GREMLIN Database
YITY - Uncharacterized FAD-linked oxidoreductase YitY
UniProt: Q796P5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (422)
Sequences: 18626 (14438)
Seq/√Len: 702.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_R202_D4.1211.00
54_E169_R3.9471.00
65_N464_D3.8261.00
147_L203_V3.5951.00
99_K113_Q3.4541.00
166_K206_E3.3161.00
68_N464_D3.0851.00
104_D107_K3.0641.00
111_R204_T3.0351.00
98_N120_D3.0261.00
111_R202_D2.9961.00
169_R179_T2.9831.00
124_Y127_P2.9021.00
352_E355_S2.8431.00
224_T227_D2.8041.00
49_V60_T2.7761.00
130_L207_L2.7201.00
170_L190_V2.7021.00
57_L201_L2.5431.00
61_V71_I2.5061.00
58_I177_I2.4831.00
113_Q202_D2.4671.00
167_S179_T2.4491.00
172_K176_M2.4191.00
116_A121_I2.3681.00
52_Q96_G2.3671.00
167_S204_T2.3371.00
173_A467_F2.2971.00
359_D426_K2.2561.00
119_N123_K2.2151.00
105_Q128_Y2.2031.00
54_E177_I2.1121.00
63_E67_K2.1111.00
100_I116_A2.0821.00
55_E58_I2.0601.00
226_S358_D2.0531.00
172_K178_I2.0231.00
117_T120_D2.0171.00
169_R177_I2.0161.00
126_N210_D2.0041.00
110_I121_I1.9991.00
170_L198_G1.9801.00
54_E58_I1.9531.00
50_K96_G1.9531.00
108_K130_L1.9441.00
97_Y113_Q1.9371.00
55_E59_D1.9271.00
92_L199_V1.9271.00
102_S111_R1.9161.00
109_T204_T1.9041.00
58_I62_K1.8871.00
54_E201_L1.8721.00
167_S181_T1.8611.00
168_F190_V1.8351.00
125_V207_L1.8291.00
109_T166_K1.8281.00
57_L199_V1.8041.00
52_Q56_M1.7871.00
189_A457_K1.7741.00
74_A77_Q1.7661.00
108_K209_D1.7601.00
53_E56_M1.7541.00
112_V143_I1.7471.00
110_I205_L1.7421.00
59_D62_K1.7311.00
61_V467_F1.7281.00
276_E279_E1.7201.00
423_V426_K1.7061.00
422_D426_K1.7041.00
73_I199_V1.6961.00
148_S193_G1.6941.00
94_M199_V1.6881.00
452_E455_F1.6611.00
103_L124_Y1.6591.00
456_Q460_T1.6511.00
169_R201_L1.6471.00
459_R465_E1.6251.00
147_L165_V1.6171.00
452_E456_Q1.5991.00
120_D123_K1.5981.00
124_Y128_Y1.5941.00
422_D446_Q1.5801.00
415_R419_R1.5791.00
366_D419_R1.5651.00
411_A415_R1.5591.00
64_A90_I1.5551.00
359_D423_V1.5501.00
61_V65_N1.5331.00
362_Q366_D1.5201.00
94_M97_Y1.5111.00
62_K65_N1.5061.00
227_D230_S1.5041.00
57_L171_L1.5021.00
100_I124_Y1.4831.00
63_E69_I1.4781.00
453_A456_Q1.4771.00
104_D109_T1.4721.00
349_P352_E1.4691.00
230_S234_K1.4631.00
359_D362_Q1.4531.00
409_D412_D1.4511.00
148_S200_I1.4511.00
164_T208_T1.4511.00
432_Y437_T1.4491.00
146_S161_L1.4271.00
26_E29_T1.4241.00
61_V199_V1.4231.00
165_V168_F1.4221.00
171_L201_L1.4211.00
147_L205_L1.4171.00
49_V90_I1.4151.00
173_A461_Y1.4151.00
112_V205_L1.4021.00
180_V183_K1.4001.00
226_S230_S1.4001.00
317_T320_S1.3861.00
455_F459_R1.3861.00
190_V198_G1.3661.00
177_I201_L1.3611.00
61_V171_L1.3541.00
113_Q116_A1.3521.00
298_W301_N1.3151.00
24_N29_T1.3151.00
270_Q273_S1.3111.00
289_A293_S1.3031.00
123_K127_P1.2971.00
62_K66_R1.2891.00
458_K465_E1.2811.00
133_K164_T1.2741.00
355_S359_D1.2701.00
451_S455_F1.2661.00
319_I323_N1.2641.00
359_D427_H1.2581.00
180_V187_F1.2501.00
171_L177_I1.2491.00
418_R422_D1.2481.00
57_L92_L1.2441.00
290_L294_R1.2401.00
297_E300_R1.2311.00
51_G56_M1.2271.00
98_N113_Q1.2261.00
110_I207_L1.2251.00
56_M59_D1.2241.00
450_K453_A1.2241.00
141_F146_S1.2231.00
51_G60_T1.2211.00
326_R330_K1.2131.00
223_S227_D1.2071.00
293_S297_E1.2061.00
300_R304_W1.1991.00
112_V121_I1.1981.00
367_E419_R1.1851.00
99_K116_A1.1841.00
50_K93_D1.1831.00
103_L110_I1.1751.00
301_N304_W1.1651.00
291_G295_R1.1641.00
60_T90_I1.1641.00
60_T92_L1.1531.00
64_A71_I1.1531.00
288_F291_G1.1511.00
308_Q311_F1.1441.00
414_A418_R1.1421.00
408_E411_A1.1421.00
165_V191_I1.1351.00
361_R365_S1.1291.00
27_Q30_A1.1271.00
283_T287_K1.1271.00
159_G163_D1.1251.00
412_D415_R1.1231.00
322_N325_M1.1201.00
65_N466_R1.1201.00
283_T286_T1.1061.00
58_I171_L1.0941.00
110_I125_V1.0881.00
287_K291_G1.0881.00
291_G294_R1.0871.00
276_E280_D1.0871.00
358_D362_Q1.0831.00
251_K255_K1.0831.00
122_Q135_M1.0781.00
323_N326_R1.0751.00
172_K461_Y1.0741.00
406_S409_D1.0731.00
71_I92_L1.0681.00
178_I183_K1.0631.00
256_D260_T1.0621.00
329_S333_E1.0611.00
325_M328_E1.0591.00
147_L161_L1.0551.00
168_F187_F1.0461.00
318_E322_N1.0461.00
190_V200_I1.0451.00
363_T419_R1.0411.00
103_L130_L1.0371.00
75_G142_T1.0371.00
290_L293_S1.0351.00
307_Q310_Y1.0291.00
188_T453_A1.0271.00
244_A247_S1.0271.00
120_D124_Y1.0201.00
328_E331_F1.0181.00
456_Q459_R1.0161.00
307_Q311_F1.0081.00
47_Q90_I1.0071.00
68_N466_R1.0071.00
284_G287_K1.0061.00
269_D272_S1.0041.00
243_L247_S0.9951.00
222_Y231_K0.9921.00
69_I90_I0.9901.00
407_K411_A0.9741.00
319_I322_N0.9731.00
363_T423_V0.9721.00
433_L436_M0.9681.00
354_G358_D0.9651.00
282_Y286_T0.9621.00
144_G203_V0.9621.00
50_K95_T0.9611.00
419_R422_D0.9591.00
356_Y360_L0.9581.00
322_N326_R0.9551.00
54_E113_Q0.9491.00
306_T310_Y0.9461.00
62_K176_M0.9441.00
226_S354_G0.9441.00
118_W135_M0.9401.00
54_E171_L0.9401.00
327_S331_F0.9381.00
445_R451_S0.9371.00
257_M260_T0.9361.00
30_A34_M0.9351.00
281_E284_G0.9331.00
304_W307_Q0.9331.00
250_K254_L0.9321.00
340_T343_L0.9301.00
431_Y434_P0.9291.00
46_K88_D0.9231.00
279_E282_Y0.9211.00
362_Q365_S0.9201.00
343_L346_Y0.9171.00
94_M114_S0.9171.00
185_D188_T0.9111.00
170_L178_I0.9061.00
305_D308_Q0.9051.00
189_A197_F0.9051.00
74_A91_V0.9041.00
33_E50_K0.9041.00
434_P437_T0.8991.00
104_D111_R0.8981.00
444_M448_Y0.8981.00
252_G255_K0.8951.00
321_R325_M0.8951.00
297_E301_N0.8911.00
164_T206_E0.8891.00
415_R418_R0.8871.00
30_A44_K0.8871.00
179_T204_T0.8851.00
278_K282_Y0.8841.00
380_Q383_E0.8821.00
284_G288_F0.8821.00
277_L280_D0.8781.00
355_S358_D0.8781.00
320_S323_N0.8761.00
119_N139_N0.8741.00
133_K208_T0.8741.00
74_A93_D0.8731.00
59_D63_E0.8731.00
347_F430_S0.8721.00
118_W146_S0.8711.00
70_K89_G0.8711.00
271_L275_S0.8691.00
254_L257_M0.8681.00
24_N50_K0.8671.00
76_A142_T0.8671.00
295_R298_W0.8611.00
71_I466_R0.8571.00
269_D273_S0.8561.00
296_Y300_R0.8551.00
130_L209_D0.8541.00
255_K263_V0.8531.00
324_V328_E0.8531.00
143_I205_L0.8501.00
330_K333_E0.8451.00
278_K281_E0.8441.00
243_L246_I0.8441.00
75_G94_M0.8421.00
31_T34_M0.8421.00
180_V190_V0.8411.00
241_M244_A0.8381.00
119_N140_I0.8371.00
241_M245_R0.8371.00
57_L94_M0.8351.00
242_H245_R0.8341.00
336_N339_N0.8331.00
423_V427_H0.8321.00
364_L368_D0.8321.00
25_S30_A0.8321.00
255_K258_Y0.8311.00
29_T32_S0.8311.00
79_S83_H0.8291.00
304_W308_Q0.8281.00
328_E332_L0.8271.00
31_T44_K0.8261.00
272_S275_S0.8241.00
35_T42_P0.8221.00
144_G148_S0.8191.00
143_I203_V0.8191.00
168_F203_V0.8171.00
75_G114_S0.8161.00
326_R329_S0.8141.00
54_E57_L0.8111.00
54_E97_Y0.8111.00
98_N116_A0.8091.00
165_V203_V0.8061.00
425_I446_Q0.8031.00
308_Q312_L0.8021.00
193_G197_F0.8011.00
116_A120_D0.8001.00
179_T202_D0.7971.00
166_K204_T0.7961.00
356_Y427_H0.7951.00
185_D460_T0.7941.00
432_Y435_Y0.7941.00
95_T142_T0.7931.00
287_K290_L0.7931.00
260_T264_L0.7921.00
228_Y233_V0.7921.00
355_S427_H0.7921.00
70_K468_M0.7921.00
200_I203_V0.7921.00
110_I124_Y0.7911.00
340_T344_Q0.7891.00
303_L308_Q0.7851.00
109_T206_E0.7841.00
327_S330_K0.7841.00
285_A291_G0.7831.00
26_E30_A0.7821.00
442_A445_R0.7801.00
320_S325_M0.7801.00
231_K234_K0.7771.00
304_W311_F0.7771.00
440_T443_Q0.7761.00
363_T366_D0.7761.00
57_L97_Y0.7721.00
118_W121_I0.7721.00
51_G94_M0.7701.00
234_K306_T0.7671.00
33_E48_T0.7671.00
374_I379_V0.7661.00
303_L306_T0.7651.00
260_T263_V0.7651.00
255_K260_T0.7651.00
25_S47_Q0.7631.00
367_E415_R0.7621.00
441_K445_R0.7601.00
419_R423_V0.7591.00
147_L200_I0.7491.00
262_Y265_A0.7481.00
294_R297_E0.7471.00
370_N373_N0.7461.00
359_D363_T0.7451.00
352_E427_H0.7441.00
252_G259_V0.7431.00
285_A293_S0.7421.00
286_T293_S0.7421.00
174_D178_I0.7421.00
325_M332_L0.7421.00
410_Q414_A0.7401.00
458_K468_M0.7371.00
229_F233_V0.7361.00
259_V262_Y0.7341.00
270_Q275_S0.7331.00
242_H247_S0.7281.00
221_N224_T0.7251.00
181_T184_D0.7251.00
282_Y285_A0.7221.00
65_N174_D0.7211.00
73_I94_M0.7211.00
213_Y216_K0.7181.00
425_I428_G0.7181.00
253_F258_Y0.7171.00
434_P438_Y0.7151.00
114_S203_V0.7131.00
168_F200_I0.7131.00
327_S333_E0.7121.00
224_T228_Y0.7091.00
51_G96_G0.7061.00
321_R324_V0.7061.00
369_L374_I0.7041.00
285_A288_F0.7031.00
131_A210_D0.7011.00
301_N305_D0.6991.00
325_M329_S0.6981.00
55_E177_I0.6951.00
317_T321_R0.6911.00
97_Y201_L0.6901.00
257_M261_N0.6881.00
452_E459_R0.6881.00
457_K461_Y0.6881.00
72_S89_G0.6871.00
407_K410_Q0.6861.00
95_T117_T0.6861.00
121_I143_I0.6841.00
30_A33_E0.6841.00
129_G210_D0.6801.00
290_L295_R0.6791.00
339_N343_L0.6781.00
118_W141_F0.6771.00
322_N329_S0.6761.00
277_L282_Y0.6761.00
48_T91_V0.6761.00
422_D425_I0.6761.00
411_A414_A0.6741.00
335_E339_N0.6731.00
316_G320_S0.6711.00
282_Y288_F0.6711.00
27_Q31_T0.6711.00
318_E321_R0.6711.00
444_M451_S0.6701.00
324_V329_S0.6701.00
445_R452_E0.6671.00
271_L274_Y0.6661.00
34_M42_P0.6661.00
286_T292_L0.6631.00
160_S163_D0.6611.00
250_K253_F0.6611.00
358_D361_R0.6611.00
230_S233_V0.6591.00
294_R298_W0.6591.00
302_W306_T0.6571.00
46_K89_G0.6561.00
285_A290_L0.6551.00
299_G302_W0.6541.00
258_Y262_Y0.6531.00
444_M447_A0.6511.00
285_A295_R0.6501.00
379_V382_N0.6501.00
289_A295_R0.6501.00
173_A466_R0.6481.00
125_V128_Y0.6481.00
319_I325_M0.6471.00
100_I112_V0.6471.00
465_E468_M0.6451.00
408_E412_D0.6451.00
273_S276_E0.6451.00
277_L281_E0.6441.00
306_T311_F0.6441.00
338_D344_Q0.6421.00
340_T345_E0.6421.00
76_A117_T0.6401.00
167_S202_D0.6401.00
293_S300_R0.6391.00
252_G256_D0.6371.00
364_L367_E0.6361.00
327_S332_L0.6361.00
328_E333_E0.6341.00
56_M60_T0.6341.00
108_K206_E0.6341.00
216_K219_K0.6341.00
365_S368_D0.6321.00
61_V173_A0.6321.00
284_G289_A0.6321.00
431_Y437_T0.6301.00
433_L437_T0.6281.00
228_Y232_H0.6281.00
445_R448_Y0.6281.00
23_V49_V0.6271.00
440_T444_M0.6251.00
123_K126_N0.6251.00
432_Y436_M0.6241.00
341_D344_Q0.6231.00
103_L128_Y0.6221.00
286_T291_G0.6201.00
341_D345_E0.6191.00
51_G57_L0.6191.00
370_N374_I0.6191.00
226_S355_S0.6191.00
45_I91_V0.6181.00
250_K255_K0.6171.00
138_Q141_F0.6171.00
255_K259_V0.6141.00
379_V383_E0.6131.00
286_T289_A0.6121.00
122_Q131_A0.6111.00
429_G436_M0.6091.00
270_Q274_Y0.6091.00
451_S454_F0.6071.00
300_R307_Q0.6071.00
303_L311_F0.6071.00
302_W305_D0.6061.00
288_F293_S0.6061.00
39_R42_P0.6061.00
58_I61_V0.6061.00
285_A289_A0.6051.00
317_T325_M0.6041.00
326_R331_F0.6031.00
228_Y231_K0.6031.00
187_F191_I0.6031.00
54_E202_D0.6031.00
356_Y364_L0.6021.00
437_T444_M0.6021.00
28_K32_S0.6011.00
275_S278_K0.5981.00
150_N160_S0.5971.00
284_G291_G0.5961.00
289_A297_E0.5961.00
252_G258_Y0.5961.00
335_E341_D0.5941.00
63_E90_I0.5921.00
431_Y436_M0.5911.00
185_D457_K0.5891.00
443_Q446_Q0.5891.00
118_W143_I0.5881.00
282_Y289_A0.5881.00
105_Q108_K0.5861.00
342_V345_E0.5851.00
222_Y228_Y0.5851.00
24_N30_A0.5851.00
102_S105_Q0.5801.00
413_T417_I0.5791.00
319_I324_V0.5771.00
445_R449_P0.5771.00
417_I421_T0.5761.00
259_V264_L0.5761.00
79_S84_T0.5761.00
296_Y301_N0.5761.00
256_D263_V0.5741.00
287_K295_R0.5741.00
119_N138_Q0.5731.00
337_N340_T0.5731.00
168_F180_V0.5721.00
316_G321_R0.5711.00
324_V332_L0.5711.00
134_V164_T0.5691.00
335_E338_D0.5691.00
103_L207_L0.5691.00
325_M331_F0.5681.00
285_A296_Y0.5681.00
250_K257_M0.5671.00
86_Y89_G0.5671.00
315_N320_S0.5671.00
281_E289_A0.5651.00
303_L307_Q0.5631.00
173_A464_D0.5631.00
107_K351_K0.5621.00
404_G410_Q0.5601.00
100_I113_Q0.5601.00
315_N324_V0.5591.00
38_S41_M0.5591.00
339_N342_V0.5591.00
304_W310_Y0.5581.00
253_F257_M0.5581.00
296_Y299_G0.5581.00
320_S324_V0.5581.00
24_N27_Q0.5561.00
324_V331_F0.5551.00
27_Q44_K0.5551.00
255_K261_N0.5531.00
429_G432_Y0.5531.00
300_R303_L0.5531.00
280_D283_T0.5531.00
410_Q413_T0.5511.00
251_K257_M0.5501.00
149_A434_P0.5491.00
261_N264_L0.5481.00
336_N340_T0.5471.00
300_R311_F0.5471.00
136_Q146_S0.5471.00
281_E291_G0.5461.00
122_Q125_V0.5461.00
435_Y438_Y0.5451.00
29_T33_E0.5451.00
104_D108_K0.5451.00
305_D311_F0.5431.00
369_L373_N0.5421.00
329_S332_L0.5421.00
259_V263_V0.5411.00
334_Y339_N0.5401.00
318_E324_V0.5401.00
169_R204_T0.5391.00
254_L258_Y0.5381.00
107_K206_E0.5381.00
122_Q210_D0.5371.00
72_S86_Y0.5361.00
117_T142_T0.5361.00
257_M262_Y0.5361.00
285_A292_L0.5341.00
183_K461_Y0.5341.00
279_E284_G0.5321.00
241_M246_I0.5321.00
395_F399_L0.5321.00
241_M247_S0.5311.00
112_V116_A0.5301.00
197_F457_K0.5301.00
338_D345_E0.5261.00
188_T191_I0.5241.00
43_V87_E0.5231.00
132_V207_L0.5221.00
99_K102_S0.5211.00
166_K182_P0.5191.00
196_L458_K0.5181.00
158_Y208_T0.5181.00
280_D285_A0.5181.00
315_N319_I0.5171.00
44_K87_E0.5171.00
168_F191_I0.5171.00
107_K204_T0.5161.00
315_N318_E0.5151.00
324_V327_S0.5151.00
300_R308_Q0.5120.99
272_S276_E0.5110.99
361_R364_L0.5110.99
280_D284_G0.5100.99
182_P187_F0.5100.99
222_Y225_Y0.5090.99
242_H246_I0.5090.99
251_K256_D0.5080.99
295_R299_G0.5080.99
303_L310_Y0.5080.99
287_K292_L0.5070.99
165_V205_L0.5070.99
132_V205_L0.5050.99
344_Q347_F0.5040.99
323_N330_K0.5040.99
263_V266_N0.5040.99
288_F292_L0.5030.99
317_T323_N0.5030.99
282_Y293_S0.5020.99
281_E285_A0.5010.99
51_G97_Y0.5010.99
105_Q130_L0.5000.99
182_P191_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9328 100 0.357 Contact Map
4xloA 2 0.9391 100 0.371 Contact Map
4p8nA 1 0.9076 100 0.374 Contact Map
2vfrA 1 0.8655 100 0.385 Contact Map
2uuuA 2 0.8992 100 0.391 Contact Map
3js8A 1 0.9496 100 0.4 Contact Map
4ud8A 1 0.9517 100 0.402 Contact Map
4pvkA 1 0.9223 100 0.404 Contact Map
3vteA 1 0.937 100 0.409 Contact Map
2i0kA 1 0.9412 100 0.411 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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