GREMLIN Database
YTFP - Uncharacterized protein YtfP
UniProt: Q795R8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 420 (388)
Sequences: 3782 (2824)
Seq/√Len: 143.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
272_D342_K4.8141.00
369_I389_L3.7161.00
187_H376_S3.5151.00
80_N83_D3.3971.00
368_E378_K3.3021.00
324_V333_P3.1531.00
11_G38_L3.0821.00
5_D158_Q2.9191.00
162_I388_I2.8231.00
407_G411_G2.7791.00
18_A161_I2.7591.00
370_D375_A2.6991.00
30_L129_R2.6101.00
221_V250_I2.5981.00
188_T368_E2.5671.00
178_G388_I2.5301.00
270_R343_Q2.5131.00
235_K276_D2.4981.00
161_I414_A2.4781.00
5_D28_G2.4301.00
268_P345_T2.4091.00
7_I155_I2.3381.00
220_A233_T2.3331.00
187_H378_K2.2801.00
93_I116_A2.2781.00
43_A114_V2.2051.00
364_V384_F2.1741.00
145_A379_M2.0471.00
220_A235_K2.0271.00
52_V95_L2.0191.00
408_R412_L2.0091.00
7_I32_I2.0071.00
7_I157_S1.9951.00
188_T365_S1.9921.00
86_K90_N1.9821.00
120_R123_Q1.9751.00
278_N281_T1.9431.00
16_L121_L1.8861.00
4_Y30_L1.8841.00
38_L128_I1.8821.00
84_I88_F1.8791.00
14_S385_C1.8441.00
136_S184_A1.8261.00
34_K133_K1.8011.00
85_I95_L1.7731.00
84_I404_L1.7691.00
21_A24_E1.7511.00
93_I113_V1.7441.00
195_T361_G1.7291.00
149_T155_I1.7271.00
111_Q115_D1.7271.00
22_A411_G1.7221.00
352_L356_K1.7201.00
21_A411_G1.7181.00
325_S328_E1.6861.00
245_L250_I1.6711.00
219_V238_M1.6681.00
120_R124_L1.6611.00
138_L146_G1.6591.00
295_K327_S1.6571.00
108_D112_S1.6481.00
7_I147_I1.6461.00
222_S233_T1.6431.00
200_T350_G1.6431.00
23_G124_L1.6421.00
32_I155_I1.6361.00
97_E103_M1.6161.00
163_A385_C1.6141.00
96_K108_D1.5761.00
179_Y360_T1.5731.00
83_D86_K1.5681.00
193_F361_G1.5681.00
24_E120_R1.5611.00
78_E409_L1.5591.00
121_L126_V1.5471.00
190_T365_S1.5461.00
375_A380_E1.5451.00
239_L246_S1.5431.00
52_V88_F1.5381.00
21_A412_L1.5231.00
178_G182_A1.5231.00
401_T405_V1.5211.00
89_E95_L1.5071.00
28_G127_T1.4901.00
180_E183_E1.4881.00
137_V160_V1.4781.00
38_L130_T1.4741.00
162_I384_F1.4691.00
27_A414_A1.4661.00
411_G414_A1.4621.00
36_N131_N1.4621.00
23_G126_V1.4611.00
157_S160_V1.4421.00
270_R345_T1.4411.00
339_R343_Q1.4391.00
170_P355_D1.4391.00
384_F388_I1.4381.00
166_G360_T1.4201.00
129_R155_I1.4141.00
91_L120_R1.4131.00
149_T152_G1.4081.00
283_F335_R1.4001.00
277_I285_K1.3921.00
39_G114_V1.3871.00
38_L118_L1.3771.00
73_Y77_S1.3731.00
40_R43_A1.3581.00
7_I30_L1.3571.00
20_I120_R1.3371.00
136_S148_V1.3341.00
5_D30_L1.3321.00
13_P42_L1.3311.00
82_E86_K1.3291.00
394_Y398_Y1.3221.00
200_T352_L1.3211.00
71_F366_V1.3191.00
56_L398_Y1.3121.00
78_E412_L1.3101.00
16_L118_L1.3091.00
133_K150_N1.3061.00
199_V348_A1.3021.00
81_N405_V1.2871.00
85_I103_M1.2761.00
36_N40_R1.2741.00
75_A409_L1.2701.00
176_G180_E1.2651.00
110_A114_V1.2621.00
118_L122_K1.2551.00
297_T300_N1.2521.00
24_E124_L1.2491.00
16_L38_L1.2371.00
273_L344_F1.2321.00
115_D118_L1.2251.00
177_D181_W1.2041.00
268_P347_L1.2031.00
6_V159_A1.2031.00
162_I182_A1.2001.00
203_E347_L1.2001.00
219_V249_A1.1991.00
17_M407_G1.1911.00
9_I162_I1.1891.00
96_K107_T1.1791.00
221_V271_I1.1751.00
132_E149_T1.1601.00
107_T112_S1.1561.00
171_H355_D1.1530.99
195_T392_H1.1500.99
139_Y143_Q1.1460.99
245_L346_V1.1460.99
409_L413_N1.1390.99
94_Q106_V1.1390.99
21_A408_R1.1370.99
94_Q112_S1.1370.99
30_L127_T1.1350.99
137_V181_W1.1270.99
374_M410_A1.1270.99
195_T255_Q1.1260.99
201_S346_V1.1210.99
21_A407_G1.1160.99
199_V351_T1.1160.99
185_A379_M1.1150.99
6_V161_I1.1150.99
60_E63_K1.1130.99
369_I384_F1.1120.99
89_E94_Q1.1120.99
49_R98_E1.1100.99
159_A414_A1.1090.99
52_V113_V1.1080.99
88_F113_V1.1060.99
400_I404_L1.0990.99
53_T103_M1.0960.99
241_T246_S1.0950.99
245_L269_I1.0930.99
20_I124_L1.0890.99
139_Y185_A1.0890.99
238_M245_L1.0880.99
255_Q392_H1.0730.99
139_Y379_M1.0720.99
223_V267_V1.0710.99
146_G153_E1.0660.99
243_F352_L1.0640.99
330_P333_P1.0590.99
279_E339_R1.0550.99
205_F344_F1.0510.99
293_A304_P1.0480.99
135_K148_V1.0400.99
84_I401_T1.0360.99
364_V388_I1.0360.99
11_G128_I1.0310.99
86_K89_E1.0290.99
232_I253_C1.0240.99
221_V269_I1.0220.99
250_I269_I1.0200.99
32_I129_R1.0190.99
168_S360_T1.0170.99
13_P400_I1.0140.99
72_L406_T1.0080.99
39_G42_L1.0050.99
210_T313_F1.0040.99
6_V22_A0.9950.98
35_G40_R0.9900.98
183_E191_E0.9880.98
43_A111_Q0.9870.98
402_S406_T0.9860.98
283_F287_Y0.9850.98
32_I157_S0.9810.98
202_G349_N0.9810.98
391_I402_S0.9780.98
45_S400_I0.9770.98
336_Q339_R0.9760.98
121_L128_I0.9730.98
71_F371_P0.9630.98
79_F84_I0.9610.98
6_V27_A0.9600.98
138_L148_V0.9580.98
389_L406_T0.9550.98
333_P336_Q0.9500.98
18_A385_C0.9490.98
4_Y158_Q0.9480.98
19_A31_L0.9470.98
26_G29_V0.9460.98
313_F317_K0.9450.98
16_L39_G0.9440.98
91_L116_A0.9430.98
17_M21_A0.9380.98
410_A414_A0.9370.98
222_S270_R0.9370.98
187_H368_E0.9350.98
217_R237_D0.9300.98
205_F317_K0.9300.98
234_H252_R0.9290.98
75_A374_M0.9270.98
159_A383_Y0.9250.98
132_E155_I0.9250.98
286_M338_V0.9240.98
215_S239_L0.9230.98
182_A384_F0.9230.98
280_E284_Q0.9220.98
279_E343_Q0.9180.97
5_D27_A0.9170.97
87_F91_L0.9150.97
30_L158_Q0.9130.97
115_D119_N0.9110.97
137_V185_A0.9060.97
42_L45_S0.9040.97
216_L219_V0.9020.97
70_R73_Y0.9000.97
192_L360_T0.9000.97
88_F95_L0.8970.97
391_I406_T0.8960.97
135_K150_N0.8960.97
4_Y7_I0.8940.97
13_P404_L0.8910.97
366_V389_L0.8900.97
88_F117_L0.8890.97
17_M411_G0.8880.97
76_F80_N0.8860.97
87_F120_R0.8860.97
118_L128_I0.8850.97
66_P391_I0.8840.97
200_T349_N0.8820.97
119_N122_K0.8810.97
20_I24_E0.8790.97
383_Y413_N0.8730.97
4_Y127_T0.8720.97
306_M341_C0.8710.97
385_C407_G0.8700.96
161_I385_C0.8690.96
375_A381_G0.8670.96
197_V351_T0.8640.96
179_Y192_L0.8630.96
211_L310_Y0.8630.96
266_Q347_L0.8620.96
335_R339_R0.8600.96
68_N366_V0.8580.96
31_L121_L0.8580.96
55_R97_E0.8510.96
167_K354_L0.8440.96
162_I181_W0.8400.96
224_L270_R0.8380.96
199_V250_I0.8370.96
53_T401_T0.8370.96
85_I89_E0.8360.96
405_V408_R0.8360.96
216_L238_M0.8310.95
140_E146_G0.8300.95
34_K177_D0.8270.95
365_S368_E0.8250.95
6_V414_A0.8250.95
32_I132_E0.8250.95
283_F334_F0.8240.95
225_N267_V0.8230.95
25_Q412_L0.8220.95
129_R151_N0.8210.95
167_K192_L0.8200.95
283_F286_M0.8190.95
296_K304_P0.8170.95
141_D144_A0.8150.95
300_N303_K0.8120.95
274_Y341_C0.8070.95
11_G33_D0.8060.95
31_L126_V0.8060.95
368_E376_S0.8040.95
369_I374_M0.8020.94
31_L38_L0.8020.94
215_S237_D0.8010.94
298_I320_I0.8010.94
139_Y144_A0.8010.94
282_L338_V0.7980.94
376_S382_L0.7970.94
19_A126_V0.7900.94
129_R153_E0.7860.94
286_M334_F0.7850.94
187_H379_M0.7830.94
33_D130_T0.7830.94
52_V103_M0.7820.94
282_L306_M0.7820.94
160_V381_G0.7790.94
212_Q242_H0.7760.93
100_H236_M0.7730.93
223_V253_C0.7720.93
119_N123_Q0.7710.93
216_L310_Y0.7700.93
8_V18_A0.7640.93
66_P72_L0.7640.93
135_K153_E0.7610.93
376_S384_F0.7590.93
318_N340_D0.7590.93
215_S248_P0.7590.93
148_V153_E0.7590.93
49_R108_D0.7570.93
98_E102_R0.7560.93
298_I315_L0.7550.93
40_R171_H0.7540.92
324_V328_E0.7540.92
297_T325_S0.7530.92
114_V118_L0.7530.92
145_A185_A0.7530.92
379_M382_L0.7510.92
144_A156_H0.7460.92
18_A411_G0.7420.92
24_E90_N0.7410.92
358_F395_T0.7410.92
27_A159_A0.7390.92
58_V81_N0.7370.92
72_L402_S0.7370.92
9_I134_I0.7370.92
223_V257_V0.7340.91
50_C88_F0.7320.91
178_G364_V0.7320.91
16_L31_L0.7310.91
239_L248_P0.7310.91
285_K288_K0.7310.91
20_I87_F0.7270.91
8_V29_V0.7270.91
317_K340_D0.7230.91
68_N71_F0.7220.91
234_H249_A0.7200.91
28_G158_Q0.7200.91
30_L155_I0.7180.91
214_L307_Q0.7170.90
22_A29_V0.7150.90
217_R235_K0.7150.90
99_D237_D0.7140.90
199_V257_V0.7120.90
27_A411_G0.7110.90
192_L354_L0.7110.90
4_Y28_G0.7110.90
189_I192_L0.7080.90
129_R132_E0.7070.90
32_I147_I0.7030.90
29_V126_V0.7020.90
188_T376_S0.7010.89
198_P243_F0.7010.89
353_S356_K0.6970.89
314_L318_N0.6960.89
336_Q340_D0.6950.89
9_I388_I0.6930.89
340_D345_T0.6930.89
93_I107_T0.6900.89
375_A383_Y0.6900.89
18_A407_G0.6900.89
37_K114_V0.6900.89
269_I348_A0.6890.89
210_T316_E0.6880.89
72_L75_A0.6870.89
240_F311_L0.6860.88
224_L267_V0.6850.88
292_E304_P0.6830.88
255_Q361_G0.6820.88
298_I329_L0.6810.88
272_D275_P0.6790.88
406_T410_A0.6790.88
75_A373_K0.6780.88
221_V253_C0.6780.88
17_M408_R0.6770.88
221_V249_A0.6770.88
283_F338_V0.6770.88
315_L318_N0.6760.88
277_I281_T0.6750.88
370_D377_K0.6750.88
6_V158_Q0.6740.88
132_E152_G0.6730.87
132_E151_N0.6730.87
137_V144_A0.6710.87
370_D373_K0.6690.87
197_V357_A0.6670.87
279_E283_F0.6670.87
88_F93_I0.6660.87
22_A414_A0.6660.87
23_G26_G0.6650.87
17_M79_F0.6640.87
121_L125_R0.6630.87
169_V172_T0.6580.86
292_E301_V0.6570.86
21_A25_Q0.6570.86
19_A121_L0.6530.86
385_C389_L0.6530.86
299_K308_E0.6510.86
302_L337_F0.6490.86
198_P352_L0.6480.85
200_T243_F0.6460.85
33_D128_I0.6460.85
78_E408_R0.6450.85
274_Y306_M0.6430.85
52_V93_I0.6420.85
296_K301_V0.6420.85
59_E73_Y0.6390.85
401_T404_L0.6370.84
181_W184_A0.6370.84
32_I149_T0.6360.84
176_G360_T0.6350.84
202_G205_F0.6350.84
50_C113_V0.6340.84
294_P301_V0.6330.84
278_N284_Q0.6330.84
135_K146_G0.6320.84
10_G15_G0.6320.84
4_Y159_A0.6310.84
207_K240_F0.6300.84
90_N123_Q0.6300.84
405_V409_L0.6290.84
139_Y145_A0.6290.84
338_V342_K0.6280.84
57_P60_E0.6250.83
249_A253_C0.6230.83
298_I318_N0.6220.83
34_K175_T0.6210.83
58_V77_S0.6200.83
12_G15_G0.6190.83
275_P342_K0.6180.83
271_I346_V0.6160.82
311_L315_L0.6160.82
281_T284_Q0.6120.82
201_S348_A0.6120.82
301_V326_F0.6120.82
31_L124_L0.6100.82
240_F273_L0.6080.82
331_K334_F0.6070.82
176_G179_Y0.6070.82
71_F75_A0.6060.81
100_H237_D0.6060.81
44_I172_T0.6040.81
179_Y182_A0.6020.81
207_K210_T0.6000.81
188_T378_K0.5990.81
220_A272_D0.5970.80
385_C410_A0.5950.80
140_E145_A0.5950.80
166_G174_S0.5940.80
318_N337_F0.5940.80
235_K249_A0.5930.80
293_A296_K0.5920.80
216_L273_L0.5910.80
9_I177_D0.5900.80
75_A405_V0.5850.79
27_A158_Q0.5850.79
94_Q108_D0.5850.79
78_E413_N0.5850.79
222_S343_Q0.5830.79
44_I47_G0.5810.79
314_L317_K0.5800.79
18_A414_A0.5800.79
58_V63_K0.5790.78
308_E312_L0.5790.78
9_I164_V0.5770.78
197_V353_S0.5750.78
30_L157_S0.5750.78
44_I171_H0.5750.78
137_V145_A0.5740.78
140_E144_A0.5720.78
63_K69_G0.5720.78
288_K292_E0.5700.77
277_I282_L0.5700.77
91_L123_Q0.5690.77
224_L268_P0.5690.77
199_V254_S0.5690.77
136_S139_Y0.5690.77
17_M87_F0.5690.77
202_G347_L0.5690.77
56_L101_G0.5680.77
179_Y189_I0.5680.77
20_I411_G0.5680.77
99_D236_M0.5670.77
111_Q114_V0.5640.77
293_A301_V0.5630.77
313_F316_E0.5630.77
215_S242_H0.5630.77
76_F83_D0.5620.76
239_L251_L0.5610.76
47_G50_C0.5590.76
282_L342_K0.5580.76
71_F74_S0.5550.76
306_M311_L0.5550.76
146_G156_H0.5550.76
367_K377_K0.5540.75
79_F87_F0.5530.75
8_V414_A0.5510.75
329_L334_F0.5480.75
359_V393_G0.5470.74
197_V350_G0.5450.74
57_P64_H0.5450.74
374_M406_T0.5450.74
11_G39_G0.5440.74
20_I121_L0.5440.74
281_T285_K0.5440.74
22_A407_G0.5430.74
104_F248_P0.5410.74
221_V238_M0.5400.74
5_D157_S0.5390.73
35_G39_G0.5390.73
205_F346_V0.5380.73
70_R74_S0.5370.73
40_R114_V0.5350.73
37_K43_A0.5340.73
94_Q107_T0.5340.73
98_E108_D0.5330.73
173_G176_G0.5330.73
310_Y313_F0.5320.72
187_H369_I0.5310.72
7_I145_A0.5300.72
96_K106_V0.5300.72
279_E342_K0.5300.72
301_V305_W0.5270.72
57_P82_E0.5240.71
393_G402_S0.5220.71
214_L309_R0.5220.71
211_L214_L0.5220.71
180_E184_A0.5210.71
74_S371_P0.5210.71
55_R82_E0.5200.71
16_L20_I0.5200.71
159_A381_G0.5190.71
331_K335_R0.5190.71
238_M249_A0.5180.70
134_I137_V0.5180.70
134_I147_I0.5180.70
373_K409_L0.5160.70
27_A410_A0.5150.70
302_L311_L0.5140.70
66_P394_Y0.5140.70
172_T175_T0.5140.70
239_L242_H0.5130.70
314_L340_D0.5110.69
31_L128_I0.5110.69
207_K314_L0.5100.69
172_T176_G0.5100.69
242_H248_P0.5090.69
310_Y318_N0.5080.69
162_I178_G0.5080.69
143_Q146_G0.5070.69
299_K312_L0.5070.69
272_D276_D0.5070.69
139_Y380_E0.5070.69
178_G181_W0.5060.69
35_G172_T0.5060.69
55_R81_N0.5050.69
109_K112_S0.5040.68
198_P251_L0.5030.68
64_H394_Y0.5030.68
140_E156_H0.5020.68
66_P195_T0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v76A 2 0.9214 100 0.381 Contact Map
2i0zA 1 0.981 100 0.403 Contact Map
4cnkA 2 0.931 100 0.445 Contact Map
2gqfA 4 0.9452 100 0.508 Contact Map
3nlcA 1 0.9262 100 0.7 Contact Map
3cesA 2 0.7857 100 0.702 Contact Map
4at0A 2 0.9071 100 0.737 Contact Map
1jnrA 2 0.9119 100 0.755 Contact Map
2wdqA 1 0.8405 100 0.757 Contact Map
3cp8A 2 0.8333 100 0.769 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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