GREMLIN Database
TNRA - HTH-type transcriptional regulator TnrA
UniProt: Q45666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (91)
Sequences: 953 (556)
Seq/√Len: 58.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_R75_I3.6231.00
84_Q89_D3.5131.00
85_M88_N3.2101.00
70_V78_D2.9741.00
91_Q94_K2.4831.00
10_D54_A2.2961.00
9_K57_E2.2311.00
38_L62_I1.9721.00
73_A76_L1.9041.00
71_Q74_E1.8200.99
61_D64_N1.8180.99
70_V74_E1.7220.99
61_D82_K1.7180.99
63_A67_E1.6940.99
14_I53_F1.6750.99
47_G50_K1.5610.98
14_I56_V1.5500.98
58_R83_E1.5180.98
29_Q66_R1.4850.98
65_K74_E1.4810.98
68_D77_K1.4780.98
44_S47_G1.4530.97
95_K98_E1.4510.97
27_V47_G1.4320.97
84_Q87_K1.3880.97
26_S29_Q1.3850.97
22_L60_M1.3810.96
77_K80_R1.3610.96
74_E78_D1.3300.96
46_R51_Y1.2980.95
23_T60_M1.1950.92
53_F56_V1.1850.92
91_Q95_K1.1520.91
12_K52_S1.1190.90
78_D81_K1.1060.89
82_K86_L1.0670.87
92_V95_K1.0350.86
16_I30_I1.0340.86
83_E94_K1.0320.85
23_T32_Y1.0310.85
26_S66_R1.0210.85
81_K85_M1.0040.84
58_R79_M1.0030.84
83_E90_P0.9980.83
34_E66_R0.9950.83
24_G50_K0.9890.83
53_F57_E0.9850.83
20_S27_V0.9570.81
34_E63_A0.9530.80
19_V25_L0.9530.80
25_L29_Q0.9440.80
65_K78_D0.9400.80
19_V56_V0.9370.79
55_D58_R0.9340.79
70_V94_K0.9110.77
77_K82_K0.9110.77
11_K53_F0.9050.77
12_K53_F0.8930.76
83_E87_K0.8870.75
12_K32_Y0.8730.74
26_S63_A0.8520.72
14_I18_I0.8480.72
63_A75_I0.8430.72
44_S50_K0.8400.71
48_T51_Y0.8390.71
14_I74_E0.8380.71
32_Y48_T0.8360.71
83_E96_M0.8340.71
23_T77_K0.8160.69
11_K21_E0.8150.69
39_I62_I0.8130.69
14_I41_P0.7970.67
25_L75_I0.7970.67
74_E81_K0.7880.66
85_M92_V0.7660.64
19_V23_T0.7580.63
27_V66_R0.7560.63
28_R35_E0.7560.63
35_E56_V0.7530.63
76_L80_R0.7450.62
35_E78_D0.7350.61
21_E50_K0.7210.60
16_I41_P0.7080.58
11_K42_Q0.7060.58
39_I56_V0.6980.57
66_R70_V0.6910.56
17_G87_K0.6830.55
68_D79_M0.6790.55
39_I76_L0.6770.55
40_Y45_S0.6760.55
13_V81_K0.6740.55
71_Q75_I0.6730.54
84_Q91_Q0.6680.54
34_E50_K0.6670.54
11_K14_I0.6600.53
34_E53_F0.6470.52
34_E48_T0.6430.51
13_V44_S0.6350.50
12_K72_T0.6290.50
70_V79_M0.6280.49
87_K91_Q0.6220.49
34_E41_P0.6190.48
56_V64_N0.6170.48
10_D64_N0.6150.48
22_L59_L0.6140.48
20_S48_T0.6120.48
65_K72_T0.6070.47
84_Q90_P0.6060.47
42_Q93_R0.6020.47
30_I60_M0.6010.46
79_M89_D0.6010.46
12_K40_Y0.6010.46
88_N92_V0.5940.46
13_V22_L0.5830.44
32_Y63_A0.5820.44
83_E88_N0.5740.43
37_K88_N0.5690.43
35_E39_I0.5670.43
80_R84_Q0.5660.43
28_R32_Y0.5640.42
16_I34_E0.5610.42
22_L90_P0.5590.42
26_S32_Y0.5550.41
91_Q98_E0.5270.38
17_G58_R0.5220.38
12_K58_R0.5200.38
34_E39_I0.5180.38
32_Y44_S0.5160.37
36_R48_T0.5150.37
45_S84_Q0.5150.37
11_K25_L0.5120.37
32_Y36_R0.5100.37
39_I94_K0.5090.37
89_D92_V0.5030.36
16_I70_V0.5010.36
90_P94_K0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qaoA 2 0.9091 99.7 0.551 Contact Map
2zhgA 2 0.8636 99.7 0.555 Contact Map
2dg6A 2 0.8 99.7 0.556 Contact Map
3ucsA 2 0.9 99.7 0.564 Contact Map
3gp4A 4 0.8909 99.7 0.566 Contact Map
3gpvA 2 0.8909 99.7 0.567 Contact Map
1q06A 2 0.8818 99.7 0.567 Contact Map
4r4eB 2 0.7636 99.7 0.568 Contact Map
4r24B 2 0.7727 99.7 0.568 Contact Map
2vz4A 2 0.8455 99.7 0.569 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0058 seconds.