GREMLIN Database
YGAC - UPF0374 protein YgaC
UniProt: Q796Z1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (165)
Sequences: 456 (305)
Seq/√Len: 23.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_Y138_D5.5971.00
128_R138_D4.1991.00
118_I145_L3.1921.00
17_H104_Y3.0261.00
39_I167_W2.6390.99
114_M155_R2.3560.98
88_I141_L2.3090.97
151_W156_Q2.1950.97
95_D99_I2.0690.95
65_F101_Y1.9600.93
128_R135_K1.9560.93
21_I48_T1.9420.93
70_W91_P1.9340.93
108_V149_L1.8860.92
86_C148_L1.8800.92
45_T56_I1.8170.91
23_R49_E1.8110.90
33_S67_A1.8100.90
70_W86_C1.8070.90
47_V55_W1.7240.88
22_H158_P1.7060.87
157_G167_W1.6860.87
71_F151_W1.6690.86
46_M118_I1.6490.86
37_C66_H1.6430.85
88_I156_Q1.5910.83
22_H63_C1.5900.83
118_I121_E1.5870.83
40_G127_H1.5720.83
142_R146_N1.5530.82
15_Y93_A1.5410.81
68_R121_E1.5400.81
95_D100_K1.5360.81
125_D128_R1.5120.80
12_I65_F1.5100.80
124_Y142_R1.5000.80
42_N101_Y1.4870.79
25_W47_V1.4750.78
125_D161_P1.4750.78
141_L144_Y1.4270.76
144_Y147_T1.4150.75
65_F70_W1.4030.75
7_G61_A1.3950.74
138_D142_R1.3890.74
73_V84_Y1.3850.74
146_N153_H1.3850.74
15_Y100_K1.3780.73
33_S38_V1.3610.72
22_H29_T1.3540.72
135_K139_S1.3480.72
150_H154_Q1.3470.72
103_D107_D1.3440.71
17_H86_C1.3430.71
139_S153_H1.3420.71
105_D133_Y1.3350.71
13_H21_I1.3220.70
93_A137_I1.3200.70
49_E55_W1.3110.70
108_V152_I1.2990.69
121_E142_R1.2900.68
23_R55_W1.2860.68
105_D127_H1.2840.68
18_N130_A1.2790.68
160_A166_M1.2440.65
157_G161_P1.2290.64
67_A89_S1.2080.63
40_G122_D1.2010.63
49_E76_M1.1810.61
64_Y167_W1.1780.61
23_R76_M1.1400.58
131_M137_I1.1350.58
104_Y141_L1.1300.58
23_R45_T1.1290.58
10_I30_I1.1280.58
72_N86_C1.1270.58
116_Y153_H1.1160.57
127_H158_P1.1060.56
99_I102_I1.0970.55
114_M126_D1.0840.55
118_I146_N1.0780.54
95_D152_I1.0690.54
25_W55_W1.0590.53
94_Y99_I1.0550.53
63_C127_H1.0430.52
8_E143_D1.0370.51
120_D123_E1.0320.51
32_K134_P1.0210.50
14_S101_Y1.0120.49
107_D120_D0.9980.49
49_E52_G0.9910.48
81_G84_Y0.9900.48
102_I131_M0.9790.47
67_A121_E0.9750.47
16_K103_D0.9710.47
103_D120_D0.9640.46
122_D152_I0.9630.46
77_L97_E0.9520.45
45_T89_S0.9500.45
13_H100_K0.9410.45
23_R51_D0.9220.43
10_I99_I0.9200.43
95_D98_A0.9180.43
8_E139_S0.9160.43
85_Y120_D0.8930.41
55_W76_M0.8870.41
111_F137_I0.8850.41
61_A76_M0.8790.40
18_N131_M0.8780.40
21_I24_I0.8720.40
84_Y87_N0.8710.40
61_A74_I0.8570.39
18_N34_T0.8510.38
62_I127_H0.8480.38
108_V145_L0.8480.38
33_S170_R0.8410.38
59_E78_R0.8340.37
113_D154_Q0.8260.37
61_A81_G0.8160.36
106_L152_I0.8000.35
115_T156_Q0.7890.34
35_E108_V0.7810.34
23_R50_S0.7810.34
118_I122_D0.7770.34
33_S122_D0.7770.34
53_R60_P0.7770.34
12_I21_I0.7760.33
20_L142_R0.7740.33
41_A89_S0.7720.33
85_Y107_D0.7710.33
87_N107_D0.7690.33
53_R119_L0.7680.33
18_N96_G0.7650.33
57_T76_M0.7640.33
48_T162_E0.7600.32
47_V83_H0.7570.32
78_R109_K0.7560.32
39_I144_Y0.7540.32
109_K119_L0.7540.32
41_A71_F0.7520.32
126_D130_A0.7380.31
55_W60_P0.7380.31
139_S143_D0.7380.31
22_H45_T0.7260.30
36_M66_H0.7260.30
21_I27_E0.7250.30
10_I143_D0.7210.30
59_E74_I0.7200.30
11_Q89_S0.7160.30
39_I102_I0.7080.29
49_E104_Y0.7080.29
127_H168_Y0.7050.29
163_F167_W0.7040.29
16_K107_D0.6970.29
142_R153_H0.6870.28
8_E46_M0.6840.28
34_T94_Y0.6810.28
14_S22_H0.6800.28
86_C104_Y0.6800.28
61_A104_Y0.6800.28
48_T84_Y0.6780.28
135_K166_M0.6770.28
23_R119_L0.6760.27
39_I57_T0.6750.27
138_D141_L0.6690.27
66_H151_W0.6630.27
66_H167_W0.6620.27
85_Y123_E0.6580.26
150_H169_E0.6540.26
167_W170_R0.6500.26
18_N79_E0.6490.26
65_F100_K0.6490.26
123_E158_P0.6470.26
55_W82_V0.6450.26
31_L149_L0.6440.26
91_P101_Y0.6440.26
42_N45_T0.6410.26
41_A134_P0.6380.25
126_D135_K0.6370.25
76_M119_L0.6320.25
115_T154_Q0.6310.25
134_P158_P0.6280.25
57_T86_C0.6260.25
21_I72_N0.6240.25
70_W101_Y0.6240.25
44_R83_H0.6240.25
123_E127_H0.6220.25
150_H165_D0.6200.24
116_Y154_Q0.6190.24
44_R111_F0.6170.24
30_I73_V0.6140.24
57_T91_P0.6120.24
55_W72_N0.6090.24
96_G130_A0.6070.24
86_C91_P0.6070.24
52_G57_T0.6050.24
19_G105_D0.6050.24
92_F148_L0.6040.24
157_G163_F0.6010.23
126_D169_E0.5980.23
64_Y145_L0.5960.23
17_H70_W0.5920.23
14_S127_H0.5850.23
13_H54_T0.5850.23
6_E170_R0.5830.23
33_S62_I0.5810.22
69_Q147_T0.5800.22
124_Y141_L0.5780.22
57_T119_L0.5780.22
132_N169_E0.5770.22
18_N136_E0.5770.22
33_S36_M0.5770.22
62_I169_E0.5730.22
56_I126_D0.5710.22
10_I112_P0.5690.22
110_V148_L0.5690.22
25_W81_G0.5650.22
25_W123_E0.5650.22
6_E64_Y0.5630.22
56_I165_D0.5570.21
17_H57_T0.5570.21
20_L119_L0.5570.21
130_A154_Q0.5550.21
69_Q160_A0.5540.21
10_I38_V0.5520.21
72_N104_Y0.5500.21
63_C100_K0.5500.21
122_D129_K0.5460.21
64_Y163_F0.5460.21
12_I102_I0.5430.21
94_Y134_P0.5410.21
14_S63_C0.5400.21
35_E87_N0.5350.20
69_Q144_Y0.5350.20
136_E143_D0.5350.20
44_R79_E0.5340.20
83_H145_L0.5290.20
60_P72_N0.5270.20
25_W76_M0.5240.20
45_T90_S0.5240.20
27_E124_Y0.5200.20
25_W120_D0.5180.20
77_L87_N0.5160.19
134_P165_D0.5070.19
52_G91_P0.5050.19
17_H124_Y0.5030.19
38_V94_Y0.5030.19
28_T42_N0.5010.19
147_T150_H0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3exmA 1 0.9773 100 0.435 Contact Map
2p12A 2 0.9034 99.9 0.602 Contact Map
3l2hA 3 0.6648 21.4 0.95 Contact Map
1mrzA 2 0.75 20.8 0.95 Contact Map
3op1A 4 0.8182 20.2 0.951 Contact Map
3wg3A 2 0.7045 19.9 0.951 Contact Map
3kv5D 2 0.8807 16.6 0.953 Contact Map
2vb2X 1 0.1648 10.9 0.956 Contact Map
2kjgA 1 0.3295 10.1 0.957 Contact Map
3kxeA 2 0.233 8.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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