GREMLIN Database
YUGO - Putative potassium channel protein YugO
UniProt: Q795M8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 328 (294)
Sequences: 2971 (2322)
Seq/√Len: 135.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_V206_V5.4061.00
182_V213_A4.1911.00
305_K323_D4.0481.00
175_N178_E4.0241.00
207_K215_C3.8981.00
119_L130_L3.8541.00
114_R178_E3.6351.00
172_K177_T3.2701.00
303_I317_Y3.0931.00
203_L233_A2.9311.00
277_V319_V2.8201.00
47_E72_Q2.7601.00
115_D180_E2.7011.00
207_K234_N2.5051.00
284_A288_T2.4891.00
55_T59_V2.4691.00
163_G170_T2.4291.00
281_L289_C2.3371.00
117_I181_S2.2751.00
55_T61_Y2.2581.00
199_S217_V2.2511.00
31_G34_I2.2381.00
285_A288_T2.2311.00
184_I199_S2.1891.00
55_T58_T2.1781.00
63_D66_P2.1131.00
161_I174_A2.1061.00
47_E50_W2.0261.00
286_Y300_I2.0241.00
319_V325_F2.0211.00
68_T71_G2.0091.00
145_I170_T2.0051.00
62_G66_P1.9701.00
50_W53_V1.9201.00
30_F34_I1.9021.00
45_V49_I1.8881.00
305_K317_Y1.8451.00
176_I206_V1.8301.00
210_N213_A1.8121.00
149_L162_R1.8111.00
34_I75_G1.8001.00
44_S47_E1.7871.00
186_A202_T1.7811.00
27_I31_G1.7781.00
305_K320_L1.7201.00
31_G35_Y1.6681.00
48_G52_A1.6621.00
30_F33_I1.6461.00
50_W58_T1.6191.00
214_Y234_N1.5981.00
23_I27_I1.5951.00
59_V63_D1.5831.00
145_I174_A1.5581.00
49_I53_V1.5461.00
35_Y45_V1.5391.00
118_I176_I1.5391.00
63_D68_T1.5201.00
116_H179_A1.5151.00
145_I161_I1.4931.00
51_W54_V1.4901.00
50_W54_V1.4831.00
58_T62_G1.4751.00
33_I37_L1.4751.00
152_G160_F1.4721.00
35_Y38_E1.4441.00
123_N126_T1.4341.00
287_K316_T1.4311.00
32_Q36_I1.4281.00
22_I26_L1.4141.00
34_I38_E1.4141.00
176_I210_N1.4141.00
31_G36_I1.4121.00
54_V79_I1.4081.00
123_N218_E1.4021.00
50_W63_D1.3961.00
46_F49_I1.3951.00
233_A236_I1.3891.00
19_I34_I1.3791.00
176_I182_V1.3691.00
75_G80_L1.3471.00
55_T60_G1.3381.00
51_W63_D1.3271.00
54_V58_T1.3171.00
48_G51_W1.2991.00
58_T61_Y1.2971.00
50_W55_T1.2911.00
289_C319_V1.2901.00
76_I80_L1.2821.00
146_D160_F1.2671.00
302_G326_L1.2631.00
27_I34_I1.2581.00
23_I35_Y1.2541.00
50_W60_G1.2501.00
286_Y290_V1.2401.00
49_I58_T1.2381.00
146_D151_E1.2321.00
34_I37_L1.2311.00
303_I323_D1.2281.00
260_Q268_L1.2261.00
195_A198_L1.2051.00
196_D224_F1.1961.00
63_D67_H1.1931.00
90_F94_S1.1820.99
50_W61_Y1.1810.99
287_K315_L1.1740.99
117_I133_L1.1730.99
206_V213_A1.1720.99
32_Q35_Y1.1700.99
54_V63_D1.1650.99
23_I34_I1.1520.99
26_L31_G1.1490.99
274_L324_Q1.1480.99
165_A202_T1.1360.99
57_S79_I1.1360.99
38_E71_G1.1290.99
147_E164_H1.1250.99
54_V66_P1.1170.99
113_G159_H1.1150.99
23_I32_Q1.1140.99
305_K310_M1.1090.99
26_L30_F1.0930.99
200_V204_L1.0920.99
30_F35_Y1.0860.99
59_V79_I1.0760.99
65_V69_P1.0730.99
129_L244_S1.0660.99
47_E51_W1.0650.99
75_G79_I1.0630.99
285_A318_K1.0630.99
118_I213_A1.0600.99
273_E277_V1.0560.99
157_N160_F1.0540.99
31_G52_A1.0480.99
27_I32_Q1.0460.99
63_D71_G1.0450.99
196_D204_L1.0450.99
125_K218_E1.0450.99
47_E58_T1.0350.99
129_L183_M1.0310.99
58_T71_G1.0300.99
148_S151_E1.0290.99
47_E53_V1.0220.98
43_T48_G1.0180.98
20_G23_I1.0150.98
142_V158_V1.0130.98
126_T218_E1.0090.98
54_V60_G1.0070.98
46_F50_W0.9970.98
20_G24_L0.9960.98
33_I74_A0.9940.98
54_V61_Y0.9840.98
300_I325_F0.9790.98
118_I182_V0.9760.98
222_D241_E0.9720.98
146_D152_G0.9720.98
122_W126_T0.9690.98
48_G56_V0.9670.98
59_V62_G0.9660.98
201_L224_F0.9620.98
19_I31_G0.9610.98
33_I38_E0.9550.98
276_A324_Q0.9550.98
130_L142_V0.9520.98
58_T63_D0.9490.98
117_I180_E0.9470.97
44_S49_I0.9420.97
215_C234_N0.9390.97
37_L74_A0.9390.97
62_G68_T0.9360.97
282_K321_E0.9360.97
172_K209_L0.9350.97
60_G63_D0.9350.97
27_I36_I0.9290.97
144_L158_V0.9260.97
50_W72_Q0.9090.97
257_P263_G0.9050.97
63_D72_Q0.8930.96
27_I35_Y0.8840.96
130_L144_L0.8830.96
61_Y66_P0.8820.96
20_G35_Y0.8770.96
54_V64_Y0.8770.96
184_I217_V0.8730.96
44_S48_G0.8690.96
54_V57_S0.8670.96
304_Q324_Q0.8600.96
21_V27_I0.8580.96
46_F76_I0.8570.95
203_L215_C0.8570.95
24_L34_I0.8560.95
70_L73_A0.8560.95
176_I209_L0.8560.95
129_L185_T0.8520.95
219_I228_A0.8520.95
184_I203_L0.8480.95
58_T64_Y0.8470.95
52_A61_Y0.8450.95
30_F36_I0.8430.95
119_L144_L0.8390.95
186_A218_E0.8380.95
50_W66_P0.8330.95
203_L228_A0.8310.95
31_G37_L0.8270.95
129_L134_Q0.8260.94
143_V161_I0.8240.94
64_Y67_H0.8230.94
51_W59_V0.8210.94
37_L70_L0.8200.94
111_Y175_N0.8120.94
272_V301_I0.8100.94
50_W75_G0.8070.94
48_G60_G0.8050.94
49_I76_I0.8050.94
172_K175_N0.8040.94
204_L231_A0.8040.94
308_G314_P0.8020.94
48_G55_T0.7980.93
53_V60_G0.7920.93
76_I79_I0.7890.93
120_I182_V0.7880.93
320_L323_D0.7880.93
25_C38_E0.7870.93
203_L217_V0.7860.93
62_G72_Q0.7840.93
53_V58_T0.7830.93
47_E60_G0.7820.93
47_E64_Y0.7770.92
44_S69_P0.7740.92
125_K185_T0.7700.92
53_V59_V0.7700.92
169_G172_K0.7690.92
286_Y292_Y0.7670.92
274_L277_V0.7630.92
29_L32_Q0.7590.92
26_L34_I0.7590.92
183_M251_Y0.7520.91
186_A198_L0.7520.91
64_Y68_T0.7510.91
225_V229_E0.7470.91
162_R169_G0.7420.91
32_Q37_L0.7410.91
51_W58_T0.7370.90
50_W59_V0.7360.90
83_A90_F0.7310.90
24_L36_I0.7290.90
129_L296_H0.7290.90
144_L237_I0.7270.90
130_L158_V0.7260.90
23_I28_L0.7260.90
29_L33_I0.7230.90
21_V29_L0.7180.89
155_I160_F0.7170.89
22_I34_I0.7160.89
282_K322_T0.7160.89
28_L31_G0.7150.89
103_R108_K0.7090.89
273_E278_P0.7080.89
70_L74_A0.7060.88
120_I165_A0.7050.88
219_I236_I0.7000.88
46_F69_P0.6990.88
49_I59_V0.6980.88
55_T63_D0.6950.88
19_I30_F0.6880.87
121_G218_E0.6860.87
30_F78_L0.6860.87
318_K322_T0.6850.87
95_A98_F0.6820.87
26_L36_I0.6820.87
83_A101_Q0.6810.87
126_T243_I0.6790.86
49_I54_V0.6750.86
23_I31_G0.6740.86
20_G33_I0.6730.86
62_G65_V0.6690.86
47_E63_D0.6680.86
300_I315_L0.6670.85
202_T219_I0.6660.85
124_E187_D0.6660.85
58_T68_T0.6660.85
140_K180_E0.6650.85
24_L30_F0.6630.85
55_T66_P0.6630.85
126_T146_D0.6620.85
26_L38_E0.6600.85
31_G38_E0.6550.84
153_P156_E0.6540.84
106_E110_A0.6530.84
263_G266_L0.6510.84
24_L28_L0.6500.84
283_G321_E0.6500.84
288_T318_K0.6500.84
59_V66_P0.6480.84
225_V241_E0.6450.83
55_T62_G0.6450.83
51_W60_G0.6420.83
50_W57_S0.6420.83
176_I213_A0.6400.83
57_S60_G0.6390.83
123_N165_A0.6380.83
53_V76_I0.6380.83
27_I30_F0.6330.82
165_A171_L0.6330.82
63_D69_P0.6320.82
126_T165_A0.6300.82
50_W64_Y0.6300.82
285_A316_T0.6260.82
89_Y92_T0.6250.82
48_G54_V0.6210.81
185_T218_E0.6210.81
305_K308_G0.6180.81
47_E61_Y0.6180.81
269_D272_V0.6180.81
25_C29_L0.6170.81
19_I35_Y0.6150.80
310_M317_Y0.6140.80
134_Q158_V0.6140.80
57_S61_Y0.6140.80
133_L138_P0.6120.80
119_L166_A0.6090.80
260_Q267_T0.6090.80
207_K213_A0.6070.80
317_Y320_L0.6050.79
122_W127_N0.6050.79
286_Y297_N0.6030.79
146_D165_A0.6020.79
260_Q263_G0.5960.78
54_V62_G0.5950.78
61_Y68_T0.5950.78
61_Y69_P0.5940.78
219_I233_A0.5940.78
43_T47_E0.5930.78
48_G58_T0.5920.78
92_T96_A0.5910.78
45_V55_T0.5900.78
201_L227_N0.5890.78
123_N146_D0.5890.78
286_Y291_L0.5880.77
31_G49_I0.5880.77
216_I247_M0.5870.77
212_L321_E0.5860.77
286_Y315_L0.5850.77
87_T91_A0.5850.77
302_G309_P0.5850.77
79_I83_A0.5850.77
22_I33_I0.5840.77
86_V89_Y0.5840.77
127_N131_K0.5820.77
23_I30_F0.5790.76
26_L35_Y0.5780.76
22_I25_C0.5780.76
49_I52_A0.5780.76
238_G241_E0.5740.76
180_E183_M0.5740.76
48_G53_V0.5740.76
126_T144_L0.5740.76
51_W61_Y0.5730.76
66_P79_I0.5730.76
32_Q38_E0.5720.76
79_I84_S0.5700.75
272_V277_V0.5700.75
47_E54_V0.5670.75
146_D218_E0.5660.75
299_T302_G0.5650.75
265_K268_L0.5640.75
217_V233_A0.5630.74
168_D205_S0.5620.74
77_L222_D0.5610.74
77_L80_L0.5600.74
19_I23_I0.5600.74
122_W158_V0.5600.74
54_V59_V0.5580.74
184_I206_V0.5580.74
197_M201_L0.5560.73
302_G313_P0.5560.73
123_N185_T0.5550.73
28_L35_Y0.5550.73
27_I38_E0.5530.73
263_G267_T0.5520.73
39_P44_S0.5500.73
118_I199_S0.5490.73
44_S64_Y0.5410.71
129_L248_L0.5400.71
139_S150_T0.5400.71
148_S152_G0.5390.71
119_L200_V0.5390.71
28_L34_I0.5380.71
50_W69_P0.5360.71
103_R107_G0.5350.71
24_L32_Q0.5340.70
28_L32_Q0.5330.70
61_Y64_Y0.5320.70
80_L84_S0.5320.70
227_N230_R0.5300.70
71_G75_G0.5290.70
43_T51_W0.5280.70
110_A114_R0.5280.70
33_I51_W0.5280.70
82_G204_L0.5280.70
20_G27_I0.5260.69
97_A100_R0.5250.69
310_M320_L0.5250.69
159_H162_R0.5240.69
186_A203_L0.5240.69
171_L209_L0.5230.69
143_V154_L0.5220.69
72_Q84_S0.5220.69
64_Y69_P0.5200.68
51_W75_G0.5200.68
49_I55_T0.5190.68
53_V61_Y0.5180.68
120_I213_A0.5180.68
25_C37_L0.5170.68
241_E245_R0.5160.68
120_I202_T0.5160.68
221_T224_F0.5160.68
319_V323_D0.5150.68
218_E243_I0.5150.68
133_L181_S0.5150.68
200_V228_A0.5140.68
24_L29_L0.5130.67
59_V64_Y0.5130.67
61_Y71_G0.5120.67
283_G320_L0.5110.67
35_Y48_G0.5110.67
134_Q141_T0.5080.67
156_E161_I0.5080.67
29_L37_L0.5060.66
98_F101_Q0.5060.66
129_L256_R0.5060.66
165_A243_I0.5050.66
161_I170_T0.5050.66
46_F53_V0.5050.66
149_L153_P0.5050.66
48_G59_V0.5050.66
242_F245_R0.5050.66
87_T98_F0.5040.66
47_E62_G0.5030.66
247_M256_R0.5010.66
50_W74_A0.5010.66
262_N268_L0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lnqA 6 0.8476 100 0.316 Contact Map
4gx0A 3 0.9207 100 0.371 Contact Map
3nafA 3 0.689 100 0.429 Contact Map
3mt5A 5 0.6494 100 0.516 Contact Map
4hpfA 3 0.625 100 0.523 Contact Map
2aefA 2 0.6128 100 0.56 Contact Map
4g65A 2 0.6189 99.9 0.64 Contact Map
3l4bC 2 0.6006 99.9 0.674 Contact Map
4j91A 3 0.6037 99.9 0.68 Contact Map
2r9rB 3 0.3201 99.9 0.699 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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