GREMLIN Database
PARE - DNA topoisomerase 4 subunit B
UniProt: Q59192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 655 (623)
Sequences: 4782 (2007)
Seq/√Len: 80.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_D77_R6.5621.00
141_F159_K4.6101.00
46_I122_A4.3091.00
208_I215_R4.0511.00
130_E173_K4.0321.00
67_H73_S3.7901.00
174_P184_Y3.6991.00
133_T146_R3.6911.00
554_A563_V3.4211.00
131_W173_K3.2681.00
75_Q169_L3.2321.00
417_S422_K3.1221.00
148_E154_V3.1151.00
593_N596_S3.0431.00
204_K217_V2.9871.00
137_E165_K2.9791.00
61_H204_K2.9751.00
495_D530_K2.9481.00
11_E84_G2.9081.00
93_P134_V2.8961.00
133_T144_Q2.8931.00
144_Q158_E2.8711.00
97_L170_T2.8011.00
93_P157_L2.7971.00
67_H210_E2.7041.00
88_L95_V2.6901.00
43_V189_L2.6871.00
107_G110_G2.6681.00
131_W146_R2.6651.00
63_I206_E2.6221.00
419_N422_K2.5931.00
492_I530_K2.5901.00
135_T169_L2.5781.00
67_H171_H2.5761.00
197_A220_Y2.5751.00
73_S171_H2.5561.00
68_K210_E2.5121.00
134_V170_T2.5111.00
299_R310_N2.5111.00
61_H77_R2.5021.00
201_K245_E2.4891.00
64_V193_L2.4011.00
539_Y557_D2.3961.00
83_T143_Y2.3701.00
155_T158_E2.3691.00
425_L479_I2.3691.00
93_P136_I2.3541.00
63_I75_Q2.3351.00
135_T144_Q2.3241.00
143_Y159_K2.2871.00
43_V72_I2.2631.00
66_I72_I2.2461.00
535_L600_V2.2391.00
632_N635_F2.2321.00
130_E176_P2.2111.00
90_K94_E2.2041.00
135_T142_V2.1961.00
255_F324_I2.1941.00
420_P495_D2.1871.00
186_F216_E2.1851.00
51_V203_L2.1781.00
498_I599_L2.1711.00
141_F162_K2.1671.00
11_E92_T2.1441.00
475_I479_I2.1051.00
523_K527_E2.0921.00
59_G77_R2.0901.00
133_T171_H2.0831.00
18_E87_K2.0731.00
627_K631_K2.0711.00
186_F207_L2.0601.00
137_E142_V2.0551.00
524_P527_E2.0511.00
278_D341_G2.0451.00
296_E300_K2.0291.00
149_N177_T2.0211.00
293_A357_S2.0211.00
73_S169_L2.0171.00
204_K219_Y2.0111.00
416_G443_R1.9741.00
159_K162_K1.9631.00
67_H71_S1.9501.00
135_T171_H1.9471.00
243_S254_D1.9311.00
542_S551_I1.9201.00
436_S584_A1.9171.00
81_M96_I1.9041.00
413_T438_K1.8861.00
269_S283_E1.8761.00
399_K402_K1.8551.00
543_K570_G1.8491.00
142_V163_T1.8441.00
271_V328_I1.8431.00
63_I208_I1.8421.00
246_G355_I1.8231.00
427_L451_L1.8181.00
294_F364_L1.8181.00
479_I497_I1.8171.00
427_L475_I1.8161.00
22_A101_H1.8141.00
145_Q153_P1.8091.00
146_R155_T1.7901.00
194_R230_Y1.7791.00
137_E169_L1.7781.00
525_L531_V1.7741.00
311_L378_A1.7671.00
61_H206_E1.7651.00
90_K99_V1.7581.00
251_I351_A1.7381.00
146_R154_V1.7291.00
349_R353_D1.7191.00
65_K210_E1.7131.00
84_G139_D1.7041.00
97_L122_A1.7021.00
65_K75_Q1.7001.00
269_S276_T1.6991.00
247_E252_E1.6881.00
226_A229_A1.6851.00
236_D261_D1.6841.00
44_Y189_L1.6791.00
609_R612_R1.6741.00
515_L531_V1.6531.00
533_I602_V1.6511.00
556_S559_E1.6481.00
363_F367_N1.6471.00
479_I492_I1.6421.00
247_E250_S1.6241.00
367_N370_T1.6191.00
18_E88_L1.6041.00
142_V161_G1.5821.00
546_G552_E1.5691.00
65_K208_I1.5681.00
144_Q160_I1.5681.00
298_A304_L1.5651.00
488_S491_D1.5591.00
286_A322_A1.5571.00
190_S216_E1.5561.00
10_N13_A1.5460.99
186_F218_F1.5440.99
251_I348_A1.5410.99
72_I184_Y1.5340.99
206_E217_V1.5170.99
232_N258_Q1.5110.99
297_Y371_A1.5100.99
122_A132_L1.5080.99
560_M564_L1.4880.99
245_E254_D1.4870.99
198_F230_Y1.4870.99
97_L132_L1.4860.99
621_K624_P1.4770.99
47_V74_V1.4720.99
360_L364_L1.4600.99
257_F320_L1.4510.99
286_A324_I1.4480.99
222_N225_E1.4460.99
417_S423_N1.4450.99
131_W148_E1.4400.99
35_D346_S1.4370.99
348_A351_A1.4340.99
421_A495_D1.4260.99
84_G92_T1.4220.99
15_Q107_G1.4180.99
84_G138_R1.4150.99
313_G317_R1.4030.99
541_V563_V1.4030.99
607_A610_V1.3810.99
524_P528_H1.3790.99
452_R471_E1.3790.99
71_S173_K1.3770.99
481_G487_F1.3730.99
423_N495_D1.3670.99
75_Q165_K1.3660.99
225_E229_A1.3590.99
464_A468_K1.3560.99
147_F153_P1.3460.99
552_E566_K1.3310.98
103_G106_F1.3220.98
142_V160_I1.3080.98
95_V99_V1.2990.98
153_P156_S1.2990.98
224_I243_S1.2980.98
201_K254_D1.2820.98
318_E381_A1.2790.98
425_L475_I1.2780.98
132_L170_T1.2720.98
271_V276_T1.2620.98
51_V196_S1.2570.98
65_K73_S1.2570.98
470_E474_T1.2570.98
97_L134_V1.2540.98
263_Y396_R1.2470.98
455_V472_I1.2420.98
420_P423_N1.2360.97
306_E310_N1.2350.97
497_I518_F1.2320.97
85_M89_G1.2310.97
574_Q586_Q1.2290.97
115_G274_V1.2250.97
514_L518_F1.2170.97
50_S170_T1.2160.97
452_R455_V1.2130.97
225_E243_S1.2120.97
541_V560_M1.2070.97
299_R308_D1.2050.97
71_S174_P1.2040.97
70_N183_T1.2030.97
552_E563_V1.2010.97
147_F157_L1.2010.97
54_V203_L1.2010.97
471_E474_T1.2000.97
244_F255_F1.1990.97
15_Q25_K1.1980.97
31_I38_G1.1940.97
559_E562_D1.1930.97
242_V257_F1.1890.97
206_E215_R1.1880.97
489_I528_H1.1840.97
626_R630_E1.1770.97
59_G62_I1.1740.97
422_K445_F1.1740.97
141_F161_G1.1740.97
232_N321_S1.1690.96
173_K176_P1.1680.96
422_K444_R1.1660.96
439_Q584_A1.1650.96
71_S171_H1.1620.96
8_D13_A1.1620.96
588_W594_P1.1620.96
540_K551_I1.1550.96
541_V554_A1.1550.96
267_I287_K1.1540.96
518_F531_V1.1530.96
359_Q362_Y1.1430.96
328_I348_A1.1410.96
294_F316_I1.1400.96
277_K341_G1.1370.96
267_I322_A1.1360.96
43_V47_V1.1320.96
337_G344_G1.1320.96
253_V355_I1.1310.96
75_Q137_E1.1300.96
186_F214_Q1.1300.96
137_E166_T1.1280.96
554_A560_M1.1260.96
66_I70_N1.1240.96
278_D337_G1.1230.96
424_E498_I1.1230.96
251_I328_I1.1190.95
47_V193_L1.1190.95
252_E327_R1.1170.95
58_H79_R1.1110.95
145_Q155_T1.1090.95
463_L467_F1.1070.95
136_I157_L1.1060.95
139_D143_Y1.1060.95
185_N188_T1.1050.95
455_V501_T1.1040.95
25_K330_E1.1020.95
288_T353_D1.1000.95
362_Y366_E1.0980.95
299_R306_E1.0970.95
481_G489_I1.0950.95
291_T313_G1.0930.95
190_S218_F1.0930.95
481_G492_I1.0900.95
70_N173_K1.0890.95
233_E612_R1.0860.95
298_A375_V1.0850.95
253_V351_A1.0820.95
299_R304_L1.0710.94
364_L371_A1.0690.94
551_I554_A1.0670.94
230_Y612_R1.0670.94
138_R166_T1.0660.94
337_G341_G1.0660.94
67_H70_N1.0640.94
193_L207_L1.0590.94
427_L471_E1.0590.94
562_D566_K1.0570.94
373_L376_K1.0550.94
71_S131_W1.0530.94
23_V100_L1.0530.94
356_V360_L1.0500.94
561_G565_K1.0490.94
14_I92_T1.0490.94
146_R158_E1.0470.94
147_F155_T1.0450.93
511_Q533_I1.0430.93
552_E559_E1.0380.93
416_G444_R1.0290.93
289_A293_A1.0290.93
336_E344_G1.0240.93
606_D609_R1.0220.93
194_R220_Y1.0220.93
222_N226_A1.0160.92
395_A399_K1.0160.92
186_F190_S1.0100.92
336_E341_G1.0090.92
296_E299_R1.0070.92
589_E593_N1.0040.92
50_S97_L1.0020.92
144_Q155_T1.0010.92
452_R470_E0.9990.92
445_F594_P0.9980.92
554_A559_E0.9980.92
241_V256_A0.9970.92
130_E177_T0.9950.92
304_L310_N0.9940.92
271_V326_V0.9930.92
176_P182_T0.9900.91
377_K396_R0.9880.91
560_M571_Y0.9860.91
86_H92_T0.9850.91
399_K414_P0.9810.91
137_E163_T0.9810.91
564_L573_I0.9810.91
334_Q344_G0.9760.91
492_I528_H0.9750.91
91_P95_V0.9740.91
276_T344_G0.9730.91
284_S288_T0.9720.91
142_V165_K0.9710.91
326_V348_A0.9690.91
259_F316_I0.9670.90
13_A110_G0.9660.90
149_N175_D0.9650.90
499_I518_F0.9610.90
276_T337_G0.9560.90
353_D357_S0.9550.90
190_S207_L0.9530.90
263_Y377_K0.9520.90
455_V471_E0.9510.90
239_S370_T0.9510.90
189_L193_L0.9490.90
85_M88_L0.9490.90
358_E362_Y0.9400.89
473_N477_H0.9400.89
42_L125_V0.9390.89
122_A134_V0.9380.89
455_V474_T0.9370.89
612_R616_T0.9320.89
413_T443_R0.9320.89
623_E627_K0.9300.89
61_H217_V0.9270.89
15_Q87_K0.9270.89
54_V59_G0.9260.88
81_M97_L0.9250.88
83_T138_R0.9250.88
384_A388_A0.9240.88
284_S353_D0.9240.88
60_D204_K0.9230.88
350_S354_A0.9210.88
8_D11_E0.9200.88
455_V469_N0.9190.88
136_I168_T0.9130.88
46_I97_L0.9120.88
108_Q330_E0.9090.88
81_M170_T0.9080.88
145_Q157_L0.9080.88
316_I378_A0.9060.87
90_K95_V0.9040.87
222_N229_A0.9030.87
198_F220_Y0.8970.87
86_H90_K0.8970.87
469_N474_T0.8900.86
55_L59_G0.8890.86
414_P493_N0.8860.86
459_E520_R0.8860.86
423_N530_K0.8860.86
576_Y586_Q0.8740.85
588_W593_N0.8700.85
51_V205_I0.8700.85
315_D385_R0.8690.85
568_G571_Y0.8690.85
92_T95_V0.8680.85
122_A170_T0.8670.85
284_S349_R0.8670.85
476_I517_F0.8660.85
85_M90_K0.8650.85
298_A311_L0.8640.85
229_A241_V0.8620.85
540_K586_Q0.8620.85
271_V344_G0.8590.84
66_I207_L0.8570.84
36_A185_N0.8570.84
345_T348_A0.8560.84
10_N84_G0.8550.84
442_D445_F0.8550.84
613_R616_T0.8540.84
77_R165_K0.8530.84
149_N152_K0.8510.84
64_V207_L0.8500.84
376_K380_K0.8480.84
278_D342_K0.8460.84
475_I501_T0.8400.83
389_R393_E0.8390.83
585_D593_N0.8370.83
471_E501_T0.8370.83
64_V205_I0.8330.83
292_R353_D0.8300.82
269_S337_G0.8280.82
603_K607_A0.8270.82
91_P157_L0.8270.82
142_V159_K0.8240.82
557_D561_G0.8240.82
245_E252_E0.8230.82
240_E370_T0.8230.82
426_Y599_L0.8200.82
614_V618_M0.8190.82
439_Q583_N0.8170.81
615_T621_K0.8170.81
467_F472_I0.8160.81
426_Y445_F0.8160.81
17_L25_K0.8150.81
22_A28_G0.8120.81
91_P153_P0.8110.81
148_E155_T0.8090.81
438_K586_Q0.8060.80
458_T466_I0.8050.80
163_T166_T0.8050.80
369_D373_L0.8040.80
267_I283_E0.8020.80
141_F160_I0.8020.80
16_V88_L0.8020.80
304_L308_D0.8020.80
402_K405_E0.8010.80
627_K630_E0.8000.80
196_S200_L0.7970.80
255_F286_A0.7950.80
58_H152_K0.7950.80
311_L375_V0.7940.79
409_S414_P0.7900.79
214_Q631_K0.7880.79
357_S361_A0.7880.79
521_Y555_W0.7870.79
90_K153_P0.7840.79
561_G564_L0.7820.78
60_D64_V0.7810.78
137_E164_K0.7810.78
160_I163_T0.7790.78
271_V335_F0.7770.78
511_Q535_L0.7760.78
20_L100_L0.7760.78
276_T336_E0.7750.78
604_I610_V0.7740.78
543_K567_V0.7730.78
551_I589_E0.7720.78
149_N178_M0.7720.78
194_R198_F0.7720.78
295_N299_R0.7700.77
70_N184_Y0.7700.77
255_F356_V0.7690.77
399_K403_K0.7660.77
11_E139_D0.7650.77
19_G23_V0.7650.77
269_S344_G0.7650.77
500_M534_A0.7620.77
475_I517_F0.7620.77
55_L207_L0.7620.77
543_K569_K0.7610.77
372_T376_K0.7610.77
481_G522_M0.7580.76
302_A306_E0.7530.76
278_D346_S0.7490.75
490_D528_H0.7490.75
22_A100_L0.7490.75
371_A375_V0.7480.75
250_S329_P0.7470.75
69_D171_H0.7440.75
417_S444_R0.7430.75
139_D159_K0.7430.75
519_Y610_V0.7420.75
172_F184_Y0.7420.75
288_T349_R0.7390.74
293_A361_A0.7370.74
130_E149_N0.7360.74
624_P627_K0.7350.74
286_A356_V0.7350.74
526_I604_I0.7330.74
132_L145_Q0.7330.74
18_E152_K0.7320.74
130_E175_D0.7290.73
363_F370_T0.7290.73
384_A395_A0.7270.73
484_G521_Y0.7250.73
142_V162_K0.7250.73
65_K71_S0.7250.73
251_I329_P0.7240.73
426_Y588_W0.7240.73
269_S334_Q0.7240.73
94_E145_Q0.7220.73
88_L99_V0.7220.73
18_E22_A0.7220.73
83_T93_P0.7210.73
526_I531_V0.7210.73
458_T472_I0.7190.72
44_Y188_T0.7190.72
175_D178_M0.7190.72
208_I213_D0.7180.72
257_F290_M0.7180.72
20_L101_H0.7170.72
497_I531_V0.7160.72
15_Q18_E0.7160.72
16_V95_V0.7150.72
437_A448_V0.7150.72
384_A391_A0.7140.72
293_A360_L0.7120.72
84_G143_Y0.7120.72
195_E227_F0.7120.72
176_P183_T0.7110.72
292_R357_S0.7110.72
500_M592_M0.7100.71
563_V566_K0.7090.71
33_S38_G0.7090.71
394_E399_K0.7090.71
512_V614_V0.7070.71
567_V570_G0.7070.71
558_E561_G0.7070.71
474_T477_H0.7040.71
479_I531_V0.7040.71
410_G478_A0.7030.71
69_D173_K0.7030.71
22_A25_K0.7030.71
420_P530_K0.7030.71
399_K423_N0.7020.71
276_T334_Q0.7020.71
334_Q345_T0.7020.71
190_S214_Q0.7020.71
253_V352_V0.7010.70
33_S344_G0.7010.70
415_A493_N0.7010.70
470_E473_N0.6990.70
633_V636_G0.6990.70
567_V571_Y0.6980.70
423_N492_I0.6960.70
244_F475_I0.6960.70
452_R472_I0.6950.70
20_L23_V0.6950.70
226_A474_T0.6950.70
287_K317_R0.6950.70
156_S159_K0.6940.70
586_Q589_E0.6940.70
421_A530_K0.6940.70
50_S62_I0.6920.69
87_K152_K0.6900.69
283_E405_E0.6890.69
143_Y166_T0.6860.69
380_K396_R0.6860.69
142_V164_K0.6840.69
131_W171_H0.6830.68
628_W632_N0.6830.68
479_I495_D0.6830.68
269_S324_I0.6830.68
278_D336_E0.6820.68
520_R611_E0.6780.68
405_E477_H0.6780.68
409_S493_N0.6780.68
524_P604_I0.6780.68
9_Y14_I0.6740.67
97_L145_Q0.6740.67
275_R283_E0.6740.67
390_K393_E0.6730.67
544_G570_G0.6730.67
489_I492_I0.6720.67
237_V258_Q0.6720.67
133_T148_E0.6700.67
202_G219_Y0.6690.67
33_S37_R0.6690.67
234_E615_T0.6680.67
614_V619_G0.6680.67
102_A123_S0.6670.67
316_I468_K0.6670.67
298_A306_E0.6660.67
552_E567_V0.6660.67
380_K383_Q0.6660.67
560_M570_G0.6650.66
283_E293_A0.6640.66
628_W633_V0.6630.66
402_K409_S0.6630.66
102_A106_F0.6590.66
302_A305_K0.6580.66
605_D609_R0.6580.66
425_L497_I0.6580.66
442_D594_P0.6570.65
93_P145_Q0.6560.65
600_V636_G0.6560.65
92_T110_G0.6560.65
228_V323_I0.6550.65
311_L379_I0.6520.65
492_I525_L0.6520.65
246_G359_Q0.6510.65
410_G438_K0.6500.65
302_A307_K0.6500.65
201_K243_S0.6500.65
146_R173_K0.6500.65
318_E377_K0.6490.65
557_D560_M0.6490.65
12_D86_H0.6470.64
165_K169_L0.6470.64
23_V123_S0.6470.64
26_R117_L0.6450.64
541_V567_V0.6450.64
173_K184_Y0.6450.64
13_A109_G0.6450.64
244_F356_V0.6440.64
456_I466_I0.6440.64
99_V147_F0.6430.64
476_I483_V0.6430.64
303_L375_V0.6410.64
387_A391_A0.6410.64
448_V592_M0.6400.63
386_E390_K0.6400.63
61_H75_Q0.6390.63
175_D276_T0.6390.63
36_A188_T0.6380.63
189_L205_I0.6380.63
326_V352_V0.6380.63
207_L216_E0.6380.63
399_K404_S0.6370.63
609_R613_R0.6370.63
424_E496_K0.6360.63
73_S131_W0.6360.63
240_E367_N0.6340.63
379_I389_R0.6330.63
517_F522_M0.6330.63
618_M622_V0.6330.63
106_F118_H0.6310.62
130_E146_R0.6310.62
268_L608_A0.6300.62
73_S210_E0.6300.62
379_I383_Q0.6300.62
463_L466_I0.6290.62
341_G345_T0.6290.62
309_K386_E0.6290.62
508_A586_Q0.6270.62
426_Y496_K0.6260.62
13_A107_G0.6260.62
553_Y586_Q0.6250.62
25_K141_F0.6230.61
576_Y589_E0.6230.61
16_V22_A0.6220.61
97_L168_T0.6220.61
42_L276_T0.6210.61
237_V241_V0.6210.61
225_E241_V0.6200.61
135_T207_L0.6200.61
236_D621_K0.6190.61
265_E317_R0.6180.61
408_L443_R0.6180.61
232_N235_K0.6170.61
299_R307_K0.6170.61
239_S258_Q0.6150.60
47_V64_V0.6150.60
574_Q588_W0.6150.60
85_M93_P0.6140.60
140_G164_K0.6130.60
94_E156_S0.6110.60
96_I170_T0.6110.60
331_E458_T0.6110.60
452_R501_T0.6100.60
46_I124_V0.6100.60
91_P156_S0.6100.60
145_Q156_S0.6080.60
452_R475_I0.6070.59
12_D87_K0.6070.59
281_T346_S0.6070.59
143_Y147_F0.6060.59
86_H95_V0.6050.59
196_S273_N0.6050.59
417_S420_P0.6040.59
153_P158_E0.6040.59
558_E562_D0.6030.59
253_V364_L0.6020.59
95_V227_F0.6010.59
289_A360_L0.6010.59
8_D12_D0.6000.59
370_T373_L0.6000.59
196_S203_L0.6000.59
394_E476_I0.6000.59
623_E626_R0.5980.58
590_T597_R0.5980.58
271_V337_G0.5970.58
368_R371_A0.5970.58
232_N260_N0.5940.58
476_I482_G0.5930.58
143_Y163_T0.5930.58
67_H208_I0.5920.58
410_G443_R0.5920.58
304_L379_I0.5920.58
85_M91_P0.5910.57
131_W154_V0.5900.57
70_N182_T0.5890.57
298_A302_A0.5890.57
70_N174_P0.5890.57
88_L91_P0.5870.57
63_I73_S0.5870.57
241_V370_T0.5860.57
111_Y329_P0.5850.57
89_G152_K0.5840.56
369_D372_T0.5840.56
13_A108_Q0.5840.56
535_L598_T0.5840.56
456_I469_N0.5830.56
190_S270_F0.5820.56
614_V621_K0.5820.56
235_K615_T0.5820.56
399_K407_T0.5820.56
423_N444_R0.5820.56
37_R336_E0.5810.56
135_T160_I0.5810.56
527_E604_I0.5810.56
438_K443_R0.5810.56
560_M573_I0.5810.56
19_G101_H0.5800.56
238_L241_V0.5800.56
388_A391_A0.5800.56
416_G423_N0.5800.56
422_K495_D0.5790.56
466_I472_I0.5780.56
542_S572_T0.5780.56
306_E309_K0.5780.56
413_T448_V0.5770.56
555_W598_T0.5770.56
97_L153_P0.5760.55
287_K313_G0.5760.55
544_G569_K0.5760.55
399_K409_S0.5760.55
559_E598_T0.5750.55
278_D345_T0.5750.55
68_K213_D0.5740.55
451_L514_L0.5730.55
425_L481_G0.5730.55
619_G629_I0.5720.55
515_L614_V0.5720.55
200_L273_N0.5720.55
35_D341_G0.5710.55
231_L321_S0.5700.55
541_V564_L0.5700.55
388_A395_A0.5700.55
386_E389_R0.5700.55
391_A395_A0.5700.55
456_I461_A0.5700.55
611_E614_V0.5700.55
535_L636_G0.5690.55
84_G95_V0.5690.55
440_G588_W0.5690.55
437_A500_M0.5690.55
409_S474_T0.5690.55
261_D393_E0.5680.54
244_F359_Q0.5670.54
452_R474_T0.5670.54
452_R467_F0.5670.54
409_S478_A0.5670.54
545_S551_I0.5670.54
308_D555_W0.5650.54
271_V329_P0.5630.54
250_S328_I0.5630.54
239_S259_F0.5630.54
508_A511_Q0.5620.54
413_T586_Q0.5610.54
555_W563_V0.5610.54
83_T141_F0.5610.54
90_K156_S0.5610.54
70_N131_W0.5610.54
402_K407_T0.5600.53
555_W560_M0.5600.53
50_S168_T0.5600.53
427_L431_D0.5590.53
16_V194_R0.5590.53
37_R277_K0.5590.53
555_W559_E0.5580.53
490_D495_D0.5580.53
406_A409_S0.5580.53
408_L411_K0.5570.53
501_T511_Q0.5560.53
331_E493_N0.5560.53
248_H354_A0.5540.53
415_A628_W0.5530.52
133_T154_V0.5530.52
291_T295_N0.5530.52
61_H208_I0.5530.52
511_Q600_V0.5530.52
75_Q135_T0.5520.52
43_V66_I0.5520.52
234_E316_I0.5520.52
440_G455_V0.5520.52
440_G508_A0.5520.52
15_Q108_Q0.5510.52
414_P419_N0.5510.52
218_F501_T0.5510.52
63_I215_R0.5510.52
319_G377_K0.5500.52
94_E147_F0.5500.52
86_H97_L0.5490.52
7_F10_N0.5490.52
142_V147_F0.5490.52
419_N423_N0.5470.52
83_T86_H0.5470.52
96_I275_R0.5460.52
294_F360_L0.5450.51
426_Y511_Q0.5440.51
192_R196_S0.5440.51
204_K221_E0.5430.51
592_M630_E0.5420.51
439_Q443_R0.5420.51
37_R345_T0.5420.51
564_L571_Y0.5420.51
383_Q462_K0.5410.51
313_G319_G0.5410.51
38_G339_T0.5400.51
72_I207_L0.5400.51
472_I517_F0.5400.51
328_I469_N0.5390.51
441_R446_Q0.5380.51
455_V470_E0.5370.50
533_I620_D0.5370.50
543_K571_Y0.5370.50
227_F452_R0.5370.50
187_E190_S0.5370.50
409_S415_A0.5370.50
307_K310_N0.5370.50
138_R253_V0.5370.50
582_M587_L0.5360.50
526_I602_V0.5360.50
411_K431_D0.5350.50
519_Y604_I0.5350.50
377_K388_A0.5340.50
463_L483_V0.5340.50
66_I211_R0.5340.50
278_D344_G0.5340.50
162_K166_T0.5330.50
133_T169_L0.5320.50
51_V350_S0.5320.50
35_D623_E0.5320.50
423_N493_N0.5320.50
414_P445_F0.5310.50
336_E342_K0.5310.50
562_D565_K0.5310.50
91_P94_E0.5310.50
607_A613_R0.5300.50
93_P132_L0.5300.50
539_Y574_Q0.5300.50
395_A400_K0.5300.50
523_K626_R0.5290.49
62_I316_I0.5290.49
50_S383_Q0.5280.49
393_E400_K0.5270.49
303_L379_I0.5260.49
53_E57_G0.5260.49
466_I501_T0.5260.49
63_I204_K0.5250.49
354_A358_E0.5250.49
585_D589_E0.5240.49
65_K207_L0.5240.49
46_I274_V0.5230.49
60_D164_K0.5220.48
64_V212_N0.5220.48
19_G25_K0.5220.48
396_R486_D0.5210.48
186_F211_R0.5210.48
53_E79_R0.5200.48
59_G78_G0.5200.48
90_K508_A0.5200.48
190_S227_F0.5190.48
28_G499_I0.5190.48
94_E114_S0.5190.48
501_T508_A0.5190.48
425_L492_I0.5190.48
606_D610_V0.5190.48
63_I74_V0.5180.48
17_L28_G0.5180.48
399_K493_N0.5180.48
382_S386_E0.5180.48
417_S421_A0.5180.48
516_T618_M0.5170.48
269_S612_R0.5170.48
312_E392_R0.5160.48
620_D624_P0.5160.48
16_V19_G0.5160.48
329_P351_A0.5160.48
197_A221_E0.5150.48
283_E362_Y0.5150.48
341_G344_G0.5150.48
149_N153_P0.5150.48
275_R341_G0.5140.47
35_D337_G0.5140.47
316_I567_V0.5140.47
370_T378_A0.5130.47
184_Y210_E0.5130.47
16_V99_V0.5130.47
20_L127_A0.5120.47
584_A588_W0.5120.47
226_A316_I0.5110.47
255_F290_M0.5110.47
614_V624_P0.5110.47
179_F182_T0.5110.47
405_E456_I0.5110.47
45_E49_N0.5100.47
618_M629_I0.5100.47
83_T210_E0.5100.47
283_E287_K0.5080.47
260_N319_G0.5080.47
437_A587_L0.5080.47
408_L438_K0.5080.47
451_L517_F0.5070.47
611_E615_T0.5070.47
461_A466_I0.5070.47
288_T350_S0.5070.47
93_P276_T0.5070.47
147_F154_V0.5070.47
86_H439_Q0.5060.46
546_G566_K0.5060.46
476_I522_M0.5060.46
44_Y205_I0.5050.46
164_K240_E0.5050.46
19_G22_A0.5050.46
104_G114_S0.5040.46
482_G487_F0.5040.46
16_V544_G0.5040.46
408_L413_T0.5040.46
81_M93_P0.5040.46
316_I382_S0.5040.46
239_S242_V0.5030.46
88_L508_A0.5030.46
47_V519_Y0.5030.46
16_V101_H0.5030.46
108_Q271_V0.5030.46
291_T317_R0.5020.46
28_G108_Q0.5020.46
426_Y594_P0.5010.46
302_A310_N0.5010.46
289_A356_V0.5010.46
400_K403_K0.5000.46
544_G551_I0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i3hA 2 0.8809 100 0.09 Contact Map
4gfhA 2 0.913 100 0.159 Contact Map
3zkbA 5 0.5878 100 0.534 Contact Map
4urlA 1 0.5557 100 0.551 Contact Map
4wubA 2 0.5802 100 0.562 Contact Map
1pvgA 2 0.5298 100 0.564 Contact Map
1zxmA 2 0.5313 100 0.57 Contact Map
3lnuA 1 0.5191 100 0.572 Contact Map
1kijA 2 0.5802 100 0.585 Contact Map
1s16A 2 0.5725 100 0.587 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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