GREMLIN Database
YVFT - Sensor histidine kinase YvfT
UniProt: Q795K2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (325)
Sequences: 30278 (27267)
Seq/√Len: 1512.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_K363_T4.4031.00
320_R359_V3.7821.00
203_S224_M3.6601.00
318_V361_A3.4251.00
318_V359_V3.3261.00
351_T361_A3.1411.00
340_E344_M3.0901.00
207_Q225_E3.0381.00
316_R363_T2.9121.00
266_Q305_A2.8931.00
207_Q222_K2.8611.00
200_T228_S2.8401.00
291_A360_V2.7651.00
316_R361_A2.7251.00
295_I304_C2.6911.00
307_T318_V2.6821.00
266_Q303_H2.6641.00
268_E307_T2.6601.00
339_M350_L2.6221.00
303_H322_D2.5961.00
199_L228_S2.4861.00
311_F316_R2.4741.00
299_S322_D2.4511.00
287_C343_L2.4451.00
211_A218_K2.3921.00
268_E305_A2.3881.00
343_L362_L2.3691.00
206_I221_A2.3361.00
343_L348_G2.3121.00
352_V360_V2.2581.00
353_S359_V2.2481.00
349_G363_T2.2441.00
309_S316_R2.2281.00
200_T229_R2.1941.00
204_Q225_E2.1651.00
302_T322_D2.1061.00
255_Q259_R2.0771.00
353_S361_A2.0671.00
169_N172_I2.0241.00
305_A320_R2.0121.00
264_T303_H1.9781.00
287_C362_L1.9621.00
279_V346_I1.9541.00
310_Q366_L1.9471.00
309_S318_V1.9461.00
169_N173_K1.9441.00
321_D325_G1.9041.00
151_G154_S1.8581.00
250_E253_N1.8421.00
326_A358_T1.8361.00
317_I362_L1.8301.00
225_E229_R1.7941.00
213_D216_R1.7841.00
307_T320_R1.7751.00
168_A171_Q1.7681.00
207_Q218_K1.7651.00
288_M317_I1.7651.00
287_C342_R1.7311.00
287_C339_M1.7211.00
354_D358_T1.6871.00
154_S158_R1.6801.00
213_D217_T1.6581.00
199_L224_M1.6431.00
321_D357_G1.6431.00
214_P217_T1.6371.00
202_K223_E1.6291.00
155_M158_R1.6291.00
252_V255_Q1.6221.00
232_L236_R1.5761.00
343_L350_L1.5731.00
202_K220_E1.5651.00
162_E166_A1.5651.00
291_A319_I1.5601.00
351_T363_T1.5601.00
299_S302_T1.5441.00
299_S304_C1.5371.00
161_L165_L1.5201.00
293_T297_K1.5051.00
255_Q258_L1.4831.00
300_K324_K1.4521.00
179_E183_R1.4401.00
344_M349_G1.4381.00
203_S225_E1.4351.00
342_R346_I1.4321.00
168_A172_I1.4221.00
200_T225_E1.4141.00
178_R182_V1.4071.00
286_M289_R1.3941.00
209_L217_T1.3881.00
178_R181_R1.3821.00
315_M366_L1.3691.00
161_L164_K1.3401.00
277_S280_T1.3221.00
206_I217_T1.3121.00
280_T283_I1.3081.00
270_A309_S1.3041.00
198_L202_K1.2821.00
203_S221_A1.2801.00
200_T232_L1.2731.00
218_K222_K1.2661.00
222_K226_T1.2601.00
311_F363_T1.2541.00
306_I319_I1.2471.00
170_E173_K1.2251.00
170_E174_E1.2221.00
160_E164_K1.2121.00
203_S228_S1.2111.00
200_T204_Q1.2091.00
284_I364_I1.1941.00
292_V304_C1.1841.00
269_G308_I1.1831.00
181_R185_A1.1811.00
279_V284_I1.1681.00
158_R162_E1.1671.00
343_L364_I1.1631.00
337_W341_E1.1601.00
352_V358_T1.1581.00
171_Q174_E1.1401.00
96_F100_Y1.1291.00
166_A169_N1.1231.00
285_S289_R1.1181.00
192_L231_A1.1161.00
164_K168_A1.1081.00
290_E339_M1.1071.00
159_I162_E1.1031.00
250_E254_I1.0991.00
305_A322_D1.0951.00
291_A339_M1.0931.00
158_R161_L1.0871.00
192_L235_V1.0871.00
283_I286_M1.0811.00
177_K181_R1.0781.00
145_M149_P1.0771.00
263_I267_Y1.0731.00
48_F52_Y1.0671.00
223_E227_S1.0611.00
154_S159_I1.0541.00
180_E183_R1.0531.00
215_E218_K1.0521.00
203_S207_Q1.0511.00
283_I342_R1.0441.00
314_K349_G1.0351.00
274_S310_Q1.0281.00
165_L169_N1.0281.00
219_L222_K1.0201.00
233_K237_E1.0171.00
228_S232_L1.0161.00
193_G236_R1.0151.00
341_E345_L1.0131.00
152_I155_M1.0051.00
292_V306_I1.0041.00
256_H259_R1.0041.00
162_E165_L1.0031.00
288_M292_V0.9991.00
288_M319_I0.9991.00
281_Q285_S0.9971.00
167_Q171_Q0.9911.00
196_L231_A0.9881.00
311_F314_K0.9871.00
166_A170_E0.9801.00
250_E257_I0.9801.00
152_I156_F0.9801.00
341_E344_M0.9731.00
163_A167_Q0.9691.00
348_G364_I0.9651.00
176_S180_E0.9611.00
253_N256_H0.9551.00
198_L227_S0.9541.00
201_L205_L0.9541.00
219_L223_E0.9511.00
183_R187_D0.9501.00
295_I299_S0.9441.00
165_L168_A0.9421.00
222_K225_E0.9401.00
350_L360_V0.9301.00
159_I163_A0.9291.00
250_E258_L0.9251.00
163_A166_A0.9231.00
154_S157_R0.9231.00
270_A307_T0.9221.00
220_E223_E0.9221.00
214_P218_K0.9211.00
273_F310_Q0.9211.00
254_I257_I0.9211.00
154_S162_E0.9181.00
191_T286_M0.9141.00
38_Q41_G0.9141.00
283_I346_I0.9111.00
92_F96_F0.9071.00
216_R219_L0.8991.00
226_T230_S0.8961.00
176_S179_E0.8941.00
177_K180_E0.8911.00
284_I315_M0.8891.00
284_I317_I0.8891.00
95_N99_Y0.8861.00
221_A224_M0.8841.00
206_I224_M0.8801.00
354_D357_G0.8781.00
280_T346_I0.8711.00
292_V296_I0.8671.00
271_D310_Q0.8651.00
270_A273_F0.8651.00
326_A354_D0.8601.00
326_A360_V0.8581.00
291_A362_L0.8571.00
284_I346_I0.8561.00
260_A263_I0.8511.00
71_Q75_I0.8471.00
161_L166_A0.8421.00
191_T234_Q0.8401.00
67_W71_Q0.8341.00
191_T195_T0.8341.00
205_L220_E0.8331.00
151_G155_M0.8321.00
204_Q207_Q0.8271.00
321_D358_T0.8261.00
184_I188_L0.8221.00
194_H198_L0.8221.00
146_L150_F0.8171.00
298_H324_K0.8161.00
334_N338_G0.8161.00
263_I299_S0.8121.00
202_K227_S0.8111.00
227_S230_S0.8081.00
253_N257_I0.8041.00
288_M306_I0.8041.00
39_G42_Y0.8031.00
236_R240_S0.8031.00
323_G357_G0.8001.00
207_Q221_A0.7991.00
227_S231_A0.7981.00
153_R157_R0.7961.00
71_Q82_Y0.7951.00
261_G296_I0.7941.00
237_E283_I0.7941.00
228_S231_A0.7931.00
350_L362_L0.7881.00
97_V101_K0.7851.00
336_L339_M0.7841.00
41_G44_M0.7831.00
98_G101_K0.7821.00
217_T221_A0.7811.00
71_Q76_L0.7791.00
202_K224_M0.7791.00
223_E226_T0.7791.00
230_S234_Q0.7751.00
283_I287_C0.7741.00
216_R220_E0.7711.00
301_A322_D0.7661.00
348_G362_L0.7651.00
131_S134_E0.7651.00
203_S206_I0.7631.00
188_L238_L0.7631.00
304_C308_I0.7621.00
275_V310_Q0.7611.00
61_K65_T0.7561.00
154_S161_L0.7551.00
151_G158_R0.7501.00
211_A214_P0.7501.00
51_A55_L0.7461.00
47_L51_A0.7441.00
233_K282_N0.7391.00
199_L203_S0.7391.00
192_L195_T0.7331.00
104_T107_N0.7321.00
105_N109_A0.7281.00
40_I43_G0.7251.00
49_V53_R0.7251.00
308_I315_M0.7221.00
190_D194_H0.7181.00
96_F101_K0.7181.00
306_I317_I0.7171.00
62_A65_T0.7151.00
338_G342_R0.7121.00
275_V315_M0.7121.00
168_A173_K0.7081.00
160_E163_A0.7081.00
268_E309_S0.7071.00
202_K205_L0.7051.00
225_E228_S0.7001.00
224_M228_S0.6991.00
52_Y55_L0.6981.00
308_I317_I0.6951.00
217_T220_E0.6951.00
64_F67_W0.6931.00
283_I345_L0.6911.00
325_G358_T0.6881.00
90_G94_A0.6861.00
155_M159_I0.6851.00
137_S141_F0.6851.00
254_I258_L0.6841.00
96_F99_Y0.6841.00
195_T231_A0.6821.00
238_L242_M0.6821.00
167_Q170_E0.6821.00
209_L220_E0.6801.00
86_Y90_G0.6801.00
117_L120_P0.6771.00
209_L213_D0.6741.00
125_F128_N0.6731.00
252_V256_H0.6691.00
235_V238_L0.6661.00
239_V243_R0.6641.00
326_A352_V0.6621.00
313_D366_L0.6611.00
204_Q208_R0.6581.00
145_M148_S0.6561.00
205_L209_L0.6551.00
126_I130_V0.6551.00
193_G232_L0.6551.00
155_M162_E0.6541.00
95_N100_Y0.6491.00
231_A234_Q0.6471.00
304_C319_I0.6471.00
320_R357_G0.6451.00
51_A54_Q0.6431.00
263_I296_I0.6401.00
124_Q128_N0.6401.00
88_Y92_F0.6401.00
94_A99_Y0.6371.00
241_D337_W0.6351.00
52_Y56_F0.6331.00
339_M343_L0.6321.00
63_S66_Y0.6311.00
318_V353_S0.6281.00
183_R341_E0.6281.00
197_S201_L0.6271.00
221_A225_E0.6271.00
263_I303_H0.6261.00
231_A235_V0.6241.00
270_A308_I0.6241.00
204_Q229_R0.6241.00
99_Y102_E0.6231.00
348_G365_P0.6231.00
109_A113_L0.6231.00
314_K366_L0.6201.00
106_F109_A0.6201.00
291_A343_L0.6201.00
244_T247_I0.6191.00
71_Q80_V0.6181.00
266_Q269_G0.6171.00
42_Y45_L0.6171.00
50_A54_Q0.6161.00
193_G231_A0.6161.00
48_F51_A0.6151.00
92_F95_N0.6141.00
95_N101_K0.6141.00
290_E293_T0.6121.00
44_M47_L0.6121.00
294_N333_G0.6101.00
232_L235_V0.6091.00
197_S200_T0.6071.00
289_R293_T0.6071.00
215_E219_L0.6031.00
46_L50_A0.6011.00
127_A131_S0.5991.00
243_R334_N0.5971.00
290_E297_K0.5961.00
265_F269_G0.5951.00
63_S67_W0.5941.00
209_L212_S0.5941.00
141_F145_M0.5921.00
116_I119_F0.5911.00
314_K365_P0.5901.00
231_A236_R0.5891.00
157_R161_L0.5881.00
273_F277_S0.5871.00
198_L223_E0.5871.00
198_L201_L0.5841.00
164_K167_Q0.5831.00
128_N134_E0.5831.00
234_Q237_E0.5821.00
252_V257_I0.5801.00
190_D290_E0.5801.00
108_R111_C0.5791.00
205_L208_R0.5731.00
286_M342_R0.5721.00
353_S358_T0.5711.00
41_G45_L0.5701.00
254_I289_R0.5701.00
110_F113_L0.5691.00
305_A318_V0.5681.00
295_I319_I0.5681.00
113_L117_L0.5681.00
185_A189_H0.5671.00
206_I220_E0.5661.00
63_S71_Q0.5651.00
98_G102_E0.5651.00
85_T89_L0.5641.00
271_D274_S0.5641.00
89_L93_P0.5631.00
138_V149_P0.5631.00
179_E182_V0.5621.00
107_N111_C0.5621.00
209_L216_R0.5621.00
126_I129_S0.5621.00
63_S70_V0.5621.00
94_A101_K0.5621.00
93_P96_F0.5621.00
257_I260_A0.5611.00
252_V269_G0.5601.00
140_P144_I0.5601.00
128_N132_L0.5591.00
78_Y81_F0.5581.00
53_R56_F0.5581.00
70_V74_V0.5571.00
189_H195_T0.5571.00
142_L146_L0.5571.00
265_F306_I0.5561.00
264_T267_Y0.5551.00
250_E256_H0.5551.00
146_L149_P0.5541.00
108_R112_A0.5541.00
263_I302_T0.5541.00
184_I187_D0.5531.00
127_A134_E0.5531.00
39_G43_G0.5521.00
53_R57_C0.5511.00
287_C346_I0.5491.00
145_M150_F0.5481.00
282_N285_S0.5481.00
195_T234_Q0.5471.00
137_S140_P0.5471.00
236_R239_V0.5461.00
68_L71_Q0.5451.00
42_Y46_L0.5451.00
191_T290_E0.5451.00
49_V52_Y0.5441.00
103_K107_N0.5431.00
195_T227_S0.5431.00
246_T249_E0.5431.00
71_Q74_V0.5431.00
229_R232_L0.5421.00
156_F159_I0.5421.00
161_L168_A0.5421.00
61_K64_F0.5401.00
86_Y91_F0.5381.00
130_V134_E0.5381.00
263_I304_C0.5361.00
87_I94_A0.5341.00
206_I209_L0.5341.00
138_V142_L0.5311.00
95_N98_G0.5291.00
105_N108_R0.5281.00
139_L143_V0.5281.00
141_F144_I0.5251.00
138_V141_F0.5231.00
293_T298_H0.5211.00
129_S132_L0.5211.00
316_R351_T0.5211.00
152_I158_R0.5201.00
181_R186_R0.5191.00
62_A66_Y0.5181.00
286_M338_G0.5171.00
65_T71_Q0.5171.00
102_E105_N0.5161.00
182_V187_D0.5161.00
351_T362_L0.5161.00
88_Y91_F0.5151.00
43_G46_L0.5151.00
310_Q315_M0.5131.00
260_A296_I0.5131.00
45_L48_F0.5131.00
91_F95_N0.5121.00
187_D194_H0.5121.00
338_G341_E0.5111.00
78_Y82_Y0.5091.00
229_R233_K0.5091.00
129_S134_E0.5091.00
112_A119_F0.5091.00
211_A215_E0.5081.00
343_L346_I0.5081.00
104_T108_R0.5071.00
65_T80_V0.5071.00
193_G239_V0.5071.00
187_D286_M0.5051.00
250_E255_Q0.5051.00
340_E349_G0.5041.00
44_M48_F0.5041.00
135_L139_L0.5041.00
187_D298_H0.5031.00
180_E184_I0.5031.00
250_E259_R0.5021.00
46_L49_V0.5021.00
185_A188_L0.5001.00
324_K358_T0.5001.00
93_P97_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ehhA 2 0.5229 100 0.441 Contact Map
4i5sA 2 0.6792 100 0.479 Contact Map
4r39A 1 0.5148 100 0.485 Contact Map
4q20A 2 0.5364 100 0.491 Contact Map
2c2aA 2 0.5553 100 0.495 Contact Map
4bixA 2 0.5418 100 0.497 Contact Map
3d36A 2 0.5175 100 0.498 Contact Map
4gczA 2 0.876 100 0.515 Contact Map
3a0rA 2 0.7951 100 0.516 Contact Map
3jz3A 2 0.3881 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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