GREMLIN Database
HEMZ - Oxygen-independent coproporphyrinogen-III oxidase-like protein HemZ
UniProt: Q796V8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 501 (463)
Sequences: 557 (456)
Seq/√Len: 21.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
299_N303_K6.1481.00
351_E354_K5.1531.00
312_E316_E4.3821.00
341_G344_E4.1941.00
137_K144_D4.1571.00
299_N312_E4.0081.00
353_E401_E3.6121.00
205_L247_L3.5881.00
276_E323_Q3.4761.00
471_D474_S3.4551.00
245_D285_Y3.4041.00
134_A138_K3.3561.00
213_Q250_E3.3311.00
202_G243_E3.3091.00
356_M426_L3.3011.00
328_N359_S3.2251.00
175_I251_M3.2231.00
245_D284_K3.1571.00
313_E316_E3.0971.00
437_I444_I2.9140.99
206_W246_L2.9050.99
282_L287_I2.8950.99
335_I345_F2.8210.99
299_N311_V2.7880.99
360_L399_T2.7810.99
298_E347_H2.7540.99
152_E400_K2.7000.99
237_T266_V2.6790.99
210_Y480_E2.6490.98
128_S131_Q2.6290.98
301_T340_E2.6170.98
358_E429_Q2.5490.98
298_E344_E2.5480.98
210_Y483_T2.5130.98
276_E280_A2.4940.98
346_R350_S2.4830.98
212_M447_I2.4520.97
119_L132_A2.4450.97
322_R358_E2.4250.97
315_I351_E2.4210.97
469_P482_Y2.4030.97
129_K155_D2.3460.97
456_I463_I2.3200.96
95_N141_L2.2790.96
171_V226_V2.2620.96
437_I452_A2.2320.96
215_I447_I2.2230.95
204_F449_C2.2210.95
183_K190_P2.2060.95
248_Y264_I2.1710.95
403_G427_P2.1400.94
457_D462_K2.1390.94
314_T331_M2.0860.94
133_H148_M2.0830.94
200_R203_S2.0770.93
273_T472_P2.0410.93
481_H485_E2.0080.92
124_Q158_L1.9970.92
252_V285_Y1.9850.92
347_H351_E1.9840.92
241_A281_V1.9520.91
266_V282_L1.9400.91
292_I321_S1.9100.90
207_G476_N1.9080.90
457_D460_T1.8890.90
405_V427_P1.8840.89
479_F483_T1.8820.89
119_L136_L1.8810.89
482_Y485_E1.8750.89
249_E285_Y1.8560.89
241_A277_E1.8240.88
457_D464_T1.8180.88
133_H147_I1.8000.87
172_S442_Q1.7970.87
152_E405_V1.7890.87
231_F247_L1.7720.86
207_G479_F1.7630.86
478_R481_H1.7520.86
288_D327_N1.7500.86
333_L348_S1.7400.85
364_T388_V1.7290.85
227_T262_R1.7130.84
15_R19_N1.6930.84
290_I321_S1.6900.83
212_M254_S1.6630.82
469_P478_R1.6570.82
210_Y214_K1.6480.82
252_V264_I1.6340.81
364_T392_M1.6330.81
280_A284_K1.6230.81
446_G451_A1.6220.81
209_H246_L1.6190.81
301_T344_E1.6160.81
335_I395_A1.6150.81
377_K380_Y1.5990.80
321_S329_I1.5950.80
153_I156_R1.5880.79
172_S228_T1.5860.79
137_K147_I1.5760.79
300_E303_K1.5700.79
258_V261_I1.5640.78
214_K217_E1.5620.78
91_Y141_L1.5580.78
452_A467_A1.5560.78
466_F489_Y1.5520.78
22_N27_E1.5370.77
144_D147_I1.5170.76
194_I451_A1.5150.76
455_F489_Y1.5150.76
245_D281_V1.4930.75
343_K346_R1.4770.74
171_V219_L1.4610.73
227_T442_Q1.4400.72
399_T404_Y1.4390.72
208_L447_I1.4380.72
94_L105_Q1.4250.71
333_L352_T1.3900.69
348_S352_T1.3900.69
342_V394_D1.3900.69
297_Y352_T1.3850.69
473_K477_E1.3800.69
455_F490_L1.3540.67
480_E483_T1.3500.67
176_G207_G1.3470.67
14_H18_Q1.3430.67
345_F404_Y1.3370.66
15_R22_N1.3300.66
397_A401_E1.3250.66
297_Y314_T1.3250.66
446_G482_Y1.3240.66
333_L349_L1.3190.65
244_M281_V1.3060.64
431_S449_C1.3040.64
245_D249_E1.3030.64
468_N486_K1.2870.63
211_E486_K1.2730.62
455_F466_F1.2720.62
127_M131_Q1.2710.62
347_H350_S1.2620.62
170_E227_T1.2500.61
271_P309_H1.2240.59
203_S206_W1.2230.59
53_V57_G1.2210.59
15_R18_Q1.2140.59
160_A432_I1.2120.59
205_L209_H1.1970.58
360_L404_Y1.1760.56
155_D223_D1.1640.55
136_L142_I1.1630.55
248_Y252_V1.1590.55
182_T185_A1.1580.55
350_S353_E1.1580.55
315_I319_H1.1520.55
90_S118_L1.1480.54
136_L140_Y1.1410.54
94_L98_Q1.1350.53
190_P193_A1.1310.53
248_Y251_M1.1290.53
484_D487_I1.1200.52
387_E391_M1.1150.52
14_H19_N1.1130.52
213_Q253_R1.1040.51
352_T360_L1.0990.51
353_E360_L1.0960.51
431_S442_Q1.0960.51
119_L151_Q1.0940.51
119_L154_V1.0940.51
366_S415_I1.0940.51
193_A273_T1.0920.51
392_M419_L1.0870.50
315_I355_L1.0810.50
99_A125_S1.0810.50
292_I309_H1.0730.49
372_E376_N1.0680.49
22_N30_L1.0680.49
281_V285_Y1.0630.49
300_E401_E1.0620.49
157_Q409_L1.0600.48
204_F469_P1.0590.48
241_A244_M1.0510.48
349_L398_W1.0490.48
409_L437_I1.0440.47
171_V224_V1.0400.47
136_L150_M1.0350.47
261_I414_N1.0340.47
297_Y331_M1.0310.47
306_G309_H1.0310.47
220_K260_N1.0280.46
133_H151_Q1.0090.45
206_W209_H1.0080.45
136_L147_I1.0050.45
303_K308_H1.0020.45
364_T416_L0.9990.44
154_V348_S0.9950.44
217_E221_E0.9830.43
371_S374_T0.9830.43
227_T436_M0.9750.43
122_K135_E0.9730.43
209_H250_E0.9710.43
18_Q32_Y0.9710.43
119_L348_S0.9680.42
292_I358_E0.9640.42
150_M238_S0.9640.42
238_S449_C0.9630.42
476_N480_E0.9540.41
393_E397_A0.9520.41
237_T391_M0.9480.41
135_E139_D0.9430.41
19_N30_L0.9420.41
398_W402_H0.9400.41
242_E275_T0.9390.41
359_S476_N0.9380.40
12_R21_A0.9380.40
359_S414_N0.9360.40
114_R338_P0.9330.40
364_T438_M0.9320.40
399_T402_H0.9320.40
349_L394_D0.9310.40
42_I54_T0.9310.40
11_D14_H0.9260.40
425_S430_E0.9260.40
438_M467_A0.9230.40
147_I159_A0.9230.40
241_A245_D0.9210.39
48_Q51_E0.9200.39
201_V243_E0.9180.39
224_V467_A0.9170.39
132_A151_Q0.9170.39
116_T349_L0.9140.39
156_R405_V0.9090.39
148_M152_E0.9070.38
292_I374_T0.9020.38
26_E239_I0.9010.38
19_N22_N0.9010.38
300_E344_E0.9000.38
350_S394_D0.8950.38
109_I273_T0.8930.38
277_E280_A0.8910.37
133_H137_K0.8860.37
248_Y285_Y0.8860.37
144_D148_M0.8860.37
225_K260_N0.8840.37
466_F490_L0.8830.37
88_T96_L0.8800.37
23_L105_Q0.8780.37
37_P57_G0.8770.37
335_I391_M0.8770.37
316_E397_A0.8760.37
244_M282_L0.8740.36
99_A148_M0.8730.36
369_R414_N0.8720.36
335_I435_I0.8710.36
301_T471_D0.8690.36
209_H213_Q0.8670.36
194_I437_I0.8660.36
47_S53_V0.8660.36
279_L321_S0.8640.36
113_I147_I0.8630.36
172_S444_I0.8630.36
183_K192_Y0.8630.36
353_E399_T0.8590.36
171_V445_I0.8570.35
86_K113_I0.8550.35
176_G469_P0.8540.35
297_Y351_E0.8520.35
147_I258_V0.8510.35
340_E344_E0.8500.35
19_N32_Y0.8480.35
52_H56_S0.8460.35
452_A455_F0.8440.35
120_H430_E0.8430.35
266_V391_M0.8420.34
129_K151_Q0.8410.34
185_A373_M0.8390.34
113_I478_R0.8390.34
181_P211_E0.8350.34
371_S416_L0.8340.34
35_E45_A0.8340.34
424_Y432_I0.8340.34
14_H30_L0.8340.34
20_I32_Y0.8320.34
202_G246_L0.8280.34
132_A154_V0.8280.34
97_L211_E0.8240.33
322_R329_I0.8230.33
348_S362_V0.8230.33
157_Q296_S0.8220.33
449_C482_Y0.8210.33
467_A485_E0.8180.33
18_Q22_N0.8170.33
194_I201_V0.8160.33
279_L326_M0.8150.33
271_P306_G0.8130.33
197_Q200_R0.8130.33
327_N429_Q0.8130.33
213_Q254_S0.8090.33
156_R427_P0.8080.32
173_I243_E0.8070.32
223_D243_E0.8030.32
14_H22_N0.8030.32
42_I47_S0.8020.32
37_P46_L0.8010.32
153_I292_I0.8010.32
173_I419_L0.8000.32
171_V436_M0.7980.32
35_E49_T0.7980.32
243_E271_P0.7930.32
228_T436_M0.7900.31
146_K420_E0.7890.31
13_L93_Y0.7880.31
90_S110_L0.7860.31
20_I23_L0.7850.31
97_L264_I0.7840.31
220_K315_I0.7800.31
393_E396_V0.7800.31
219_L226_V0.7780.31
340_E471_D0.7770.31
86_K147_I0.7770.31
439_E456_I0.7760.31
130_E134_A0.7760.31
229_I260_N0.7730.30
148_M280_A0.7710.30
274_I281_V0.7710.30
247_L296_S0.7710.30
318_Y464_T0.7700.30
280_A324_H0.7680.30
367_F374_T0.7680.30
123_L154_V0.7670.30
120_H190_P0.7650.30
193_A379_K0.7610.30
350_S398_W0.7590.30
474_S478_R0.7590.30
243_E419_L0.7560.29
39_D49_T0.7550.29
118_L142_I0.7530.29
315_I359_S0.7520.29
248_Y281_V0.7510.29
257_D260_N0.7510.29
437_I467_A0.7510.29
116_T153_I0.7490.29
158_L162_P0.7480.29
176_G192_Y0.7450.29
174_Y336_G0.7440.29
304_A339_G0.7430.29
157_Q446_G0.7420.29
27_E69_T0.7410.29
177_I438_M0.7410.29
42_I53_V0.7410.29
219_L224_V0.7400.29
18_Q27_E0.7390.29
192_Y445_I0.7370.28
177_I364_T0.7370.28
98_Q104_T0.7360.28
315_I318_Y0.7320.28
273_T364_T0.7320.28
322_R357_P0.7310.28
50_D53_V0.7310.28
362_V395_A0.7300.28
41_V46_L0.7300.28
183_K436_M0.7300.28
335_I453_S0.7280.28
130_E354_K0.7270.28
30_L48_Q0.7250.28
168_K397_A0.7240.28
268_A349_L0.7220.28
476_N483_T0.7210.28
183_K373_M0.7190.27
47_S51_E0.7180.27
252_V258_V0.7170.27
335_I392_M0.7170.27
86_K344_E0.7170.27
46_L56_S0.7170.27
116_T439_E0.7160.27
248_Y287_I0.7150.27
128_S132_A0.7150.27
130_E138_K0.7150.27
200_R473_K0.7130.27
33_G52_H0.7130.27
241_A268_A0.7120.27
320_L324_H0.7110.27
171_V273_T0.7110.27
172_S431_S0.7100.27
118_L297_Y0.7090.27
238_S446_G0.7080.27
18_Q29_E0.7080.27
276_E324_H0.7080.27
210_Y479_F0.7070.27
268_A438_M0.7050.27
12_R42_I0.7040.27
395_A443_T0.7030.27
240_T243_E0.7030.27
347_H451_A0.7020.27
150_M453_S0.7020.27
447_I453_S0.7020.27
238_S317_K0.7020.27
358_E426_L0.7010.27
94_L204_F0.6950.26
346_R426_L0.6950.26
226_V255_F0.6940.26
443_T490_L0.6940.26
216_G415_I0.6930.26
169_D327_N0.6900.26
150_M364_T0.6880.26
116_T409_L0.6880.26
19_N90_S0.6870.26
395_A419_L0.6850.26
101_T409_L0.6850.26
457_D461_G0.6840.26
392_M438_M0.6840.26
156_R159_A0.6840.26
52_H55_V0.6830.26
341_G359_S0.6820.26
148_M277_E0.6780.25
173_I447_I0.6760.25
437_I456_I0.6750.25
340_E424_Y0.6750.25
100_H425_S0.6740.25
116_T288_D0.6720.25
57_G132_A0.6720.25
50_D55_V0.6720.25
297_Y322_R0.6710.25
461_G464_T0.6700.25
207_G210_Y0.6700.25
103_I273_T0.6680.25
238_S437_I0.6680.25
346_R394_D0.6670.25
251_M264_I0.6670.25
178_P422_V0.6660.25
25_Y101_T0.6650.25
31_A39_D0.6640.25
446_G449_C0.6630.25
93_Y96_L0.6630.25
223_D372_E0.6620.25
358_E431_S0.6610.24
53_V56_S0.6600.24
452_A465_H0.6580.24
147_I317_K0.6580.24
147_I151_Q0.6570.24
449_C469_P0.6560.24
154_V470_K0.6550.24
204_F367_F0.6540.24
229_I266_V0.6540.24
335_I394_D0.6530.24
179_F291_S0.6510.24
42_I57_G0.6500.24
271_P452_A0.6490.24
129_K133_H0.6490.24
212_M238_S0.6490.24
74_P77_T0.6480.24
33_G38_A0.6480.24
57_G100_H0.6480.24
239_I364_T0.6460.24
216_G220_K0.6450.24
211_E468_N0.6440.24
87_N139_D0.6440.24
120_H416_L0.6400.23
466_F485_E0.6400.23
359_S370_A0.6400.23
50_D71_F0.6390.23
478_R482_Y0.6390.23
314_T318_Y0.6380.23
129_K286_D0.6380.23
394_D398_W0.6380.23
248_Y300_E0.6370.23
252_V261_I0.6360.23
109_I141_L0.6350.23
245_D287_I0.6350.23
350_S390_Q0.6350.23
124_Q441_V0.6350.23
19_N23_L0.6320.23
370_A414_N0.6310.23
435_I439_E0.6300.23
182_T199_G0.6290.23
41_V71_F0.6290.23
345_F366_S0.6280.23
373_M415_I0.6260.23
160_A164_L0.6260.23
204_F431_S0.6250.23
48_Q55_V0.6250.23
478_R485_E0.6250.23
409_L415_I0.6230.23
22_N34_G0.6220.23
469_P481_H0.6210.23
318_Y327_N0.6210.23
292_I416_L0.6210.23
16_P23_L0.6200.23
458_R461_G0.6200.23
340_E360_L0.6180.22
46_L53_V0.6170.22
122_K132_A0.6170.22
175_I459_D0.6170.22
224_V474_S0.6160.22
13_L82_F0.6150.22
275_T281_V0.6150.22
172_S443_T0.6140.22
305_I317_K0.6140.22
150_M297_Y0.6140.22
388_V391_M0.6120.22
290_I359_S0.6120.22
182_T194_I0.6100.22
73_S99_A0.6100.22
185_A338_P0.6090.22
227_T430_E0.6080.22
39_D74_P0.6070.22
433_Y444_I0.6070.22
173_I226_V0.6040.22
117_K440_E0.6020.22
192_Y472_P0.6020.22
35_E39_D0.6010.22
93_Y352_T0.6010.22
46_L50_D0.6000.22
415_I436_M0.6000.22
111_T362_V0.5980.22
38_A50_D0.5980.22
178_P475_Y0.5970.21
203_S284_K0.5970.21
201_V482_Y0.5960.21
204_F482_Y0.5960.21
101_T251_M0.5950.21
168_K378_H0.5940.21
333_L345_F0.5930.21
193_A296_S0.5930.21
240_T281_V0.5910.21
33_G41_V0.5880.21
435_I488_K0.5880.21
204_F279_L0.5880.21
205_L390_Q0.5860.21
469_P472_P0.5860.21
34_G42_I0.5850.21
176_G201_V0.5850.21
268_A437_I0.5840.21
41_V57_G0.5840.21
160_A175_I0.5840.21
245_D252_V0.5830.21
36_E42_I0.5830.21
29_E53_V0.5830.21
30_L41_V0.5820.21
27_E42_I0.5810.21
296_S445_I0.5800.21
71_F134_A0.5800.21
192_Y301_T0.5800.21
195_Q212_M0.5790.21
35_E48_Q0.5790.21
168_K488_K0.5770.21
51_E54_T0.5770.21
145_E393_E0.5760.21
378_H382_V0.5760.21
42_I51_E0.5760.21
396_V424_Y0.5750.21
38_A41_V0.5750.21
191_A326_M0.5750.21
157_Q160_A0.5740.20
320_L323_Q0.5740.20
35_E99_A0.5730.20
148_M284_K0.5730.20
305_I309_H0.5730.20
36_E73_S0.5720.20
204_F321_S0.5710.20
291_S439_E0.5700.20
362_V399_T0.5690.20
182_T462_K0.5690.20
313_E490_L0.5690.20
31_A52_H0.5680.20
241_A275_T0.5660.20
14_H32_Y0.5660.20
176_G447_I0.5640.20
179_F321_S0.5630.20
323_Q397_A0.5630.20
105_Q273_T0.5620.20
18_Q30_L0.5620.20
46_L220_K0.5610.20
150_M298_E0.5610.20
441_V461_G0.5600.20
118_L132_A0.5600.20
177_I450_G0.5600.20
172_S227_T0.5600.20
144_D253_R0.5600.20
469_P485_E0.5590.20
195_Q202_G0.5590.20
188_T204_F0.5590.20
31_A42_I0.5590.20
202_G428_G0.5580.20
175_I447_I0.5570.20
438_M450_G0.5560.20
49_T89_I0.5560.20
328_N414_N0.5560.20
413_K439_E0.5550.20
345_F399_T0.5550.20
146_K418_N0.5550.20
449_C472_P0.5550.20
40_F51_E0.5540.20
16_P22_N0.5540.20
72_F484_D0.5530.20
49_T52_H0.5520.20
341_G378_H0.5520.20
309_H391_M0.5500.19
271_P391_M0.5500.19
394_D397_A0.5490.19
239_I450_G0.5490.19
465_H468_N0.5480.19
128_S323_Q0.5470.19
207_G244_M0.5470.19
191_A446_G0.5460.19
352_T367_F0.5440.19
292_I478_R0.5440.19
359_S425_S0.5430.19
48_Q53_V0.5430.19
211_E447_I0.5430.19
153_I340_E0.5430.19
183_K431_S0.5420.19
111_T273_T0.5420.19
118_L290_I0.5410.19
356_M403_G0.5410.19
471_D482_Y0.5400.19
21_A37_P0.5390.19
29_E40_F0.5390.19
150_M157_Q0.5390.19
177_I239_I0.5390.19
280_A445_I0.5370.19
271_P292_I0.5360.19
111_T418_N0.5360.19
157_Q193_A0.5360.19
243_E246_L0.5350.19
371_S377_K0.5350.19
300_E304_A0.5350.19
415_I418_N0.5340.19
12_R49_T0.5330.19
87_N116_T0.5330.19
94_L143_H0.5330.19
172_S436_M0.5330.19
239_I366_S0.5330.19
346_R453_S0.5320.19
171_V255_F0.5320.19
31_A50_D0.5320.19
35_E47_S0.5320.19
205_L250_E0.5320.19
150_M344_E0.5310.19
317_K324_H0.5300.19
120_H469_P0.5290.19
281_V367_F0.5290.19
33_G56_S0.5280.19
12_R39_D0.5270.18
370_A441_V0.5270.18
214_K483_T0.5270.18
387_E390_Q0.5250.18
30_L339_G0.5250.18
349_L399_T0.5230.18
467_A478_R0.5220.18
466_F473_K0.5220.18
40_F47_S0.5220.18
42_I49_T0.5210.18
371_S375_R0.5190.18
374_T377_K0.5180.18
82_F409_L0.5180.18
297_Y479_F0.5170.18
21_A33_G0.5170.18
49_T56_S0.5170.18
89_I259_K0.5160.18
292_I306_G0.5160.18
319_H354_K0.5160.18
36_E45_A0.5150.18
93_Y101_T0.5150.18
34_G45_A0.5120.18
299_N422_V0.5120.18
474_S489_Y0.5110.18
211_E449_C0.5100.18
53_V69_T0.5100.18
149_L422_V0.5090.18
116_T231_F0.5090.18
355_L418_N0.5080.18
432_I436_M0.5080.18
335_I474_S0.5080.18
194_I452_A0.5070.18
22_N29_E0.5060.18
370_A450_G0.5050.18
31_A48_Q0.5050.18
287_I297_Y0.5050.18
183_K474_S0.5040.18
210_Y213_Q0.5040.18
188_T367_F0.5030.18
349_L360_L0.5030.18
449_C465_H0.5030.18
51_E73_S0.5030.18
86_K185_A0.5020.18
198_A296_S0.5020.18
238_S243_E0.5020.18
89_I140_Y0.5020.18
264_I326_M0.5020.18
113_I392_M0.5010.17
485_E488_K0.5010.17
219_L445_I0.5010.17
402_H419_L0.5010.17
301_T360_L0.5000.17
47_S56_S0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oltA 1 0.6846 100 0.74 Contact Map
4r33A 2 0.6766 100 0.839 Contact Map
1r30A 2 0.6088 100 0.864 Contact Map
2yx0A 1 0.5749 99.9 0.875 Contact Map
4rtbA 2 0.7305 99.9 0.876 Contact Map
4wcxA 1 0.7006 99.9 0.876 Contact Map
4u0oB 1 0.517 99.9 0.877 Contact Map
3t7vA 1 0.6208 99.9 0.88 Contact Map
2qgqA 1 0.499 99.9 0.881 Contact Map
4jc0A 1 0.8044 99.9 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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