YUGO - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YUGO - Putative potassium channel protein YugO

UniProt:	Q795M8	Sequences: MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTSVFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQHRYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHFIRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVEILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLAVPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	328 (294)
Sequences:	2971 (2322)
Seq/√Len:	135.4

ECOLI - KCH
BACSU - YUGO
HALSA - Q9HRN5 Q9HP16
SULSO - Q97XI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
182_V	206_V	5.406	1.00
182_V	213_A	4.191	1.00
305_K	323_D	4.048	1.00
175_N	178_E	4.024	1.00
207_K	215_C	3.898	1.00
119_L	130_L	3.854	1.00
114_R	178_E	3.635	1.00
172_K	177_T	3.270	1.00
303_I	317_Y	3.093	1.00
203_L	233_A	2.931	1.00
277_V	319_V	2.820	1.00
47_E	72_Q	2.760	1.00
115_D	180_E	2.701	1.00
207_K	234_N	2.505	1.00
284_A	288_T	2.489	1.00
55_T	59_V	2.469	1.00
163_G	170_T	2.429	1.00
281_L	289_C	2.337	1.00
117_I	181_S	2.275	1.00
55_T	61_Y	2.258	1.00
199_S	217_V	2.251	1.00
31_G	34_I	2.238	1.00
285_A	288_T	2.231	1.00
184_I	199_S	2.189	1.00
55_T	58_T	2.178	1.00
63_D	66_P	2.113	1.00
161_I	174_A	2.106	1.00
47_E	50_W	2.026	1.00
286_Y	300_I	2.024	1.00
319_V	325_F	2.021	1.00
68_T	71_G	2.009	1.00
145_I	170_T	2.005	1.00
62_G	66_P	1.970	1.00
50_W	53_V	1.920	1.00
30_F	34_I	1.902	1.00
45_V	49_I	1.888	1.00
305_K	317_Y	1.845	1.00
176_I	206_V	1.830	1.00
210_N	213_A	1.812	1.00
149_L	162_R	1.811	1.00
34_I	75_G	1.800	1.00
44_S	47_E	1.787	1.00
186_A	202_T	1.781	1.00
27_I	31_G	1.778	1.00
305_K	320_L	1.720	1.00
31_G	35_Y	1.668	1.00
48_G	52_A	1.662	1.00
30_F	33_I	1.646	1.00
50_W	58_T	1.619	1.00
214_Y	234_N	1.598	1.00
23_I	27_I	1.595	1.00
59_V	63_D	1.583	1.00
145_I	174_A	1.558	1.00
49_I	53_V	1.546	1.00
35_Y	45_V	1.539	1.00
118_I	176_I	1.539	1.00
63_D	68_T	1.520	1.00
116_H	179_A	1.515	1.00
145_I	161_I	1.493	1.00
51_W	54_V	1.490	1.00
50_W	54_V	1.483	1.00
58_T	62_G	1.475	1.00
33_I	37_L	1.475	1.00
152_G	160_F	1.472	1.00
35_Y	38_E	1.444	1.00
123_N	126_T	1.434	1.00
287_K	316_T	1.431	1.00
32_Q	36_I	1.428	1.00
22_I	26_L	1.414	1.00
34_I	38_E	1.414	1.00
176_I	210_N	1.414	1.00
31_G	36_I	1.412	1.00
54_V	79_I	1.408	1.00
123_N	218_E	1.402	1.00
50_W	63_D	1.396	1.00
46_F	49_I	1.395	1.00
233_A	236_I	1.389	1.00
19_I	34_I	1.379	1.00
176_I	182_V	1.369	1.00
75_G	80_L	1.347	1.00
55_T	60_G	1.338	1.00
51_W	63_D	1.327	1.00
54_V	58_T	1.317	1.00
48_G	51_W	1.299	1.00
58_T	61_Y	1.297	1.00
50_W	55_T	1.291	1.00
289_C	319_V	1.290	1.00
76_I	80_L	1.282	1.00
146_D	160_F	1.267	1.00
302_G	326_L	1.263	1.00
27_I	34_I	1.258	1.00
23_I	35_Y	1.254	1.00
50_W	60_G	1.250	1.00
286_Y	290_V	1.240	1.00
49_I	58_T	1.238	1.00
146_D	151_E	1.232	1.00
34_I	37_L	1.231	1.00
303_I	323_D	1.228	1.00
260_Q	268_L	1.226	1.00
195_A	198_L	1.205	1.00
196_D	224_F	1.196	1.00
63_D	67_H	1.193	1.00
90_F	94_S	1.182	0.99
50_W	61_Y	1.181	0.99
287_K	315_L	1.174	0.99
117_I	133_L	1.173	0.99
206_V	213_A	1.172	0.99
32_Q	35_Y	1.170	0.99
54_V	63_D	1.165	0.99
23_I	34_I	1.152	0.99
26_L	31_G	1.149	0.99
274_L	324_Q	1.148	0.99
165_A	202_T	1.136	0.99
57_S	79_I	1.136	0.99
38_E	71_G	1.129	0.99
147_E	164_H	1.125	0.99
54_V	66_P	1.117	0.99
113_G	159_H	1.115	0.99
23_I	32_Q	1.114	0.99
305_K	310_M	1.109	0.99
26_L	30_F	1.093	0.99
200_V	204_L	1.092	0.99
30_F	35_Y	1.086	0.99
59_V	79_I	1.076	0.99
65_V	69_P	1.073	0.99
129_L	244_S	1.066	0.99
47_E	51_W	1.065	0.99
75_G	79_I	1.063	0.99
285_A	318_K	1.063	0.99
118_I	213_A	1.060	0.99
273_E	277_V	1.056	0.99
157_N	160_F	1.054	0.99
31_G	52_A	1.048	0.99
27_I	32_Q	1.046	0.99
63_D	71_G	1.045	0.99
196_D	204_L	1.045	0.99
125_K	218_E	1.045	0.99
47_E	58_T	1.035	0.99
129_L	183_M	1.031	0.99
58_T	71_G	1.030	0.99
148_S	151_E	1.029	0.99
47_E	53_V	1.022	0.98
43_T	48_G	1.018	0.98
20_G	23_I	1.015	0.98
142_V	158_V	1.013	0.98
126_T	218_E	1.009	0.98
54_V	60_G	1.007	0.98
46_F	50_W	0.997	0.98
20_G	24_L	0.996	0.98
33_I	74_A	0.994	0.98
54_V	61_Y	0.984	0.98
300_I	325_F	0.979	0.98
118_I	182_V	0.976	0.98
222_D	241_E	0.972	0.98
146_D	152_G	0.972	0.98
122_W	126_T	0.969	0.98
48_G	56_V	0.967	0.98
59_V	62_G	0.966	0.98
201_L	224_F	0.962	0.98
19_I	31_G	0.961	0.98
33_I	38_E	0.955	0.98
276_A	324_Q	0.955	0.98
130_L	142_V	0.952	0.98
58_T	63_D	0.949	0.98
117_I	180_E	0.947	0.97
44_S	49_I	0.942	0.97
215_C	234_N	0.939	0.97
37_L	74_A	0.939	0.97
62_G	68_T	0.936	0.97
282_K	321_E	0.936	0.97
172_K	209_L	0.935	0.97
60_G	63_D	0.935	0.97
27_I	36_I	0.929	0.97
144_L	158_V	0.926	0.97
50_W	72_Q	0.909	0.97
257_P	263_G	0.905	0.97
63_D	72_Q	0.893	0.96
27_I	35_Y	0.884	0.96
130_L	144_L	0.883	0.96
61_Y	66_P	0.882	0.96
20_G	35_Y	0.877	0.96
54_V	64_Y	0.877	0.96
184_I	217_V	0.873	0.96
44_S	48_G	0.869	0.96
54_V	57_S	0.867	0.96
304_Q	324_Q	0.860	0.96
21_V	27_I	0.858	0.96
46_F	76_I	0.857	0.95
203_L	215_C	0.857	0.95
24_L	34_I	0.856	0.95
70_L	73_A	0.856	0.95
176_I	209_L	0.856	0.95
129_L	185_T	0.852	0.95
219_I	228_A	0.852	0.95
184_I	203_L	0.848	0.95
58_T	64_Y	0.847	0.95
52_A	61_Y	0.845	0.95
30_F	36_I	0.843	0.95
119_L	144_L	0.839	0.95
186_A	218_E	0.838	0.95
50_W	66_P	0.833	0.95
203_L	228_A	0.831	0.95
31_G	37_L	0.827	0.95
129_L	134_Q	0.826	0.94
143_V	161_I	0.824	0.94
64_Y	67_H	0.823	0.94
51_W	59_V	0.821	0.94
37_L	70_L	0.820	0.94
111_Y	175_N	0.812	0.94
272_V	301_I	0.810	0.94
50_W	75_G	0.807	0.94
48_G	60_G	0.805	0.94
49_I	76_I	0.805	0.94
172_K	175_N	0.804	0.94
204_L	231_A	0.804	0.94
308_G	314_P	0.802	0.94
48_G	55_T	0.798	0.93
53_V	60_G	0.792	0.93
76_I	79_I	0.789	0.93
120_I	182_V	0.788	0.93
320_L	323_D	0.788	0.93
25_C	38_E	0.787	0.93
203_L	217_V	0.786	0.93
62_G	72_Q	0.784	0.93
53_V	58_T	0.783	0.93
47_E	60_G	0.782	0.93
47_E	64_Y	0.777	0.92
44_S	69_P	0.774	0.92
125_K	185_T	0.770	0.92
53_V	59_V	0.770	0.92
169_G	172_K	0.769	0.92
286_Y	292_Y	0.767	0.92
274_L	277_V	0.763	0.92
29_L	32_Q	0.759	0.92
26_L	34_I	0.759	0.92
183_M	251_Y	0.752	0.91
186_A	198_L	0.752	0.91
64_Y	68_T	0.751	0.91
225_V	229_E	0.747	0.91
162_R	169_G	0.742	0.91
32_Q	37_L	0.741	0.91
51_W	58_T	0.737	0.90
50_W	59_V	0.736	0.90
83_A	90_F	0.731	0.90
24_L	36_I	0.729	0.90
129_L	296_H	0.729	0.90
144_L	237_I	0.727	0.90
130_L	158_V	0.726	0.90
23_I	28_L	0.726	0.90
29_L	33_I	0.723	0.90
21_V	29_L	0.718	0.89
155_I	160_F	0.717	0.89
22_I	34_I	0.716	0.89
282_K	322_T	0.716	0.89
28_L	31_G	0.715	0.89
103_R	108_K	0.709	0.89
273_E	278_P	0.708	0.89
70_L	74_A	0.706	0.88
120_I	165_A	0.705	0.88
219_I	236_I	0.700	0.88
46_F	69_P	0.699	0.88
49_I	59_V	0.698	0.88
55_T	63_D	0.695	0.88
19_I	30_F	0.688	0.87
121_G	218_E	0.686	0.87
30_F	78_L	0.686	0.87
318_K	322_T	0.685	0.87
95_A	98_F	0.682	0.87
26_L	36_I	0.682	0.87
83_A	101_Q	0.681	0.87
126_T	243_I	0.679	0.86
49_I	54_V	0.675	0.86
23_I	31_G	0.674	0.86
20_G	33_I	0.673	0.86
62_G	65_V	0.669	0.86
47_E	63_D	0.668	0.86
300_I	315_L	0.667	0.85
202_T	219_I	0.666	0.85
124_E	187_D	0.666	0.85
58_T	68_T	0.666	0.85
140_K	180_E	0.665	0.85
24_L	30_F	0.663	0.85
55_T	66_P	0.663	0.85
126_T	146_D	0.662	0.85
26_L	38_E	0.660	0.85
31_G	38_E	0.655	0.84
153_P	156_E	0.654	0.84
106_E	110_A	0.653	0.84
263_G	266_L	0.651	0.84
24_L	28_L	0.650	0.84
283_G	321_E	0.650	0.84
288_T	318_K	0.650	0.84
59_V	66_P	0.648	0.84
225_V	241_E	0.645	0.83
55_T	62_G	0.645	0.83
51_W	60_G	0.642	0.83
50_W	57_S	0.642	0.83
176_I	213_A	0.640	0.83
57_S	60_G	0.639	0.83
123_N	165_A	0.638	0.83
53_V	76_I	0.638	0.83
27_I	30_F	0.633	0.82
165_A	171_L	0.633	0.82
63_D	69_P	0.632	0.82
126_T	165_A	0.630	0.82
50_W	64_Y	0.630	0.82
285_A	316_T	0.626	0.82
89_Y	92_T	0.625	0.82
48_G	54_V	0.621	0.81
185_T	218_E	0.621	0.81
305_K	308_G	0.618	0.81
47_E	61_Y	0.618	0.81
269_D	272_V	0.618	0.81
25_C	29_L	0.617	0.81
19_I	35_Y	0.615	0.80
310_M	317_Y	0.614	0.80
134_Q	158_V	0.614	0.80
57_S	61_Y	0.614	0.80
133_L	138_P	0.612	0.80
119_L	166_A	0.609	0.80
260_Q	267_T	0.609	0.80
207_K	213_A	0.607	0.80
317_Y	320_L	0.605	0.79
122_W	127_N	0.605	0.79
286_Y	297_N	0.603	0.79
146_D	165_A	0.602	0.79
260_Q	263_G	0.596	0.78
54_V	62_G	0.595	0.78
61_Y	68_T	0.595	0.78
61_Y	69_P	0.594	0.78
219_I	233_A	0.594	0.78
43_T	47_E	0.593	0.78
48_G	58_T	0.592	0.78
92_T	96_A	0.591	0.78
45_V	55_T	0.590	0.78
201_L	227_N	0.589	0.78
123_N	146_D	0.589	0.78
286_Y	291_L	0.588	0.77
31_G	49_I	0.588	0.77
216_I	247_M	0.587	0.77
212_L	321_E	0.586	0.77
286_Y	315_L	0.585	0.77
87_T	91_A	0.585	0.77
302_G	309_P	0.585	0.77
79_I	83_A	0.585	0.77
22_I	33_I	0.584	0.77
86_V	89_Y	0.584	0.77
127_N	131_K	0.582	0.77
23_I	30_F	0.579	0.76
26_L	35_Y	0.578	0.76
22_I	25_C	0.578	0.76
49_I	52_A	0.578	0.76
238_G	241_E	0.574	0.76
180_E	183_M	0.574	0.76
48_G	53_V	0.574	0.76
126_T	144_L	0.574	0.76
51_W	61_Y	0.573	0.76
66_P	79_I	0.573	0.76
32_Q	38_E	0.572	0.76
79_I	84_S	0.570	0.75
272_V	277_V	0.570	0.75
47_E	54_V	0.567	0.75
146_D	218_E	0.566	0.75
299_T	302_G	0.565	0.75
265_K	268_L	0.564	0.75
217_V	233_A	0.563	0.74
168_D	205_S	0.562	0.74
77_L	222_D	0.561	0.74
77_L	80_L	0.560	0.74
19_I	23_I	0.560	0.74
122_W	158_V	0.560	0.74
54_V	59_V	0.558	0.74
184_I	206_V	0.558	0.74
197_M	201_L	0.556	0.73
302_G	313_P	0.556	0.73
123_N	185_T	0.555	0.73
28_L	35_Y	0.555	0.73
27_I	38_E	0.553	0.73
263_G	267_T	0.552	0.73
39_P	44_S	0.550	0.73
118_I	199_S	0.549	0.73
44_S	64_Y	0.541	0.71
129_L	248_L	0.540	0.71
139_S	150_T	0.540	0.71
148_S	152_G	0.539	0.71
119_L	200_V	0.539	0.71
28_L	34_I	0.538	0.71
50_W	69_P	0.536	0.71
103_R	107_G	0.535	0.71
24_L	32_Q	0.534	0.70
28_L	32_Q	0.533	0.70
61_Y	64_Y	0.532	0.70
80_L	84_S	0.532	0.70
227_N	230_R	0.530	0.70
71_G	75_G	0.529	0.70
43_T	51_W	0.528	0.70
110_A	114_R	0.528	0.70
33_I	51_W	0.528	0.70
82_G	204_L	0.528	0.70
20_G	27_I	0.526	0.69
97_A	100_R	0.525	0.69
310_M	320_L	0.525	0.69
159_H	162_R	0.524	0.69
186_A	203_L	0.524	0.69
171_L	209_L	0.523	0.69
143_V	154_L	0.522	0.69
72_Q	84_S	0.522	0.69
64_Y	69_P	0.520	0.68
51_W	75_G	0.520	0.68
49_I	55_T	0.519	0.68
53_V	61_Y	0.518	0.68
120_I	213_A	0.518	0.68
25_C	37_L	0.517	0.68
241_E	245_R	0.516	0.68
120_I	202_T	0.516	0.68
221_T	224_F	0.516	0.68
319_V	323_D	0.515	0.68
218_E	243_I	0.515	0.68
133_L	181_S	0.515	0.68
200_V	228_A	0.514	0.68
24_L	29_L	0.513	0.67
59_V	64_Y	0.513	0.67
61_Y	71_G	0.512	0.67
283_G	320_L	0.511	0.67
35_Y	48_G	0.511	0.67
134_Q	141_T	0.508	0.67
156_E	161_I	0.508	0.67
29_L	37_L	0.506	0.66
98_F	101_Q	0.506	0.66
129_L	256_R	0.506	0.66
165_A	243_I	0.505	0.66
161_I	170_T	0.505	0.66
46_F	53_V	0.505	0.66
149_L	153_P	0.505	0.66
48_G	59_V	0.505	0.66
242_F	245_R	0.505	0.66
87_T	98_F	0.504	0.66
47_E	62_G	0.503	0.66
247_M	256_R	0.501	0.66
50_W	74_A	0.501	0.66
262_N	268_L	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1lnqA	6	0.8476	100	0.316	Contact Map
4gx0A	3	0.9207	100	0.371	Contact Map
3nafA	3	0.689	100	0.429	Contact Map
3mt5A	5	0.6494	100	0.516	Contact Map
4hpfA	3	0.625	100	0.523	Contact Map
2aefA	2	0.6128	100	0.56	Contact Map
4g65A	2	0.6189	99.9	0.64	Contact Map
3l4bC	2	0.6006	99.9	0.674	Contact Map
4j91A	3	0.6037	99.9	0.68	Contact Map
2r9rB	3	0.3201	99.9	0.699	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.