GREMLIN Database
FRA - Intracellular iron chaperone frataxin
UniProt: Q797E6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 123 (122)
Sequences: 199 (143)
Seq/√Len: 12.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_I106_M3.9771.00
77_D105_K3.9581.00
30_K104_E3.4860.99
31_Y108_E3.1110.97
23_V62_L2.7720.94
110_N122_R2.5410.91
33_N47_D2.4770.90
35_H49_G2.2540.85
63_A90_I2.2140.84
83_Y92_I2.1810.83
84_D91_R2.0470.79
11_I16_H2.0030.78
20_T62_L1.9710.76
42_Q65_A1.9610.76
24_L27_I1.9270.75
60_K93_P1.9130.74
93_P96_G1.8880.73
42_Q55_F1.8100.70
68_K88_Q1.7250.66
75_E85_Y1.6410.62
47_D117_C1.6200.61
13_D16_H1.6160.61
71_I85_Y1.5210.56
86_T89_L1.4740.53
42_Q56_S1.4700.53
109_F115_A1.4460.52
31_Y103_L1.4450.52
44_M56_S1.4420.52
74_V85_Y1.3990.50
109_F113_D1.3850.49
31_Y85_Y1.3780.48
3_V10_G1.3600.48
24_L87_E1.3530.47
7_Y57_V1.3140.45
66_P94_W1.3080.45
45_F78_I1.2870.44
14_P89_L1.2690.43
3_V7_Y1.2540.42
31_Y74_V1.2530.42
65_A96_G1.2320.41
42_Q63_A1.2220.40
27_I55_F1.2150.40
5_S25_T1.2020.39
101_T104_E1.1820.38
8_L17_R1.1500.37
48_H117_C1.1390.36
53_I66_P1.1370.36
20_T71_I1.1160.35
47_D81_A1.1150.35
86_T115_A1.1090.35
17_R21_E1.0790.34
22_E97_P1.0690.33
107_I122_R1.0460.32
58_S87_E1.0400.32
26_W100_Y1.0240.31
4_F36_T1.0120.30
35_H100_Y0.9910.30
112_L115_A0.9880.29
58_S84_D0.9710.29
16_H80_K0.9680.29
63_A69_V0.9600.28
75_E79_V0.9530.28
68_K86_T0.9490.28
48_H116_D0.9430.28
79_V92_I0.9350.27
39_K63_A0.9300.27
92_I96_G0.9250.27
15_F96_G0.9210.27
59_K83_Y0.9130.26
109_F122_R0.9090.26
59_K122_R0.9040.26
92_I106_M0.9020.26
31_Y105_K0.9020.26
79_V85_Y0.8830.25
58_S88_Q0.8820.25
14_P38_I0.8790.25
45_F53_I0.8760.25
57_V62_L0.8720.25
33_N62_L0.8670.24
71_I75_E0.8650.24
57_V113_D0.8620.24
70_T106_M0.8610.24
59_K110_N0.8460.24
29_N70_T0.8460.24
13_D80_K0.8440.24
49_G116_D0.8430.24
65_A70_T0.8410.23
18_E39_K0.8390.23
37_E88_Q0.8370.23
65_A93_P0.8290.23
60_K63_A0.8260.23
23_V103_L0.8230.23
62_L68_K0.8110.22
64_V90_I0.8070.22
31_Y34_L0.7990.22
24_L105_K0.7910.22
50_T103_L0.7870.22
66_P109_F0.7840.21
72_A101_T0.7790.21
10_G30_K0.7700.21
78_I81_A0.7680.21
12_A73_H0.7640.21
6_E51_F0.7430.20
58_S64_V0.7380.20
68_K72_A0.7370.20
63_A87_E0.7360.20
10_G17_R0.7320.20
66_P113_D0.7300.20
72_A81_A0.7300.20
3_V38_I0.7270.19
110_N113_D0.7230.19
108_E112_L0.7160.19
68_K84_D0.7160.19
84_D90_I0.7140.19
5_S30_K0.7130.19
55_F94_W0.6950.18
9_A27_I0.6830.18
81_A116_D0.6790.18
12_A95_N0.6780.18
107_I110_N0.6760.18
83_Y99_D0.6750.18
40_W51_F0.6730.18
83_Y98_V0.6720.18
55_F119_T0.6710.18
16_H44_M0.6670.18
58_S116_D0.6620.17
47_D111_I0.6610.17
64_V103_L0.6580.17
87_E119_T0.6500.17
113_D122_R0.6480.17
78_I92_I0.6470.17
15_F37_E0.6450.17
54_G87_E0.6420.17
27_I74_V0.6390.17
12_A16_H0.6340.17
63_A88_Q0.6240.16
18_E73_H0.6220.16
76_D118_S0.6170.16
15_F83_Y0.6090.16
31_Y49_G0.6050.16
73_H84_D0.6030.16
16_H101_T0.6020.16
44_M65_A0.5960.16
27_I104_E0.5920.15
26_W104_E0.5910.15
17_R108_E0.5840.15
49_G98_V0.5830.15
54_G88_Q0.5820.15
112_L119_T0.5800.15
30_K37_E0.5760.15
42_Q88_Q0.5740.15
92_I98_V0.5730.15
36_T78_I0.5710.15
31_Y50_T0.5700.15
83_Y106_M0.5670.15
5_S80_K0.5630.15
37_E73_H0.5620.15
26_W103_L0.5590.15
81_A99_D0.5590.15
30_K76_D0.5520.14
51_F54_G0.5510.14
16_H112_L0.5500.14
29_N101_T0.5450.14
16_H72_A0.5400.14
112_L118_S0.5360.14
93_P116_D0.5350.14
36_T74_V0.5330.14
47_D116_D0.5320.14
66_P122_R0.5320.14
23_V90_I0.5270.14
80_K87_E0.5260.14
12_A41_N0.5250.14
85_Y99_D0.5240.14
31_Y36_T0.5240.14
74_V93_P0.5230.14
6_E14_P0.5210.14
12_A18_E0.5190.14
19_R62_L0.5190.14
85_Y90_I0.5180.14
8_L29_N0.5090.13
22_E109_F0.5020.13
22_E84_D0.5000.13
38_I86_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oc6A 1 1 100 0.542 Contact Map
2i8dA 2 0.9756 100 0.55 Contact Map
2kl4A 1 0.935 99.9 0.615 Contact Map
4hrrB 2 0.9024 17.2 0.954 Contact Map
3wctB 3 0.9106 15.5 0.955 Contact Map
3d3aA 1 0.9675 13.1 0.956 Contact Map
1b0bA 1 0.9024 12.7 0.956 Contact Map
2b9sA 1 0.7886 12 0.957 Contact Map
4hrrA 1 0.9024 11.5 0.957 Contact Map
3g46A 2 0.9024 10.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.