GREMLIN Database
YUGH - Putative aminotransferase YugH
UniProt: Q795M6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (348)
Sequences: 43511 (29739)
Seq/√Len: 1594.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_I55_E3.1811.00
115_E136_I2.9641.00
95_T101_A2.8631.00
73_E280_K2.7971.00
299_L372_Q2.7411.00
342_E380_R2.7111.00
294_R298_N2.7001.00
110_V135_G2.6411.00
310_S323_S2.6341.00
181_K185_N2.5711.00
79_S85_S2.5141.00
156_E193_K2.4441.00
295_R368_I2.4331.00
114_E164_K2.4211.00
248_A253_R2.3581.00
69_S276_L2.3281.00
373_E377_R2.2721.00
337_E341_Q2.2451.00
44_W48_E2.2271.00
103_D107_R2.0911.00
115_E138_V2.0841.00
180_S183_E2.0771.00
301_V305_N1.9921.00
303_S306_E1.9781.00
303_S375_L1.9201.00
72_E88_P1.9121.00
243_L275_A1.8881.00
120_E139_H1.8671.00
185_N189_E1.8641.00
80_N283_M1.8481.00
301_V313_H1.8301.00
73_E76_R1.8071.00
76_R280_K1.7941.00
149_K183_E1.7701.00
48_E52_L1.7671.00
154_D158_A1.7571.00
330_S333_Q1.7421.00
68_Y72_E1.7281.00
299_L303_S1.7251.00
130_V135_G1.7191.00
303_S379_K1.7141.00
75_S88_P1.7141.00
303_S307_I1.7111.00
373_E376_V1.7101.00
199_L229_I1.7071.00
156_E186_E1.7071.00
47_R51_I1.6841.00
154_D157_A1.6841.00
151_T154_D1.6651.00
91_E250_S1.6571.00
191_A198_V1.6451.00
127_D131_S1.6451.00
367_S370_Q1.6291.00
52_L277_E1.6231.00
72_E76_R1.6111.00
337_E381_F1.6091.00
302_E306_E1.6071.00
303_S376_V1.6011.00
305_N311_C1.5961.00
195_D225_R1.5921.00
203_I231_G1.5921.00
105_A227_V1.5871.00
298_N302_E1.5811.00
342_E377_R1.5761.00
299_L368_I1.5681.00
115_E162_K1.5611.00
268_P271_A1.5571.00
116_V130_V1.5291.00
73_E276_L1.5281.00
336_E340_T1.5211.00
33_L374_A1.5141.00
153_A186_E1.5111.00
106_I130_V1.5051.00
74_I245_F1.4971.00
105_A199_L1.4951.00
333_Q337_E1.4831.00
115_E160_T1.4731.00
143_T183_E1.4691.00
186_E189_E1.4661.00
246_A256_M1.4611.00
127_D139_H1.4601.00
300_F320_A1.4561.00
181_K214_T1.4561.00
152_A186_E1.4551.00
120_E141_H1.4511.00
115_E163_T1.4451.00
307_I379_K1.4311.00
48_E51_I1.4241.00
98_A229_I1.4221.00
165_A199_L1.4141.00
117_I163_T1.4041.00
301_V311_C1.3991.00
287_E291_K1.3941.00
67_L273_F1.3901.00
86_Y247_A1.3851.00
346_V360_I1.3821.00
306_E379_K1.3801.00
65_A257_L1.3761.00
183_E186_E1.3721.00
49_A277_E1.3561.00
331_S350_S1.3521.00
301_V320_A1.3501.00
292_S295_R1.3481.00
321_F349_G1.3431.00
78_L247_A1.3371.00
232_F275_A1.3251.00
118_I137_P1.3251.00
159_V190_F1.3241.00
333_Q336_E1.3011.00
47_R55_E1.2991.00
76_R80_N1.2961.00
152_A190_F1.2901.00
191_A196_V1.2891.00
276_L280_K1.2881.00
300_F375_L1.2861.00
89_D250_S1.2831.00
112_P134_G1.2821.00
68_Y88_P1.2791.00
292_S368_I1.2771.00
303_S372_Q1.2721.00
156_E194_H1.2671.00
332_E350_S1.2671.00
69_S280_K1.2651.00
189_E193_K1.2591.00
28_E343_K1.2541.00
323_S359_Y1.2491.00
49_A52_L1.2481.00
181_K218_A1.2451.00
141_H154_D1.2421.00
182_E185_N1.2351.00
230_S245_F1.2301.00
50_S274_A1.2281.00
255_A258_K1.2261.00
52_L56_Q1.2251.00
87_S91_E1.2211.00
323_S358_G1.2091.00
322_P362_C1.2031.00
156_E190_F1.1951.00
190_F196_V1.1931.00
190_F194_H1.1921.00
189_E192_K1.1921.00
305_N313_H1.1901.00
156_E160_T1.1881.00
372_Q376_V1.1851.00
50_S54_L1.1821.00
107_R133_A1.1801.00
106_I110_V1.1781.00
117_I140_V1.1651.00
224_E249_P1.1641.00
292_S296_R1.1641.00
376_V380_R1.1631.00
65_A71_R1.1611.00
93_I253_R1.1611.00
101_A246_A1.1581.00
185_N219_L1.1551.00
368_I372_Q1.1521.00
106_I167_L1.1471.00
96_V100_Q1.1431.00
69_S273_F1.1421.00
111_N114_E1.1371.00
291_K294_R1.1311.00
71_R75_S1.1311.00
297_R364_Y1.1291.00
287_E290_K1.1261.00
370_Q373_E1.1261.00
227_V248_A1.1231.00
77_Y283_M1.1221.00
254_D258_K1.1221.00
283_M287_E1.1201.00
182_E186_E1.1181.00
185_N222_M1.1131.00
277_E280_K1.1081.00
100_Q260_H1.1071.00
192_K223_K1.0971.00
260_H264_M1.0931.00
297_R301_V1.0861.00
108_A259_I1.0791.00
160_T163_T1.0771.00
307_I376_V1.0771.00
74_I94_V1.0761.00
143_T154_D1.0731.00
143_T151_T1.0661.00
52_L55_E1.0661.00
296_R299_L1.0651.00
181_K219_L1.0651.00
197_I227_V1.0631.00
157_A161_E1.0631.00
110_V116_V1.0611.00
210_D315_G1.0531.00
277_E281_N1.0441.00
166_I196_V1.0431.00
78_L245_F1.0411.00
330_S357_E1.0361.00
299_L302_E1.0321.00
45_N281_N1.0301.00
335_A346_V1.0281.00
291_K295_R1.0211.00
45_N48_E1.0181.00
227_V246_A1.0141.00
44_W47_R1.0091.00
87_S250_S1.0081.00
159_V196_V1.0051.00
130_V137_P1.0031.00
338_L346_V1.0021.00
69_S72_E0.9971.00
192_K224_E0.9941.00
273_F276_L0.9891.00
70_L94_V0.9881.00
215_S218_A0.9821.00
325_K358_G0.9721.00
29_G343_K0.9701.00
140_V158_A0.9641.00
331_S358_G0.9611.00
302_E305_N0.9581.00
197_I225_R0.9571.00
298_N313_H0.9561.00
188_A226_T0.9531.00
160_T194_H0.9531.00
109_I165_A0.9521.00
288_K292_S0.9511.00
188_A222_M0.9431.00
116_V165_A0.9411.00
209_Y294_R0.9381.00
91_E253_R0.9381.00
104_I260_H0.9381.00
310_S325_K0.9371.00
74_I92_L0.9301.00
284_E288_K0.9241.00
40_F292_S0.9191.00
332_E336_E0.9161.00
337_E342_E0.9151.00
75_S92_L0.9151.00
192_K225_R0.9081.00
197_I252_L0.9071.00
75_S87_S0.9061.00
216_I219_L0.9041.00
153_A157_A0.9021.00
338_L378_M0.9021.00
152_A156_E0.8961.00
122_C169_C0.8941.00
47_R54_L0.8911.00
101_A229_I0.8881.00
336_E341_Q0.8861.00
309_L324_I0.8851.00
109_I197_I0.8771.00
288_K291_K0.8761.00
285_D288_K0.8761.00
342_E381_F0.8741.00
253_R257_L0.8681.00
48_E55_E0.8651.00
208_T213_F0.8621.00
93_I256_M0.8611.00
227_V252_L0.8601.00
248_A256_M0.8581.00
131_S137_P0.8581.00
108_A256_M0.8571.00
96_V268_P0.8571.00
152_A187_I0.8551.00
229_I246_A0.8551.00
67_L276_L0.8511.00
29_G373_E0.8511.00
92_L247_A0.8501.00
98_A231_G0.8491.00
284_E287_E0.8421.00
68_Y71_R0.8421.00
208_T211_E0.8411.00
110_V165_A0.8401.00
250_S254_D0.8401.00
119_P150_A0.8391.00
163_T196_V0.8351.00
324_I360_I0.8311.00
297_R314_P0.8301.00
117_I158_A0.8301.00
243_L267_A0.8271.00
153_A156_E0.8261.00
332_E348_P0.8231.00
198_V216_I0.8231.00
300_F303_S0.8221.00
91_E223_K0.8141.00
45_N277_E0.8131.00
285_D289_M0.8091.00
243_L271_A0.8081.00
331_S348_P0.8081.00
27_M343_K0.8061.00
334_F360_I0.8051.00
216_I226_T0.8051.00
77_Y206_E0.8031.00
76_R79_S0.8021.00
377_R380_R0.8001.00
98_A203_I0.8001.00
41_V47_R0.7951.00
120_E355_S0.7941.00
58_Y273_F0.7931.00
307_I375_L0.7911.00
362_C374_A0.7901.00
128_A131_S0.7901.00
181_K212_E0.7881.00
119_P140_V0.7851.00
84_L217_A0.7851.00
152_A183_E0.7841.00
100_Q264_M0.7811.00
49_A53_S0.7771.00
126_Y167_L0.7741.00
188_A198_V0.7731.00
192_K222_M0.7721.00
99_S125_A0.7721.00
67_L272_Q0.7681.00
302_E372_Q0.7681.00
117_I155_F0.7671.00
295_R299_L0.7631.00
105_A256_M0.7601.00
159_V163_T0.7581.00
142_T172_S0.7581.00
192_K221_G0.7541.00
346_V362_C0.7541.00
329_M333_Q0.7501.00
217_A228_V0.7481.00
298_N301_V0.7461.00
206_E235_A0.7441.00
296_R367_S0.7421.00
334_F338_L0.7361.00
295_R298_N0.7361.00
200_A216_I0.7291.00
145_D149_K0.7261.00
77_Y82_F0.7261.00
120_E353_G0.7261.00
50_S270_M0.7251.00
350_S357_E0.7231.00
38_P293_Y0.7211.00
309_L322_P0.7131.00
100_Q104_I0.7131.00
93_I246_A0.7131.00
366_T370_Q0.7121.00
149_K180_S0.7091.00
104_I256_M0.7061.00
138_V158_A0.7051.00
300_F364_Y0.7041.00
172_S175_T0.7041.00
77_Y236_F0.7041.00
71_R88_P0.7031.00
335_A348_P0.7001.00
344_V378_M0.6991.00
286_V290_K0.6991.00
235_A286_V0.6991.00
369_E372_Q0.6981.00
202_E228_V0.6981.00
45_N285_D0.6951.00
103_D133_A0.6931.00
344_V377_R0.6921.00
321_F359_Y0.6901.00
143_T149_K0.6871.00
214_T218_A0.6871.00
334_F381_F0.6871.00
140_V154_D0.6861.00
29_G370_Q0.6851.00
150_A183_E0.6851.00
178_V316_G0.6841.00
297_R313_H0.6821.00
53_S274_A0.6791.00
159_V194_H0.6741.00
110_V114_E0.6731.00
117_I166_I0.6731.00
251_L254_D0.6731.00
222_M225_R0.6731.00
107_R259_I0.6721.00
33_L371_L0.6711.00
75_S86_Y0.6701.00
73_E279_L0.6671.00
116_V135_G0.6671.00
331_S357_E0.6661.00
210_D294_R0.6631.00
257_L260_H0.6611.00
376_V379_K0.6611.00
138_V163_T0.6591.00
138_V160_T0.6571.00
322_P359_Y0.6571.00
300_F371_L0.6481.00
294_R297_R0.6481.00
42_T45_N0.6451.00
269_A273_F0.6451.00
99_S123_F0.6441.00
82_F205_A0.6431.00
232_F245_F0.6401.00
118_I130_V0.6401.00
119_P172_S0.6401.00
248_A252_L0.6401.00
331_S335_A0.6391.00
95_T246_A0.6361.00
204_Y319_Y0.6311.00
97_G242_R0.6311.00
155_F190_F0.6301.00
179_Y183_E0.6301.00
168_I184_L0.6281.00
126_Y130_V0.6271.00
202_E215_S0.6261.00
115_E164_K0.6261.00
299_L375_L0.6241.00
56_Q277_E0.6241.00
155_F166_I0.6241.00
209_Y316_G0.6241.00
149_K177_S0.6211.00
289_M293_Y0.6191.00
254_D257_L0.6171.00
106_I165_A0.6151.00
27_M30_V0.6151.00
157_A160_T0.6131.00
329_M334_F0.6111.00
32_S37_E0.6111.00
113_G136_I0.6101.00
103_D263_A0.6091.00
205_A230_S0.6091.00
273_F277_E0.6071.00
42_T46_V0.6071.00
290_K294_R0.6061.00
296_R368_I0.6051.00
43_A46_V0.6051.00
304_L322_P0.6041.00
329_M337_E0.6041.00
144_A310_S0.6021.00
179_Y184_L0.6021.00
103_D129_L0.6001.00
274_A277_E0.6001.00
221_G224_E0.5991.00
170_S202_E0.5991.00
63_A68_Y0.5921.00
141_H158_A0.5921.00
118_I139_H0.5911.00
93_I257_L0.5881.00
144_A323_S0.5861.00
344_V374_A0.5851.00
306_E372_Q0.5811.00
260_H267_A0.5811.00
39_D296_R0.5791.00
66_G71_R0.5791.00
210_D297_R0.5781.00
93_I248_A0.5771.00
312_H323_S0.5761.00
31_I373_E0.5751.00
94_V243_L0.5731.00
70_L74_I0.5721.00
53_S56_Q0.5721.00
42_T47_R0.5711.00
191_A195_D0.5711.00
70_L275_A0.5691.00
102_L129_L0.5691.00
310_S326_S0.5681.00
72_E75_S0.5671.00
224_E251_L0.5671.00
78_L228_V0.5661.00
30_V345_A0.5661.00
202_E205_A0.5641.00
106_I133_A0.5621.00
167_L199_L0.5601.00
186_E190_F0.5591.00
49_A274_A0.5571.00
69_S73_E0.5571.00
209_Y297_R0.5561.00
71_R257_L0.5551.00
104_I259_I0.5551.00
223_K226_T0.5541.00
222_M226_T0.5541.00
207_L293_Y0.5511.00
177_S315_G0.5511.00
236_F283_M0.5501.00
367_S372_Q0.5491.00
62_T67_L0.5491.00
106_I135_G0.5491.00
311_C320_A0.5481.00
46_V278_G0.5471.00
272_Q276_L0.5451.00
178_V208_T0.5451.00
108_A255_A0.5431.00
118_I127_D0.5421.00
106_I129_L0.5401.00
32_S35_V0.5391.00
44_W55_E0.5391.00
373_E380_R0.5391.00
150_A155_F0.5381.00
338_L381_F0.5361.00
67_L269_A0.5361.00
323_S326_S0.5351.00
77_Y205_A0.5351.00
160_T193_K0.5331.00
349_G359_Y0.5321.00
232_F279_L0.5291.00
299_L371_L0.5281.00
96_V267_A0.5281.00
170_S178_V0.5261.00
349_G352_F0.5261.00
371_L374_A0.5251.00
207_L290_K0.5251.00
45_N49_A0.5211.00
124_V351_V0.5191.00
166_I191_A0.5181.00
171_P316_G0.5181.00
214_T219_L0.5181.00
158_A161_E0.5181.00
335_A360_I0.5171.00
141_H151_T0.5171.00
45_N284_E0.5171.00
51_I54_L0.5171.00
377_R381_F0.5161.00
114_E162_K0.5161.00
36_G204_Y0.5151.00
251_L255_A0.5151.00
72_E280_K0.5141.00
86_Y91_E0.5131.00
101_A244_G0.5121.00
53_S273_F0.5111.00
163_T166_I0.5091.00
289_M292_S0.5051.00
99_S265_M0.5051.00
53_S277_E0.5021.00
145_D183_E0.5021.00
184_L216_I0.5021.00
330_S350_S0.5011.00
111_N164_K0.5011.00
300_F362_C0.5011.00
339_L345_A0.5011.00
79_S84_L0.5001.00
34_G345_A0.5001.00
238_M278_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gd9A 2 0.9922 100 0.274 Contact Map
4my5A 2 0.9896 100 0.275 Contact Map
1yizA 2 0.9896 100 0.282 Contact Map
3h14A 2 0.943 100 0.283 Contact Map
1u08A 2 0.9767 100 0.286 Contact Map
2o1bA 2 0.9611 100 0.287 Contact Map
1o4sA 2 0.9715 100 0.287 Contact Map
2x5dA 3 0.9611 100 0.288 Contact Map
1b5pA 2 0.9715 100 0.288 Contact Map
3dydA 2 0.9508 100 0.292 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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