124_K1.8351.00
81_G114_Y1.8251.00
51_I198_I1.8011.00
116_I128_V1.7911.00
54_Y58_Q1.7591.00
36_V102_I1.7571.00
110_A134_A1.7191.00
139_S166_I1.7031.00
35_V103_V1.6741.00
41_I138_V1.6561.00
33_N126_Q1.6231.00
114_Y118_Y1.6011.00
127_N153_L1.5941.00
43_G47_N1.5811.00
127_N155_T1.5701.00
85_A115_Y1.5611.00
135_N156_S1.5301.00
36_V87_Y1.5211.00
88_V100_V1.5051.00
68_I84_L1.4941.00
81_G115_Y1.4811.00
90_R94_E1.4451.00
85_A89_D1.4001.00
184_G187_G1.3881.00
41_I164_I1.3831.00
36_V91_V1.3671.00
102_I125_I1.3371.00
88_V115_Y1.3331.00
115_Y121_G1.2901.00
116_I125_I1.2821.00
131_L194_V1.2681.00
92_L97_A1.2581.00
183_I191_N1.2491.00
37_L48_F1.2471.00
101_D202_L1.2101.00
87_Y91_V1.2041.00
197_Y200_E1.1951.00
158_Y170_S1.1931.00
51_I195_N1.1921.00
68_I87_Y1.1901.00
138_V141_T1.1871.00
104_A133_G1.1871.00
91_V95_T1.1841.00
52_K56_I1.1761.00
37_L52_K1.1701.00
103_V198_I1.1631.00
37_L55_L1.1471.00
47_N189_L1.1471.00
39_H69_D1.1461.00
36_V100_V1.1461.00
109_G130_T1.1421.00
66_Y91_V1.1261.00
132_G159_S1.1251.00
101_D127_N1.1121.00
78_L114_Y1.0981.00
40_G106_S1.0791.00
82_P86_S1.0711.00
75_G79_N1.0561.00
86_S90_R1.0461.00
165_V170_S1.0401.00
35_V55_L1.0311.00
133_G156_S1.0301.00
80_N111_N1.0291.00
175_A178_I1.0281.00
70_F73_K1.0261.00
87_Y90_R1.0191.00
129_V201_G1.0181.00
129_V198_I1.0171.00
77_N107_M1.0081.00
199_K203_N1.0021.00
177_N180_L1.0011.00
37_L103_V0.9991.00
39_H67_A0.9851.00
49_F53_N0.9661.00
134_A165_V0.9651.00
183_I187_G0.9641.00
34_P66_Y0.9561.00
28_A32_H0.9510.99
52_K67_A0.9400.99
196_G199_K0.9390.99
109_G134_A0.9380.99
167_N170_S0.9320.99
70_F107_M0.9080.99
146_T150_Q0.9070.99
54_Y199_K0.9060.99
147_D150_Q0.9030.99
66_Y87_Y0.8990.99
160_L182_G0.8980.99
39_H72_D0.8960.99
76_N79_N0.8910.99
56_I65_L0.8860.99
137_L141_T0.8790.99
25_G28_A0.8720.99
43_G189_L0.8690.99
66_Y95_T0.8680.99
158_Y179_Q0.8650.99
39_H48_F0.8610.99
163_Q167_N0.8600.99
28_A31_V0.8600.99
46_Y190_S0.8490.99
92_L98_K0.8490.99
117_K145_G0.8450.99
103_V131_L0.8330.99
58_Q195_N0.8260.99
90_R93_K0.8250.99
72_D107_M0.8210.98
113_L134_A0.8190.98
89_D92_L0.8110.98
91_V97_A0.8020.98
195_N199_K0.8010.98
25_G61_Q0.8000.98
159_S167_N0.8000.98
140_S164_I0.7930.98
53_N56_I0.7920.98
148_P154_Y0.7870.98
50_A53_N0.7810.98
148_P151_K0.7800.98
83_Q86_S0.7710.98
130_T156_S0.7700.98
78_L82_P0.7700.98
89_D121_G0.7690.98
131_L188_L0.7680.98
183_I188_L0.7630.98
158_Y171_R0.7620.98
179_Q182_G0.7600.98
104_A116_I0.7450.97
125_I152_I0.7440.97
70_F111_N0.7320.97
155_T158_Y0.7280.97
158_Y167_N0.7250.97
160_L167_N0.7240.97
168_S171_R0.7230.97
131_L198_I0.7200.97
110_A141_T0.7190.97
166_I170_S0.7070.96
82_P85_A0.7010.96
70_F80_N0.6960.96
91_V96_G0.6950.96
166_I169_L0.6930.96
55_L59_G0.6930.96
193_Q196_G0.6890.96
46_Y49_F0.6860.95
83_Q87_Y0.6860.95
51_I55_L0.6850.95
79_N82_P0.6820.95
157_I178_I0.6800.95
159_S188_L0.6760.95
114_Y117_K0.6740.95
155_T178_I0.6720.95
54_Y57_S0.6620.95
81_G85_A0.6610.94
37_L65_L0.6570.94
163_Q184_G0.6480.94
186_I189_L0.6470.94
31_V98_K0.6450.94
43_G105_H0.6430.94
109_G128_V0.6410.94
130_T134_A0.6410.94
44_A47_N0.6380.93
88_V102_I0.6370.93
77_N111_N0.6330.93
188_L194_V0.6300.93
45_S67_A0.6290.93
66_Y72_D0.6280.93
25_G29_E0.6280.93
35_V101_D0.6250.93
81_G111_N0.6240.93
149_N152_I0.6230.93
105_H189_L0.6230.93
197_Y201_G0.6220.92
39_H73_K0.6210.92
29_E32_H0.6200.92
84_L111_N0.6190.92
50_A54_Y0.6120.92
110_A137_L0.6020.91
26_A29_E0.6010.91
145_G148_P0.5970.91
39_H164_I0.5920.91
149_N154_Y0.5900.90
25_G32_H0.5880.90
101_D129_V0.5870.90
147_D153_L0.5870.90
35_V155_T0.5850.90
25_G30_S0.5840.90
138_V167_N0.5840.90
72_D75_G0.5830.90
81_G119_L0.5830.90
143_L148_P0.5820.90
60_W65_L0.5810.90
48_F51_I0.5810.90
143_L154_Y0.5800.90
115_Y124_K0.5790.90
42_S74_T0.5780.90
136_G143_L0.5760.89
39_H70_F0.5720.89
138_V164_I0.5690.89
156_S171_R0.5690.89
154_Y159_S0.5680.89
197_Y203_N0.5680.89
51_I131_L0.5670.89
103_V129_V0.5660.89
37_L51_I0.5610.88
89_D120_G0.5580.88
164_I189_L0.5560.88
136_G147_D0.5550.88
194_V198_I0.5530.87
132_G170_S0.5500.87
43_G107_M0.5480.87
31_V203_N0.5480.87
105_H108_G0.5470.87
104_A130_T0.5470.87
95_T99_K0.5460.87
105_H158_Y0.5420.86
116_I152_I0.5420.86
183_I194_V0.5420.86
39_H68_I0.5410.86
50_A190_S0.5400.86
43_G164_I0.5390.86
156_S170_S0.5390.86
196_G200_E0.5360.86
153_L156_S0.5360.86
88_V92_L0.5360.86
34_P125_I0.5310.85
52_K65_L0.5290.85
44_A73_K0.5280.85
91_V100_V0.5270.85
53_N57_S0.5250.85
177_N181_Y0.5230.84
104_A128_V0.5230.84
39_H43_G0.5210.84
48_F107_M0.5210.84
41_I70_F0.5130.83
200_E203_N0.5130.83
138_V166_I0.5090.83
100_V126_Q0.5070.82
111_N133_G0.5040.82
154_Y158_Y0.5040.82
82_P145_G0.5020.82
34_P96_G0.5010.82
82_P118_Y0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ispA 1 0.8524 100 0.448 Contact Map
3ds8A 1 0.8571 99.9 0.491 Contact Map
3lp5A 1 0.8476 99.9 0.528 Contact Map
4k5qA 1 0.9714 99.9 0.535 Contact Map
2x5xA 2 0.9476 99.9 0.536 Contact Map
4hs9A 1 0.819 99.9 0.54 Contact Map
3icvA 2 0.9619 99.9 0.544 Contact Map
3fleA 1 0.8143 99.9 0.555 Contact Map
4x90A 4 0.9714 99.9 0.556 Contact Map
4fkbA 2 0.8333 99.9 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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