GREMLIN Database
YTKL - UPF0173 metal-dependent hydrolase YtkL
UniProt: Q795U4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (207)
Sequences: 5090 (3525)
Seq/√Len: 245.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_I192_V3.4071.00
103_L127_A3.2461.00
132_T137_T2.9951.00
100_K132_T2.8531.00
14_E19_H2.8361.00
104_T130_L2.7801.00
67_L86_H2.7701.00
181_A189_V2.7361.00
162_A186_A2.6841.00
93_S100_K2.6291.00
47_T140_H2.6061.00
175_E210_S2.3121.00
146_L183_W2.3111.00
20_I43_V2.3001.00
130_L159_I2.2431.00
102_K132_T2.2051.00
95_Q100_K2.2011.00
172_M180_A2.1521.00
75_A87_P2.1151.00
141_A165_P2.1131.00
160_D187_K2.0981.00
104_T128_G2.0851.00
163_F190_V2.0831.00
151_K155_E2.0701.00
138_I163_F2.0371.00
22_F47_T2.0371.00
18_H97_D2.0121.00
93_S102_K1.9891.00
11_I163_F1.9371.00
88_M103_L1.9311.00
35_K38_D1.9041.00
12_T19_H1.8881.00
168_D173_G1.8691.00
151_K183_W1.8321.00
45_L131_L1.7701.00
181_A186_A1.7651.00
205_E209_D1.7611.00
109_G170_F1.7011.00
75_A79_G1.6881.00
179_L183_W1.6821.00
3_V161_L1.6721.00
179_L182_E1.6471.00
56_D60_I1.6291.00
141_A164_L1.6221.00
206_A210_S1.6171.00
45_L129_I1.6151.00
27_T55_G1.5341.00
57_T60_I1.5101.00
95_Q98_F1.4881.00
161_L190_V1.4861.00
22_F140_H1.4401.00
43_V67_L1.4341.00
15_T133_V1.4321.00
140_H192_V1.4151.00
166_I177_A1.4091.00
43_V96_F1.3981.00
154_G185_R1.3561.00
86_H94_R1.3411.00
163_F192_V1.3381.00
72_N89_H1.3061.00
137_T159_I1.2981.00
22_F131_L1.2571.00
45_L101_V1.2421.00
49_G77_Y1.2391.00
13_V138_I1.2381.00
91_G105_Q1.2331.00
150_M180_A1.2111.00
43_V69_I1.2111.00
6_H33_D1.2041.00
173_G176_D1.2021.00
3_V11_I1.2011.00
18_H42_D1.2001.00
44_I68_V1.1861.00
177_A189_V1.1711.00
89_H109_G1.1581.00
141_A162_A1.1521.00
4_T14_E1.1391.00
57_T68_V1.1281.00
91_G156_L1.1201.00
103_L129_I1.1191.00
18_H99_G1.1191.00
206_A209_D1.1041.00
101_V129_I1.0991.00
161_L188_Q1.0881.00
89_H92_G1.0851.00
70_A74_L1.0851.00
6_H10_V1.0841.00
152_L156_L1.0801.00
128_G141_A1.0771.00
10_V22_F1.0771.00
181_A211_L1.0651.00
13_V22_F1.0471.00
204_P207_F1.0411.00
146_L179_L1.0391.00
152_L155_E1.0371.00
67_L84_N1.0331.00
164_L180_A1.0291.00
25_F30_S1.0161.00
26_L36_P1.0151.00
69_I88_M1.0131.00
69_I94_R1.0081.00
137_T157_N1.0031.00
203_D206_A0.9981.00
70_A75_A0.9971.00
202_Q207_F0.9971.00
21_I41_A0.9871.00
5_Y192_V0.9741.00
32_T35_K0.9701.00
104_T139_F0.9631.00
71_P127_A0.9571.00
72_N76_V0.9551.00
20_I99_G0.9501.00
6_H12_T0.9491.00
162_A184_L0.9481.00
12_T41_A0.9441.00
131_L138_I0.9311.00
132_T135_D0.9271.00
6_H26_L0.9261.00
78_L83_L0.9261.00
78_L81_K0.9241.00
57_T61_A0.9191.00
205_E208_A0.9151.00
164_L184_L0.9131.00
3_V163_F0.9101.00
19_H40_K0.9081.00
68_V83_L0.8971.00
130_L153_I0.8961.00
107_F147_F0.8921.00
19_H42_D0.8911.00
88_M94_R0.8851.00
74_L124_G0.8841.00
19_H41_A0.8831.00
43_V101_V0.8831.00
12_T21_I0.8791.00
58_E62_K0.8760.99
166_I194_Y0.8670.99
148_S151_K0.8670.99
48_H143_D0.8660.99
88_M92_G0.8650.99
154_G184_L0.8630.99
86_H169_N0.8490.99
162_A181_A0.8440.99
139_F180_A0.8400.99
65_N84_N0.8330.99
106_A144_T0.8310.99
141_A144_T0.8270.99
133_V138_I0.8250.99
194_Y208_A0.8240.99
69_I129_I0.8210.99
148_S152_L0.8150.99
20_I101_V0.8130.99
208_A212_P0.8130.99
137_T160_D0.8090.99
188_Q191_P0.8000.99
45_L127_A0.7990.99
49_G124_G0.7970.99
18_H43_V0.7970.99
164_L181_A0.7940.99
22_F45_L0.7920.99
77_Y81_K0.7910.99
174_P206_A0.7810.99
6_H32_T0.7800.99
182_E214_G0.7770.99
75_A85_V0.7760.99
70_A129_I0.7750.99
26_L56_D0.7750.99
76_V79_G0.7730.99
11_I190_V0.7720.99
101_V131_L0.7670.99
111_A122_Y0.7660.99
59_Q63_Q0.7650.99
14_E17_D0.7540.98
69_I101_V0.7540.98
210_S213_G0.7440.98
63_Q66_A0.7430.98
56_D59_Q0.7430.98
173_G177_A0.7410.98
178_K182_E0.7390.98
164_L172_M0.7280.98
72_N87_P0.7250.98
10_V26_L0.7250.98
154_G162_A0.7160.98
209_D213_G0.7150.98
154_G159_I0.7130.98
13_V20_I0.7110.98
210_S214_G0.7050.98
9_S165_P0.6990.97
102_K130_L0.6970.97
50_H143_D0.6960.97
168_D202_Q0.6950.97
34_I38_D0.6930.97
68_V78_L0.6900.97
167_G171_T0.6880.97
90_I127_A0.6850.97
15_T20_I0.6800.97
133_V136_K0.6780.97
178_K210_S0.6770.97
174_P202_Q0.6760.97
12_T39_V0.6750.97
3_V190_V0.6730.97
61_A68_V0.6710.97
48_H193_H0.6700.97
71_P74_L0.6700.97
18_H98_F0.6700.97
186_A189_V0.6670.97
139_F184_L0.6640.97
128_G139_F0.6630.97
70_A85_V0.6590.96
90_I145_A0.6580.96
57_T78_L0.6560.96
174_P178_K0.6510.96
10_V32_T0.6510.96
4_T12_T0.6490.96
207_F211_L0.6440.96
58_E81_K0.6430.96
69_I96_F0.6430.96
165_P177_A0.6400.96
111_A121_T0.6390.96
91_G152_L0.6390.96
176_D179_L0.6380.96
10_V25_F0.6360.96
191_P194_Y0.6330.96
91_G104_T0.6320.95
61_A65_N0.6290.95
203_D207_F0.6290.95
138_I161_L0.6260.95
58_E83_L0.6260.95
106_A128_G0.6260.95
111_A114_D0.6230.95
146_L150_M0.6230.95
5_Y194_Y0.6220.95
10_V55_G0.6190.95
130_L137_T0.6160.95
180_A184_L0.6150.95
15_T134_E0.6150.95
178_K189_V0.6130.95
3_V13_V0.6130.95
166_I191_P0.6120.95
144_T150_M0.6100.95
178_K211_L0.6080.94
71_P129_I0.5960.94
140_H163_F0.5940.94
27_T59_Q0.5930.94
16_K133_V0.5910.94
102_K157_N0.5900.94
98_F134_E0.5900.94
144_T172_M0.5890.93
153_I159_I0.5890.93
15_T99_G0.5820.93
79_G82_G0.5790.93
15_T131_L0.5750.93
131_L140_H0.5710.92
47_T129_I0.5710.92
9_S192_V0.5700.92
107_F145_A0.5630.92
32_T44_I0.5620.92
40_K64_N0.5610.92
16_K135_D0.5560.91
48_H52_D0.5530.91
71_P103_L0.5520.91
178_K214_G0.5510.91
15_T136_K0.5510.91
109_G121_T0.5510.91
49_G123_T0.5500.91
143_D193_H0.5500.91
91_G153_I0.5470.91
144_T147_F0.5460.91
174_P210_S0.5450.91
170_F200_I0.5450.91
150_M153_I0.5450.91
21_I39_V0.5400.90
136_K161_L0.5400.90
182_E185_R0.5330.90
197_F200_I0.5320.90
28_G55_G0.5320.90
96_F99_G0.5290.89
90_I125_M0.5270.89
41_A44_I0.5260.89
168_D199_V0.5250.89
158_H185_R0.5240.89
110_S124_G0.5230.89
27_T31_L0.5230.89
5_Y195_N0.5230.89
15_T18_H0.5220.89
147_F150_M0.5220.89
155_E185_R0.5200.88
60_I63_Q0.5190.88
10_V36_P0.5170.88
105_Q149_D0.5170.88
195_N208_A0.5160.88
130_L139_F0.5150.88
5_Y11_I0.5120.88
159_I162_A0.5120.88
16_K136_K0.5120.88
136_K160_D0.5100.87
104_T153_I0.5100.87
26_L108_H0.5100.87
158_H187_K0.5080.87
154_G183_W0.5070.87
149_D152_L0.5070.87
104_T156_L0.5070.87
8_H51_N0.5070.87
165_P173_G0.5050.87
162_A189_V0.5040.87
34_I39_V0.5030.87
20_I96_F0.5020.87
31_L201_E0.5020.87
72_N75_A0.5020.87
74_L78_L0.5010.87
49_G125_M0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qn9A 2 0.9824 100 0.345 Contact Map
3rpcA 2 0.9912 100 0.364 Contact Map
3bv6A 5 1 100 0.449 Contact Map
2wylA 5 0.9559 100 0.463 Contact Map
4jo0A 2 0.9515 100 0.494 Contact Map
3kl7A 1 0.8899 100 0.528 Contact Map
1zkpA 2 0.9251 100 0.541 Contact Map
2cbnA 2 0.9868 100 0.546 Contact Map
1vjnA 1 0.7797 100 0.554 Contact Map
3jxpA 2 0.9604 100 0.557 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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