EPSN - BACSU - GREMLIN Contacts

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EPSN - Putative pyridoxal phosphate-dependent aminotransferase EpsN

UniProt:	Q795J3	Sequences: MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLAERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFIDSEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIEDAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQAREPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVRFMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFYSHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	388 (354)
Sequences:	10862 (8272)
Seq/√Len:	439.6

ECOLI - ARNB RFFA
BACSU - EPSN SPSC NTDA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
266_K	291_T	3.704	1.00
42_Q	245_I	3.069	1.00
116_E	153_A	2.935	1.00
268_A	368_I	2.811	1.00
22_E	35_L	2.639	1.00
148_V	152_D	2.632	1.00
143_K	146_E	2.602	1.00
345_D	349_R	2.555	1.00
294_T	349_R	2.542	1.00
17_Q	21_S	2.478	1.00
148_V	158_V	2.441	1.00
264_R	364_Q	2.436	1.00
145_D	171_K	2.424	1.00
46_R	252_D	2.400	1.00
169_V	174_Q	2.375	1.00
311_E	370_V	2.312	1.00
264_R	365_G	2.277	1.00
114_A	117_R	2.197	1.00
307_R	374_L	2.151	1.00
50_K	203_N	2.130	1.00
141_S	175_S	2.116	1.00
51_A	205_E	2.110	1.00
113_T	146_E	2.074	1.00
115_L	147_I	2.068	1.00
257_K	260_T	2.041	1.00
42_Q	249_E	2.039	1.00
38_S	42_Q	2.024	1.00
169_V	285_V	1.988	1.00
311_E	373_H	1.980	1.00
17_Q	25_R	1.957	1.00
360_T	363_E	1.941	1.00
14_G	18_H	1.937	1.00
111_S	114_A	1.923	1.00
104_E	107_T	1.903	1.00
157_P	180_R	1.876	1.00
366_R	370_V	1.874	1.00
15_R	249_E	1.870	1.00
114_A	118_A	1.855	1.00
324_T	344_E	1.843	1.00
101_I	118_A	1.841	1.00
69_L	157_P	1.839	1.00
300_S	303_D	1.838	1.00
306_Q	310_E	1.812	1.00
200_L	211_A	1.800	1.00
50_K	205_E	1.787	1.00
194_T	244_G	1.780	1.00
237_S	240_L	1.774	1.00
205_E	209_E	1.773	1.00
149_S	153_A	1.766	1.00
43_L	199_M	1.765	1.00
268_A	365_G	1.754	1.00
61_A	183_I	1.736	1.00
35_L	245_I	1.733	1.00
186_F	199_M	1.731	1.00
76_S	129_P	1.720	1.00
65_A	181_F	1.716	1.00
184_F	201_V	1.701	1.00
76_S	122_A	1.689	1.00
202_S	208_I	1.688	1.00
264_R	361_E	1.683	1.00
21_S	25_R	1.678	1.00
264_R	268_A	1.673	1.00
307_R	310_E	1.659	1.00
132_V	151_C	1.653	1.00
304_I	374_L	1.642	1.00
210_K	229_E	1.634	1.00
44_A	52_A	1.620	1.00
41_E	45_E	1.611	1.00
56_G	60_A	1.594	1.00
53_A	208_I	1.574	1.00
364_Q	368_I	1.567	1.00
83_T	322_L	1.540	1.00
71_V	96_A	1.529	1.00
165_S	175_S	1.526	1.00
151_C	158_V	1.521	1.00
181_F	207_A	1.520	1.00
75_D	130_K	1.514	1.00
271_H	372_L	1.510	1.00
308_L	315_A	1.509	1.00
105_P	342_V	1.506	1.00
307_R	311_E	1.497	1.00
119_L	150_L	1.490	1.00
76_S	97_V	1.479	1.00
120_E	129_P	1.477	1.00
259_R	285_V	1.476	1.00
46_R	174_Q	1.466	1.00
38_S	245_I	1.464	1.00
180_R	204_D	1.455	1.00
208_I	212_R	1.441	1.00
52_A	199_M	1.434	1.00
43_L	166_L	1.415	1.00
173_K	177_T	1.403	1.00
268_A	372_L	1.392	1.00
152_D	180_R	1.389	1.00
272_L	372_L	1.383	1.00
263_T	267_N	1.368	1.00
76_S	120_E	1.365	1.00
276_R	294_T	1.364	1.00
146_E	149_S	1.362	1.00
108_W	346_L	1.354	1.00
136_N	144_M	1.345	1.00
204_D	207_A	1.341	1.00
145_D	170_Y	1.315	1.00
304_I	351_I	1.315	1.00
79_C	91_I	1.312	1.00
16_E	246_A	1.308	1.00
81_S	343_C	1.307	1.00
35_L	38_S	1.307	1.00
256_E	260_T	1.297	1.00
305_V	315_A	1.296	1.00
257_K	261_I	1.292	1.00
105_P	345_D	1.285	1.00
257_K	361_E	1.282	1.00
47_V	201_V	1.279	1.00
269_L	371_L	1.276	1.00
148_V	178_F	1.267	1.00
313_I	370_V	1.266	1.00
140_Q	281_Y	1.258	1.00
101_I	114_A	1.256	1.00
72_K	75_D	1.250	1.00
246_A	249_E	1.249	1.00
65_A	159_I	1.244	1.00
39_F	244_G	1.225	1.00
42_Q	45_E	1.219	1.00
106_D	279_P	1.218	1.00
78_F	101_I	1.212	1.00
220_E	228_S	1.210	1.00
108_W	294_T	1.209	1.00
304_I	371_L	1.205	1.00
295_L	304_I	1.202	1.00
15_R	250_V	1.200	1.00
365_G	369_E	1.199	1.00
103_S	346_L	1.197	1.00
15_R	18_H	1.196	1.00
18_H	22_E	1.189	1.00
171_K	283_A	1.189	1.00
63_H	234_Y	1.181	1.00
18_H	21_S	1.179	1.00
19_Y	246_A	1.175	1.00
63_H	93_Y	1.173	1.00
69_L	181_F	1.172	1.00
115_L	150_L	1.172	1.00
305_V	351_I	1.167	1.00
147_I	158_V	1.166	1.00
81_S	323_H	1.165	1.00
260_T	361_E	1.156	1.00
64_L	211_A	1.151	1.00
264_R	368_I	1.150	1.00
213_F	229_E	1.144	1.00
69_L	159_I	1.140	1.00
37_N	41_E	1.133	1.00
136_N	179_G	1.130	1.00
134_A	158_V	1.126	1.00
342_V	345_D	1.114	1.00
122_A	129_P	1.111	1.00
64_L	214_L	1.108	1.00
323_H	344_E	1.099	1.00
277_F	291_T	1.098	1.00
110_M	115_L	1.092	1.00
303_D	307_R	1.088	1.00
276_R	296_D	1.088	1.00
261_I	364_Q	1.088	1.00
323_H	340_G	1.083	1.00
292_T	350_G	1.082	1.00
116_E	146_E	1.077	1.00
51_A	208_I	1.076	1.00
63_H	67_R	1.073	1.00
19_Y	249_E	1.072	1.00
63_H	232_H	1.069	1.00
32_L	215_A	1.063	1.00
34_P	38_S	1.059	1.00
72_K	96_A	1.052	1.00
226_Q	326_P	1.044	1.00
112_P	150_L	1.039	1.00
116_E	154_Y	1.036	1.00
16_E	243_V	1.034	1.00
104_E	111_S	1.032	1.00
73_E	95_K	1.029	1.00
67_R	94_E	1.024	1.00
55_V	64_L	1.020	1.00
166_L	251_L	1.012	1.00
261_I	355_S	1.007	1.00
116_E	120_E	1.004	1.00
42_Q	248_L	1.003	1.00
54_A	236_L	1.001	1.00
131_A	157_P	1.000	1.00
144_M	178_F	0.995	1.00
13_S	16_E	0.994	1.00
13_S	250_V	0.993	1.00
19_Y	35_L	0.991	1.00
236_L	241_A	0.984	1.00
191_I	289_W	0.980	1.00
266_K	277_F	0.979	1.00
250_V	253_E	0.977	1.00
66_L	133_I	0.972	1.00
78_F	115_L	0.972	1.00
140_Q	284_G	0.968	1.00
369_E	373_H	0.967	1.00
296_D	349_R	0.967	1.00
58_G	61_A	0.965	1.00
13_S	17_Q	0.964	1.00
261_I	359_M	0.961	1.00
274_G	296_D	0.959	1.00
259_R	280_E	0.959	1.00
101_I	110_M	0.959	1.00
51_A	202_S	0.958	1.00
56_G	234_Y	0.956	1.00
89_N	217_Q	0.956	1.00
151_C	156_V	0.955	1.00
370_V	373_H	0.954	1.00
148_V	180_R	0.952	1.00
66_L	91_I	0.949	1.00
256_E	259_R	0.948	1.00
266_K	280_E	0.945	1.00
92_L	328_F	0.943	1.00
19_Y	22_E	0.943	1.00
113_T	116_E	0.941	1.00
81_S	340_G	0.936	1.00
262_F	288_R	0.935	1.00
361_E	365_G	0.929	1.00
228_S	326_P	0.925	1.00
116_E	150_L	0.925	1.00
49_V	203_N	0.923	1.00
194_T	197_G	0.920	1.00
150_L	154_Y	0.918	1.00
88_A	322_L	0.917	1.00
88_A	100_F	0.917	1.00
68_L	211_A	0.913	1.00
292_T	352_C	0.912	1.00
306_Q	309_A	0.910	1.00
361_E	364_Q	0.909	1.00
70_E	210_K	0.906	1.00
302_Y	306_Q	0.905	1.00
108_W	278_M	0.905	1.00
65_A	183_I	0.903	1.00
78_F	129_P	0.893	1.00
49_V	177_T	0.893	1.00
53_A	212_R	0.890	1.00
305_V	309_A	0.890	1.00
60_A	234_Y	0.888	1.00
202_S	207_A	0.882	1.00
52_A	201_V	0.878	1.00
162_A	175_S	0.877	1.00
303_D	306_Q	0.875	1.00
362_D	365_G	0.874	1.00
43_L	184_F	0.872	1.00
321_P	343_C	0.871	1.00
335_S	338_D	0.868	1.00
71_V	77_V	0.866	1.00
311_E	366_R	0.864	1.00
307_R	370_V	0.862	1.00
253_E	256_E	0.858	1.00
257_K	358_N	0.857	1.00
36_V	241_A	0.851	1.00
226_Q	320_K	0.851	1.00
131_A	159_I	0.850	1.00
338_D	344_E	0.850	1.00
79_C	88_A	0.849	1.00
38_S	41_E	0.848	1.00
265_Y	367_V	0.845	1.00
263_T	266_K	0.845	1.00
168_T	287_N	0.845	1.00
303_D	374_L	0.841	1.00
345_D	348_K	0.840	1.00
41_E	44_A	0.839	1.00
136_N	160_E	0.838	1.00
76_S	99_V	0.836	1.00
142_A	147_I	0.827	1.00
359_M	367_V	0.826	1.00
149_S	152_D	0.823	1.00
173_K	178_F	0.819	1.00
71_V	131_A	0.817	1.00
91_I	98_P	0.815	1.00
255_V	287_N	0.814	1.00
174_Q	177_T	0.813	1.00
34_P	37_N	0.813	1.00
47_V	174_Q	0.811	1.00
44_A	47_V	0.811	1.00
75_D	96_A	0.807	1.00
260_T	263_T	0.806	1.00
40_E	54_A	0.801	1.00
259_R	263_T	0.799	1.00
20_I	239_I	0.795	1.00
366_R	369_E	0.793	1.00
301_P	317_P	0.792	1.00
318_L	352_C	0.792	1.00
264_R	267_N	0.791	1.00
35_L	238_N	0.788	1.00
304_I	308_L	0.785	1.00
266_K	288_R	0.784	1.00
80_Q	91_I	0.784	1.00
144_M	148_V	0.783	1.00
134_A	147_I	0.783	1.00
134_A	142_A	0.782	1.00
55_V	200_L	0.778	1.00
13_S	25_R	0.778	1.00
91_I	96_A	0.777	1.00
262_F	291_T	0.777	1.00
253_E	257_K	0.775	1.00
145_D	149_S	0.774	1.00
78_F	118_A	0.774	1.00
206_A	209_E	0.770	1.00
46_R	167_G	0.767	1.00
104_E	112_P	0.762	1.00
112_P	142_A	0.761	1.00
84_F	225_Y	0.760	1.00
14_G	25_R	0.759	1.00
64_L	215_A	0.759	1.00
32_L	36_V	0.758	1.00
321_P	324_T	0.757	1.00
23_A	242_G	0.757	1.00
175_S	182_G	0.757	1.00
223_V	226_Q	0.756	1.00
252_D	256_E	0.755	1.00
20_I	24_F	0.751	1.00
213_F	228_S	0.751	1.00
340_G	343_C	0.748	1.00
363_E	366_R	0.744	1.00
71_V	130_K	0.744	1.00
209_E	220_E	0.743	1.00
167_G	255_V	0.742	1.00
178_F	182_G	0.741	1.00
268_A	369_E	0.741	1.00
92_L	98_P	0.741	1.00
268_A	271_H	0.741	1.00
53_A	211_A	0.741	1.00
72_K	130_K	0.741	1.00
281_Y	284_G	0.741	1.00
89_N	328_F	0.740	1.00
342_V	346_L	0.740	1.00
77_V	91_I	0.739	1.00
336_H	348_K	0.739	1.00
66_L	159_I	0.739	1.00
14_G	17_Q	0.737	1.00
298_G	348_K	0.736	1.00
43_L	248_L	0.734	1.00
261_I	265_Y	0.729	1.00
179_G	182_G	0.729	1.00
260_T	264_R	0.726	1.00
87_T	90_P	0.725	1.00
65_A	200_L	0.723	1.00
20_I	243_V	0.722	1.00
90_P	94_E	0.721	1.00
267_N	270_G	0.720	1.00
67_R	93_Y	0.717	1.00
66_L	71_V	0.717	1.00
191_I	255_V	0.716	1.00
22_E	26_S	0.715	1.00
324_T	338_D	0.714	1.00
368_I	372_L	0.710	1.00
151_C	154_Y	0.709	1.00
269_L	372_L	0.705	1.00
169_V	172_G	0.704	1.00
68_L	181_F	0.702	1.00
181_F	200_L	0.702	1.00
36_V	236_L	0.701	1.00
365_G	368_I	0.699	1.00
104_E	143_K	0.698	1.00
82_F	318_L	0.697	1.00
93_Y	232_H	0.694	1.00
63_H	94_E	0.694	1.00
160_E	179_G	0.688	1.00
36_V	54_A	0.688	1.00
160_E	182_G	0.687	1.00
119_L	156_V	0.687	1.00
177_T	203_N	0.682	1.00
47_V	177_T	0.681	1.00
47_V	52_A	0.680	1.00
58_G	183_I	0.680	1.00
148_V	179_G	0.679	1.00
43_L	52_A	0.679	1.00
132_V	156_V	0.674	1.00
115_L	132_V	0.672	1.00
77_V	131_A	0.670	1.00
15_R	246_A	0.669	1.00
174_Q	252_D	0.669	1.00
197_G	236_L	0.668	1.00
112_P	147_I	0.665	1.00
321_P	347_F	0.664	1.00
49_V	201_V	0.663	1.00
335_S	339_T	0.661	1.00
16_E	250_V	0.661	1.00
344_E	348_K	0.658	1.00
266_K	279_P	0.656	1.00
11_H	358_N	0.655	1.00
15_R	19_Y	0.653	1.00
80_Q	135_V	0.651	0.99
137_L	164_E	0.648	0.99
217_Q	235_R	0.648	0.99
259_R	288_R	0.643	0.99
261_I	264_R	0.643	0.99
134_A	144_M	0.643	0.99
356_G	359_M	0.641	0.99
295_L	298_G	0.641	0.99
140_Q	280_E	0.640	0.99
168_T	175_S	0.640	0.99
90_P	133_I	0.636	0.99
326_P	329_D	0.636	0.99
339_T	344_E	0.635	0.99
170_Y	178_F	0.635	0.99
57_S	233_N	0.634	0.99
262_F	355_S	0.632	0.99
146_E	170_Y	0.631	0.99
83_T	87_T	0.631	0.99
144_M	158_V	0.630	0.99
61_A	200_L	0.629	0.99
181_F	202_S	0.629	0.99
55_V	61_A	0.627	0.99
230_I	327_L	0.627	0.99
91_I	133_I	0.626	0.99
262_F	266_K	0.625	0.99
170_Y	284_G	0.623	0.99
182_G	201_V	0.620	0.99
67_R	214_L	0.619	0.99
252_D	285_V	0.618	0.99
210_K	214_L	0.618	0.99
92_L	327_L	0.616	0.99
19_Y	242_G	0.616	0.99
136_N	142_A	0.616	0.99
309_A	315_A	0.615	0.99
22_E	38_S	0.614	0.99
195_S	239_I	0.613	0.99
294_T	345_D	0.611	0.99
141_S	168_T	0.611	0.99
255_V	259_R	0.610	0.99
12_M	16_E	0.609	0.99
11_H	250_V	0.609	0.99
250_V	254_R	0.608	0.99
87_T	135_V	0.608	0.99
17_Q	24_F	0.607	0.99
23_A	35_L	0.606	0.99
136_N	175_S	0.606	0.99
102_D	342_V	0.604	0.99
304_I	307_R	0.600	0.99
9_P	358_N	0.600	0.99
299_L	303_D	0.599	0.99
162_A	182_G	0.598	0.99
81_S	100_F	0.598	0.99
57_S	60_A	0.597	0.99
294_T	350_G	0.596	0.99
72_K	94_E	0.595	0.99
23_A	26_S	0.595	0.99
103_S	343_C	0.595	0.99
295_L	300_S	0.593	0.99
77_V	133_I	0.592	0.99
119_L	129_P	0.590	0.99
82_F	350_G	0.590	0.99
67_R	232_H	0.588	0.99
220_E	223_V	0.588	0.99
180_R	203_N	0.587	0.99
65_A	69_L	0.587	0.99
66_L	94_E	0.587	0.99
146_E	150_L	0.586	0.99
106_D	276_R	0.586	0.99
88_A	328_F	0.582	0.99
92_L	230_I	0.582	0.99
49_V	182_G	0.582	0.99
163_A	190_K	0.580	0.99
236_L	240_L	0.579	0.99
138_Y	292_T	0.579	0.99
26_S	34_P	0.578	0.99
209_E	213_F	0.577	0.99
87_T	133_I	0.577	0.99
70_E	96_A	0.577	0.99
266_K	270_G	0.577	0.99
138_Y	318_L	0.575	0.99
44_A	51_A	0.574	0.99
252_D	255_V	0.573	0.99
265_Y	364_Q	0.571	0.99
307_R	373_H	0.571	0.99
181_F	211_A	0.570	0.99
84_F	219_R	0.570	0.99
341_S	344_E	0.570	0.99
293_L	351_I	0.569	0.99
269_L	272_L	0.568	0.99
290_L	352_C	0.567	0.99
170_Y	173_K	0.567	0.99
58_G	163_A	0.563	0.99
160_E	176_G	0.562	0.99
141_S	170_Y	0.561	0.98
280_E	284_G	0.560	0.98
275_V	293_L	0.559	0.98
280_E	288_R	0.557	0.98
177_T	182_G	0.557	0.98
302_Y	305_V	0.556	0.98
268_A	364_Q	0.556	0.98
103_S	342_V	0.555	0.98
77_V	96_A	0.554	0.98
186_F	244_G	0.552	0.98
71_V	75_D	0.552	0.98
17_Q	20_I	0.549	0.98
294_T	346_L	0.548	0.98
165_S	168_T	0.548	0.98
32_L	238_N	0.547	0.98
140_Q	286_S	0.545	0.98
54_A	199_M	0.545	0.98
213_F	220_E	0.542	0.98
36_V	238_N	0.541	0.98
130_K	157_P	0.539	0.98
82_F	137_L	0.538	0.98
167_G	251_L	0.538	0.98
19_Y	23_A	0.537	0.98
112_P	143_K	0.537	0.98
44_A	49_V	0.535	0.98
280_E	286_S	0.535	0.98
63_H	90_P	0.535	0.98
293_L	371_L	0.534	0.98
187_N	196_G	0.531	0.98
74_G	97_V	0.531	0.98
51_A	212_R	0.530	0.98
176_G	184_F	0.530	0.98
119_L	154_Y	0.528	0.98
324_T	348_K	0.526	0.98
111_S	146_E	0.524	0.98
79_C	87_T	0.523	0.98
136_N	162_A	0.519	0.98
251_L	255_V	0.519	0.98
170_Y	283_A	0.518	0.97
145_D	173_K	0.518	0.97
152_D	155_G	0.518	0.97
147_I	150_L	0.514	0.97
191_I	287_N	0.514	0.97
109_N	141_S	0.512	0.97
16_E	20_I	0.509	0.97
157_P	204_D	0.508	0.97
113_T	117_R	0.506	0.97
299_L	374_L	0.506	0.97
110_M	134_A	0.503	0.97
219_R	227_H	0.503	0.97
300_S	374_L	0.502	0.97
26_S	35_L	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zwvA	2	0.9227	100	0.434	Contact Map
1o69A	2	0.9021	100	0.464	Contact Map
3frkA	2	0.9278	100	0.467	Contact Map
2fnuA	2	0.9485	100	0.47	Contact Map
4lc3A	2	0.951	100	0.476	Contact Map
2c81A	2	0.9356	100	0.477	Contact Map
3b8xA	2	0.9304	100	0.479	Contact Map
3bb8A	2	0.9562	100	0.484	Contact Map
3nytA	2	0.9149	100	0.5	Contact Map
3dr4A	2	0.933	100	0.503	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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