GREMLIN Database
YYCH - Two-component system YycF/YycG regulatory protein YycH
UniProt: Q794W0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (415)
Sequences: 464 (399)
Seq/√Len: 19.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_E7_K4.2521.00
308_T365_R4.0651.00
68_H124_D3.9491.00
310_S365_R3.2111.00
404_D432_K2.9960.99
388_V431_M2.9420.99
89_L92_W2.7670.99
301_S328_F2.7530.98
9_I123_L2.6610.98
132_P306_E2.6090.98
411_Q439_P2.5810.98
245_F429_W2.5670.98
409_A437_I2.5650.98
308_T363_Y2.5590.98
68_H73_H2.5450.97
409_A430_A2.5110.97
11_L18_S2.4980.97
338_I409_A2.4810.97
59_T302_Q2.4180.96
4_E8_T2.3990.96
304_Y360_I2.3830.96
105_D191_I2.3750.96
13_V17_I2.3720.96
195_L408_L2.3490.96
23_W27_T2.3430.96
59_T408_L2.3050.95
430_A437_I2.3010.95
8_T60_V2.2960.95
281_F304_Y2.2330.94
21_F128_S2.2280.94
153_D244_L2.2150.94
25_I219_P2.2130.94
349_S412_L2.1770.94
273_N276_Q2.1420.93
133_I170_L2.1410.93
48_K59_T2.1400.93
400_T403_I2.1340.93
6_I10_L2.0930.92
167_K180_E2.0560.92
50_E54_Q2.0450.91
264_T328_F2.0410.91
338_I430_A2.0390.91
105_D108_G2.0210.91
310_S363_Y2.0130.91
20_V24_G1.9900.90
65_M123_L1.9770.90
224_T379_E1.9410.89
169_Y244_L1.9380.89
30_P308_T1.9180.88
386_S390_M1.9150.88
406_I431_M1.9020.88
187_N337_V1.8900.88
15_V351_I1.8880.88
279_V415_T1.8810.87
126_Q154_H1.8670.87
140_F266_G1.8650.87
30_P365_R1.8640.87
232_T337_V1.8490.86
109_F173_Y1.8200.86
318_F430_A1.8150.85
312_T366_P1.8130.85
170_L181_V1.8040.85
7_K14_L1.7960.85
152_F170_L1.7680.84
8_T14_L1.7460.83
281_F378_S1.7450.83
22_T28_F1.7400.83
230_F332_M1.7380.83
316_Q331_F1.7240.82
14_L429_W1.7130.82
398_Y403_I1.6860.81
7_K219_P1.6760.80
7_K245_F1.6720.80
305_L310_S1.6670.80
168_I299_K1.6380.79
13_V296_E1.5900.77
7_K60_V1.5780.76
240_F301_S1.5760.76
60_V284_R1.5740.76
56_L331_F1.5710.76
129_D317_F1.5650.75
318_F338_I1.5620.75
18_S21_F1.5440.74
22_T171_V1.5390.74
295_G317_F1.5150.73
407_F437_I1.5130.73
98_K317_F1.5110.73
127_F425_L1.5020.72
8_T219_P1.4960.72
30_P304_Y1.4820.71
20_V127_F1.4720.71
127_F330_I1.4690.71
124_D154_H1.4670.70
15_V204_A1.4650.70
11_L21_F1.4600.70
410_Y425_L1.4550.70
331_F336_P1.4510.70
155_I293_Q1.4450.69
70_D435_G1.4410.69
30_P429_W1.4410.69
187_N299_K1.4270.68
18_S427_P1.4250.68
318_F328_F1.4230.68
264_T268_S1.4160.68
318_F329_Y1.4110.67
131_I317_F1.4020.67
94_V168_I1.4010.67
76_V82_Y1.3940.66
87_S123_L1.3940.66
7_K365_R1.3890.66
236_K440_I1.3880.66
144_N380_T1.3780.66
121_A401_D1.3750.65
21_F334_Q1.3730.65
411_Q428_V1.3720.65
382_L408_L1.3630.65
216_F225_M1.3520.64
10_L19_L1.3450.64
156_L169_Y1.3440.64
10_L155_I1.3410.63
114_Y217_L1.3390.63
221_K325_Q1.3280.63
135_I187_N1.3130.62
71_G157_I1.3120.62
321_N435_G1.3100.61
54_Q58_E1.3060.61
187_N195_L1.3040.61
85_I387_E1.3030.61
155_I329_Y1.3010.61
349_S366_P1.3010.61
228_K333_D1.3010.61
132_P385_G1.2940.61
153_D416_S1.2900.60
47_H50_E1.2870.60
22_T243_A1.2840.60
245_F365_R1.2800.60
71_G185_S1.2790.60
142_W337_V1.2720.59
404_D435_G1.2680.59
75_K205_F1.2660.59
402_K434_N1.2640.59
228_K298_I1.2610.58
15_V30_P1.2490.58
9_I435_G1.2390.57
318_F407_F1.2180.56
8_T373_N1.2130.55
312_T330_I1.2060.55
332_M425_L1.2050.55
168_I191_I1.1990.55
67_I92_W1.1970.54
123_L187_N1.1960.54
9_I300_K1.1940.54
30_P310_S1.1940.54
303_K334_Q1.1900.54
191_I241_K1.1860.54
15_V18_S1.1820.53
298_I310_S1.1760.53
181_V281_F1.1740.53
172_S353_V1.1730.53
60_V131_I1.1700.53
56_L233_E1.1670.53
20_V32_F1.1670.53
269_R429_W1.1650.52
138_T441_T1.1610.52
227_K378_S1.1590.52
240_F366_P1.1530.52
241_K270_L1.1520.52
58_E390_M1.1390.51
133_I326_L1.1380.51
75_K335_I1.1370.51
64_D113_F1.1330.50
392_L409_A1.1330.50
70_D107_A1.1290.50
110_K357_N1.1230.50
333_D338_I1.1220.50
311_W365_R1.1180.49
31_N406_I1.1130.49
85_I214_K1.1120.49
152_F301_S1.1110.49
241_K252_R1.1100.49
150_S179_L1.1060.49
123_L276_Q1.1020.48
68_H311_W1.0990.48
312_T315_Y1.0950.48
82_Y251_V1.0900.48
308_T311_W1.0890.48
220_N386_S1.0770.47
247_D429_W1.0690.46
85_I328_F1.0670.46
241_K261_N1.0670.46
14_L310_S1.0650.46
247_D252_R1.0610.46
319_N328_F1.0610.46
11_L62_P1.0600.46
153_D173_Y1.0520.45
132_P365_R1.0510.45
413_V426_E1.0510.45
400_T440_I1.0460.45
191_I210_I1.0400.44
30_P360_I1.0290.44
11_L14_L1.0270.44
124_D311_W1.0270.44
8_T12_T1.0220.43
228_K254_D1.0200.43
52_T394_K1.0190.43
279_V367_N1.0180.43
229_E424_E1.0140.43
360_I408_L1.0130.43
4_E429_W1.0100.42
68_H218_L1.0050.42
109_F119_S0.9990.42
392_L416_S0.9980.42
57_S388_V0.9950.42
265_D268_S0.9870.41
433_V436_K0.9850.41
251_V270_L0.9850.41
248_P265_D0.9820.41
284_R308_T0.9790.41
283_Q384_G0.9780.40
110_K139_L0.9770.40
16_V36_S0.9750.40
279_V368_Y0.9720.40
367_N431_M0.9710.40
13_V89_L0.9700.40
4_E306_E0.9700.40
136_F195_L0.9690.40
15_V285_N0.9660.40
306_E310_S0.9640.40
281_F310_S0.9630.40
136_F152_F0.9570.39
8_T317_F0.9550.39
405_Q432_K0.9540.39
173_Y298_I0.9530.39
256_N430_A0.9520.39
105_D259_N0.9510.39
132_P263_L0.9510.39
15_V374_P0.9500.39
49_I152_F0.9490.39
268_S287_V0.9450.38
60_V218_L0.9440.38
76_V271_D0.9440.38
217_L429_W0.9430.38
354_Q362_S0.9400.38
266_G284_R0.9400.38
23_W297_L0.9290.37
383_M388_V0.9260.37
383_M440_I0.9260.37
65_M393_S0.9240.37
248_P281_F0.9240.37
7_K304_Y0.9200.37
7_K11_L0.9190.37
12_T32_F0.9180.37
64_D367_N0.9140.37
206_S220_N0.9110.36
64_D84_E0.9100.36
245_F251_V0.9080.36
138_T174_S0.9010.36
269_R368_Y0.8990.36
7_K205_F0.8980.36
17_I151_S0.8970.36
314_H332_M0.8950.35
383_M387_E0.8930.35
66_F242_Q0.8910.35
252_R304_Y0.8900.35
131_I136_F0.8900.35
244_L370_L0.8870.35
20_V357_N0.8840.35
174_S392_L0.8790.35
15_V80_A0.8760.34
35_G76_V0.8750.34
304_Y308_T0.8740.34
15_V304_Y0.8720.34
266_G332_M0.8670.34
67_I71_G0.8670.34
16_V172_S0.8670.34
30_P363_Y0.8670.34
422_L425_L0.8630.34
131_I229_E0.8620.34
18_S22_T0.8620.34
62_P309_G0.8610.34
18_S392_L0.8600.33
259_N317_F0.8600.33
129_D153_D0.8600.33
124_D367_N0.8530.33
181_V381_E0.8520.33
49_I431_M0.8520.33
230_F295_G0.8490.33
308_T356_A0.8450.33
261_N270_L0.8450.33
64_D337_V0.8440.33
332_M373_N0.8410.32
26_W312_T0.8370.32
304_Y363_Y0.8300.32
99_D111_S0.8290.32
99_D177_L0.8270.32
12_T82_Y0.8220.31
15_V253_E0.8200.31
64_D334_Q0.8170.31
77_D157_I0.8090.31
11_L22_T0.8060.30
26_W244_L0.8060.30
202_M245_F0.8040.30
179_L425_L0.8040.30
29_Q440_I0.8020.30
89_L393_S0.8000.30
301_S360_I0.8000.30
166_K183_V0.7990.30
61_R127_F0.7990.30
279_V366_P0.7980.30
152_F158_P0.7970.30
376_K415_T0.7940.30
170_L173_Y0.7940.30
122_K156_L0.7920.30
141_K331_F0.7920.30
22_T313_D0.7880.29
309_G336_P0.7840.29
20_V193_N0.7830.29
248_P363_Y0.7830.29
87_S198_R0.7800.29
172_S370_L0.7800.29
168_I325_Q0.7790.29
25_I240_F0.7790.29
14_L245_F0.7780.29
337_V383_M0.7760.29
268_S367_N0.7760.29
22_T398_Y0.7760.29
240_F319_N0.7750.29
7_K308_T0.7730.29
311_W429_W0.7700.29
284_R365_R0.7700.29
76_V268_S0.7680.28
190_N323_S0.7640.28
306_E315_Y0.7620.28
388_V437_I0.7610.28
179_L381_E0.7600.28
193_N425_L0.7600.28
250_I403_I0.7590.28
14_L30_P0.7590.28
225_M433_V0.7590.28
125_L392_L0.7580.28
16_V381_E0.7560.28
59_T386_S0.7550.28
277_R367_N0.7540.28
127_F172_S0.7540.28
108_G112_W0.7500.27
261_N337_V0.7500.27
22_T26_W0.7470.27
15_V238_N0.7450.27
393_S406_I0.7430.27
310_S330_I0.7410.27
403_I434_N0.7390.27
304_Y365_R0.7390.27
25_I379_E0.7390.27
177_L406_I0.7390.27
11_L245_F0.7360.27
121_A435_G0.7360.27
65_M378_S0.7340.27
10_L14_L0.7310.27
225_M352_T0.7310.27
21_F177_L0.7300.26
234_S276_Q0.7290.26
6_I94_V0.7280.26
43_V142_W0.7280.26
167_K307_D0.7270.26
59_T402_K0.7250.26
23_W426_E0.7230.26
60_V359_D0.7220.26
34_E270_L0.7190.26
105_D110_K0.7180.26
61_R316_Q0.7180.26
106_K111_S0.7180.26
124_D385_G0.7180.26
329_Y367_N0.7170.26
71_G161_E0.7160.26
318_F432_K0.7160.26
3_R409_A0.7150.26
170_L251_V0.7150.26
19_L167_K0.7150.26
139_L438_V0.7150.26
149_Y222_P0.7120.26
58_E275_S0.7120.26
315_Y363_Y0.7110.26
123_L296_E0.7100.25
168_I334_Q0.7060.25
403_I433_V0.7060.25
254_D437_I0.7060.25
120_E266_G0.7050.25
229_E437_I0.7030.25
17_I113_F0.7020.25
392_L427_P0.7010.25
111_S435_G0.7010.25
79_N187_N0.7000.25
71_G288_Q0.6980.25
206_S386_S0.6960.25
197_N381_E0.6960.25
91_H378_S0.6940.25
19_L215_E0.6930.25
73_H124_D0.6920.25
382_L427_P0.6920.25
130_T384_G0.6920.25
152_F199_Q0.6920.25
189_R328_F0.6870.24
25_I224_T0.6870.24
149_Y279_V0.6870.24
70_D419_D0.6870.24
22_T409_A0.6860.24
338_I437_I0.6830.24
277_R361_L0.6830.24
33_S314_H0.6820.24
352_T404_D0.6800.24
351_I429_W0.6800.24
99_D317_F0.6790.24
304_Y310_S0.6780.24
9_I21_F0.6780.24
87_S90_P0.6740.24
6_I136_F0.6730.24
106_K401_D0.6710.24
52_T59_T0.6680.23
11_L429_W0.6680.23
132_P429_W0.6680.23
331_F423_V0.6680.23
225_M273_N0.6670.23
11_L427_P0.6650.23
131_I146_S0.6630.23
232_T352_T0.6560.23
131_I360_I0.6560.23
124_D305_L0.6530.23
121_A328_F0.6520.23
4_E22_T0.6520.23
216_F234_S0.6500.23
94_V353_V0.6490.23
138_T399_D0.6480.23
6_I358_D0.6480.23
171_V312_T0.6480.23
158_P169_Y0.6470.23
254_D425_L0.6470.23
306_E365_R0.6470.23
263_L331_F0.6470.23
243_A281_F0.6420.22
275_S303_K0.6420.22
92_W412_L0.6390.22
152_F430_A0.6360.22
7_K30_P0.6360.22
86_W262_V0.6360.22
309_G330_I0.6350.22
82_Y430_A0.6330.22
56_L172_S0.6300.22
4_E11_L0.6270.22
132_P363_Y0.6260.22
66_F405_Q0.6260.22
153_D236_K0.6260.22
10_L323_S0.6260.22
22_T186_A0.6250.22
236_K435_G0.6250.22
168_I368_Y0.6240.22
376_K390_M0.6240.22
39_T70_D0.6240.22
125_L133_I0.6240.22
281_F376_K0.6230.21
270_L382_L0.6210.21
265_D385_G0.6210.21
58_E173_Y0.6190.21
315_Y412_L0.6170.21
213_K288_Q0.6170.21
349_S397_A0.6160.21
89_L139_L0.6160.21
160_N192_M0.6150.21
33_S413_V0.6140.21
229_E301_S0.6140.21
7_K429_W0.6130.21
37_S98_K0.6130.21
178_I382_L0.6130.21
311_W385_G0.6120.21
48_K354_Q0.6110.21
71_G408_L0.6110.21
134_D157_I0.6100.21
308_T412_L0.6090.21
249_S265_D0.6090.21
272_V425_L0.6080.21
42_T423_V0.6080.21
258_N262_V0.6050.21
26_W437_I0.6020.21
37_S85_I0.6020.21
64_D75_K0.6010.21
374_P428_V0.6010.21
134_D176_Q0.6000.20
124_D245_F0.6000.20
262_V284_R0.5990.20
14_L304_Y0.5990.20
205_F297_L0.5990.20
64_D263_L0.5980.20
26_W249_S0.5970.20
244_L348_T0.5960.20
401_D441_T0.5940.20
139_L383_M0.5930.20
39_T134_D0.5930.20
105_D303_K0.5910.20
201_N317_F0.5910.20
294_T318_F0.5900.20
179_L416_S0.5900.20
84_E376_K0.5890.20
154_H365_R0.5890.20
19_L136_F0.5870.20
63_R334_Q0.5860.20
136_F350_A0.5850.20
70_D386_S0.5850.20
39_T42_T0.5840.20
300_K339_N0.5830.20
189_R321_N0.5830.20
297_L355_W0.5830.20
381_E391_L0.5810.20
67_I213_K0.5800.20
244_L298_I0.5790.20
198_R362_S0.5770.20
58_E100_I0.5760.20
85_I184_E0.5760.20
176_Q259_N0.5760.20
153_D337_V0.5760.20
242_Q328_F0.5750.19
301_S423_V0.5740.19
338_I433_V0.5730.19
270_L368_Y0.5730.19
35_G57_S0.5730.19
399_D402_K0.5720.19
258_N390_M0.5720.19
225_M272_V0.5720.19
281_F370_L0.5710.19
400_T406_I0.5710.19
388_V406_I0.5710.19
311_W363_Y0.5710.19
126_Q218_L0.5700.19
155_I168_I0.5670.19
18_S429_W0.5670.19
29_Q312_T0.5670.19
18_S265_D0.5660.19
245_F298_I0.5660.19
125_L390_M0.5650.19
7_K18_S0.5650.19
142_W362_S0.5650.19
35_G356_A0.5650.19
404_D436_K0.5650.19
191_I194_D0.5580.19
323_S340_S0.5570.19
304_Y309_G0.5570.19
25_I86_W0.5570.19
186_A408_L0.5570.19
169_Y326_L0.5560.19
243_A248_P0.5560.19
30_P311_W0.5550.19
22_T302_Q0.5530.19
281_F410_Y0.5520.19
222_P381_E0.5520.19
233_E351_I0.5500.18
20_V281_F0.5490.18
207_L403_I0.5480.18
89_L380_T0.5470.18
168_I273_N0.5470.18
92_W183_V0.5450.18
87_S98_K0.5450.18
210_I327_S0.5450.18
29_Q412_L0.5440.18
17_I36_S0.5440.18
357_N371_G0.5430.18
59_T188_Y0.5420.18
331_F430_A0.5420.18
13_V242_Q0.5400.18
228_K233_E0.5400.18
291_S423_V0.5400.18
348_T353_V0.5390.18
29_Q366_P0.5380.18
17_I296_E0.5340.18
197_N401_D0.5330.18
231_V432_K0.5320.18
15_V433_V0.5310.18
253_E302_Q0.5310.18
223_L382_L0.5310.18
54_Q191_I0.5300.18
165_N187_N0.5300.18
427_P437_I0.5290.18
91_H377_T0.5290.18
13_V48_K0.5280.18
287_V367_N0.5280.18
160_N289_S0.5280.18
7_K315_Y0.5280.18
98_K197_N0.5270.18
8_T315_Y0.5260.18
132_P311_W0.5250.18
218_L265_D0.5250.18
161_E206_S0.5240.17
138_T298_I0.5240.17
12_T185_S0.5230.17
88_D92_W0.5230.17
75_K82_Y0.5210.17
81_L173_Y0.5200.17
109_F263_L0.5200.17
4_E251_V0.5190.17
137_Q180_E0.5190.17
85_I340_S0.5190.17
312_T337_V0.5180.17
340_S408_L0.5180.17
269_R360_I0.5180.17
98_K184_E0.5180.17
249_S414_S0.5170.17
38_S349_S0.5160.17
64_D139_L0.5160.17
178_I213_K0.5140.17
8_T424_E0.5130.17
32_F216_F0.5110.17
43_V280_Q0.5100.17
235_I315_Y0.5100.17
275_S387_E0.5100.17
362_S404_D0.5090.17
21_F321_N0.5070.17
86_W181_V0.5070.17
11_L15_V0.5060.17
18_S370_L0.5050.17
184_E263_L0.5030.17
83_E353_V0.5020.17
245_F330_I0.5020.17
4_E412_L0.5020.17
374_P408_L0.5010.17
4_E244_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fgtA 1 0.8 100 0.286 Contact Map
2o3oA 2 0.5099 99.9 0.771 Contact Map
4k90B 1 0.3604 96 0.932 Contact Map
3nqzA 1 0.3363 78.4 0.954 Contact Map
2mc7A 1 0.0659 10.8 0.973 Contact Map
5ajdB 1 0.1121 7.7 0.975 Contact Map
2j5lA 1 0 5.7 0.976 Contact Map
4pj0Y 1 0.0637 5 0.977 Contact Map
1m56D 1 0.0484 4.9 0.977 Contact Map
2l6wA 2 0.0725 4 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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