GREMLIN Database
FDHL - Putative formate dehydrogenase YrhE
UniProt: Q795Y4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 980 (965)
Sequences: 235 (132)
Seq/√Len: 4.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
570_S579_Y6.9030.99
612_Q623_F6.1910.99
416_T783_L6.1460.99
280_E779_W5.9310.98
29_N37_Q5.5800.97
656_L681_F5.1850.96
507_N804_D5.1230.96
575_A809_F4.9540.95
502_I809_F4.9020.94
782_F791_S4.8560.94
486_A524_A4.8230.94
369_T721_L4.7250.93
505_N799_G4.4920.91
505_N580_R4.3510.90
444_V551_L4.2740.89
328_K333_V4.2530.89
326_I335_S4.2260.88
342_D744_R4.1930.88
178_R188_G4.1500.87
420_I551_L4.0820.86
203_V211_L3.8480.83
708_D723_Q3.7750.81
556_V565_T3.6690.80
326_I343_L3.6580.79
870_V889_A3.6410.79
162_V201_Q3.6310.79
965_E968_R3.5950.78
502_I509_F3.5570.77
547_G584_A3.5380.77
492_I509_F3.4120.74
559_N932_Q3.4030.74
496_W543_R3.3820.73
341_L744_R3.3750.73
184_I188_G3.3590.73
732_K740_E3.3080.72
360_V653_A3.2990.71
291_I724_A3.2380.70
858_V902_L3.1990.69
348_L360_V3.1760.68
373_N603_T3.1430.67
184_I187_E3.1010.66
794_L797_E3.0700.65
335_S343_L3.0370.65
601_M761_M3.0270.64
343_L347_R3.0140.64
306_V849_I3.0110.64
796_Y801_N2.9970.63
424_G547_G2.9110.61
420_I444_V2.8350.59
561_G814_W2.7520.56
736_W740_E2.7420.56
492_I497_H2.7260.56
643_L675_L2.6560.54
799_G805_K2.6500.53
828_I913_I2.6390.53
718_V771_A2.5990.52
827_H905_N2.5670.51
758_F771_A2.5640.51
879_V936_R2.5310.50
612_Q765_S2.5260.50
22_A30_E2.4930.49
743_N748_N2.4910.49
540_E544_D2.4880.49
184_I959_H2.4670.48
187_E959_H2.4510.47
467_E958_R2.4460.47
428_I431_A2.4370.47
647_E674_I2.4310.47
313_D846_S2.4150.46
424_G546_D2.4130.46
346_S350_S2.4000.46
127_Y292_Q2.3990.46
23_T26_D2.3840.45
739_Q750_N2.3270.44
379_L741_V2.3000.43
362_F379_L2.2660.42
219_Q287_D2.2440.41
82_V474_S2.2430.41
12_D86_Q2.2420.41
38_I93_L2.2410.41
546_D584_A2.2310.41
177_E968_R2.2110.40
188_G959_H2.2060.40
887_L902_L2.1790.40
521_L525_E2.1690.39
509_F513_K2.1580.39
291_I688_L2.1540.39
473_I538_I2.1330.38
770_K785_G2.1070.37
348_L842_M2.1060.37
879_V884_A2.1030.37
143_H198_S2.0940.37
638_D926_N2.0760.37
623_F765_S2.0700.36
874_S939_V2.0500.36
49_T964_V2.0470.36
281_V291_I2.0240.35
357_K384_F2.0140.35
90_M122_I2.0120.35
448_H455_L2.0060.35
424_G584_A2.0040.35
652_K849_I1.9940.34
236_D937_M1.9810.34
106_N217_L1.9780.34
272_F604_L1.9030.32
62_V870_V1.8870.32
169_N464_E1.8830.31
872_D891_I1.8820.31
623_F764_L1.8780.31
169_N958_R1.8780.31
93_L113_L1.8730.31
226_I330_G1.8660.31
344_V361_G1.8600.31
427_I528_T1.8520.31
743_N747_A1.8450.30
243_P433_P1.8420.30
738_I741_V1.8380.30
223_M833_M1.8370.30
58_N177_E1.8100.30
165_N962_N1.8000.29
190_P193_E1.7730.29
532_K536_I1.7650.28
291_I930_Y1.7600.28
226_I329_N1.7560.28
11_V28_L1.7540.28
622_K787_F1.7480.28
445_K464_E1.7440.28
41_V44_V1.7370.28
580_R805_K1.7270.28
149_D857_F1.7250.28
553_G627_Y1.7250.28
612_Q629_V1.7220.27
408_V579_Y1.7210.27
299_V599_C1.7200.27
759_S772_S1.7170.27
140_D214_K1.7150.27
484_L569_I1.7030.27
828_I935_V1.6980.27
38_I113_L1.6910.27
359_S653_A1.6910.27
344_V656_L1.6870.27
201_Q442_T1.6800.26
679_D731_A1.6790.26
348_L653_A1.6740.26
708_D724_A1.6740.26
758_F775_V1.6680.26
96_N442_T1.6680.26
326_I333_V1.6650.26
462_K467_E1.6590.26
24_I543_R1.6580.26
357_K385_E1.6540.26
178_R184_I1.6400.26
672_H694_Y1.6230.25
347_R350_S1.6180.25
522_D532_K1.6150.25
184_I690_R1.6020.25
106_N215_S1.5970.25
456_I538_I1.5920.24
499_Q503_D1.5860.24
559_N627_Y1.5850.24
118_E249_F1.5810.24
601_M768_F1.5800.24
878_L937_M1.5700.24
871_C943_C1.5650.24
231_M235_I1.5570.24
323_K334_E1.5500.24
301_A809_F1.5460.23
723_Q726_P1.5450.23
667_N919_P1.5450.23
166_L853_V1.5420.23
211_L215_S1.5400.23
338_E347_R1.5390.23
962_N965_E1.5290.23
314_F467_E1.5240.23
652_K679_D1.5220.23
454_K541_M1.5200.23
184_I189_V1.5130.23
362_F384_F1.5070.23
973_P976_V1.5000.22
949_P955_N1.4860.22
421_A451_H1.4780.22
826_L937_M1.4700.22
732_K736_W1.4640.22
825_D868_R1.4620.22
786_S790_E1.4620.22
369_T376_I1.4620.22
117_A249_F1.4610.22
482_V527_I1.4560.22
131_P285_G1.4500.21
142_S214_K1.4480.21
360_V622_K1.4470.21
330_G698_V1.4410.21
877_R938_E1.4410.21
122_I886_K1.4280.21
485_M488_T1.4260.21
690_R693_Q1.4260.21
622_K769_A1.4200.21
936_R976_V1.4190.21
428_I465_M1.4110.21
771_A786_S1.4090.21
745_L899_E1.4090.21
692_A899_E1.4060.21
86_Q858_V1.4030.21
725_L731_A1.3980.20
77_L292_Q1.3950.20
16_I27_I1.3930.20
599_C604_L1.3920.20
738_I750_N1.3900.20
374_Y609_P1.3860.20
609_P687_F1.3810.20
434_A469_S1.3750.20
509_F675_L1.3700.20
106_N253_E1.3700.20
11_V16_I1.3690.20
505_N783_L1.3640.20
786_S789_G1.3630.20
47_I901_Y1.3620.20
661_M681_F1.3580.20
193_E462_K1.3580.20
420_I440_L1.3560.20
534_N538_I1.3560.20
454_K806_K1.3560.20
812_S815_T1.3560.20
870_V874_S1.3540.20
492_I502_I1.3470.19
27_I58_N1.3460.19
369_T563_S1.3360.19
382_Q631_I1.3300.19
637_L808_R1.3300.19
508_Y580_R1.3290.19
698_V765_S1.3260.19
323_K730_D1.3240.19
243_P333_V1.3150.19
785_G790_E1.3100.19
344_V694_Y1.3080.19
580_R718_V1.3030.19
171_T464_E1.3020.19
385_E463_N1.3010.19
11_V666_S1.3000.19
785_G789_G1.3000.19
138_A849_I1.2990.19
549_C587_Y1.2990.19
155_A158_Q1.2930.18
61_L82_V1.2910.18
559_N564_D1.2890.18
492_I538_I1.2870.18
627_Y932_Q1.2840.18
581_R586_A1.2830.18
256_A414_A1.2820.18
88_E127_Y1.2790.18
522_D913_I1.2770.18
98_L232_E1.2760.18
248_I549_C1.2750.18
664_V839_E1.2740.18
68_V971_N1.2720.18
836_H853_V1.2670.18
647_E677_S1.2670.18
255_E705_L1.2660.18
90_M297_A1.2660.18
171_T570_S1.2650.18
477_Q559_N1.2640.18
483_W535_I1.2640.18
508_Y809_F1.2630.18
68_V75_I1.2630.18
743_N750_N1.2620.18
608_L619_A1.2600.18
889_A937_M1.2590.18
877_R884_A1.2580.18
481_Q485_M1.2550.18
913_I935_V1.2510.18
511_D726_P1.2500.18
251_I673_D1.2460.18
758_F782_F1.2460.18
373_N599_C1.2400.18
492_I513_K1.2400.18
445_K450_L1.2390.18
408_V758_F1.2300.17
601_M627_Y1.2280.17
113_L208_C1.2270.17
9_V75_I1.2260.17
122_I872_D1.2230.17
412_G486_A1.2220.17
673_D676_S1.2220.17
169_N445_K1.2210.17
98_L612_Q1.2200.17
465_M563_S1.2180.17
80_N951_T1.2180.17
860_I874_S1.2160.17
496_W540_E1.2150.17
502_I513_K1.2150.17
514_E517_K1.2150.17
564_D812_S1.2150.17
486_A575_A1.2140.17
231_M234_M1.2090.17
718_V946_A1.2030.17
83_K86_Q1.2020.17
73_M203_V1.2000.17
364_S436_G1.2000.17
622_K626_A1.1970.17
718_V900_L1.1920.17
406_R567_A1.1880.17
448_H803_P1.1860.17
12_D949_P1.1860.17
553_G932_Q1.1850.17
106_N211_L1.1790.16
427_I550_V1.1770.16
382_Q747_A1.1750.16
770_K790_E1.1750.16
460_L846_S1.1750.16
522_D652_K1.1680.16
774_E956_K1.1650.16
559_N567_A1.1650.16
642_M651_M1.1620.16
121_G343_L1.1610.16
782_F785_G1.1590.16
879_V938_E1.1570.16
770_K786_S1.1540.16
785_G805_K1.1530.16
80_N575_A1.1490.16
45_D155_A1.1470.16
771_A785_G1.1430.16
18_A75_I1.1370.16
155_A785_G1.1360.16
401_T767_L1.1320.16
203_V215_S1.1280.16
151_N956_K1.1280.16
881_P934_K1.1270.16
344_V654_M1.1270.16
847_K971_N1.1260.16
211_L581_R1.1250.16
47_I679_D1.1250.16
627_Y811_L1.1210.16
91_D975_Y1.1210.16
441_A445_K1.1210.16
487_V491_M1.1190.16
9_V652_K1.1190.16
376_I721_L1.1160.15
872_D889_A1.1140.15
321_I771_A1.1120.15
500_A860_I1.1100.15
581_R584_A1.1100.15
414_A891_I1.1100.15
514_E622_K1.1100.15
489_K493_D1.1080.15
420_I426_V1.1070.15
549_C900_L1.1070.15
939_V968_R1.1060.15
623_F766_P1.1030.15
105_D392_C1.1020.15
797_E869_G1.1020.15
402_D599_C1.0990.15
42_P180_R1.0980.15
426_V440_L1.0970.15
79_G941_G1.0950.15
405_F465_M1.0950.15
361_G702_T1.0940.15
192_N851_A1.0930.15
333_V431_A1.0930.15
725_L729_G1.0930.15
540_E660_D1.0910.15
48_Q66_A1.0910.15
775_V785_G1.0900.15
338_E345_A1.0900.15
18_A301_A1.0880.15
601_M932_Q1.0880.15
382_Q814_W1.0870.15
144_P198_S1.0850.15
110_N427_I1.0840.15
38_I497_H1.0830.15
756_D847_K1.0810.15
815_T918_G1.0810.15
357_K769_A1.0810.15
44_V508_Y1.0800.15
747_A750_N1.0730.15
442_T872_D1.0710.15
506_V809_F1.0700.15
272_F436_G1.0690.15
272_F675_L1.0670.15
26_D58_N1.0670.15
392_C712_T1.0640.15
89_A672_H1.0630.15
422_K583_G1.0610.15
28_L75_I1.0590.15
285_G460_L1.0580.15
105_D231_M1.0550.15
247_S416_T1.0550.15
584_A612_Q1.0550.15
640_I647_E1.0540.15
48_Q58_N1.0530.15
201_Q303_S1.0530.15
93_L889_A1.0530.15
518_T813_D1.0520.15
249_F373_N1.0500.14
18_A331_A1.0480.14
498_D580_R1.0480.14
416_T792_T1.0450.14
246_G505_N1.0440.14
311_G478_G1.0440.14
139_V151_N1.0430.14
71_N344_V1.0420.14
769_A786_S1.0420.14
414_A429_V1.0380.14
758_F761_M1.0330.14
410_M767_L1.0320.14
285_G708_D1.0300.14
712_T944_E1.0280.14
559_N933_T1.0260.14
373_N828_I1.0250.14
444_V668_A1.0230.14
43_E295_S1.0220.14
321_I698_V1.0210.14
61_L68_V1.0180.14
237_L759_S1.0180.14
362_F733_P1.0180.14
214_K425_L1.0180.14
395_Y665_D1.0170.14
22_A936_R1.0170.14
473_I530_L1.0160.14
98_L238_V1.0150.14
334_E842_M1.0130.14
431_A463_N1.0120.14
772_S847_K1.0120.14
58_N113_L1.0070.14
553_G559_N1.0070.14
505_N805_K1.0070.14
26_D347_R1.0050.14
251_I291_I1.0030.14
55_V334_E1.0030.14
481_Q567_A1.0030.14
627_Y770_K1.0030.14
192_N845_K1.0000.14
513_K732_K1.0000.14
870_V885_V0.9970.14
412_G524_A0.9970.14
229_D741_V0.9960.14
151_N421_A0.9950.14
18_A338_E0.9930.14
408_V570_S0.9920.14
955_N971_N0.9900.14
91_D285_G0.9900.14
19_R86_Q0.9900.14
761_M782_F0.9870.14
75_I560_T0.9870.14
724_A918_G0.9870.14
689_S887_L0.9860.14
141_M433_P0.9820.13
38_I824_Y0.9820.13
513_K660_D0.9810.13
436_G958_R0.9810.13
55_V477_Q0.9790.13
874_S889_A0.9790.13
623_F629_V0.9780.13
58_N349_G0.9770.13
627_Y785_G0.9760.13
11_V643_L0.9760.13
71_N622_K0.9740.13
90_M814_W0.9680.13
106_N203_V0.9650.13
522_D534_N0.9650.13
178_R189_V0.9650.13
618_K732_K0.9640.13
222_F262_R0.9630.13
280_E885_V0.9620.13
222_F750_N0.9610.13
129_Y953_P0.9590.13
21_G60_K0.9590.13
56_E76_D0.9580.13
45_D974_G0.9580.13
708_D870_V0.9570.13
18_A22_A0.9560.13
463_N688_L0.9540.13
656_L661_M0.9540.13
510_E792_T0.9540.13
508_Y575_A0.9520.13
775_V782_F0.9520.13
336_S487_V0.9510.13
612_Q933_T0.9500.13
165_N173_S0.9490.13
98_L129_Y0.9490.13
73_M169_N0.9470.13
106_N110_N0.9470.13
770_K789_G0.9470.13
251_I689_S0.9450.13
416_T779_W0.9450.13
513_K652_K0.9440.13
341_L732_K0.9430.13
330_G726_P0.9420.13
85_A645_A0.9400.13
601_M805_K0.9400.13
535_I858_V0.9390.13
301_A758_F0.9390.13
82_V844_N0.9380.13
117_A870_V0.9370.13
802_F808_R0.9360.13
238_V918_G0.9340.13
40_H44_V0.9330.13
281_V724_A0.9330.13
382_Q743_N0.9330.13
762_A771_A0.9320.13
46_P821_P0.9260.13
143_H889_A0.9260.13
285_G888_N0.9250.13
245_Y667_N0.9240.13
201_Q805_K0.9240.13
481_Q559_N0.9200.13
477_Q627_Y0.9200.13
231_M392_C0.9200.13
24_I66_A0.9180.13
263_T315_V0.9180.13
280_E294_V0.9160.13
106_N212_M0.9140.13
410_M416_T0.9130.13
941_G944_E0.9120.13
433_P436_G0.9110.13
426_V453_Q0.9090.13
335_S948_L0.9060.12
770_K775_V0.9050.12
886_K890_L0.9040.12
167_Q392_C0.9040.12
285_G915_F0.9030.12
73_M88_E0.9020.12
328_K431_A0.9010.12
118_E243_P0.9010.12
694_Y731_A0.9000.12
231_M712_T0.8980.12
522_D765_S0.8960.12
98_L675_L0.8960.12
105_D651_M0.8940.12
318_K891_I0.8940.12
758_F785_G0.8940.12
231_M262_R0.8930.12
433_P599_C0.8930.12
826_L889_A0.8930.12
90_M120_M0.8920.12
198_S505_N0.8910.12
265_K903_P0.8890.12
122_I690_R0.8890.12
553_G736_W0.8880.12
133_E601_M0.8880.12
612_Q739_Q0.8870.12
442_T661_M0.8840.12
27_I331_A0.8840.12
118_E603_T0.8820.12
24_I57_A0.8800.12
64_S77_L0.8800.12
60_K675_L0.8790.12
264_K357_K0.8780.12
900_L935_V0.8780.12
672_H915_F0.8770.12
36_P462_K0.8760.12
676_S958_R0.8760.12
782_F786_S0.8750.12
120_M814_W0.8730.12
344_V667_N0.8710.12
657_V738_I0.8710.12
66_A662_A0.8700.12
891_I967_E0.8700.12
382_Q801_N0.8690.12
959_H962_N0.8680.12
718_V758_F0.8680.12
682_V938_E0.8670.12
367_K593_N0.8660.12
105_D262_R0.8650.12
666_S725_L0.8650.12
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686_I729_G0.5390.08
712_T802_F0.5390.08
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654_M745_L0.5370.08
265_K357_K0.5370.08
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20_A818_A0.5360.08
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249_F853_V0.5350.08
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317_S556_V0.5240.08
52_T108_N0.5240.08
460_L471_L0.5240.08
538_I942_G0.5230.08
232_E906_S0.5230.08
965_E971_N0.5230.08
335_S870_V0.5220.08
398_S474_S0.5220.08
484_L838_H0.5220.08
693_Q713_N0.5220.08
184_I287_D0.5220.08
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537_Q725_L0.5210.08
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201_Q627_Y0.5210.08
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732_K744_R0.5210.08
491_M496_W0.5210.08
431_A816_E0.5200.08
256_A660_D0.5200.08
334_E976_V0.5190.08
384_F779_W0.5190.08
26_D741_V0.5190.08
512_Y519_Y0.5190.08
86_Q780_N0.5190.08
26_D122_I0.5180.08
402_D924_R0.5180.08
535_I672_H0.5170.08
34_E37_Q0.5170.08
885_V888_N0.5170.08
508_Y653_A0.5170.08
16_I55_V0.5170.08
112_T906_S0.5170.08
234_M893_D0.5170.08
368_I747_A0.5170.08
836_H905_N0.5170.08
705_L961_Q0.5170.08
458_A473_I0.5160.08
364_S584_A0.5160.08
335_S697_V0.5150.08
598_A877_R0.5150.08
16_I28_L0.5150.08
318_K957_K0.5150.08
901_Y926_N0.5150.08
345_A530_L0.5140.08
580_R799_G0.5140.08
56_E354_Q0.5140.08
24_I881_P0.5140.08
344_V504_E0.5140.08
18_A30_E0.5130.08
299_V373_N0.5130.08
567_A924_R0.5120.08
41_V165_N0.5120.08
617_D808_R0.5110.08
81_R798_D0.5110.08
261_T548_T0.5110.08
303_S380_A0.5100.08
70_E344_V0.5100.08
306_V902_L0.5100.08
732_K942_G0.5100.08
350_S863_E0.5100.08
632_D646_I0.5090.08
842_M904_M0.5090.08
18_A27_I0.5090.08
619_A622_K0.5090.08
770_K805_K0.5090.08
15_E352_K0.5090.08
937_M944_E0.5090.08
58_N767_L0.5080.08
344_V347_R0.5080.08
689_S694_Y0.5070.08
675_L958_R0.5070.08
792_T798_D0.5070.08
959_H965_E0.5060.08
301_A445_K0.5050.08
121_G882_F0.5040.08
201_Q553_G0.5040.08
14_T538_I0.5040.08
193_E743_N0.5040.08
64_S87_T0.5040.08
592_H837_F0.5040.08
245_Y364_S0.5030.08
726_P973_P0.5030.08
428_I621_A0.5030.08
258_M534_N0.5020.08
858_V884_A0.5020.08
9_V18_A0.5020.08
60_K936_R0.5020.08
729_G792_T0.5020.08
960_P974_G0.5010.08
76_D138_A0.5010.08
41_V508_Y0.5000.08
326_I339_E0.5000.08
121_G335_S0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iv2X 1 0.6878 100 0.646 Contact Map
1h0hA 1 0.698 100 0.656 Contact Map
1kqfA 3 0.6969 100 0.657 Contact Map
2napA 1 0.6908 100 0.663 Contact Map
3ml1A 1 0.698 100 0.665 Contact Map
3i9v3 1 0.7245 100 0.681 Contact Map
1g8kA 3 0.6816 100 0.683 Contact Map
2e7zA 1 0.6694 100 0.685 Contact Map
4aayA 6 0.6878 100 0.692 Contact Map
2vpzA 1 0.6888 100 0.698 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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