GREMLIN Database
YTCQ - Putative ABC transporter peptide-binding protein YtcQ
UniProt: Q795R2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 498 (397)
Sequences: 24259 (19773)
Seq/√Len: 992.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_K72_D4.0641.00
253_K257_D3.5621.00
414_P417_T3.4871.00
166_D305_K3.3721.00
246_K416_R3.0861.00
42_K70_E3.0161.00
250_N254_K2.9071.00
119_E146_K2.8771.00
67_T349_A2.8431.00
165_K307_E2.8391.00
44_S72_D2.8371.00
187_K258_N2.7941.00
183_Y254_K2.7691.00
165_K169_D2.7231.00
118_W340_T2.6441.00
57_D61_K2.6041.00
254_K258_N2.5821.00
178_T181_E2.5201.00
163_I307_E2.5181.00
62_E65_K2.4641.00
416_R420_E2.4391.00
69_T346_R2.3841.00
63_I349_A2.3811.00
80_V83_D2.3741.00
64_E70_E2.3721.00
420_E424_E2.3371.00
142_T147_L2.2891.00
349_A352_D2.2641.00
339_K346_R2.2591.00
135_K139_K2.2501.00
243_Q247_D2.2321.00
187_K191_E2.2241.00
61_K65_K2.2151.00
184_E188_A2.2141.00
168_L284_I2.2051.00
40_K70_E2.1841.00
121_G146_K2.1751.00
166_D170_N2.1321.00
174_K177_K2.0821.00
181_E184_E2.0801.00
58_R61_K2.0761.00
356_E359_V2.0581.00
46_M88_A2.0471.00
173_L185_V2.0421.00
44_S74_T2.0381.00
241_M420_E2.0311.00
413_D421_E2.0001.00
188_A192_D1.9601.00
423_T427_E1.9451.00
15_A18_G1.9191.00
62_E66_L1.8821.00
231_E235_K1.8771.00
247_D250_N1.8561.00
184_E187_K1.8111.00
417_T421_E1.8011.00
269_S272_Q1.8011.00
62_E353_R1.7981.00
139_K142_T1.7971.00
64_E67_T1.7861.00
123_Y348_L1.7481.00
117_F332_A1.7351.00
180_D183_Y1.7191.00
16_L19_V1.7091.00
250_N415_L1.6961.00
41_V346_R1.6841.00
98_V334_P1.6661.00
183_Y258_N1.6551.00
60_I350_F1.6491.00
149_G330_V1.6081.00
141_V330_V1.6041.00
163_I309_I1.6021.00
119_E122_D1.5931.00
60_I64_E1.5931.00
61_K64_E1.5851.00
361_S365_Y1.5801.00
424_E428_K1.5771.00
183_Y187_K1.5751.00
183_Y255_L1.5691.00
206_A282_A1.5491.00
337_S340_T1.5411.00
190_T204_G1.5241.00
63_I67_T1.5191.00
187_K260_Y1.5051.00
189_F283_G1.4981.00
161_I309_I1.4971.00
417_T420_E1.4941.00
167_W189_F1.4861.00
40_K68_N1.4701.00
246_K250_N1.4681.00
421_E424_E1.4661.00
251_Y255_L1.4621.00
407_Y413_D1.4611.00
63_I69_T1.4591.00
246_K415_L1.4451.00
167_W283_G1.4411.00
165_K305_K1.4381.00
421_E425_D1.4221.00
89_L94_L1.4181.00
357_E361_S1.4141.00
413_D418_A1.3991.00
118_W335_K1.3981.00
84_R88_A1.3951.00
277_F306_L1.3951.00
408_L418_A1.3931.00
333_F351_F1.3921.00
180_D184_E1.3821.00
62_E362_L1.3711.00
132_K375_G1.3481.00
41_V339_K1.3431.00
141_V147_L1.3421.00
63_I353_R1.3391.00
359_V362_L1.3381.00
112_F148_Y1.3321.00
186_A284_I1.3261.00
97_I351_F1.3251.00
171_L189_F1.3251.00
407_Y412_G1.3091.00
337_S347_I1.3071.00
161_I284_I1.2911.00
254_K257_D1.2881.00
176_P181_E1.2841.00
58_R62_E1.2781.00
276_L281_K1.2761.00
183_Y251_Y1.2751.00
375_G378_K1.2741.00
47_A73_I1.2711.00
241_M423_T1.2681.00
244_E247_D1.2671.00
250_N416_R1.2661.00
251_Y254_K1.2541.00
173_L188_A1.2481.00
69_T349_A1.2451.00
60_I73_I1.2331.00
394_I397_L1.2301.00
420_E423_T1.2251.00
13_V17_G1.2231.00
180_D315_P1.2221.00
100_I332_A1.2201.00
122_D125_K1.2141.00
160_G308_I1.2111.00
77_P80_V1.2101.00
96_Q337_S1.2061.00
63_I350_F1.2041.00
190_T260_Y1.2011.00
182_L186_A1.2001.00
186_A260_Y1.1911.00
167_W202_T1.1881.00
177_K181_E1.1861.00
167_W171_L1.1821.00
373_N376_E1.1681.00
346_R349_A1.1671.00
333_F348_L1.1611.00
353_R359_V1.1611.00
425_D428_K1.1591.00
424_E427_E1.1591.00
404_D413_D1.1561.00
362_L366_G1.1471.00
118_W337_S1.1431.00
341_E346_R1.1391.00
413_D417_T1.1371.00
12_L15_A1.1321.00
185_V188_A1.1251.00
350_F354_I1.1211.00
168_L173_L1.1161.00
202_T281_K1.1141.00
334_P337_S1.1141.00
112_F143_I1.1131.00
129_N132_K1.1101.00
12_L18_G1.1101.00
169_D175_T1.1041.00
17_G20_L1.1031.00
43_L350_F1.1021.00
404_D407_Y1.0981.00
8_L15_A1.0981.00
168_L185_V1.0971.00
41_V68_N1.0971.00
174_K181_E1.0971.00
272_Q275_E1.0961.00
404_D421_E1.0951.00
182_L284_I1.0911.00
97_I347_I1.0911.00
203_F263_K1.0881.00
348_L352_D1.0741.00
253_K408_L1.0731.00
350_F353_R1.0711.00
64_E68_N1.0701.00
408_L415_L1.0691.00
167_W170_N1.0681.00
341_E349_A1.0671.00
85_L98_V1.0641.00
115_G335_K1.0611.00
138_N142_T1.0561.00
164_R304_M1.0561.00
16_L20_L1.0521.00
166_D304_M1.0491.00
170_N202_T1.0401.00
94_L334_P1.0371.00
45_W331_F1.0371.00
182_L205_L1.0361.00
173_L189_F1.0331.00
379_T382_R1.0301.00
275_E279_Q1.0261.00
11_V15_A1.0251.00
399_A403_I1.0221.00
171_L192_D1.0191.00
71_L350_F1.0181.00
418_A422_L1.0141.00
89_L116_M1.0111.00
63_I346_R0.9961.00
358_D361_S0.9941.00
13_V19_V0.9941.00
6_R18_G0.9881.00
247_D251_Y0.9861.00
164_R167_W0.9841.00
335_K340_T0.9831.00
149_G332_A0.9831.00
12_L16_L0.9831.00
60_I71_L0.9701.00
97_I350_F0.9691.00
186_A204_G0.9631.00
333_F347_I0.9611.00
313_K316_D0.9571.00
222_Y227_T0.9551.00
188_A191_E0.9471.00
253_K415_L0.9411.00
11_V18_G0.9411.00
62_E358_D0.9401.00
66_L358_D0.9391.00
14_L17_G0.9371.00
250_N253_K0.9361.00
23_C26_T0.9361.00
400_L425_D0.9341.00
129_N352_D0.9331.00
19_V22_G0.9321.00
98_V332_A0.9301.00
121_G125_K0.9291.00
169_D305_K0.9291.00
128_P131_N0.9281.00
407_Y421_E0.9271.00
294_N297_D0.9251.00
183_Y260_Y0.9241.00
166_D169_D0.9231.00
11_V17_G0.9211.00
96_Q339_K0.9211.00
84_R87_A0.9171.00
15_A19_V0.9161.00
276_L282_A0.9111.00
82_E107_S0.9101.00
171_L188_A0.9031.00
185_V284_I0.9031.00
58_R366_G0.9021.00
23_C27_D0.9011.00
222_Y245_Y0.9011.00
124_I147_L0.9011.00
59_A62_E0.9001.00
92_G336_T0.8901.00
13_V16_L0.8791.00
362_L365_Y0.8741.00
259_G263_K0.8731.00
46_M76_V0.8721.00
225_M247_D0.8701.00
121_G142_T0.8691.00
287_G291_D0.8691.00
163_I175_T0.8681.00
12_L19_V0.8661.00
87_A91_A0.8621.00
414_P418_A0.8611.00
403_I407_Y0.8611.00
240_F245_Y0.8551.00
314_G317_G0.8551.00
246_K419_Y0.8521.00
96_Q338_V0.8511.00
121_G147_L0.8511.00
255_L260_Y0.8481.00
112_F117_F0.8481.00
403_I425_D0.8471.00
8_L11_V0.8461.00
98_V117_F0.8431.00
14_L18_G0.8431.00
43_L346_R0.8411.00
239_D242_T0.8411.00
138_N147_L0.8411.00
117_F148_Y0.8381.00
118_W334_P0.8381.00
58_R362_L0.8351.00
385_S389_D0.8341.00
45_W97_I0.8271.00
118_W333_F0.8251.00
243_Q246_K0.8221.00
238_P427_E0.8211.00
46_M95_P0.8201.00
301_D304_M0.8191.00
68_N349_A0.8181.00
9_L16_L0.8171.00
8_L12_L0.8171.00
404_D422_L0.8101.00
125_K131_N0.8081.00
385_S388_K0.8071.00
6_R19_V0.8061.00
357_E375_G0.8061.00
41_V69_T0.8051.00
135_K374_K0.8051.00
88_A93_N0.8021.00
8_L18_G0.7991.00
190_T259_G0.7951.00
118_W123_Y0.7911.00
358_D362_L0.7841.00
333_F337_S0.7821.00
76_V84_R0.7821.00
8_L19_V0.7821.00
152_R331_F0.7791.00
388_K392_T0.7761.00
168_L189_F0.7761.00
175_T181_E0.7731.00
97_I331_F0.7731.00
83_D87_A0.7711.00
186_A190_T0.7701.00
175_T309_I0.7701.00
43_L347_I0.7651.00
391_Q394_I0.7641.00
302_K306_L0.7631.00
162_V287_G0.7611.00
361_S379_T0.7551.00
228_D232_S0.7531.00
249_M419_Y0.7521.00
64_E71_L0.7491.00
62_E359_V0.7491.00
393_D396_P0.7471.00
406_A410_N0.7471.00
347_I351_F0.7471.00
118_W122_D0.7451.00
300_S303_S0.7441.00
14_L19_V0.7431.00
6_R16_L0.7411.00
59_A353_R0.7371.00
135_K138_N0.7331.00
66_L353_R0.7321.00
23_C28_Q0.7301.00
20_L23_C0.7281.00
275_E278_S0.7281.00
11_V14_L0.7261.00
385_S392_T0.7251.00
133_M355_A0.7231.00
142_T145_G0.7231.00
386_Q389_D0.7231.00
6_R15_A0.7221.00
171_L185_V0.7211.00
54_P57_D0.7181.00
404_D425_D0.7161.00
22_G25_G0.7091.00
361_S376_E0.7081.00
315_P318_K0.7071.00
404_D418_A0.7061.00
133_M138_N0.7051.00
179_L183_Y0.7001.00
40_K67_T0.7001.00
175_T185_V0.7001.00
393_D397_L0.7001.00
390_W394_I0.7001.00
262_N276_L0.6991.00
395_Q398_S0.6961.00
9_L13_V0.6951.00
38_D68_N0.6911.00
10_I17_G0.6911.00
170_N192_D0.6901.00
415_L419_Y0.6891.00
203_F262_N0.6881.00
249_M418_A0.6861.00
122_D348_L0.6861.00
378_K382_R0.6861.00
185_V189_F0.6851.00
23_C29_S0.6851.00
390_W397_L0.6841.00
119_E148_Y0.6831.00
171_L283_G0.6821.00
171_L202_T0.6821.00
179_L251_Y0.6781.00
43_L337_S0.6771.00
313_K317_G0.6751.00
190_T203_F0.6751.00
394_I398_S0.6741.00
9_L12_L0.6741.00
392_T395_Q0.6731.00
39_S68_N0.6721.00
6_R17_G0.6691.00
9_L15_A0.6691.00
242_T245_Y0.6661.00
187_K190_T0.6651.00
136_L139_K0.6651.00
231_E234_G0.6631.00
134_N374_K0.6631.00
227_T245_Y0.6621.00
189_F202_T0.6611.00
163_I168_L0.6571.00
89_L334_P0.6561.00
271_T274_Q0.6551.00
164_R305_K0.6531.00
183_Y186_A0.6531.00
46_M74_T0.6501.00
419_Y423_T0.6491.00
190_T202_T0.6461.00
391_Q395_Q0.6451.00
223_E228_D0.6441.00
59_A359_V0.6421.00
340_T348_L0.6401.00
123_Y341_E0.6401.00
403_I406_A0.6401.00
23_C30_S0.6381.00
249_M408_L0.6371.00
302_K305_K0.6361.00
10_I13_V0.6351.00
122_D126_D0.6351.00
189_F284_I0.6311.00
419_Y422_L0.6311.00
384_E388_K0.6311.00
17_G21_A0.6301.00
59_A354_I0.6291.00
164_R280_G0.6291.00
271_T275_E0.6291.00
247_D314_G0.6281.00
192_D202_T0.6271.00
94_L336_T0.6271.00
300_S304_M0.6271.00
41_V67_T0.6271.00
101_Q106_S0.6261.00
223_E226_P0.6261.00
6_R9_L0.6261.00
384_E387_V0.6251.00
122_D146_K0.6241.00
45_W60_I0.6241.00
416_R419_Y0.6221.00
225_M251_Y0.6221.00
400_L422_L0.6211.00
374_K378_K0.6211.00
9_L19_V0.6211.00
376_E379_T0.6201.00
45_W350_F0.6191.00
43_L339_K0.6191.00
242_T246_K0.6191.00
155_P329_G0.6191.00
231_E239_D0.6181.00
26_T29_S0.6181.00
268_T276_L0.6181.00
18_G21_A0.6171.00
168_L175_T0.6171.00
67_T350_F0.6161.00
375_G379_T0.6151.00
293_V297_D0.6131.00
273_Q285_Y0.6111.00
81_K85_L0.6101.00
108_V149_G0.6101.00
404_D408_L0.6091.00
66_L356_E0.6091.00
10_I14_L0.6061.00
27_D30_S0.6051.00
374_K377_D0.6051.00
248_T252_M0.6031.00
128_P132_K0.6031.00
118_W348_L0.5961.00
82_E110_N0.5951.00
125_K128_P0.5951.00
100_I111_A0.5941.00
296_R306_L0.5941.00
388_K394_I0.5941.00
40_K69_T0.5921.00
405_K409_K0.5921.00
357_E373_N0.5911.00
256_R261_M0.5911.00
392_T396_P0.5901.00
118_W336_T0.5881.00
206_A273_Q0.5881.00
390_W393_D0.5871.00
7_V18_G0.5861.00
130_L138_N0.5861.00
22_G26_T0.5851.00
220_G223_E0.5841.00
210_D269_S0.5831.00
108_V112_F0.5821.00
10_I16_L0.5811.00
422_L426_N0.5811.00
176_P284_I0.5791.00
173_L176_P0.5781.00
169_D172_N0.5771.00
86_N110_N0.5771.00
162_V308_I0.5761.00
191_E202_T0.5761.00
6_R12_L0.5751.00
7_V14_L0.5741.00
64_E69_T0.5741.00
110_N114_S0.5721.00
67_T353_R0.5721.00
124_I348_L0.5711.00
162_V292_A0.5711.00
389_D393_D0.5701.00
179_L224_G0.5691.00
377_D380_F0.5681.00
418_A421_E0.5681.00
132_K373_N0.5671.00
74_T84_R0.5661.00
391_Q397_L0.5651.00
390_W395_Q0.5651.00
13_V18_G0.5651.00
78_D82_E0.5641.00
25_G28_Q0.5641.00
48_I81_K0.5641.00
67_T346_R0.5631.00
123_Y340_T0.5621.00
107_S110_N0.5621.00
38_D41_V0.5611.00
253_K256_R0.5591.00
43_L96_Q0.5581.00
292_A296_R0.5581.00
20_L25_G0.5571.00
278_S298_H0.5561.00
155_P328_N0.5551.00
228_D231_E0.5541.00
59_A362_L0.5531.00
276_L279_Q0.5531.00
174_K185_V0.5521.00
115_G118_W0.5521.00
341_E348_L0.5511.00
6_R20_L0.5511.00
399_A402_A0.5501.00
43_L97_I0.5501.00
109_M113_R0.5501.00
82_E101_Q0.5501.00
8_L16_L0.5491.00
427_E430_I0.5491.00
161_I286_I0.5491.00
116_M119_E0.5481.00
21_A25_G0.5461.00
180_D251_Y0.5461.00
204_G260_Y0.5421.00
24_K27_D0.5411.00
238_P423_T0.5411.00
63_I71_L0.5391.00
44_S88_A0.5371.00
186_A255_L0.5371.00
189_F192_D0.5361.00
338_V341_E0.5351.00
26_T30_S0.5351.00
394_I401_I0.5351.00
19_V23_C0.5341.00
252_M256_R0.5331.00
407_Y411_T0.5331.00
123_Y126_D0.5321.00
112_F115_G0.5311.00
313_K318_K0.5301.00
415_L418_A0.5301.00
268_T272_Q0.5291.00
121_G348_L0.5291.00
74_T88_A0.5291.00
11_V16_L0.5281.00
108_V117_F0.5271.00
202_T283_G0.5271.00
425_D429_I0.5271.00
389_D394_I0.5271.00
408_L413_D0.5261.00
88_A95_P0.5241.00
44_S96_Q0.5221.00
331_F354_I0.5221.00
356_E360_Y0.5201.00
294_N298_H0.5201.00
120_I351_F0.5201.00
400_L404_D0.5191.00
28_Q31_A0.5191.00
328_N331_F0.5181.00
120_I333_F0.5171.00
31_A37_P0.5171.00
172_N192_D0.5171.00
83_D86_N0.5171.00
109_M143_I0.5161.00
80_V84_R0.5151.00
169_D307_E0.5151.00
57_D60_I0.5141.00
392_T398_S0.5111.00
100_I117_F0.5111.00
393_D398_S0.5111.00
177_K313_K0.5101.00
240_F426_N0.5091.00
390_W396_P0.5081.00
392_T397_L0.5081.00
141_V149_G0.5081.00
12_L17_G0.5081.00
101_Q327_H0.5071.00
18_G22_G0.5051.00
383_K386_Q0.5051.00
348_L351_F0.5031.00
222_Y248_T0.5021.00
56_K59_A0.5021.00
6_R21_A0.5011.00
6_R22_G0.5011.00
232_S235_K0.5001.00
111_A117_F0.5001.00
132_K374_K0.5001.00
21_A24_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ombA 1 0.9016 100 0.266 Contact Map
4r2fA 1 0.7309 100 0.312 Contact Map
4r9fA 1 0.7369 100 0.323 Contact Map
3uorA 1 0.759 100 0.327 Contact Map
4mfiA 1 0.753 100 0.339 Contact Map
4r6kA 1 0.741 100 0.339 Contact Map
3vxbA 1 0.7349 100 0.341 Contact Map
3a09A 1 0.9076 100 0.349 Contact Map
4r6hA 1 0.747 100 0.359 Contact Map
2w7yA 1 0.7088 100 0.364 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.