GREMLIN Database
YGAK - Uncharacterized FAD-linked oxidoreductase YgaK
UniProt: Q796Y5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (410)
Sequences: 18620 (14045)
Seq/√Len: 693.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_D167_D4.8051.00
156_E196_S4.0591.00
42_K156_E3.9311.00
53_R433_E3.7911.00
133_T197_M3.4581.00
87_K100_E3.3101.00
153_V200_K3.1861.00
56_R433_E3.0511.00
91_N94_K3.0211.00
86_K107_E2.9671.00
98_Y196_S2.8681.00
156_E170_T2.8671.00
111_T114_Q2.8301.00
98_Y198_T2.8071.00
117_L201_A2.7161.00
37_V48_A2.6921.00
157_M183_S2.6721.00
45_A195_T2.4981.00
218_D221_E2.4881.00
46_L168_L2.4091.00
100_E196_S2.3981.00
40_Q84_E2.3481.00
49_L59_F2.3001.00
154_Q170_T2.2921.00
92_Q115_Y2.2911.00
159_V167_D2.2841.00
103_A108_V2.2721.00
154_Q198_T2.2481.00
335_N338_V2.1991.00
160_A436_F2.1851.00
106_G110_R2.1351.00
51_W55_N2.1131.00
113_W204_I2.0861.00
88_I103_A1.9971.00
43_Q46_L1.9911.00
97_A108_V1.9741.00
390_T394_K1.9731.00
112_L201_A1.9461.00
38_F84_E1.9381.00
95_K117_L1.9331.00
156_E168_L1.9321.00
62_R65_R1.9291.00
104_E107_E1.9281.00
42_K46_L1.9211.00
43_Q47_N1.9131.00
269_K273_K1.8991.00
159_V169_I1.8821.00
40_Q44_D1.8671.00
157_M192_G1.8641.00
391_S394_K1.8561.00
42_K195_T1.8531.00
42_K168_L1.8471.00
85_M100_E1.8321.00
80_I193_I1.8271.00
45_A193_I1.8151.00
89_T98_Y1.8121.00
96_L198_T1.8071.00
182_A426_V1.7921.00
96_L153_V1.7851.00
155_L183_S1.7841.00
99_I129_L1.7491.00
172_S175_N1.7381.00
46_L50_K1.7331.00
47_N50_K1.7231.00
49_L436_F1.7201.00
425_R429_T1.7171.00
342_A394_K1.7081.00
82_L193_I1.6991.00
383_R387_G1.6991.00
379_R383_R1.6691.00
61_I193_I1.6631.00
90_V111_T1.6391.00
107_E110_R1.6381.00
97_A199_F1.6371.00
95_K203_P1.6341.00
134_L186_G1.6221.00
41_N44_D1.6091.00
261_K265_K1.6061.00
156_E195_T1.6021.00
421_E424_R1.5881.00
133_T152_L1.5741.00
134_L194_V1.5661.00
50_K53_R1.5631.00
52_A78_L1.5631.00
428_T434_N1.5491.00
111_T115_Y1.5251.00
390_T414_T1.5241.00
82_L85_M1.5191.00
407_E440_Q1.5171.00
151_S202_V1.5081.00
154_Q172_S1.5051.00
91_N96_L1.5031.00
421_E425_R1.4631.00
45_A158_I1.4591.00
51_W57_V1.4531.00
158_I195_T1.4511.00
183_S192_G1.4351.00
132_L148_T1.4281.00
88_I111_T1.4251.00
306_K310_S1.4241.00
422_R425_R1.4181.00
100_E103_A1.4171.00
345_G349_R1.4171.00
49_L53_R1.4141.00
133_T199_F1.3991.00
171_V176_H1.3961.00
37_V78_L1.3811.00
386_E390_T1.3731.00
424_R428_T1.3721.00
346_A349_R1.3561.00
99_I199_F1.3501.00
152_L155_L1.3491.00
171_V180_F1.3461.00
168_L195_T1.3421.00
160_A430_Y1.3401.00
427_K434_N1.3221.00
227_Q230_A1.3211.00
342_A345_G1.3161.00
240_S244_W1.3141.00
374_S377_E1.3141.00
225_T228_N1.3071.00
49_L193_I1.3061.00
419_N422_R1.3031.00
231_P234_D1.2991.00
220_E224_N1.2961.00
127_V132_L1.2871.00
382_V386_E1.2871.00
49_L158_I1.2871.00
338_V342_A1.2861.00
172_S176_H1.2831.00
50_K54_E1.2821.00
232_Y235_D1.2771.00
38_F81_D1.2771.00
412_P416_Y1.2761.00
110_R114_Q1.2721.00
86_K100_E1.2461.00
221_E224_N1.2361.00
45_A80_I1.2331.00
260_P263_E1.2301.00
87_K103_A1.2261.00
99_I108_V1.2211.00
39_C48_A1.2211.00
90_V97_A1.1961.00
380_Q383_R1.1891.00
286_P289_E1.1831.00
22_R25_I1.1811.00
226_W229_W1.1801.00
224_N228_N1.1751.00
39_C44_D1.1741.00
158_I168_L1.1741.00
263_E266_K1.1701.00
52_A59_F1.1671.00
270_P273_K1.1631.00
169_I176_H1.1581.00
420_V424_R1.1571.00
152_L184_Q1.1531.00
342_A395_E1.1461.00
46_L158_I1.1441.00
44_D47_N1.1441.00
97_A201_A1.1441.00
146_G150_D1.1441.00
239_S243_F1.1431.00
90_V117_L1.1421.00
265_K269_K1.1391.00
305_M308_S1.1391.00
349_R387_G1.1281.00
341_Q345_G1.1251.00
245_P248_V1.1231.00
220_E341_Q1.1121.00
183_S194_V1.1101.00
350_V387_G1.1101.00
159_V430_Y1.1041.00
21_A24_N1.1031.00
97_A112_L1.1021.00
325_K329_E1.1011.00
235_D349_R1.0951.00
172_S177_P1.0921.00
48_A78_L1.0911.00
236_R242_E1.0901.00
56_R435_V1.0871.00
272_L276_S1.0831.00
48_A80_I1.0831.00
425_R428_T1.0801.00
391_S395_E1.0771.00
59_F80_I1.0731.00
53_R435_V1.0731.00
241_I244_W1.0621.00
376_G379_R1.0561.00
411_W415_Y1.0431.00
63_G128_G1.0341.00
117_L203_P1.0301.00
412_P415_Y1.0211.00
133_T148_T1.0171.00
287_F290_A1.0161.00
387_G390_T1.0151.00
26_N29_L1.0081.00
285_T289_E1.0071.00
62_R79_V1.0021.00
289_E292_T1.0011.00
38_F83_S1.0001.00
327_F330_H0.9961.00
341_Q344_G0.9951.00
155_L180_F0.9871.00
240_S243_F0.9841.00
107_E111_T0.9771.00
59_F435_V0.9731.00
157_M169_I0.9701.00
35_I78_L0.9701.00
308_S311_F0.9691.00
181_W422_R0.9691.00
135_G402_N0.9651.00
130_T197_M0.9651.00
383_R386_E0.9651.00
231_P235_D0.9641.00
377_E380_Q0.9591.00
236_R239_S0.9591.00
82_L101_A0.9571.00
109_Y121_A0.9571.00
42_K158_I0.9561.00
186_G191_F0.9531.00
58_P77_G0.9521.00
324_I327_F0.9511.00
228_N232_Y0.9501.00
255_G258_V0.9491.00
323_T327_F0.9481.00
177_P190_N0.9471.00
269_K272_L0.9441.00
320_A323_T0.9441.00
310_S313_E0.9441.00
375_P378_K0.9421.00
286_P290_A0.9411.00
106_G125_A0.9401.00
34_D76_N0.9381.00
284_T290_A0.9371.00
171_V183_S0.9361.00
42_K100_E0.9331.00
266_K269_K0.9321.00
155_L197_M0.9291.00
294_F297_P0.9281.00
342_A391_S0.9261.00
326_H329_E0.9181.00
239_S244_W0.9091.00
170_T198_T0.9081.00
411_W416_Y0.9081.00
63_G82_L0.9051.00
251_I255_G0.9041.00
239_S242_E0.9011.00
105_L121_A0.9001.00
313_E317_S0.8971.00
182_A191_F0.8971.00
263_E267_L0.8951.00
400_Y405_D0.8941.00
325_K328_L0.8931.00
410_N413_R0.8901.00
344_G348_G0.8881.00
57_V78_L0.8871.00
346_A391_S0.8851.00
129_L199_F0.8841.00
105_L132_L0.8841.00
45_A82_L0.8831.00
21_A25_I0.8771.00
317_S320_A0.8731.00
223_Y227_Q0.8701.00
178_D181_W0.8691.00
152_L197_M0.8641.00
262_T266_K0.8591.00
345_G348_G0.8571.00
151_S200_K0.8521.00
284_T288_I0.8511.00
64_G128_G0.8511.00
226_W230_A0.8501.00
103_A107_E0.8491.00
67_S71_F0.8461.00
106_G126_N0.8461.00
324_I328_L0.8431.00
292_T295_N0.8421.00
284_T287_F0.8421.00
306_K309_G0.8411.00
62_R81_D0.8401.00
322_S326_H0.8391.00
291_V295_N0.8371.00
129_L197_M0.8371.00
236_R243_F0.8351.00
309_G313_E0.8351.00
83_S128_G0.8341.00
50_K167_D0.8341.00
288_I291_V0.8311.00
236_R240_S0.8311.00
222_V226_W0.8291.00
101_A197_M0.8271.00
173_C177_P0.8241.00
194_V197_M0.8211.00
45_A85_M0.8201.00
307_R310_S0.8201.00
303_Q307_R0.8171.00
238_T241_I0.8161.00
392_L396_T0.8151.00
237_L241_I0.8121.00
161_D169_I0.8111.00
86_K103_A0.8091.00
399_D402_N0.8071.00
63_G101_A0.8041.00
321_I324_I0.8011.00
237_L242_E0.8001.00
304_K308_S0.7991.00
47_N51_W0.7981.00
97_A111_T0.7961.00
351_A354_Q0.7931.00
39_C82_L0.7931.00
34_D77_G0.7911.00
219_F223_Y0.7901.00
74_L77_G0.7891.00
236_R241_I0.7871.00
96_L200_K0.7871.00
342_A346_A0.7851.00
170_T196_S0.7851.00
328_L331_A0.7851.00
238_T242_E0.7851.00
326_H330_H0.7841.00
238_T243_F0.7801.00
321_I328_L0.7781.00
390_T393_S0.7781.00
323_T326_H0.7771.00
254_L258_V0.7761.00
393_S414_T0.7751.00
91_N98_Y0.7751.00
290_A293_F0.7721.00
215_G218_D0.7721.00
116_G204_I0.7691.00
273_K276_S0.7681.00
39_C84_E0.7651.00
245_P249_N0.7651.00
160_A435_V0.7641.00
58_P437_R0.7621.00
155_L194_V0.7621.00
288_I292_T0.7621.00
174_S177_P0.7611.00
359_Y362_A0.7611.00
321_I325_K0.7601.00
36_I79_V0.7591.00
240_S250_R0.7571.00
42_K85_M0.7561.00
178_D429_T0.7541.00
283_K287_F0.7541.00
285_T290_A0.7511.00
153_V198_T0.7501.00
222_V225_T0.7501.00
105_L127_V0.7501.00
289_E293_F0.7501.00
412_P420_V0.7471.00
302_P306_K0.7471.00
293_F297_P0.7451.00
339_W342_A0.7431.00
307_R312_I0.7421.00
379_R382_V0.7421.00
427_K437_R0.7421.00
421_E428_T0.7411.00
385_I389_R0.7391.00
85_M195_T0.7391.00
43_Q168_L0.7381.00
375_P379_R0.7371.00
400_Y403_W0.7361.00
130_T134_L0.7331.00
61_I82_L0.7321.00
105_L108_V0.7311.00
438_F441_S0.7311.00
317_S321_I0.7311.00
133_T194_V0.7271.00
224_N227_Q0.7211.00
285_T288_I0.7201.00
53_R161_D0.7201.00
23_T27_L0.7181.00
180_F184_Q0.7171.00
222_V229_W0.7161.00
70_N74_L0.7121.00
83_S104_E0.7101.00
42_K45_A0.7081.00
154_Q196_S0.7071.00
319_R323_T0.7061.00
338_V341_Q0.7061.00
271_L275_G0.6991.00
49_L160_A0.6991.00
346_A350_V0.6971.00
155_L171_V0.6951.00
302_P309_G0.6941.00
136_G147_L0.6921.00
228_N231_P0.6901.00
147_L150_D0.6901.00
178_D426_V0.6881.00
267_L270_P0.6881.00
227_Q231_P0.6881.00
426_V430_Y0.6871.00
251_I256_Q0.6831.00
337_S341_Q0.6831.00
273_K277_P0.6831.00
118_T204_I0.6831.00
411_W414_T0.6821.00
39_C45_A0.6811.00
292_T296_S0.6781.00
303_Q308_S0.6761.00
95_K200_K0.6761.00
110_R113_W0.6761.00
398_G401_V0.6741.00
170_T175_N0.6741.00
307_R311_F0.6731.00
287_F294_F0.6731.00
253_A258_V0.6731.00
23_T30_E0.6731.00
27_L30_E0.6711.00
262_T265_K0.6691.00
119_L201_A0.6681.00
124_I127_V0.6671.00
162_E167_D0.6651.00
108_V129_L0.6651.00
223_Y226_W0.6641.00
350_V383_R0.6621.00
112_L115_Y0.6621.00
272_L275_G0.6611.00
318_E322_S0.6611.00
285_T293_F0.6581.00
283_K289_E0.6571.00
304_K307_R0.6571.00
302_P310_S0.6561.00
210_F255_G0.6551.00
387_G391_S0.6551.00
378_K382_V0.6541.00
318_E324_I0.6541.00
237_L240_S0.6541.00
90_V115_Y0.6521.00
302_P307_R0.6511.00
302_P308_S0.6501.00
249_N252_E0.6491.00
317_S322_S0.6491.00
313_E316_L0.6481.00
33_P79_V0.6481.00
46_L49_L0.6471.00
252_E255_G0.6461.00
223_Y229_W0.6451.00
90_V201_A0.6441.00
109_Y118_T0.6431.00
302_P305_M0.6421.00
122_G132_L0.6411.00
88_I99_I0.6411.00
376_G380_Q0.6391.00
108_V119_L0.6391.00
281_M284_T0.6381.00
305_M311_F0.6371.00
339_W343_L0.6361.00
303_Q306_K0.6351.00
25_I29_L0.6351.00
253_A256_Q0.6351.00
67_S72_S0.6341.00
176_H430_Y0.6331.00
251_I258_V0.6331.00
286_P293_F0.6321.00
372_W378_K0.6321.00
225_T229_W0.6321.00
91_N95_K0.6301.00
374_S378_K0.6301.00
291_V294_F0.6281.00
290_A297_P0.6281.00
268_L272_L0.6271.00
318_E321_I0.6271.00
21_A38_F0.6261.00
336_A341_Q0.6251.00
434_N437_R0.6221.00
219_F222_V0.6211.00
401_V404_P0.6211.00
416_Y419_N0.6201.00
282_V285_T0.6201.00
219_F230_A0.6191.00
301_Q307_R0.6191.00
220_E322_S0.6191.00
157_M171_V0.6181.00
399_D403_W0.6181.00
338_V395_E0.6181.00
321_I327_F0.6171.00
230_A234_D0.6161.00
305_M310_S0.6161.00
386_E389_R0.6141.00
208_S265_K0.6141.00
44_D48_A0.6091.00
60_R77_G0.6081.00
218_D229_W0.6061.00
389_R393_S0.6041.00
356_A359_Y0.6041.00
292_T297_P0.6031.00
301_Q304_K0.6021.00
191_F426_V0.6021.00
323_T328_L0.6011.00
223_Y230_A0.6001.00
104_E128_G0.6001.00
109_Y112_L0.5991.00
237_L243_F0.5981.00
105_L129_L0.5971.00
398_G403_W0.5951.00
39_C85_M0.5951.00
264_L268_L0.5951.00
309_G312_I0.5941.00
155_L184_Q0.5941.00
144_A236_R0.5931.00
181_W184_Q0.5931.00
218_D222_V0.5931.00
304_K310_S0.5921.00
409_R413_R0.5911.00
230_A233_T0.5901.00
228_N278_T0.5891.00
92_Q95_K0.5871.00
358_Y361_D0.5871.00
264_L267_L0.5851.00
291_V297_P0.5851.00
301_Q305_M0.5841.00
156_E198_T0.5811.00
89_T96_L0.5811.00
385_I388_L0.5791.00
20_E23_T0.5791.00
208_S264_L0.5791.00
405_D412_P0.5781.00
22_R30_E0.5771.00
220_E223_Y0.5761.00
281_M285_T0.5741.00
427_K431_D0.5741.00
283_K288_I0.5711.00
257_F264_L0.5711.00
336_A339_W0.5701.00
64_G104_E0.5681.00
42_K196_S0.5681.00
70_N73_L0.5671.00
287_F291_V0.5661.00
381_N385_I0.5661.00
320_A328_L0.5651.00
250_R257_F0.5641.00
270_P274_A0.5641.00
213_T252_E0.5641.00
89_T92_Q0.5641.00
179_L430_Y0.5621.00
389_R392_L0.5621.00
210_F213_T0.5611.00
142_T147_L0.5611.00
51_W78_L0.5601.00
266_K270_P0.5591.00
109_Y204_I0.5591.00
303_Q309_G0.5571.00
222_V227_Q0.5541.00
290_A296_S0.5531.00
319_R322_S0.5521.00
24_N27_L0.5501.00
340_Q344_G0.5491.00
35_I57_V0.5481.00
346_A387_G0.5461.00
71_F74_L0.5461.00
31_R75_N0.5461.00
283_K286_P0.5461.00
400_Y404_P0.5461.00
22_R36_I0.5461.00
109_Y113_W0.5421.00
284_T293_F0.5421.00
251_I257_F0.5401.00
399_D404_P0.5391.00
251_I254_L0.5371.00
260_P266_K0.5371.00
106_G124_I0.5361.00
412_P417_G0.5351.00
398_G404_P0.5341.00
294_F305_M0.5331.00
221_E225_T0.5331.00
236_R244_W0.5311.00
393_S396_T0.5311.00
283_K293_F0.5301.00
58_P438_F0.5301.00
253_A257_F0.5301.00
386_E410_N0.5281.00
269_K276_S0.5281.00
229_W233_T0.5281.00
304_K311_F0.5271.00
41_N85_M0.5261.00
99_I103_A0.5261.00
286_P291_V0.5251.00
397_M404_P0.5241.00
422_R429_T0.5241.00
413_R420_V0.5211.00
381_N384_W0.5211.00
392_L395_E0.5191.00
139_G142_T0.5191.00
363_I367_E0.5191.00
304_K309_G0.5181.00
210_F214_W0.5181.00
316_L320_A0.5171.00
59_F78_L0.5171.00
274_A277_P0.5160.99
175_N400_Y0.5150.99
99_I197_M0.5150.99
287_F293_F0.5140.99
46_L159_V0.5120.99
169_I422_R0.5110.99
305_M309_G0.5110.99
94_K334_Q0.5100.99
92_Q117_L0.5090.99
31_R73_L0.5090.99
173_C184_Q0.5080.99
284_T291_V0.5070.99
88_I100_E0.5070.99
22_R26_N0.5070.99
307_R313_E0.5060.99
186_G189_G0.5040.99
145_A202_V0.5030.99
353_D356_A0.5020.99
259_G263_E0.5020.99
418_E421_E0.5020.99
309_G315_P0.5020.99
315_P318_E0.5020.99
398_G402_N0.5020.99
25_I28_S0.5020.99
57_V77_G0.5010.99
252_E256_Q0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xloA 2 0.969 100 0.276 Contact Map
3vteA 1 0.9734 100 0.32 Contact Map
2bvfA 1 0.9512 100 0.32 Contact Map
4pvkA 1 0.9712 100 0.327 Contact Map
3popA 2 0.9623 100 0.328 Contact Map
4ud8A 1 0.9756 100 0.328 Contact Map
2ipiA 1 0.9623 100 0.331 Contact Map
2y3sA 2 0.969 100 0.332 Contact Map
4k3tA 4 0.9623 100 0.338 Contact Map
3rjaA 1 0.9712 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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