GREMLIN Database
YHJH - Uncharacterized HTH-type transcriptional regulator YhjH
UniProt: Q796S4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (137)
Sequences: 2193 (1778)
Seq/√Len: 151.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_P110_R2.7451.00
93_G114_A2.6081.00
96_H110_R2.5691.00
67_N70_S2.5361.00
148_A151_L2.5161.00
53_E92_A2.3611.00
98_T110_R2.3471.00
144_E154_D2.3351.00
141_T144_E2.3241.00
60_V66_I2.2841.00
77_T82_V2.1681.00
60_V95_L2.1321.00
99_Q107_V2.0411.00
147_F150_R1.9761.00
81_T84_R1.9491.00
86_S95_L1.9491.00
114_A117_K1.9441.00
87_T104_K1.9291.00
140_Y151_L1.8861.00
97_R104_K1.8421.00
67_N106_E1.8411.00
103_N106_E1.8291.00
113_P116_K1.8271.00
144_E150_R1.8091.00
122_H126_H1.7971.00
61_G119_H1.7481.00
100_L106_E1.7361.00
140_Y154_D1.7211.00
100_L103_N1.6171.00
63_N66_I1.6071.00
86_S90_L1.6031.00
116_K120_S1.6021.00
71_I109_F1.5641.00
68_V109_F1.5111.00
90_L97_R1.4991.00
56_V85_I1.4981.00
84_R88_K1.4461.00
55_H122_H1.4411.00
50_T53_E1.4321.00
56_V71_I1.4201.00
61_G116_K1.4161.00
66_I74_K1.3741.00
57_L119_H1.3731.00
57_L111_L1.3701.00
68_V86_S1.3351.00
78_T81_T1.3341.00
86_S109_F1.3301.00
139_R158_K1.3121.00
87_T97_R1.2951.00
78_T84_R1.2941.00
29_K33_S1.2871.00
100_L108_Y1.2781.00
39_L42_E1.2441.00
58_S80_A1.2111.00
69_T79_K1.1931.00
144_E147_F1.1801.00
55_H126_H1.1781.00
83_S87_T1.1401.00
69_T73_E1.1341.00
83_S103_N1.1271.00
61_G111_L1.1100.99
57_L61_G1.1010.99
59_C75_M1.0950.99
49_L94_F1.0920.99
139_R154_D1.0860.99
97_R107_V1.0820.99
143_E146_L1.0770.99
104_K107_V1.0720.99
67_N108_Y1.0600.99
124_Y128_K1.0600.99
146_L150_R1.0380.99
142_E146_L1.0350.99
34_D160_Y1.0050.99
100_L105_K1.0010.99
147_F151_L0.9900.99
128_K131_Q0.9820.99
68_V79_K0.9820.99
37_R41_V0.9630.98
70_S73_E0.9520.98
66_I70_S0.9450.98
150_R154_D0.9400.98
111_L115_G0.9390.98
68_V83_S0.9260.98
49_L54_I0.9010.98
23_K153_R0.9000.98
56_V75_M0.8880.97
27_L153_R0.8660.97
36_L40_D0.8650.97
99_Q104_K0.8650.97
50_T88_K0.8620.97
128_K132_R0.8570.97
52_T81_T0.8550.97
149_E153_R0.8460.97
120_S124_Y0.8300.96
113_P117_K0.8290.96
27_L149_E0.8240.96
64_E109_F0.8230.96
28_I31_F0.8220.96
117_K121_L0.8170.96
52_T85_I0.8140.96
127_Q131_Q0.8040.95
122_H125_Y0.7860.95
56_V82_V0.7850.95
63_N74_K0.7780.94
58_S62_D0.7750.94
117_K120_S0.7740.94
82_V90_L0.7710.94
150_R153_R0.7660.94
83_S106_E0.7630.94
87_T91_G0.7600.94
151_L154_D0.7590.94
123_K127_Q0.7590.94
59_C71_I0.7560.94
53_E68_V0.7460.93
80_A126_H0.7380.93
68_V82_V0.7370.93
94_F114_A0.7290.92
96_H112_T0.7270.92
38_K42_E0.7220.92
105_K109_F0.7140.92
143_E147_F0.7140.92
77_T84_R0.7090.91
65_P98_T0.7000.91
69_T81_T0.6970.91
53_E84_R0.6940.90
35_E39_L0.6890.90
116_K142_E0.6840.90
57_L94_F0.6800.89
55_H72_A0.6770.89
52_T56_V0.6720.89
145_I149_E0.6700.89
90_L109_F0.6690.89
64_E110_R0.6670.89
47_S121_L0.6610.88
69_T107_V0.6550.88
146_L157_T0.6500.87
29_K32_L0.6490.87
126_H130_E0.6480.87
84_R87_T0.6450.87
27_L34_D0.6400.86
48_Q114_A0.6370.86
59_C66_I0.6360.86
141_T145_I0.6360.86
37_R40_D0.6340.86
55_H58_S0.6310.86
27_L32_L0.6260.85
72_A79_K0.6170.84
69_T106_E0.6100.84
48_Q92_A0.6100.84
72_A81_T0.6090.84
53_E71_I0.6090.84
77_T85_I0.6030.83
27_L30_A0.5990.83
25_E29_K0.5990.83
34_D156_V0.5960.82
93_G96_H0.5960.82
138_D146_L0.5930.82
69_T72_A0.5920.82
97_R109_F0.5910.82
136_F148_A0.5840.81
149_E156_V0.5830.81
58_S69_T0.5830.81
84_R103_N0.5830.81
26_G33_S0.5800.81
55_H61_G0.5730.80
75_M80_A0.5720.80
30_A34_D0.5720.80
54_I125_Y0.5710.80
114_A157_T0.5700.79
77_T81_T0.5670.79
74_K128_K0.5650.79
42_E46_K0.5630.79
54_I122_H0.5600.78
50_T130_E0.5560.78
85_I88_K0.5500.77
87_T95_L0.5490.77
41_V119_H0.5430.76
35_E38_K0.5420.76
81_T152_F0.5410.76
116_K150_R0.5410.76
24_W33_S0.5390.76
81_T136_F0.5390.76
65_P108_Y0.5350.75
78_T126_H0.5350.75
78_T122_H0.5340.75
58_S119_H0.5320.75
23_K30_A0.5280.74
53_E78_T0.5270.74
140_Y148_A0.5270.74
153_R161_P0.5250.74
145_I158_K0.5220.73
124_Y127_Q0.5210.73
72_A78_T0.5200.73
59_C83_S0.5200.73
62_D120_S0.5190.73
52_T77_T0.5180.73
55_H107_V0.5180.73
62_D119_H0.5100.72
69_T90_L0.5100.72
148_A154_D0.5100.72
53_E88_K0.5090.71
23_K93_G0.5080.71
75_M82_V0.5080.71
83_S126_H0.5030.71
120_S146_L0.5010.70
149_E155_L0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lj9A 2 0.8229 99.9 0.461 Contact Map
2fbkA 2 0.8171 99.9 0.465 Contact Map
3oopA 2 0.7886 99.9 0.469 Contact Map
3nqoA 2 0.8914 99.9 0.469 Contact Map
3bj6A 2 0.8514 99.9 0.47 Contact Map
1s3jA 2 0.8057 99.9 0.471 Contact Map
4mnuA 2 0.8629 99.9 0.477 Contact Map
3s2wA 3 0.8514 99.9 0.477 Contact Map
4yifA 2 0.8057 99.9 0.478 Contact Map
3deuA 2 0.7486 99.9 0.478 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.