GREMLIN Database
EPSN - Putative pyridoxal phosphate-dependent aminotransferase EpsN
UniProt: Q795J3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 388 (354)
Sequences: 10862 (8272)
Seq/√Len: 439.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_K291_T3.7041.00
42_Q245_I3.0691.00
116_E153_A2.9351.00
268_A368_I2.8111.00
22_E35_L2.6391.00
148_V152_D2.6321.00
143_K146_E2.6021.00
345_D349_R2.5551.00
294_T349_R2.5421.00
17_Q21_S2.4781.00
148_V158_V2.4411.00
264_R364_Q2.4361.00
145_D171_K2.4241.00
46_R252_D2.4001.00
169_V174_Q2.3751.00
311_E370_V2.3121.00
264_R365_G2.2771.00
114_A117_R2.1971.00
307_R374_L2.1511.00
50_K203_N2.1301.00
141_S175_S2.1161.00
51_A205_E2.1101.00
113_T146_E2.0741.00
115_L147_I2.0681.00
257_K260_T2.0411.00
42_Q249_E2.0391.00
38_S42_Q2.0241.00
169_V285_V1.9881.00
311_E373_H1.9801.00
17_Q25_R1.9571.00
360_T363_E1.9411.00
14_G18_H1.9371.00
111_S114_A1.9231.00
104_E107_T1.9031.00
157_P180_R1.8761.00
366_R370_V1.8741.00
15_R249_E1.8701.00
114_A118_A1.8551.00
324_T344_E1.8431.00
101_I118_A1.8411.00
69_L157_P1.8391.00
300_S303_D1.8381.00
306_Q310_E1.8121.00
200_L211_A1.8001.00
50_K205_E1.7871.00
194_T244_G1.7801.00
237_S240_L1.7741.00
205_E209_E1.7731.00
149_S153_A1.7661.00
43_L199_M1.7651.00
268_A365_G1.7541.00
61_A183_I1.7361.00
35_L245_I1.7331.00
186_F199_M1.7311.00
76_S129_P1.7201.00
65_A181_F1.7161.00
184_F201_V1.7011.00
76_S122_A1.6891.00
202_S208_I1.6881.00
264_R361_E1.6831.00
21_S25_R1.6781.00
264_R268_A1.6731.00
307_R310_E1.6591.00
132_V151_C1.6531.00
304_I374_L1.6421.00
210_K229_E1.6341.00
44_A52_A1.6201.00
41_E45_E1.6111.00
56_G60_A1.5941.00
53_A208_I1.5741.00
364_Q368_I1.5671.00
83_T322_L1.5401.00
71_V96_A1.5291.00
165_S175_S1.5261.00
151_C158_V1.5211.00
181_F207_A1.5201.00
75_D130_K1.5141.00
271_H372_L1.5101.00
308_L315_A1.5091.00
105_P342_V1.5061.00
307_R311_E1.4971.00
119_L150_L1.4901.00
76_S97_V1.4791.00
120_E129_P1.4771.00
259_R285_V1.4761.00
46_R174_Q1.4661.00
38_S245_I1.4641.00
180_R204_D1.4551.00
208_I212_R1.4411.00
52_A199_M1.4341.00
43_L166_L1.4151.00
173_K177_T1.4031.00
268_A372_L1.3921.00
152_D180_R1.3891.00
272_L372_L1.3831.00
263_T267_N1.3681.00
76_S120_E1.3651.00
276_R294_T1.3641.00
146_E149_S1.3621.00
108_W346_L1.3541.00
136_N144_M1.3451.00
204_D207_A1.3411.00
145_D170_Y1.3151.00
304_I351_I1.3151.00
79_C91_I1.3121.00
16_E246_A1.3081.00
81_S343_C1.3071.00
35_L38_S1.3071.00
256_E260_T1.2971.00
305_V315_A1.2961.00
257_K261_I1.2921.00
105_P345_D1.2851.00
257_K361_E1.2821.00
47_V201_V1.2791.00
269_L371_L1.2761.00
148_V178_F1.2671.00
313_I370_V1.2661.00
140_Q281_Y1.2581.00
101_I114_A1.2561.00
72_K75_D1.2501.00
246_A249_E1.2491.00
65_A159_I1.2441.00
39_F244_G1.2251.00
42_Q45_E1.2191.00
106_D279_P1.2181.00
78_F101_I1.2121.00
220_E228_S1.2101.00
108_W294_T1.2091.00
304_I371_L1.2051.00
295_L304_I1.2021.00
15_R250_V1.2001.00
365_G369_E1.1991.00
103_S346_L1.1971.00
15_R18_H1.1961.00
18_H22_E1.1891.00
171_K283_A1.1891.00
63_H234_Y1.1811.00
18_H21_S1.1791.00
19_Y246_A1.1751.00
63_H93_Y1.1731.00
69_L181_F1.1721.00
115_L150_L1.1721.00
305_V351_I1.1671.00
147_I158_V1.1661.00
81_S323_H1.1651.00
260_T361_E1.1561.00
64_L211_A1.1511.00
264_R368_I1.1501.00
213_F229_E1.1441.00
69_L159_I1.1401.00
37_N41_E1.1331.00
136_N179_G1.1301.00
134_A158_V1.1261.00
342_V345_D1.1141.00
122_A129_P1.1111.00
64_L214_L1.1081.00
323_H344_E1.0991.00
277_F291_T1.0981.00
110_M115_L1.0921.00
303_D307_R1.0881.00
276_R296_D1.0881.00
261_I364_Q1.0881.00
323_H340_G1.0831.00
292_T350_G1.0821.00
116_E146_E1.0771.00
51_A208_I1.0761.00
63_H67_R1.0731.00
19_Y249_E1.0721.00
63_H232_H1.0691.00
32_L215_A1.0631.00
34_P38_S1.0591.00
72_K96_A1.0521.00
226_Q326_P1.0441.00
112_P150_L1.0391.00
116_E154_Y1.0361.00
16_E243_V1.0341.00
104_E111_S1.0321.00
73_E95_K1.0291.00
67_R94_E1.0241.00
55_V64_L1.0201.00
166_L251_L1.0121.00
261_I355_S1.0071.00
116_E120_E1.0041.00
42_Q248_L1.0031.00
54_A236_L1.0011.00
131_A157_P1.0001.00
144_M178_F0.9951.00
13_S16_E0.9941.00
13_S250_V0.9931.00
19_Y35_L0.9911.00
236_L241_A0.9841.00
191_I289_W0.9801.00
266_K277_F0.9791.00
250_V253_E0.9771.00
66_L133_I0.9721.00
78_F115_L0.9721.00
140_Q284_G0.9681.00
369_E373_H0.9671.00
296_D349_R0.9671.00
58_G61_A0.9651.00
13_S17_Q0.9641.00
261_I359_M0.9611.00
274_G296_D0.9591.00
259_R280_E0.9591.00
101_I110_M0.9591.00
51_A202_S0.9581.00
56_G234_Y0.9561.00
89_N217_Q0.9561.00
151_C156_V0.9551.00
370_V373_H0.9541.00
148_V180_R0.9521.00
66_L91_I0.9491.00
256_E259_R0.9481.00
266_K280_E0.9451.00
92_L328_F0.9431.00
19_Y22_E0.9431.00
113_T116_E0.9411.00
81_S340_G0.9361.00
262_F288_R0.9351.00
361_E365_G0.9291.00
228_S326_P0.9251.00
116_E150_L0.9251.00
49_V203_N0.9231.00
194_T197_G0.9201.00
150_L154_Y0.9181.00
88_A322_L0.9171.00
88_A100_F0.9171.00
68_L211_A0.9131.00
292_T352_C0.9121.00
306_Q309_A0.9101.00
361_E364_Q0.9091.00
70_E210_K0.9061.00
302_Y306_Q0.9051.00
108_W278_M0.9051.00
65_A183_I0.9031.00
78_F129_P0.8931.00
49_V177_T0.8931.00
53_A212_R0.8901.00
305_V309_A0.8901.00
60_A234_Y0.8881.00
202_S207_A0.8821.00
52_A201_V0.8781.00
162_A175_S0.8771.00
303_D306_Q0.8751.00
362_D365_G0.8741.00
43_L184_F0.8721.00
321_P343_C0.8711.00
335_S338_D0.8681.00
71_V77_V0.8661.00
311_E366_R0.8641.00
307_R370_V0.8621.00
253_E256_E0.8581.00
257_K358_N0.8571.00
36_V241_A0.8511.00
226_Q320_K0.8511.00
131_A159_I0.8501.00
338_D344_E0.8501.00
79_C88_A0.8491.00
38_S41_E0.8481.00
265_Y367_V0.8451.00
263_T266_K0.8451.00
168_T287_N0.8451.00
303_D374_L0.8411.00
345_D348_K0.8401.00
41_E44_A0.8391.00
136_N160_E0.8381.00
76_S99_V0.8361.00
142_A147_I0.8271.00
359_M367_V0.8261.00
149_S152_D0.8231.00
173_K178_F0.8191.00
71_V131_A0.8171.00
91_I98_P0.8151.00
255_V287_N0.8141.00
174_Q177_T0.8131.00
34_P37_N0.8131.00
47_V174_Q0.8111.00
44_A47_V0.8111.00
75_D96_A0.8071.00
260_T263_T0.8061.00
40_E54_A0.8011.00
259_R263_T0.7991.00
20_I239_I0.7951.00
366_R369_E0.7931.00
301_P317_P0.7921.00
318_L352_C0.7921.00
264_R267_N0.7911.00
35_L238_N0.7881.00
304_I308_L0.7851.00
266_K288_R0.7841.00
80_Q91_I0.7841.00
144_M148_V0.7831.00
134_A147_I0.7831.00
134_A142_A0.7821.00
55_V200_L0.7781.00
13_S25_R0.7781.00
91_I96_A0.7771.00
262_F291_T0.7771.00
253_E257_K0.7751.00
145_D149_S0.7741.00
78_F118_A0.7741.00
206_A209_E0.7701.00
46_R167_G0.7671.00
104_E112_P0.7621.00
112_P142_A0.7611.00
84_F225_Y0.7601.00
14_G25_R0.7591.00
64_L215_A0.7591.00
32_L36_V0.7581.00
321_P324_T0.7571.00
23_A242_G0.7571.00
175_S182_G0.7571.00
223_V226_Q0.7561.00
252_D256_E0.7551.00
20_I24_F0.7511.00
213_F228_S0.7511.00
340_G343_C0.7481.00
363_E366_R0.7441.00
71_V130_K0.7441.00
209_E220_E0.7431.00
167_G255_V0.7421.00
178_F182_G0.7411.00
268_A369_E0.7411.00
92_L98_P0.7411.00
268_A271_H0.7411.00
53_A211_A0.7411.00
72_K130_K0.7411.00
281_Y284_G0.7411.00
89_N328_F0.7401.00
342_V346_L0.7401.00
77_V91_I0.7391.00
336_H348_K0.7391.00
66_L159_I0.7391.00
14_G17_Q0.7371.00
298_G348_K0.7361.00
43_L248_L0.7341.00
261_I265_Y0.7291.00
179_G182_G0.7291.00
260_T264_R0.7261.00
87_T90_P0.7251.00
65_A200_L0.7231.00
20_I243_V0.7221.00
90_P94_E0.7211.00
267_N270_G0.7201.00
67_R93_Y0.7171.00
66_L71_V0.7171.00
191_I255_V0.7161.00
22_E26_S0.7151.00
324_T338_D0.7141.00
368_I372_L0.7101.00
151_C154_Y0.7091.00
269_L372_L0.7051.00
169_V172_G0.7041.00
68_L181_F0.7021.00
181_F200_L0.7021.00
36_V236_L0.7011.00
365_G368_I0.6991.00
104_E143_K0.6981.00
82_F318_L0.6971.00
93_Y232_H0.6941.00
63_H94_E0.6941.00
160_E179_G0.6881.00
36_V54_A0.6881.00
160_E182_G0.6871.00
119_L156_V0.6871.00
177_T203_N0.6821.00
47_V177_T0.6811.00
47_V52_A0.6801.00
58_G183_I0.6801.00
148_V179_G0.6791.00
43_L52_A0.6791.00
132_V156_V0.6741.00
115_L132_V0.6721.00
77_V131_A0.6701.00
15_R246_A0.6691.00
174_Q252_D0.6691.00
197_G236_L0.6681.00
112_P147_I0.6651.00
321_P347_F0.6641.00
49_V201_V0.6631.00
335_S339_T0.6611.00
16_E250_V0.6611.00
344_E348_K0.6581.00
266_K279_P0.6561.00
11_H358_N0.6551.00
15_R19_Y0.6531.00
80_Q135_V0.6510.99
137_L164_E0.6480.99
217_Q235_R0.6480.99
259_R288_R0.6430.99
261_I264_R0.6430.99
134_A144_M0.6430.99
356_G359_M0.6410.99
295_L298_G0.6410.99
140_Q280_E0.6400.99
168_T175_S0.6400.99
90_P133_I0.6360.99
326_P329_D0.6360.99
339_T344_E0.6350.99
170_Y178_F0.6350.99
57_S233_N0.6340.99
262_F355_S0.6320.99
146_E170_Y0.6310.99
83_T87_T0.6310.99
144_M158_V0.6300.99
61_A200_L0.6290.99
181_F202_S0.6290.99
55_V61_A0.6270.99
230_I327_L0.6270.99
91_I133_I0.6260.99
262_F266_K0.6250.99
170_Y284_G0.6230.99
182_G201_V0.6200.99
67_R214_L0.6190.99
252_D285_V0.6180.99
210_K214_L0.6180.99
92_L327_L0.6160.99
19_Y242_G0.6160.99
136_N142_A0.6160.99
309_A315_A0.6150.99
22_E38_S0.6140.99
195_S239_I0.6130.99
294_T345_D0.6110.99
141_S168_T0.6110.99
255_V259_R0.6100.99
12_M16_E0.6090.99
11_H250_V0.6090.99
250_V254_R0.6080.99
87_T135_V0.6080.99
17_Q24_F0.6070.99
23_A35_L0.6060.99
136_N175_S0.6060.99
102_D342_V0.6040.99
304_I307_R0.6000.99
9_P358_N0.6000.99
299_L303_D0.5990.99
162_A182_G0.5980.99
81_S100_F0.5980.99
57_S60_A0.5970.99
294_T350_G0.5960.99
72_K94_E0.5950.99
23_A26_S0.5950.99
103_S343_C0.5950.99
295_L300_S0.5930.99
77_V133_I0.5920.99
119_L129_P0.5900.99
82_F350_G0.5900.99
67_R232_H0.5880.99
220_E223_V0.5880.99
180_R203_N0.5870.99
65_A69_L0.5870.99
66_L94_E0.5870.99
146_E150_L0.5860.99
106_D276_R0.5860.99
88_A328_F0.5820.99
92_L230_I0.5820.99
49_V182_G0.5820.99
163_A190_K0.5800.99
236_L240_L0.5790.99
138_Y292_T0.5790.99
26_S34_P0.5780.99
209_E213_F0.5770.99
87_T133_I0.5770.99
70_E96_A0.5770.99
266_K270_G0.5770.99
138_Y318_L0.5750.99
44_A51_A0.5740.99
252_D255_V0.5730.99
265_Y364_Q0.5710.99
307_R373_H0.5710.99
181_F211_A0.5700.99
84_F219_R0.5700.99
341_S344_E0.5700.99
293_L351_I0.5690.99
269_L272_L0.5680.99
290_L352_C0.5670.99
170_Y173_K0.5670.99
58_G163_A0.5630.99
160_E176_G0.5620.99
141_S170_Y0.5610.98
280_E284_G0.5600.98
275_V293_L0.5590.98
280_E288_R0.5570.98
177_T182_G0.5570.98
302_Y305_V0.5560.98
268_A364_Q0.5560.98
103_S342_V0.5550.98
77_V96_A0.5540.98
186_F244_G0.5520.98
71_V75_D0.5520.98
17_Q20_I0.5490.98
294_T346_L0.5480.98
165_S168_T0.5480.98
32_L238_N0.5470.98
140_Q286_S0.5450.98
54_A199_M0.5450.98
213_F220_E0.5420.98
36_V238_N0.5410.98
130_K157_P0.5390.98
82_F137_L0.5380.98
167_G251_L0.5380.98
19_Y23_A0.5370.98
112_P143_K0.5370.98
44_A49_V0.5350.98
280_E286_S0.5350.98
63_H90_P0.5350.98
293_L371_L0.5340.98
187_N196_G0.5310.98
74_G97_V0.5310.98
51_A212_R0.5300.98
176_G184_F0.5300.98
119_L154_Y0.5280.98
324_T348_K0.5260.98
111_S146_E0.5240.98
79_C87_T0.5230.98
136_N162_A0.5190.98
251_L255_V0.5190.98
170_Y283_A0.5180.97
145_D173_K0.5180.97
152_D155_G0.5180.97
147_I150_L0.5140.97
191_I287_N0.5140.97
109_N141_S0.5120.97
16_E20_I0.5090.97
157_P204_D0.5080.97
113_T117_R0.5060.97
299_L374_L0.5060.97
110_M134_A0.5030.97
219_R227_H0.5030.97
300_S374_L0.5020.97
26_S35_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwvA 2 0.9227 100 0.434 Contact Map
1o69A 2 0.9021 100 0.464 Contact Map
3frkA 2 0.9278 100 0.467 Contact Map
2fnuA 2 0.9485 100 0.47 Contact Map
4lc3A 2 0.951 100 0.476 Contact Map
2c81A 2 0.9356 100 0.477 Contact Map
3b8xA 2 0.9304 100 0.479 Contact Map
3bb8A 2 0.9562 100 0.484 Contact Map
3nytA 2 0.9149 100 0.5 Contact Map
3dr4A 2 0.933 100 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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