GREMLIN Database
YISV - Uncharacterized HTH-type transcriptional regulator YisV
UniProt: Q796Q6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 484 (375)
Sequences: 18896 (13075)
Seq/√Len: 675.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_S286_K3.4141.00
389_E464_L3.2231.00
437_R476_E2.9711.00
388_K392_D2.9331.00
209_V230_R2.8471.00
407_T420_T2.8111.00
274_E278_K2.7491.00
237_D276_R2.6181.00
197_Q201_I2.4951.00
469_T473_A2.4571.00
208_S256_Q2.3701.00
288_Q318_N2.3391.00
393_A468_E2.3071.00
147_Q369_E2.2831.00
189_V195_A2.2651.00
204_L229_M2.2651.00
175_K180_H2.2651.00
163_N365_W2.2531.00
433_E436_K2.2421.00
469_T472_K2.1991.00
284_S291_I2.1881.00
169_A372_S2.1731.00
171_A183_P2.1691.00
235_P245_L2.1641.00
340_G345_I2.1261.00
463_S466_D2.1121.00
285_K316_E2.0011.00
397_F472_K1.9501.00
396_H400_R1.9411.00
397_F471_I1.9201.00
126_L470_G1.9101.00
164_R168_E1.9081.00
325_F367_A1.8671.00
174_L339_A1.8521.00
247_S279_E1.8511.00
199_I320_L1.8481.00
245_L248_S1.8441.00
242_K245_L1.8241.00
395_V410_I1.8211.00
437_R473_A1.8191.00
165_Q368_A1.8131.00
278_K282_S1.8071.00
257_L292_I1.7581.00
393_A464_L1.7461.00
399_E408_W1.7431.00
395_V399_E1.7141.00
169_A172_D1.6991.00
273_S276_R1.6971.00
292_I322_L1.6791.00
279_E282_S1.6771.00
338_L348_L1.6761.00
245_L249_N1.6741.00
244_G279_E1.6731.00
401_Y472_K1.6721.00
282_S286_K1.6681.00
185_A342_E1.6591.00
243_A283_L1.6501.00
139_D143_R1.6481.00
395_V417_I1.6481.00
360_S363_S1.6471.00
145_F366_A1.6401.00
172_D372_S1.6391.00
394_A471_I1.6361.00
214_K235_P1.6251.00
161_K349_A1.6211.00
386_K389_E1.6181.00
393_A397_F1.6111.00
397_F468_E1.6101.00
427_V445_Y1.6101.00
250_R283_L1.5941.00
192_A322_L1.5921.00
165_Q372_S1.5831.00
296_A324_A1.5791.00
209_V232_R1.5761.00
394_A417_I1.5701.00
395_V408_W1.5421.00
274_E308_Q1.5361.00
243_A279_E1.5341.00
200_S224_F1.5331.00
168_E172_D1.5331.00
168_E183_P1.5321.00
369_E373_Q1.5321.00
303_E412_A1.5211.00
426_P429_R1.5201.00
441_V455_I1.5171.00
142_G146_Q1.5101.00
247_S251_K1.5081.00
181_V339_A1.5061.00
247_S287_E1.5011.00
433_E477_T1.4981.00
429_R433_E1.4861.00
170_V188_I1.4791.00
434_L474_A1.4761.00
161_K167_R1.4761.00
386_K464_L1.4671.00
250_R289_M1.4601.00
397_F400_R1.4551.00
274_E313_M1.4361.00
399_E410_I1.4341.00
284_S289_M1.4291.00
420_T454_S1.4281.00
214_K233_G1.4271.00
169_A368_A1.4211.00
282_S285_K1.4191.00
397_F475_A1.4121.00
224_F229_M1.4081.00
352_K356_D1.4051.00
335_I367_A1.3981.00
211_L234_L1.3961.00
320_L340_G1.3901.00
211_L255_G1.3791.00
429_R432_Y1.3681.00
210_I224_F1.3591.00
309_P312_A1.3241.00
386_K390_R1.3221.00
391_R395_V1.3161.00
209_V254_G1.3151.00
170_V186_I1.3041.00
239_E276_R1.3031.00
466_D469_T1.2931.00
199_I292_I1.2911.00
392_D396_H1.2741.00
418_W444_G1.2741.00
397_F401_Y1.2701.00
400_R475_A1.2691.00
194_Q356_D1.2661.00
206_R228_G1.2591.00
210_I257_L1.2591.00
146_Q151_G1.2581.00
396_H468_E1.2471.00
276_R279_E1.2441.00
182_S342_E1.2441.00
472_K476_E1.2441.00
166_L188_I1.2411.00
144_M369_E1.2391.00
179_I311_K1.2381.00
431_F441_V1.2301.00
200_S204_L1.2301.00
167_R171_A1.2261.00
283_L287_E1.2251.00
275_Q279_E1.2181.00
202_G351_I1.2181.00
369_E372_S1.2181.00
468_E472_K1.2141.00
203_L257_L1.2121.00
184_S342_E1.2091.00
143_R146_Q1.2061.00
211_L246_V1.2051.00
171_A186_I1.2041.00
186_I339_A1.2021.00
328_T376_Y1.2021.00
283_L289_M1.2001.00
464_L468_E1.1991.00
368_A372_S1.1841.00
278_K313_M1.1831.00
143_R147_Q1.1791.00
275_Q278_K1.1711.00
322_L338_L1.1691.00
195_A322_L1.1621.00
239_E273_S1.1611.00
400_R468_E1.1601.00
407_T422_H1.1591.00
170_V337_W1.1571.00
260_T280_I1.1501.00
165_Q365_W1.1471.00
221_L225_Q1.1441.00
401_Y475_A1.1441.00
381_T385_R1.1431.00
237_D242_K1.1401.00
220_S259_Y1.1391.00
347_R350_D1.1381.00
314_D317_G1.1331.00
202_G348_L1.1331.00
241_V258_L1.1261.00
164_R167_R1.1231.00
385_R388_K1.1191.00
154_S365_W1.1151.00
194_Q352_K1.1141.00
251_K287_E1.1121.00
308_Q313_M1.1091.00
164_R183_P1.1061.00
101_S205_K1.1051.00
176_G377_E1.1021.00
139_D142_G1.0991.00
323_G337_W1.0991.00
381_T384_R1.0961.00
394_A467_L1.0931.00
340_G348_L1.0931.00
205_K208_S1.0911.00
185_A345_I1.0891.00
140_T144_M1.0871.00
258_L289_M1.0861.00
135_L386_K1.0851.00
201_I227_A1.0841.00
199_I348_L1.0831.00
428_S445_Y1.0811.00
187_L345_I1.0801.00
301_W307_P1.0721.00
173_H377_E1.0681.00
374_G378_E1.0641.00
162_G167_R1.0631.00
187_L348_L1.0591.00
437_R477_T1.0571.00
138_A142_G1.0561.00
391_R459_Y1.0531.00
291_I310_L1.0481.00
204_L210_I1.0361.00
121_A438_Q1.0301.00
430_F455_I1.0301.00
426_P452_R1.0281.00
439_V474_A1.0261.00
209_V255_G1.0241.00
104_H107_N1.0211.00
320_L338_L1.0151.00
281_I313_M1.0111.00
224_F231_L1.0081.00
352_K359_S1.0061.00
281_I291_I1.0021.00
285_K315_H0.9991.00
345_I349_A0.9941.00
173_H299_D0.9901.00
303_E391_R0.9861.00
144_M148_I0.9801.00
190_S194_Q0.9751.00
131_L387_L0.9691.00
285_K318_N0.9641.00
163_N368_A0.9631.00
401_Y471_I0.9601.00
314_D318_N0.9581.00
234_L249_N0.9521.00
311_K321_Y0.9511.00
213_E265_H0.9451.00
174_L321_Y0.9441.00
393_A396_H0.9431.00
295_D298_G0.9411.00
192_A324_A0.9401.00
122_D438_Q0.9401.00
241_V276_R0.9401.00
234_L241_V0.9371.00
385_R389_E0.9321.00
434_L441_V0.9291.00
439_V473_A0.9291.00
290_P320_L0.9281.00
211_L249_N0.9271.00
301_W304_E0.9261.00
427_V453_N0.9191.00
120_R438_Q0.9181.00
346_E350_D0.9171.00
198_L348_L0.9171.00
290_P318_N0.9171.00
420_T453_N0.9131.00
222_H225_Q0.9121.00
171_A181_V0.9101.00
281_I319_I0.9091.00
430_F477_T0.9091.00
242_K276_R0.9031.00
220_S224_F0.9031.00
126_L467_L0.8991.00
433_E437_R0.8971.00
113_A116_Q0.8891.00
169_A371_L0.8871.00
240_G276_R0.8851.00
197_Q355_T0.8831.00
101_S104_H0.8811.00
394_A457_L0.8801.00
274_E306_P0.8791.00
168_E372_S0.8751.00
396_H399_E0.8731.00
141_I145_F0.8731.00
392_D410_I0.8731.00
281_I314_D0.8721.00
132_S390_R0.8701.00
431_F443_P0.8701.00
405_I422_H0.8661.00
172_D175_K0.8651.00
428_S432_Y0.8651.00
225_Q231_L0.8621.00
419_V457_L0.8591.00
444_G454_S0.8531.00
427_V443_P0.8511.00
325_F337_W0.8491.00
418_W454_S0.8451.00
247_S283_L0.8441.00
173_H177_K0.8421.00
406_A419_V0.8351.00
141_I148_I0.8351.00
236_M265_H0.8331.00
444_G447_Y0.8311.00
434_L477_T0.8301.00
200_S259_Y0.8281.00
148_I366_A0.8261.00
212_T224_F0.8251.00
165_Q168_E0.8221.00
173_H176_G0.8181.00
311_K314_D0.8141.00
329_V367_A0.8131.00
174_L337_W0.8131.00
430_F434_L0.8111.00
182_S185_A0.8091.00
193_L219_Q0.8081.00
250_R287_E0.8081.00
281_I310_L0.8031.00
190_S360_S0.8011.00
244_G248_S0.7981.00
110_I113_A0.7981.00
246_V283_L0.7881.00
195_A338_L0.7861.00
382_W385_R0.7851.00
439_V470_G0.7851.00
391_R410_I0.7811.00
243_A276_R0.7801.00
200_S227_A0.7761.00
473_A477_T0.7721.00
398_L408_W0.7691.00
473_A476_E0.7691.00
255_G289_M0.7671.00
427_V431_F0.7671.00
191_G334_R0.7661.00
211_L258_L0.7631.00
264_F413_G0.7571.00
394_A397_F0.7571.00
425_L430_F0.7561.00
435_L440_L0.7481.00
140_T143_R0.7471.00
142_G145_F0.7471.00
251_K255_G0.7461.00
190_S359_S0.7351.00
177_K298_G0.7321.00
204_L208_S0.7321.00
102_G105_R0.7321.00
246_V280_I0.7311.00
239_E275_Q0.7311.00
258_L283_L0.7301.00
393_A467_L0.7271.00
379_H383_V0.7261.00
309_P321_Y0.7261.00
235_P242_K0.7231.00
176_G299_D0.7201.00
265_H268_T0.7201.00
194_Q198_L0.7171.00
320_L344_V0.7151.00
401_Y405_I0.7131.00
277_R313_M0.7131.00
272_M277_R0.7121.00
469_T476_E0.7111.00
246_V258_L0.7111.00
110_I114_I0.7081.00
382_W386_K0.7071.00
187_L340_G0.7071.00
335_I359_S0.7051.00
342_E346_E0.7051.00
432_Y435_L0.7051.00
188_I335_I0.7021.00
406_A421_F0.7011.00
204_L257_L0.7011.00
427_V452_R0.6991.00
167_R183_P0.6991.00
290_P344_V0.6961.00
171_A182_S0.6941.00
140_T375_Y0.6921.00
145_F149_N0.6911.00
163_N361_G0.6901.00
125_R440_L0.6891.00
383_V387_L0.6891.00
210_I229_M0.6881.00
126_L457_L0.6861.00
142_G149_N0.6851.00
389_E393_A0.6841.00
422_H453_N0.6831.00
465_G468_E0.6821.00
391_R411_P0.6821.00
285_K314_D0.6811.00
378_E381_T0.6811.00
148_I369_E0.6791.00
377_E381_T0.6781.00
173_H298_G0.6771.00
472_K475_A0.6761.00
310_L319_I0.6751.00
158_E163_N0.6751.00
147_Q373_Q0.6741.00
103_I106_A0.6731.00
263_S295_D0.6731.00
397_F467_L0.6731.00
390_R464_L0.6721.00
462_A466_D0.6721.00
195_A336_G0.6691.00
188_I364_Q0.6671.00
303_E388_K0.6671.00
431_F435_L0.6661.00
106_A109_S0.6601.00
181_V185_A0.6591.00
145_F148_I0.6581.00
401_Y468_E0.6581.00
203_L290_P0.6571.00
105_R108_S0.6561.00
149_N369_E0.6541.00
196_L223_V0.6521.00
421_F455_I0.6511.00
244_G247_S0.6501.00
209_V253_Y0.6481.00
213_E241_V0.6481.00
258_L291_I0.6481.00
163_N364_Q0.6471.00
158_E361_G0.6471.00
200_S257_L0.6461.00
124_I462_A0.6461.00
432_Y436_K0.6461.00
258_L284_S0.6451.00
301_W306_P0.6451.00
124_I473_A0.6451.00
250_R284_S0.6451.00
316_E319_I0.6431.00
192_A296_A0.6411.00
102_G106_A0.6411.00
198_L352_K0.6391.00
201_I355_T0.6381.00
365_W369_E0.6351.00
314_D319_I0.6351.00
241_V272_M0.6331.00
241_V246_V0.6321.00
158_E358_G0.6311.00
308_Q312_A0.6311.00
212_T231_L0.6271.00
189_V336_G0.6271.00
129_G416_Y0.6261.00
196_L292_I0.6251.00
311_K319_I0.6241.00
274_E312_A0.6191.00
243_A280_I0.6181.00
103_I107_N0.6161.00
427_V455_I0.6141.00
123_I438_Q0.6121.00
398_L419_V0.6111.00
293_E310_L0.6081.00
302_F459_Y0.6061.00
379_H382_W0.6061.00
243_A247_S0.6051.00
107_N110_I0.6031.00
187_L349_A0.6031.00
109_S112_Q0.6011.00
389_E392_D0.6001.00
104_H108_S0.6001.00
327_K334_R0.5991.00
209_V251_K0.5981.00
281_I315_H0.5981.00
303_E410_I0.5971.00
238_D407_T0.5961.00
188_I359_S0.5961.00
237_D245_L0.5941.00
441_V457_L0.5931.00
144_M366_A0.5921.00
200_S229_M0.5901.00
420_T452_R0.5901.00
144_M147_Q0.5861.00
236_M270_T0.5851.00
272_M276_R0.5841.00
363_S366_A0.5821.00
238_D409_R0.5811.00
212_T233_G0.5811.00
335_I363_S0.5801.00
232_R249_N0.5781.00
378_E382_W0.5781.00
108_S112_Q0.5761.00
170_V325_F0.5741.00
248_S251_K0.5731.00
212_T221_L0.5731.00
431_F455_I0.5721.00
263_S271_V0.5721.00
341_P344_V0.5721.00
384_R388_K0.5721.00
272_M280_I0.5711.00
107_N111_I0.5711.00
326_S334_R0.5701.00
199_I322_L0.5671.00
197_Q227_A0.5671.00
122_D466_D0.5651.00
146_Q149_N0.5651.00
346_E349_A0.5651.00
394_A459_Y0.5651.00
157_Y327_K0.5651.00
365_W368_A0.5641.00
264_F301_W0.5641.00
375_Y378_E0.5621.00
297_Y416_Y0.5621.00
193_L217_Y0.5601.00
216_S221_L0.5601.00
198_L351_I0.5571.00
263_S277_R0.5571.00
343_P346_E0.5571.00
113_A432_Y0.5561.00
249_N253_Y0.5551.00
445_Y452_R0.5531.00
293_E321_Y0.5521.00
221_L233_G0.5511.00
405_I408_W0.5491.00
137_P140_T0.5481.00
260_T272_M0.5471.00
366_A369_E0.5471.00
179_I309_P0.5471.00
398_L406_A0.5471.00
421_F427_V0.5461.00
166_L170_V0.5461.00
199_I257_L0.5461.00
181_V311_K0.5451.00
425_L433_E0.5451.00
279_E283_L0.5441.00
201_I351_I0.5431.00
340_G344_V0.5431.00
295_D321_Y0.5431.00
409_R420_T0.5411.00
144_M375_Y0.5411.00
191_G336_G0.5411.00
380_L384_R0.5401.00
124_I469_T0.5401.00
427_V430_F0.5391.00
100_R103_I0.5391.00
387_L460_S0.5371.00
289_M318_N0.5371.00
280_I310_L0.5361.00
264_F297_Y0.5341.00
362_L366_A0.5331.00
140_T145_F0.5331.00
408_W417_I0.5321.00
359_S363_S0.5311.00
150_P153_L0.5301.00
102_G107_N0.5291.00
167_R184_S0.5281.00
361_G365_W0.5271.00
264_F271_V0.5261.00
197_Q223_V0.5261.00
168_E171_A0.5251.00
344_V348_L0.5240.99
209_V256_Q0.5240.99
281_I316_E0.5220.99
193_L223_V0.5210.99
338_L345_I0.5190.99
111_I115_N0.5190.99
420_T423_K0.5180.99
204_L256_Q0.5160.99
398_L471_I0.5160.99
145_F362_L0.5150.99
418_W456_R0.5130.99
373_Q377_E0.5130.99
200_S223_V0.5120.99
299_D328_T0.5120.99
217_Y294_D0.5110.99
439_V477_T0.5110.99
112_Q115_N0.5110.99
127_G440_L0.5100.99
250_R255_G0.5070.99
407_T423_K0.5070.99
284_S287_E0.5070.99
142_G148_I0.5060.99
398_L457_L0.5030.99
144_M370_W0.5030.99
124_I470_G0.5020.99
106_A110_I0.5020.99
298_G323_G0.5010.99
302_F388_K0.5010.99
232_R255_G0.5010.99
216_S236_M0.5000.99
171_A175_K0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tv7A 2 0.9339 100 0.316 Contact Map
3pplA 2 0.7996 100 0.404 Contact Map
3f6tA 2 0.8802 100 0.419 Contact Map
3qguA 2 0.7955 100 0.434 Contact Map
3ez1A 2 0.781 100 0.442 Contact Map
2r2nA 2 0.8058 100 0.45 Contact Map
4je5A 2 0.8202 100 0.45 Contact Map
1vp4A 2 0.8285 100 0.457 Contact Map
2x5fA 2 0.8244 100 0.461 Contact Map
3d6kA 2 0.7851 100 0.463 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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