GREMLIN Database
PTXBC - Putative PTS system EIIBC component YbbF
UniProt: Q797S1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (435)
Sequences: 3329 (2119)
Seq/√Len: 101.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_D48_A4.5051.00
396_F432_I4.0561.00
389_G436_A3.8051.00
295_A391_G3.6671.00
9_H13_K3.5891.00
342_A438_F3.5411.00
223_A259_T3.3931.00
38_P44_A3.2591.00
250_V254_I3.1511.00
41_E60_E3.1241.00
396_F425_L3.0441.00
15_L80_F2.9461.00
17_L45_D2.8801.00
47_Q50_R2.8641.00
174_G188_G2.8251.00
10_L52_L2.8121.00
392_I436_A2.8041.00
46_A64_L2.7611.00
227_I251_S2.6691.00
40_D43_K2.6401.00
385_T444_F2.5291.00
108_A113_L2.5111.00
57_G67_I2.4901.00
336_Q376_T2.4861.00
79_A82_K2.4701.00
238_I246_V2.4351.00
53_D351_T2.4301.00
8_H12_Q2.4141.00
396_F400_F2.4111.00
233_F237_F2.3741.00
36_I66_I2.3331.00
234_I250_V2.3231.00
316_L323_D2.3191.00
400_F425_L2.2931.00
175_I189_A2.2761.00
226_F258_V2.2761.00
25_S39_Y2.2661.00
235_R243_D2.2501.00
21_K85_S2.2481.00
46_A50_R2.1931.00
17_L52_L2.1851.00
17_L48_A2.1811.00
36_I80_F2.1611.00
8_H79_A2.1541.00
280_S284_I2.1371.00
46_A60_E2.1331.00
18_C36_I2.1031.00
175_I185_P2.0871.00
171_I193_I2.0811.00
427_I431_F2.0351.00
79_A83_L2.0341.00
27_Y80_F2.0251.00
294_G390_A2.0201.00
204_S207_G2.0131.00
242_L246_V1.9621.00
15_L84_V1.9511.00
14_I49_L1.9321.00
12_Q83_L1.9311.00
347_T352_L1.9301.00
13_K52_L1.9221.00
439_L443_A1.9151.00
117_K181_F1.8931.00
27_Y36_I1.8721.00
338_G434_Y1.8231.00
397_Q429_G1.8191.00
142_I147_W1.8131.00
171_I189_A1.7721.00
269_F273_A1.7711.00
26_S37_T1.7411.00
49_L52_L1.7361.00
385_T440_L1.7271.00
290_G394_G1.7261.00
229_Y233_F1.7131.00
440_L444_F1.6801.00
229_Y232_Q1.6781.00
222_F267_G1.6761.00
372_I383_F1.6711.00
136_T163_S1.6631.00
322_N403_A1.6551.00
13_K16_E1.6481.00
48_A51_K1.6331.00
234_I238_I1.6291.00
29_H77_T1.6251.00
425_L428_V1.6241.00
77_T81_S1.6241.00
183_G224_A1.6121.00
344_F357_A1.6081.00
379_L382_P1.6021.00
138_I142_I1.6001.00
338_G437_G1.5821.00
12_Q16_E1.5821.00
436_A440_L1.5631.00
157_I210_L1.5571.00
299_P387_C1.5161.00
178_S224_A1.5151.00
225_I228_A1.5111.00
384_L388_L1.5111.00
349_K352_L1.5081.00
14_I68_L1.4961.00
337_V363_G1.4931.00
246_V250_V1.4891.00
116_R180_E1.4841.00
291_F395_A1.4761.00
110_P113_L1.4721.00
59_V67_I1.4681.00
272_D276_S1.4661.00
341_F360_L1.4651.00
18_C38_P1.4631.00
179_K185_P1.4591.00
11_A80_F1.4561.00
340_A371_L1.4551.00
134_L249_T1.4441.00
230_T255_T1.4421.00
298_L333_G1.4321.00
385_T389_G1.3831.00
24_I86_A1.3801.00
225_I229_Y1.3430.99
352_L379_L1.3360.99
379_L446_Y1.3350.99
395_A399_Y1.3240.99
273_A277_G1.3220.99
389_G437_G1.2970.99
175_I186_A1.2940.99
343_V347_T1.2890.99
226_F263_F1.2820.99
435_A439_L1.2790.99
330_A426_Y1.2770.99
396_F429_G1.2740.99
290_G395_A1.2690.99
230_T254_I1.2670.99
177_A225_I1.2650.99
27_Y81_S1.2610.99
15_L83_L1.2590.99
396_F428_V1.2570.99
183_G227_I1.2430.99
188_G192_G1.2420.99
191_A252_L1.2400.99
178_S188_G1.2390.99
110_P114_F1.2280.99
49_L64_L1.2230.99
176_N186_A1.2190.99
295_A299_P1.2170.99
345_V438_F1.2170.99
291_F391_G1.2050.99
392_I432_I1.1920.99
346_K446_Y1.1730.98
342_A442_Y1.1710.98
173_V217_L1.1700.98
438_F442_Y1.1650.98
24_I84_V1.1650.98
381_R445_G1.1520.98
255_T259_T1.1510.98
161_I256_G1.1510.98
122_F217_L1.1480.98
346_K445_G1.1470.98
49_L55_V1.1460.98
15_L24_I1.1400.98
243_D247_T1.1360.98
10_L54_G1.1350.98
17_L49_L1.1340.98
149_S152_S1.1320.98
125_L169_L1.1230.98
11_A83_L1.1180.98
52_L55_V1.1130.98
132_S165_L1.1110.98
274_I300_L1.1040.98
181_F228_A1.1020.98
277_G280_S1.1010.98
13_K48_A1.0990.98
177_A181_F1.0980.97
9_H12_Q1.0940.97
178_S185_P1.0930.97
178_S183_G1.0890.97
388_L440_L1.0810.97
68_L76_V1.0780.97
81_S86_A1.0710.97
182_G232_Q1.0650.97
233_F236_R1.0610.97
135_I162_G1.0590.97
389_G393_G1.0540.97
339_A376_T1.0530.97
181_F225_I1.0530.97
192_G220_V1.0500.97
80_F84_V1.0500.97
228_A232_Q1.0500.97
385_T441_T1.0470.97
31_M367_I1.0430.97
393_G433_S1.0430.97
194_L256_G1.0410.97
422_Q425_L1.0380.96
184_T231_E1.0380.96
278_L324_P1.0360.96
234_I247_T1.0360.96
164_G193_I1.0330.96
139_T155_A1.0330.96
267_G271_S1.0330.96
331_M397_Q1.0300.96
338_G364_L1.0290.96
191_A255_T1.0290.96
8_H83_L1.0280.96
125_L176_N1.0250.96
262_V266_L1.0220.96
355_A365_L1.0180.96
80_F83_L1.0170.96
218_I222_F1.0160.96
163_S197_N1.0110.96
376_T382_P1.0110.96
78_A82_K1.0090.96
21_K84_V1.0070.96
285_G288_A1.0060.96
270_I273_A1.0060.96
117_K121_I1.0050.96
315_E319_S1.0040.96
7_Y71_G1.0040.96
300_L309_L1.0030.96
358_G362_S1.0020.96
71_G75_H1.0010.96
424_I428_V0.9990.96
347_T448_D0.9890.95
183_G188_G0.9850.95
71_G240_Q0.9820.95
338_G342_A0.9820.95
191_A220_V0.9810.95
291_F392_I0.9780.95
287_I399_Y0.9780.95
218_I267_G0.9780.95
372_I386_A0.9770.95
163_S167_T0.9690.95
102_D105_R0.9680.95
177_A221_L0.9620.95
343_V375_V0.9570.94
14_I52_L0.9550.94
290_G398_A0.9550.94
381_R447_K0.9520.94
400_F432_I0.9510.94
224_A228_A0.9500.94
356_I360_L0.9490.94
360_L364_L0.9480.94
324_P327_P0.9460.94
410_S414_L0.9440.94
58_V64_L0.9440.94
107_N113_L0.9400.94
74_N78_A0.9400.94
172_L190_L0.9370.94
332_G336_Q0.9370.94
205_L261_V0.9340.94
8_H82_K0.9300.94
120_S180_E0.9290.94
41_E64_L0.9280.94
382_P385_T0.9240.93
168_Y198_P0.9190.93
290_G294_G0.9140.93
213_G219_G0.9100.93
10_L14_I0.9080.93
182_G188_G0.9080.93
402_V429_G0.9060.93
335_G386_A0.9020.93
240_Q243_D0.9000.92
352_L448_D0.8970.92
16_E48_A0.8940.92
154_I157_I0.8930.92
235_R247_T0.8920.92
121_I221_L0.8900.92
299_P303_T0.8880.92
226_F255_T0.8840.92
11_A79_A0.8840.92
141_A145_A0.8820.92
171_I192_G0.8820.92
360_L363_G0.8820.92
368_G371_L0.8820.92
25_S37_T0.8800.92
339_A382_P0.8790.92
432_I436_A0.8770.91
393_G432_I0.8770.91
220_V224_A0.8730.91
382_P441_T0.8720.91
336_Q386_A0.8710.91
287_I395_A0.8640.91
410_S413_P0.8630.91
339_A386_A0.8620.91
334_A337_V0.8590.91
132_S164_G0.8580.91
46_A58_V0.8580.91
299_P383_F0.8530.90
161_I194_L0.8510.90
50_R378_P0.8450.90
173_V220_V0.8380.89
38_P64_L0.8350.89
290_G328_I0.8350.89
27_Y84_V0.8340.89
196_I214_R0.8330.89
67_I373_F0.8300.89
13_K17_L0.8290.89
433_S437_G0.8280.89
413_P416_F0.8280.89
18_C64_L0.8260.89
183_G231_E0.8250.89
121_I181_F0.8240.89
352_L375_V0.8230.89
174_G224_A0.8210.89
238_I242_L0.8200.88
160_V197_N0.8170.88
424_I427_I0.8160.88
392_I396_F0.8110.88
226_F230_T0.8100.88
49_L66_I0.8090.88
279_L283_D0.8080.88
349_K353_R0.8070.88
344_F353_R0.8070.88
330_A414_L0.8040.87
13_K53_D0.8020.87
230_T234_I0.7990.87
106_K113_L0.7970.87
281_I292_I0.7960.87
114_F117_K0.7930.87
172_L193_I0.7920.87
346_K442_Y0.7920.87
296_T387_C0.7890.86
60_E64_L0.7890.86
350_T353_R0.7890.86
343_V352_L0.7890.86
116_R120_S0.7890.86
273_A276_S0.7870.86
106_K110_P0.7850.86
263_F267_G0.7840.86
222_F263_F0.7770.86
100_K104_N0.7770.86
411_G416_F0.7770.86
331_M393_G0.7740.85
106_K109_T0.7720.85
411_G417_L0.7690.85
172_L189_A0.7690.85
41_E46_A0.7680.85
376_T386_A0.7670.85
146_G150_A0.7660.85
408_G417_L0.7650.85
75_H240_Q0.7640.85
254_I257_I0.7620.85
242_L365_L0.7600.84
44_A58_V0.7600.84
258_V263_F0.7590.84
238_I247_T0.7590.84
341_F345_V0.7580.84
410_S417_L0.7580.84
174_G220_V0.7560.84
397_Q402_V0.7560.84
15_L18_C0.7530.84
238_I250_V0.7520.84
105_R113_L0.7480.83
405_I409_V0.7460.83
187_L227_I0.7460.83
46_A49_L0.7450.83
14_I17_L0.7450.83
141_A144_Q0.7440.83
309_L313_H0.7440.83
434_Y437_G0.7420.83
47_Q51_K0.7420.83
343_V382_P0.7400.83
174_G192_G0.7390.83
230_T251_S0.7360.82
269_F272_D0.7360.82
442_Y446_Y0.7320.82
344_F356_I0.7280.82
44_A64_L0.7270.82
9_H53_D0.7270.82
402_V425_L0.7240.81
115_L377_L0.7240.81
133_G137_G0.7230.81
336_Q371_L0.7210.81
357_A362_S0.7200.81
406_A417_L0.7170.81
12_Q21_K0.7150.81
100_K103_I0.7130.80
375_V379_L0.7100.80
42_S45_D0.7100.80
224_A227_I0.7090.80
442_Y445_G0.7080.80
22_S43_K0.7060.80
68_L72_V0.7030.79
431_F435_A0.7010.79
335_G339_A0.7000.79
213_G264_M0.6980.79
441_T445_G0.6970.79
345_V442_Y0.6970.79
14_I18_C0.6940.79
336_Q368_G0.6940.79
135_I249_T0.6930.78
43_K51_K0.6930.78
389_G440_L0.6930.78
7_Y72_V0.6930.78
31_M410_S0.6920.78
109_T112_K0.6920.78
126_I411_G0.6830.77
8_H75_H0.6830.77
341_F438_F0.6830.77
16_E45_D0.6810.77
315_E318_N0.6810.77
111_F114_F0.6800.77
393_G429_G0.6770.77
308_G311_P0.6750.77
266_L270_I0.6750.77
78_A81_S0.6740.77
298_L332_G0.6730.76
174_G189_A0.6730.76
361_P365_L0.6700.76
89_G92_V0.6700.76
409_V413_P0.6690.76
39_Y43_K0.6670.76
381_R446_Y0.6660.76
22_S39_Y0.6660.76
408_G413_P0.6660.76
21_K86_A0.6660.76
231_E247_T0.6660.76
153_Q204_S0.6650.76
50_R57_G0.6650.76
251_S255_T0.6640.75
218_I302_V0.6640.75
188_G224_A0.6630.75
346_K448_D0.6630.75
30_C33_R0.6610.75
287_I291_F0.6600.75
50_R58_V0.6600.75
271_S305_L0.6590.75
298_L336_Q0.6590.75
117_K225_I0.6580.75
355_A361_P0.6550.75
175_I179_K0.6550.75
165_L172_L0.6550.75
239_P242_L0.6550.75
293_L300_L0.6540.74
81_S84_V0.6520.74
331_M433_S0.6520.74
335_G389_G0.6510.74
268_G272_D0.6510.74
136_T197_N0.6500.74
334_A434_Y0.6470.74
353_R357_A0.6470.74
48_A52_L0.6470.74
154_I206_F0.6460.73
276_S279_L0.6450.73
356_I361_P0.6450.73
129_L378_P0.6440.73
415_S427_I0.6430.73
51_K351_T0.6410.73
167_T214_R0.6400.73
275_T309_L0.6380.73
301_V336_Q0.6380.73
349_K448_D0.6370.72
363_G368_G0.6330.72
39_Y86_A0.6320.72
122_F311_P0.6310.72
200_I260_Y0.6310.72
357_A361_P0.6300.72
204_S208_E0.6300.72
384_L387_C0.6280.71
10_L68_L0.6280.71
10_L13_K0.6270.71
378_P382_P0.6270.71
338_G433_S0.6250.71
82_K85_S0.6240.71
81_S85_S0.6230.71
296_T299_P0.6220.71
134_L137_G0.6210.71
137_G290_G0.6190.70
134_L200_I0.6180.70
411_G414_L0.6180.70
414_L418_V0.6180.70
36_I64_L0.6180.70
444_F448_D0.6150.70
136_T167_T0.6150.70
346_K381_R0.6150.70
11_A84_V0.6140.70
203_I207_G0.6140.70
316_L320_I0.6140.70
425_L432_I0.6120.69
156_I159_T0.6120.69
298_L383_F0.6120.69
274_I419_L0.6100.69
284_I288_A0.6100.69
30_C35_R0.6090.69
357_A365_L0.6090.69
114_F240_Q0.6080.69
305_L312_V0.6080.69
293_L328_I0.6080.69
165_L169_L0.6070.69
332_G390_A0.6070.69
18_C24_I0.6070.69
34_L68_L0.6070.69
109_T113_L0.6060.69
392_I395_A0.6060.69
298_L372_I0.6050.69
388_L391_G0.6040.68
161_I255_T0.6030.68
183_G228_A0.6030.68
394_G398_A0.6010.68
390_A394_G0.6010.68
129_L307_Q0.5980.68
15_L21_K0.5980.68
295_A298_L0.5970.68
339_A441_T0.5960.67
431_F439_L0.5950.67
340_A376_T0.5950.67
333_G368_G0.5950.67
230_T258_V0.5940.67
410_S418_V0.5930.67
17_L51_K0.5930.67
12_Q24_I0.5920.67
178_S227_I0.5920.67
103_I106_K0.5910.67
57_G303_T0.5910.67
129_L165_L0.5900.67
277_G281_I0.5900.67
166_F169_L0.5870.66
13_K55_V0.5870.66
244_I247_T0.5860.66
276_S280_S0.5860.66
39_Y92_V0.5860.66
17_L44_A0.5850.66
332_G368_G0.5840.66
10_L76_V0.5840.66
126_I366_G0.5830.66
280_S286_G0.5830.66
376_T383_F0.5820.66
402_V423_I0.5810.65
11_A82_K0.5800.65
294_G391_G0.5800.65
182_G185_P0.5770.65
7_Y76_V0.5770.65
343_V379_L0.5760.65
164_G194_L0.5760.65
407_I414_L0.5760.65
258_V262_V0.5760.65
430_L433_S0.5750.65
145_A148_L0.5750.65
44_A66_I0.5740.65
22_S91_D0.5730.64
355_A362_S0.5720.64
173_V177_A0.5700.64
272_D319_S0.5670.64
404_T417_L0.5670.64
154_I205_L0.5660.63
126_I130_V0.5630.63
432_I435_A0.5620.63
137_G328_I0.5610.63
415_S430_L0.5610.63
303_T373_F0.5590.63
381_R448_D0.5590.63
204_S209_E0.5590.63
293_L309_L0.5580.62
71_G74_N0.5570.62
291_F294_G0.5570.62
184_T235_R0.5560.62
131_A249_T0.5560.62
17_L47_Q0.5550.62
323_D327_P0.5540.62
313_H323_D0.5540.62
444_F449_E0.5540.62
325_L329_L0.5520.62
362_S365_L0.5520.62
43_K66_I0.5520.62
41_E44_A0.5520.62
138_I141_A0.5510.61
128_A190_L0.5500.61
342_A441_T0.5500.61
346_K349_K0.5500.61
80_F85_S0.5490.61
24_I81_S0.5490.61
157_I203_I0.5480.61
219_G264_M0.5480.61
127_P130_V0.5480.61
310_T314_M0.5480.61
278_L312_V0.5480.61
339_A385_T0.5470.61
226_F229_Y0.5470.61
10_L17_L0.5470.61
105_R108_A0.5450.61
153_Q392_I0.5440.60
346_K447_K0.5440.60
301_V332_G0.5440.60
222_F225_I0.5420.60
295_A387_C0.5420.60
294_G394_G0.5420.60
413_P418_V0.5420.60
153_Q203_I0.5420.60
182_G231_E0.5410.60
31_M244_I0.5410.60
382_P386_A0.5410.60
81_S88_E0.5400.60
143_I155_A0.5380.60
167_T197_N0.5370.59
191_A223_A0.5370.59
297_F328_I0.5360.59
12_Q79_A0.5340.59
363_G371_L0.5330.59
164_G190_L0.5320.59
292_I296_T0.5310.59
121_I177_A0.5310.59
358_G361_P0.5310.59
158_L206_F0.5300.58
355_A358_G0.5300.58
43_K49_L0.5290.58
363_G372_I0.5290.58
416_F419_L0.5280.58
343_V376_T0.5280.58
85_S89_G0.5280.58
38_P60_E0.5270.58
352_L356_I0.5260.58
231_E235_R0.5260.58
207_G210_L0.5260.58
183_G251_S0.5250.58
340_A344_F0.5240.58
83_L86_A0.5230.57
67_I303_T0.5230.57
234_I237_F0.5230.57
7_Y79_A0.5230.57
332_G372_I0.5210.57
147_W152_S0.5200.57
42_S49_L0.5190.57
389_G392_I0.5190.57
266_L269_F0.5180.57
10_L49_L0.5180.57
167_T198_P0.5170.57
185_P224_A0.5170.57
333_G411_G0.5160.56
351_T354_K0.5140.56
153_Q156_I0.5140.56
289_A323_D0.5140.56
334_A430_L0.5140.56
332_G386_A0.5130.56
445_G448_D0.5130.56
121_I137_G0.5120.56
182_G224_A0.5120.56
383_F386_A0.5110.56
7_Y240_Q0.5110.56
293_L329_L0.5100.56
210_L261_V0.5090.55
371_L376_T0.5090.55
356_I363_G0.5090.55
364_L434_Y0.5080.55
177_A256_G0.5070.55
275_T312_V0.5070.55
357_A360_L0.5070.55
416_F420_P0.5060.55
139_T162_G0.5060.55
255_T258_V0.5060.55
175_I224_A0.5050.55
171_I174_G0.5040.55
68_L71_G0.5030.55
408_G414_L0.5030.55
409_V417_L0.5030.55
249_T252_L0.5020.54
314_M318_N0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.789 100 0.649 Contact Map
3ipjA 1 0.2044 100 0.802 Contact Map
1ibaA 1 0.167 99.9 0.806 Contact Map
3bp3A 1 0.1758 99.9 0.808 Contact Map
4n8nA 1 0.1165 46 0.973 Contact Map
4nejA 1 0.233 38.5 0.974 Contact Map
2h8eA 2 0.1978 37 0.975 Contact Map
4nv5A 1 0.1429 23.9 0.977 Contact Map
3u12A 2 0.1341 22.9 0.977 Contact Map
1kftA 1 0.1011 20 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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