GREMLIN Database
YKWB - Uncharacterized N-acetyltransferase YkwB
UniProt: Q796K9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 226 (205)
Sequences: 608 (434)
Seq/√Len: 30.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_D178_R4.1831.00
37_E121_S3.9051.00
69_L72_G3.7631.00
29_E51_E3.6851.00
56_S60_T3.4761.00
111_N147_E3.3901.00
68_A129_I3.0521.00
112_T148_R2.9501.00
161_Y179_K2.9141.00
38_C119_S2.9131.00
76_G120_V2.7491.00
134_M137_M2.6461.00
99_D104_K2.6211.00
34_L74_I2.6121.00
171_V184_L2.6071.00
21_R27_D2.6041.00
130_G186_F2.6021.00
180_N185_S2.4080.99
151_G214_M2.3740.99
99_D105_N2.2670.99
21_R69_L2.1550.98
162_A208_L2.1240.98
75_I124_Y2.0970.98
78_M115_V2.0880.98
73_R123_H2.0780.98
30_R74_I1.9370.97
78_M137_M1.9210.96
20_I68_A1.8870.96
155_I214_M1.8200.95
187_L190_C1.8190.95
167_A197_V1.7060.93
142_V220_F1.6830.93
82_I146_L1.6690.92
81_L105_N1.6530.92
98_T105_N1.6530.92
75_I129_I1.6330.91
57_H79_T1.6070.91
51_E55_A1.6010.90
19_T69_L1.5900.90
138_Y190_C1.5630.89
184_L194_P1.5440.89
171_V212_V1.5370.89
83_V97_A1.4710.86
81_L103_I1.4700.86
41_P206_E1.4650.86
115_V134_M1.4290.85
78_M134_M1.4190.84
151_G212_V1.4150.84
115_V137_M1.4080.84
25_E55_A1.4050.84
155_I184_L1.3780.82
149_L192_R1.3750.82
33_S73_R1.3660.82
98_T116_V1.3550.81
23_Y67_C1.3520.81
154_R207_S1.3190.79
85_F90_P1.2940.78
115_V132_W1.2830.77
37_E123_H1.2720.77
82_I144_K1.2630.76
57_H102_S1.2440.75
58_I74_I1.2430.75
158_Y162_A1.2350.75
173_D179_K1.2200.74
203_E209_N1.2170.74
99_D103_I1.2140.73
113_L146_L1.1990.72
109_H200_N1.1970.72
166_S169_Q1.1750.71
95_A100_N1.1700.71
55_A59_K1.1600.70
194_P212_V1.1290.68
145_R221_Y1.1190.67
32_I35_Q1.1140.67
179_K211_G1.1000.66
18_L68_A1.0920.65
66_L136_T1.0820.64
150_L188_L1.0720.64
194_P214_M1.0690.63
115_V192_R1.0580.63
80_A220_F1.0580.63
73_R124_Y1.0560.63
20_I132_W1.0540.62
93_T96_Q1.0510.62
81_L116_V1.0490.62
135_N138_Y1.0460.62
165_I173_D1.0440.62
187_L192_R1.0390.61
93_T200_N1.0310.61
147_E221_Y1.0260.60
78_M132_W1.0220.60
53_Q209_N1.0220.60
28_I54_L1.0200.60
22_N66_L1.0000.58
158_Y167_A0.9950.58
85_F89_S0.9810.57
21_R101_G0.9740.56
152_G211_G0.9720.56
37_E99_D0.9710.56
18_L80_A0.9680.56
50_S76_G0.9600.55
16_E71_N0.9560.55
61_F144_K0.9550.55
70_I75_I0.9520.54
57_H81_L0.9500.54
98_T102_S0.9500.54
76_G129_I0.9480.54
134_M190_C0.9360.53
136_T185_S0.9350.53
57_H103_I0.9320.53
61_F64_G0.9260.52
66_L140_L0.9240.52
139_E143_D0.9180.52
25_E59_K0.9140.51
85_F88_D0.9110.51
128_G132_W0.9060.51
159_Y206_E0.9060.51
76_G155_I0.9050.51
14_K200_N0.8970.50
86_E147_E0.8870.49
35_Q39_F0.8800.49
200_N217_K0.8780.49
21_R67_C0.8780.49
127_L135_N0.8760.48
131_K185_S0.8660.48
31_L77_S0.8650.48
103_I116_V0.8640.47
23_Y31_L0.8580.47
196_R213_L0.8570.47
35_Q48_L0.8550.47
87_P107_E0.8550.47
66_L74_I0.8540.47
84_Q107_E0.8530.47
61_F149_L0.8500.46
149_L186_F0.8480.46
138_Y184_L0.8440.46
148_R215_E0.8410.46
49_W57_H0.8360.45
167_A210_Y0.8330.45
112_T215_E0.8310.45
163_H179_K0.8200.44
120_V168_V0.8200.44
115_V149_L0.8150.44
18_L70_I0.8110.43
75_I107_E0.8100.43
100_N105_N0.7930.42
37_E206_E0.7900.42
63_E118_I0.7850.41
142_V168_V0.7840.41
53_Q183_V0.7820.41
48_L141_T0.7750.40
51_E179_K0.7750.40
87_P90_P0.7720.40
134_M187_L0.7690.40
123_H147_E0.7540.39
109_H163_H0.7530.39
91_D196_R0.7500.39
71_N100_N0.7490.38
25_E179_K0.7450.38
23_Y79_T0.7420.38
132_W192_R0.7400.38
83_V90_P0.7390.38
134_M138_Y0.7370.38
156_P207_S0.7360.38
52_D107_E0.7290.37
58_I127_L0.7280.37
54_L116_V0.7260.37
95_A157_L0.7240.37
59_K175_M0.7240.37
138_Y192_R0.7240.37
131_K189_R0.7230.37
93_T198_V0.7210.36
107_E144_K0.7170.36
57_H77_S0.7110.36
68_A76_G0.7090.36
137_M149_L0.7070.35
104_K150_L0.7070.35
67_C151_G0.7030.35
98_T101_G0.7030.35
101_G105_N0.7030.35
37_E74_I0.7020.35
125_R188_L0.7000.35
95_A205_K0.7000.35
95_A123_H0.7000.35
134_M192_R0.6990.35
15_F67_C0.6970.35
42_P194_P0.6940.34
120_V157_L0.6910.34
86_E96_Q0.6910.34
155_I167_A0.6900.34
34_L121_S0.6860.34
35_Q141_T0.6840.34
151_G194_P0.6830.34
34_L38_C0.6720.33
30_R72_G0.6710.33
65_A134_M0.6710.33
118_I186_F0.6680.33
61_F114_Y0.6670.33
35_Q47_L0.6640.32
39_F99_D0.6640.32
151_G183_V0.6590.32
22_N136_T0.6560.32
27_D69_L0.6550.32
155_I212_V0.6520.31
70_I98_T0.6500.31
48_L203_E0.6450.31
157_L179_K0.6390.31
85_F147_E0.6390.31
58_I71_N0.6390.31
167_A199_S0.6300.30
75_I194_P0.6290.30
26_T221_Y0.6240.30
67_C72_G0.6240.30
33_S37_E0.6200.29
65_A187_L0.6140.29
139_E211_G0.6140.29
82_I107_E0.6140.29
32_I167_A0.6100.29
63_E140_L0.6090.29
175_M191_G0.6080.29
195_I217_K0.6080.29
35_Q119_S0.6070.28
84_Q87_P0.6060.28
185_S194_P0.6050.28
32_I36_E0.6030.28
40_P148_R0.6030.28
19_T100_N0.6020.28
153_G214_M0.6020.28
78_M187_L0.6010.28
183_V201_Y0.6000.28
79_T103_I0.5980.28
85_F111_N0.5980.28
204_D207_S0.5980.28
32_I48_L0.5970.28
25_E123_H0.5970.28
19_T95_A0.5970.28
101_G120_V0.5950.28
123_H143_D0.5920.27
80_A140_L0.5920.27
207_S218_N0.5850.27
50_S205_K0.5840.27
118_I157_L0.5830.27
78_M140_L0.5810.27
16_E70_I0.5810.27
79_T192_R0.5790.27
23_Y77_S0.5760.26
39_F57_H0.5730.26
34_L193_S0.5720.26
188_L194_P0.5700.26
53_Q117_D0.5690.26
184_L221_Y0.5670.26
65_A103_I0.5670.26
185_S188_L0.5660.26
17_A159_Y0.5620.26
67_C76_G0.5610.26
95_A118_I0.5590.25
149_L190_C0.5580.25
184_L214_M0.5560.25
115_V187_L0.5550.25
164_E205_K0.5550.25
31_L47_L0.5520.25
57_H219_V0.5520.25
92_H216_W0.5510.25
132_W137_M0.5500.25
31_L70_I0.5500.25
18_L164_E0.5480.25
174_V211_G0.5470.25
189_R220_F0.5470.25
138_Y187_L0.5430.24
155_I207_S0.5420.24
50_S164_E0.5390.24
81_L215_E0.5390.24
21_R148_R0.5380.24
52_D143_D0.5370.24
35_Q38_C0.5350.24
115_V138_Y0.5350.24
30_R145_R0.5350.24
31_L67_C0.5340.24
50_S53_Q0.5310.24
81_L166_S0.5300.24
161_Y164_E0.5290.24
68_A180_N0.5290.24
128_G141_T0.5290.24
49_W77_S0.5280.24
83_V89_S0.5280.24
201_Y216_W0.5280.24
140_L144_K0.5250.23
113_L172_E0.5230.23
64_G114_Y0.5220.23
69_L101_G0.5220.23
137_M187_L0.5210.23
131_K190_C0.5210.23
115_V133_L0.5200.23
132_W190_C0.5180.23
198_V211_G0.5180.23
180_N219_V0.5170.23
101_G156_P0.5150.23
91_D123_H0.5130.23
149_L187_L0.5130.23
73_R121_S0.5130.23
172_E176_E0.5100.23
107_E147_E0.5090.23
87_P99_D0.5090.23
167_A212_V0.5070.22
158_Y213_L0.5060.22
153_G192_R0.5010.22
81_L104_K0.5000.22
41_P109_H0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2reeA 1 0.8673 100 0.612 Contact Map
1cjwA 1 0.7301 99.7 0.798 Contact Map
1kuxA 1 0.7301 99.6 0.803 Contact Map
4r3lA 1 0.6903 99.6 0.806 Contact Map
4kvxA 1 0.6593 99.6 0.808 Contact Map
4pv6C 3 0.6814 99.6 0.813 Contact Map
1n71A 4 0.7522 99.5 0.817 Contact Map
2q0yA 2 0.646 99.5 0.818 Contact Map
2cntA 1 0.6681 99.5 0.818 Contact Map
2ob0A 1 0.6991 99.5 0.819 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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