GREMLIN Database
YFNA - Uncharacterized amino acid permease YfnA
UniProt: Q797A7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (413)
Sequences: 24577 (15666)
Seq/√Len: 770.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_T359_G4.3651.00
340_L353_R4.2651.00
68_G264_T3.1981.00
395_V399_K3.0321.00
343_K353_R3.0311.00
250_K254_V3.0181.00
27_S246_K2.8481.00
345_H348_F2.7811.00
92_Y334_D2.7791.00
387_T420_A2.7461.00
245_V251_N2.7441.00
108_G331_M2.6651.00
247_N250_K2.5921.00
332_S342_A2.5521.00
201_G273_V2.5331.00
345_H352_F2.5001.00
162_A363_A2.4751.00
32_T258_S2.4631.00
340_L343_K2.4411.00
80_E397_R2.4231.00
243_E333_R2.4221.00
28_A258_S2.4061.00
300_A304_I2.3841.00
199_I203_G2.2511.00
96_Y104_A2.2481.00
356_W360_I2.2041.00
28_A251_N2.1821.00
329_F333_R2.1501.00
244_E326_R2.1451.00
28_A32_T2.1321.00
170_A174_R2.1301.00
169_T355_T2.1021.00
31_L245_V2.0971.00
166_L363_A2.0951.00
417_I421_G2.0891.00
161_A366_A2.0561.00
51_V60_L2.0261.00
177_K181_R2.0091.00
173_S352_F2.0081.00
412_V416_P1.9861.00
77_C390_S1.9731.00
390_S419_S1.9631.00
254_V258_S1.9621.00
96_Y101_E1.9521.00
22_L344_V1.9491.00
112_M358_T1.9441.00
188_L192_A1.9391.00
99_L395_V1.9371.00
27_S30_D1.9301.00
162_A366_A1.9221.00
335_G339_G1.9021.00
341_F357_L1.8791.00
69_L73_L1.8451.00
99_L391_I1.8251.00
447_L451_L1.8141.00
279_P282_K1.7991.00
291_F294_K1.7791.00
421_G425_W1.7741.00
30_D184_N1.7611.00
257_I261_A1.7571.00
123_A317_M1.7341.00
63_S224_S1.7291.00
166_L359_G1.7171.00
172_V318_L1.7171.00
95_S107_I1.7041.00
247_N251_N1.7011.00
282_K295_F1.6791.00
107_I388_V1.6731.00
411_F415_V1.6631.00
285_V291_F1.6551.00
441_W445_G1.6541.00
59_A221_V1.6501.00
35_G259_A1.6381.00
212_P215_P1.6341.00
173_S356_W1.6181.00
119_L362_A1.6101.00
32_T262_V1.6081.00
100_G103_L1.5961.00
165_I362_A1.5861.00
192_A196_L1.5761.00
26_L30_D1.5721.00
130_F160_P1.5531.00
241_A322_Y1.5381.00
395_V398_K1.5271.00
425_W429_S1.5141.00
345_H350_T1.4811.00
109_W445_G1.4731.00
193_I308_G1.4681.00
439_V443_A1.4671.00
414_V418_I1.4651.00
67_A228_V1.4651.00
247_N254_V1.4601.00
261_A265_V1.4541.00
353_R357_L1.4451.00
328_T354_N1.4351.00
191_I195_L1.4341.00
126_W310_I1.4181.00
174_R348_F1.4171.00
287_D291_F1.4151.00
75_A260_L1.4111.00
329_F344_V1.4071.00
169_T356_W1.4001.00
123_A165_I1.3991.00
324_Q358_T1.3981.00
23_A349_K1.3971.00
339_G343_K1.3961.00
162_A166_L1.3931.00
348_F352_F1.3911.00
391_I395_V1.3841.00
30_D180_T1.3831.00
285_V288_P1.3811.00
400_H403_I1.3781.00
22_L329_F1.3761.00
69_L418_I1.3681.00
325_V355_T1.3661.00
95_S388_V1.3651.00
401_P405_A1.3631.00
165_I359_G1.3621.00
88_S243_E1.3601.00
294_K302_A1.3571.00
339_G342_A1.3561.00
126_W164_I1.3451.00
248_P253_P1.3241.00
202_I273_V1.3241.00
99_L103_L1.3201.00
303_G307_V1.3001.00
251_N254_V1.2971.00
445_G448_V1.2921.00
26_L31_L1.2881.00
343_K352_F1.2821.00
26_L180_T1.2801.00
168_I317_M1.2761.00
85_I97_V1.2731.00
413_P417_I1.2721.00
46_V125_G1.2711.00
39_V263_C1.2711.00
75_A256_I1.2671.00
446_T450_F1.2661.00
205_V276_G1.2621.00
73_L418_I1.2551.00
70_A422_I1.2551.00
74_A390_S1.2541.00
28_A254_V1.2521.00
87_I93_S1.2511.00
291_F295_F1.2491.00
265_V269_A1.2481.00
98_T392_A1.2401.00
76_F257_I1.2401.00
59_A214_M1.2361.00
93_S97_V1.2361.00
198_I269_A1.2291.00
391_I420_A1.2241.00
84_S405_A1.2221.00
122_V316_V1.2201.00
328_T337_L1.2121.00
29_F33_L1.2071.00
171_I182_F1.2061.00
61_I272_L1.2051.00
87_I97_V1.2021.00
201_G277_M1.2001.00
416_P420_A1.1991.00
102_L452_Y1.1951.00
280_Y283_L1.1871.00
197_F201_G1.1861.00
411_F414_V1.1701.00
440_I444_V1.1681.00
158_N162_A1.1601.00
203_G208_D1.1591.00
424_L428_Y1.1551.00
77_C416_P1.1541.00
78_Y91_V1.1421.00
435_W438_F1.1381.00
112_M328_T1.1351.00
105_F109_W1.1311.00
419_S423_C1.1281.00
413_P416_P1.1211.00
183_N318_L1.1141.00
436_L440_I1.1071.00
92_Y330_A1.1061.00
423_C426_F1.1031.00
31_L255_G1.1011.00
36_I262_V1.0981.00
246_K251_N1.0981.00
159_L163_V1.0951.00
95_S103_L1.0941.00
433_V436_L1.0921.00
82_S94_Y1.0851.00
353_R356_W1.0781.00
52_A60_L1.0751.00
411_F416_P1.0701.00
205_V208_D1.0631.00
196_L200_V1.0631.00
156_V159_L1.0571.00
25_T246_K1.0551.00
428_Y432_G1.0551.00
35_G238_V1.0531.00
344_V349_K1.0481.00
181_R185_V1.0471.00
163_V167_L1.0451.00
434_T438_F1.0381.00
84_S403_I1.0371.00
420_A424_L1.0361.00
298_Q301_V1.0361.00
416_P423_C1.0361.00
182_F186_I1.0301.00
34_L241_A1.0291.00
433_V437_S1.0291.00
202_I206_K1.0281.00
203_G207_P1.0271.00
360_I364_G1.0201.00
127_S160_P1.0201.00
80_E83_S1.0171.00
36_I263_C1.0171.00
436_L439_V1.0151.00
169_T173_S1.0071.00
333_R342_A1.0061.00
448_V451_L1.0011.00
173_S350_T1.0011.00
102_L446_T0.9991.00
97_V400_H0.9981.00
294_K299_D0.9961.00
166_L170_A0.9921.00
387_T424_L0.9881.00
416_P429_S0.9861.00
130_F310_I0.9851.00
343_K346_P0.9851.00
437_S440_I0.9821.00
195_L199_I0.9721.00
414_V417_I0.9691.00
440_I443_A0.9691.00
191_I266_L0.9681.00
443_A447_L0.9671.00
394_I417_I0.9661.00
448_V452_Y0.9631.00
428_Y431_P0.9631.00
176_V322_Y0.9621.00
435_W439_V0.9581.00
297_G301_V0.9551.00
399_K403_I0.9521.00
425_W430_L0.9521.00
186_I315_T0.9511.00
387_T391_I0.9481.00
419_S422_I0.9481.00
422_I425_W0.9461.00
425_W428_Y0.9421.00
167_L314_T0.9411.00
233_L382_T0.9391.00
289_V293_L0.9341.00
203_G206_K0.9291.00
423_C427_M0.9271.00
65_I268_I0.9261.00
198_I273_V0.9251.00
236_D240_N0.9211.00
242_S252_M0.9171.00
402_E405_A0.9131.00
130_F134_L0.9131.00
258_S262_V0.9061.00
426_F430_L0.9031.00
399_K402_E0.9011.00
380_M438_F0.9001.00
403_I406_S0.8981.00
444_V447_L0.8971.00
352_F356_W0.8961.00
416_P419_S0.8951.00
68_G232_Y0.8921.00
321_L359_G0.8911.00
121_A230_F0.8911.00
210_W215_P0.8891.00
109_W337_L0.8861.00
416_P422_I0.8861.00
299_D303_G0.8851.00
30_D181_R0.8831.00
61_I275_T0.8821.00
415_V419_S0.8791.00
393_V416_P0.8781.00
121_A375_A0.8781.00
22_L244_E0.8771.00
127_S161_A0.8771.00
407_F410_P0.8741.00
412_V415_V0.8741.00
83_S406_S0.8681.00
89_G92_Y0.8661.00
33_L184_N0.8641.00
160_P163_V0.8631.00
168_I318_L0.8621.00
209_N212_P0.8621.00
96_Y334_D0.8591.00
89_G93_S0.8591.00
441_W448_V0.8581.00
419_S430_L0.8551.00
264_T268_I0.8541.00
25_T177_K0.8511.00
272_L276_G0.8511.00
102_L106_L0.8501.00
197_F293_L0.8501.00
198_I202_I0.8501.00
223_L227_T0.8491.00
404_K408_R0.8421.00
214_M221_V0.8411.00
22_L326_R0.8381.00
126_W313_I0.8281.00
127_S157_F0.8281.00
168_I321_L0.8271.00
438_F442_I0.8261.00
217_G220_G0.8261.00
29_F184_N0.8261.00
40_I43_G0.8221.00
84_S406_S0.8221.00
341_F353_R0.8201.00
170_A173_S0.8201.00
377_L381_G0.8191.00
126_W314_T0.8151.00
190_K312_G0.8151.00
72_A76_F0.8141.00
425_W432_G0.8111.00
81_F393_V0.8111.00
28_A255_G0.8091.00
72_A257_I0.8081.00
62_I221_V0.8061.00
237_A323_A0.8041.00
222_I425_W0.7981.00
65_I69_L0.7971.00
434_T437_S0.7961.00
359_G363_A0.7951.00
422_I429_S0.7941.00
103_L388_V0.7941.00
415_V429_S0.7931.00
202_I269_A0.7921.00
416_P430_L0.7881.00
288_P292_A0.7881.00
287_D290_S0.7861.00
173_S345_H0.7821.00
337_L341_F0.7821.00
233_L386_F0.7801.00
95_S392_A0.7781.00
172_V355_T0.7771.00
73_L77_C0.7771.00
288_P291_F0.7751.00
181_R184_N0.7741.00
416_P432_G0.7741.00
165_I366_A0.7711.00
247_N253_P0.7681.00
279_P295_F0.7631.00
444_V448_V0.7601.00
73_L415_V0.7571.00
398_K413_P0.7541.00
394_I398_K0.7541.00
429_S432_G0.7531.00
158_N366_A0.7511.00
284_N287_D0.7501.00
394_I416_P0.7491.00
210_W275_T0.7481.00
412_V417_I0.7471.00
32_T255_G0.7461.00
131_Q157_F0.7441.00
445_G449_Y0.7421.00
413_P430_L0.7371.00
209_N215_P0.7361.00
57_G275_T0.7351.00
210_W276_G0.7311.00
441_W444_V0.7311.00
321_L325_V0.7291.00
346_P352_F0.7271.00
44_I270_V0.7261.00
174_R178_E0.7261.00
447_L450_F0.7261.00
40_I190_K0.7221.00
98_T395_V0.7211.00
419_S429_S0.7201.00
180_T184_N0.7201.00
173_S348_F0.7201.00
39_V259_A0.7201.00
418_I421_G0.7201.00
412_V429_S0.7181.00
81_F94_Y0.7181.00
393_V397_R0.7151.00
284_N291_F0.7131.00
62_I65_I0.7121.00
258_S261_A0.7121.00
124_T374_L0.7101.00
205_V273_V0.7071.00
392_A396_L0.7071.00
120_S374_L0.7071.00
62_I66_L0.7051.00
405_A408_R0.7021.00
84_S401_P0.7021.00
66_L225_A0.7001.00
118_A122_V0.6971.00
449_Y452_Y0.6971.00
162_A367_G0.6971.00
381_G385_A0.6961.00
284_N288_P0.6951.00
37_G187_V0.6941.00
277_M292_A0.6921.00
253_P256_I0.6911.00
218_M221_V0.6871.00
325_V354_N0.6871.00
172_V322_Y0.6871.00
120_S365_I0.6851.00
25_T176_V0.6841.00
418_I429_S0.6801.00
111_L115_Y0.6791.00
61_I65_I0.6771.00
29_F181_R0.6761.00
390_S420_A0.6761.00
78_Y389_I0.6761.00
417_I420_A0.6761.00
442_I446_T0.6761.00
114_E382_T0.6721.00
345_H349_K0.6721.00
168_I314_T0.6711.00
127_S130_F0.6701.00
427_M430_L0.6691.00
92_Y96_Y0.6671.00
360_I363_A0.6641.00
116_V361_V0.6621.00
341_F354_N0.6621.00
118_A378_V0.6621.00
332_S341_F0.6621.00
422_I426_F0.6611.00
326_R329_F0.6601.00
129_Y309_A0.6591.00
351_P354_N0.6581.00
164_I317_M0.6571.00
262_V266_L0.6571.00
180_T318_L0.6551.00
423_C430_L0.6531.00
220_G223_L0.6531.00
328_T357_L0.6521.00
433_V438_F0.6511.00
439_V442_I0.6501.00
40_I45_F0.6501.00
178_E181_R0.6491.00
110_D385_A0.6491.00
243_E329_F0.6481.00
100_G104_A0.6481.00
71_C235_F0.6481.00
239_S256_I0.6461.00
204_Y207_P0.6441.00
412_V419_S0.6411.00
269_A273_V0.6401.00
118_A121_A0.6401.00
166_L169_T0.6401.00
32_T35_G0.6391.00
130_F164_I0.6391.00
200_V298_Q0.6391.00
98_T396_L0.6381.00
58_P213_F0.6361.00
22_L25_T0.6341.00
25_T29_F0.6331.00
300_A303_G0.6331.00
218_M222_I0.6331.00
346_P349_K0.6321.00
173_S355_T0.6311.00
82_S239_S0.6301.00
340_L357_L0.6281.00
244_E351_P0.6261.00
75_A235_F0.6231.00
198_I270_V0.6231.00
176_V241_A0.6211.00
200_V204_Y0.6211.00
88_S329_F0.6211.00
44_I48_T0.6211.00
158_N161_A0.6201.00
80_E408_R0.6181.00
249_Q404_K0.6171.00
270_V274_L0.6151.00
132_S306_S0.6141.00
38_C319_A0.6141.00
413_P429_S0.6111.00
245_V252_M0.6111.00
79_A83_S0.6101.00
435_W442_I0.6101.00
82_S252_M0.6071.00
262_V265_V0.6071.00
175_G178_E0.6041.00
77_C419_S0.6031.00
387_T423_C0.6021.00
252_M256_I0.6001.00
122_V317_M0.5981.00
434_T441_W0.5971.00
415_V430_L0.5971.00
51_V228_V0.5961.00
426_F429_S0.5961.00
205_V277_M0.5941.00
370_N373_T0.5931.00
92_Y104_A0.5931.00
91_V240_N0.5931.00
64_F231_A0.5931.00
91_V236_D0.5921.00
420_A423_C0.5921.00
41_G267_Y0.5911.00
117_I377_L0.5901.00
340_L344_V0.5891.00
59_A213_F0.5891.00
411_F430_L0.5891.00
416_P431_P0.5881.00
80_E410_P0.5881.00
92_Y108_G0.5861.00
233_L236_D0.5861.00
60_L271_S0.5851.00
38_C320_L0.5851.00
115_Y320_L0.5851.00
35_G39_V0.5851.00
312_G315_T0.5831.00
74_A423_C0.5831.00
273_V276_G0.5821.00
120_S362_A0.5801.00
394_I413_P0.5801.00
56_A59_A0.5791.00
216_F219_K0.5791.00
371_L375_A0.5771.00
438_F443_A0.5751.00
442_I445_G0.5741.00
189_M308_G0.5741.00
38_C237_A0.5741.00
47_I375_A0.5731.00
51_V55_G0.5721.00
169_T321_L0.5701.00
416_P428_Y0.5701.00
397_R401_P0.5701.00
307_V311_I0.5661.00
443_A446_T0.5661.00
326_R351_P0.5661.00
116_V358_T0.5651.00
55_G224_S0.5631.00
324_Q328_T0.5631.00
167_L171_I0.5631.00
75_A79_A0.5631.00
420_A431_P0.5621.00
134_L137_F0.5611.00
420_A430_L0.5601.00
133_L307_V0.5601.00
441_W446_T0.5601.00
435_W448_V0.5591.00
270_V289_V0.5571.00
99_L392_A0.5571.00
50_T372_G0.5561.00
40_I266_L0.5561.00
222_I429_S0.5561.00
102_L449_Y0.5561.00
446_T449_Y0.5561.00
262_V269_A0.5541.00
80_E407_F0.5541.00
250_K253_P0.5531.00
214_M218_M0.5521.00
178_E182_F0.5521.00
209_N276_G0.5521.00
122_V125_G0.5511.00
210_W213_F0.5511.00
133_L306_S0.5501.00
61_I268_I0.5491.00
41_G45_F0.5491.00
421_G424_L0.5491.00
48_T271_S0.5481.00
418_I422_I0.5481.00
240_N323_A0.5471.00
184_N188_L0.5461.00
406_S410_P0.5461.00
125_G129_Y0.5461.00
179_S322_Y0.5441.00
44_I194_I0.5441.00
249_Q406_S0.5441.00
165_I363_A0.5441.00
36_I187_V0.5431.00
435_W440_I0.5391.00
48_T51_V0.5391.00
74_A236_D0.5381.00
22_L88_S0.5381.00
440_I447_L0.5371.00
412_V422_I0.5371.00
95_S104_A0.5351.00
110_D384_A0.5351.00
422_I430_L0.5341.00
401_P404_K0.5341.00
189_M193_I0.5341.00
164_I168_I0.5331.00
192_A195_L0.5321.00
67_A229_F0.5301.00
123_A168_I0.5301.00
29_F32_T0.5301.00
185_V188_L0.5291.00
396_L405_A0.5291.00
27_S177_K0.5291.00
114_E381_G0.5281.00
45_F194_I0.5271.00
183_N315_T0.5271.00
80_E84_S0.5261.00
189_M311_I0.5261.00
402_E408_R0.5251.00
372_G375_A0.5241.00
185_V189_M0.5231.00
427_M435_W0.5211.00
183_N190_K0.5211.00
67_A232_Y0.5201.00
236_D386_F0.5201.00
209_N214_M0.5201.00
36_I39_V0.5181.00
164_I314_T0.5171.00
61_I64_F0.5141.00
326_R344_V0.5131.00
436_L441_W0.5121.00
438_F441_W0.5121.00
416_P427_M0.5121.00
81_F98_T0.5111.00
116_V365_I0.5111.00
405_A409_V0.5111.00
245_V255_G0.5101.00
437_S441_W0.5101.00
79_A256_I0.5091.00
382_T385_A0.5081.00
248_P251_N0.5081.00
123_A127_S0.5071.00
412_V420_A0.5071.00
133_L310_I0.5051.00
120_S123_A0.5031.00
278_M282_K0.5031.00
352_F355_T0.5021.00
193_I304_I0.5021.00
357_L361_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8894 100 0.326 Contact Map
3giaA 1 0.9067 100 0.369 Contact Map
4djkA 2 0.8785 100 0.389 Contact Map
2jlnA 1 0.8872 99 0.854 Contact Map
3dh4A 3 0.872 98.6 0.873 Contact Map
2xq2A 2 0.885 98.3 0.885 Contact Map
4xp4A 1 0.9241 98.1 0.892 Contact Map
2a65A 2 0.9089 98 0.894 Contact Map
4wgvA 2 0.7766 97.6 0.903 Contact Map
4us3A 1 0.8612 97.4 0.906 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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