GREMLIN Database
YYCI - Two-component system YycFG regulatory protein
UniProt: Q45612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 280 (251)
Sequences: 453 (389)
Seq/√Len: 24.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_N180_E5.4371.00
223_K250_E4.6111.00
85_Q103_M4.5281.00
148_F173_L3.5701.00
105_F108_P3.5321.00
3_W7_K3.4101.00
3_W11_I2.9811.00
124_V171_V2.8981.00
7_K11_I2.8100.99
134_Y186_Q2.7890.99
8_S11_I2.5150.99
231_A239_Q2.4990.99
68_T240_V2.4020.98
225_C247_I2.3250.98
58_N203_E2.2970.98
2_E9_I2.2300.97
5_K9_I2.1460.96
3_W8_S2.1260.96
110_A180_E2.1010.96
51_H219_Y2.0660.96
124_V148_F2.0180.95
203_E225_C2.0150.95
6_T10_F1.9950.95
54_Y222_V1.9910.95
145_E172_V1.9390.94
4_N7_K1.9350.94
18_D25_F1.8780.93
239_Q242_A1.8760.93
131_G186_Q1.8220.91
105_F123_L1.7940.91
130_D133_K1.7850.91
2_E5_K1.7740.90
6_T20_F1.7520.90
50_D211_Y1.6930.88
120_A205_D1.6770.87
268_V275_I1.6500.87
55_E222_V1.6380.86
137_W149_F1.6290.86
176_N179_N1.6240.86
5_K48_K1.6210.86
131_G184_Y1.6080.85
10_F249_V1.6060.85
224_S248_T1.5840.84
128_I134_Y1.5820.84
123_L127_K1.5700.84
146_I173_L1.5590.83
1_M14_F1.5570.83
247_I266_F1.5550.83
206_A247_I1.5540.83
15_L175_L1.5380.82
1_M21_L1.5280.82
101_L154_G1.5280.82
216_L233_Y1.5100.81
200_L271_L1.4990.81
80_E178_K1.4890.80
82_L85_Q1.4770.80
207_V247_I1.4730.80
3_W228_G1.4630.79
14_F21_L1.4610.79
269_N272_E1.4480.78
3_W267_T1.4470.78
69_A189_L1.4420.78
57_L225_C1.4230.77
6_T203_E1.4150.77
157_I192_F1.3950.76
69_A241_L1.3930.76
86_K128_I1.3930.76
241_L267_T1.3490.73
178_K207_V1.3250.72
103_M128_I1.2970.70
156_Y186_Q1.2930.70
50_D220_S1.2860.69
22_G26_F1.2850.69
147_I268_V1.2690.68
10_F211_Y1.2600.68
18_D81_A1.2570.68
71_Q222_V1.2560.68
54_Y220_S1.2480.67
66_R269_N1.2480.67
85_Q108_P1.2350.66
103_M184_Y1.2280.66
230_V270_A1.2140.65
135_K151_T1.2130.65
5_K101_L1.2060.64
9_I13_A1.2060.64
136_L271_L1.1930.63
10_F50_D1.1900.63
244_V267_T1.1890.63
7_K158_Y1.1830.63
56_G109_I1.1810.63
48_K113_K1.1670.62
19_I138_K1.1630.61
150_Q186_Q1.1540.61
146_I175_L1.1500.61
171_V184_Y1.1450.60
149_F173_L1.1300.59
12_V16_I1.1300.59
158_Y269_N1.1210.59
101_L106_A1.1170.58
14_F184_Y1.1120.58
17_L21_L1.1110.58
158_Y241_L1.0990.57
207_V274_T1.0970.57
45_H49_A1.0930.57
4_N11_I1.0880.56
15_L54_Y1.0630.54
158_Y228_G1.0560.54
133_K188_T1.0540.54
208_E222_V1.0520.54
2_E220_S1.0470.53
2_E123_L1.0450.53
126_S218_E1.0430.53
47_M276_L1.0400.53
41_N88_L1.0360.53
201_I273_S1.0340.52
18_D123_L1.0310.52
59_K196_Q1.0290.52
149_F159_Q1.0260.52
227_F242_A1.0200.51
134_Y184_Y1.0180.51
157_I240_V1.0170.51
7_K17_L1.0140.51
2_E58_N1.0120.51
140_D187_T1.0050.50
64_G267_T1.0010.50
40_K189_L0.9910.49
9_I17_L0.9870.49
10_F64_G0.9860.49
207_V222_V0.9850.49
11_I231_A0.9830.49
19_I189_L0.9830.49
184_Y268_V0.9800.49
14_F134_Y0.9730.48
86_K207_V0.9650.47
213_Q247_I0.9620.47
29_W205_D0.9600.47
6_T38_V0.9580.47
9_I150_Q0.9580.47
136_L139_V0.9530.47
130_D188_T0.9450.46
37_E237_S0.9430.46
185_D202_T0.9300.45
12_V107_N0.9300.45
2_E181_V0.9300.45
206_A268_V0.9290.45
75_S222_V0.9280.45
109_I226_K0.9250.45
7_K24_Q0.9250.45
7_K239_Q0.9230.44
186_Q241_L0.9220.44
87_P106_A0.9150.44
16_I73_S0.9120.44
229_Y270_A0.9090.43
9_I181_V0.9070.43
232_Q238_T0.9030.43
159_Q168_I0.8990.43
102_K185_D0.8980.43
111_L152_Y0.8960.43
9_I20_F0.8900.42
6_T216_L0.8890.42
201_I234_P0.8830.42
52_I220_S0.8790.41
101_L190_E0.8770.41
77_E221_T0.8750.41
184_Y217_K0.8750.41
99_T222_V0.8730.41
27_Q98_V0.8710.41
10_F231_A0.8700.41
18_D105_F0.8530.40
184_Y245_W0.8510.39
27_Q148_F0.8500.39
81_A101_L0.8460.39
208_E268_V0.8450.39
195_I240_V0.8430.39
87_P132_E0.8410.39
137_W275_I0.8380.39
3_W241_L0.8340.38
136_L154_G0.8250.38
10_F74_F0.8220.37
3_W6_T0.8220.37
18_D86_K0.8210.37
134_Y210_L0.8180.37
23_Y191_T0.8180.37
67_I145_E0.8170.37
217_K220_S0.8170.37
18_D50_D0.8110.37
22_G175_L0.8030.36
82_L109_I0.8010.36
3_W246_R0.8000.36
203_E267_T0.7980.36
183_S273_S0.7890.35
2_E266_F0.7880.35
56_G200_L0.7840.35
3_W203_E0.7840.35
15_L22_G0.7800.35
10_F25_F0.7750.34
48_K122_A0.7740.34
186_Q210_L0.7700.34
135_K156_Y0.7650.34
143_K197_K0.7640.34
17_L273_S0.7630.34
83_K146_I0.7620.33
157_I190_E0.7550.33
208_E275_I0.7540.33
22_G25_F0.7520.33
126_S178_K0.7500.33
122_A180_E0.7500.33
10_F186_Q0.7500.33
148_F202_T0.7490.33
150_Q187_T0.7460.32
57_L176_N0.7450.32
104_K221_T0.7410.32
4_N226_K0.7400.32
18_D142_S0.7350.32
35_E47_M0.7340.32
154_G192_F0.7330.32
2_E98_V0.7320.32
125_S169_G0.7320.32
69_A134_Y0.7280.31
140_D143_K0.7270.31
11_I203_E0.7220.31
18_D110_A0.7210.31
12_V60_E0.7190.31
3_W266_F0.7180.31
48_K110_A0.7140.30
27_Q181_V0.7130.30
143_K277_D0.7070.30
119_D171_V0.7070.30
2_E105_F0.7040.30
186_Q216_L0.7030.30
64_G227_F0.6970.29
5_K271_L0.6930.29
128_I171_V0.6920.29
12_V175_L0.6920.29
173_L181_V0.6910.29
59_K126_S0.6900.29
89_M105_F0.6840.29
128_I184_Y0.6840.29
246_R265_Y0.6830.29
213_Q271_L0.6820.29
13_A214_N0.6780.28
195_I241_L0.6760.28
9_I220_S0.6740.28
4_N24_Q0.6730.28
47_M152_Y0.6720.28
68_T230_V0.6710.28
87_P225_C0.6710.28
18_D185_D0.6670.28
121_Q191_T0.6640.28
40_K45_H0.6610.27
12_V180_E0.6610.27
7_K267_T0.6580.27
40_K59_K0.6580.27
43_V207_V0.6560.27
134_Y275_I0.6560.27
19_I35_E0.6550.27
222_V238_T0.6550.27
230_V267_T0.6540.27
46_D253_K0.6520.27
222_V249_V0.6520.27
19_I145_E0.6510.27
82_L103_M0.6500.27
215_Q277_D0.6500.27
3_W44_E0.6470.27
7_K238_T0.6400.26
3_W58_N0.6390.26
15_L24_Q0.6370.26
64_G195_I0.6340.26
68_T232_Q0.6320.26
3_W231_A0.6280.26
89_M174_H0.6260.25
158_Y193_K0.6250.25
19_I63_E0.6250.25
110_A226_K0.6250.25
85_Q89_M0.6230.25
7_K212_Y0.6200.25
24_Q108_P0.6200.25
252_E275_I0.6190.25
27_Q175_L0.6180.25
207_V228_G0.6170.25
201_I206_A0.6150.25
78_E153_E0.6150.25
3_W24_Q0.6140.25
112_S119_D0.6140.25
54_Y217_K0.6140.25
137_W246_R0.6120.25
108_P176_N0.6120.25
155_H226_K0.6100.25
173_L275_I0.6100.25
141_K144_K0.6100.25
172_V218_E0.6070.24
135_K193_K0.6070.24
63_E216_L0.6060.24
148_F169_G0.6050.24
35_E222_V0.6050.24
181_V223_K0.6040.24
150_Q228_G0.6020.24
69_A231_A0.5930.24
57_L270_A0.5910.24
151_T182_V0.5890.23
57_L131_G0.5870.23
15_L77_E0.5870.23
153_E203_E0.5840.23
107_N130_D0.5830.23
63_E78_E0.5830.23
157_I272_E0.5820.23
99_T104_K0.5810.23
150_Q222_V0.5810.23
77_E102_K0.5790.23
236_T276_L0.5790.23
56_G67_I0.5760.23
196_Q248_T0.5740.23
134_Y245_W0.5740.23
14_F186_Q0.5730.23
128_I190_E0.5730.23
46_D246_R0.5720.23
47_M167_M0.5690.22
4_N13_A0.5690.22
4_N99_T0.5670.22
168_I228_G0.5660.22
27_Q129_Q0.5610.22
12_V15_L0.5610.22
1_M229_Y0.5600.22
67_I220_S0.5580.22
233_Y240_V0.5560.22
90_D97_K0.5550.22
152_Y194_Q0.5540.22
5_K138_K0.5540.22
103_M240_V0.5530.22
50_D195_I0.5520.22
145_E151_T0.5510.22
68_T239_Q0.5490.21
149_F245_W0.5490.21
158_Y244_V0.5480.21
211_Y270_A0.5470.21
125_S238_T0.5460.21
26_F124_V0.5460.21
173_L212_Y0.5450.21
69_A234_P0.5450.21
75_S138_K0.5410.21
109_I138_K0.5400.21
4_N17_L0.5380.21
80_E104_K0.5350.21
75_S266_F0.5350.21
135_K275_I0.5330.21
241_L244_V0.5320.21
136_L196_Q0.5320.21
192_F227_F0.5290.20
12_V172_V0.5290.20
27_Q167_M0.5290.20
46_D198_E0.5280.20
184_Y273_S0.5280.20
15_L19_I0.5280.20
43_V128_I0.5250.20
9_I222_V0.5230.20
184_Y210_L0.5210.20
5_K250_E0.5180.20
148_F198_E0.5180.20
148_F201_I0.5150.20
85_Q207_V0.5150.20
6_T54_Y0.5150.20
156_Y159_Q0.5150.20
4_N148_F0.5130.20
151_T154_G0.5130.20
16_I217_K0.5110.20
136_L185_D0.5100.20
30_Q179_N0.5100.20
194_Q268_V0.5080.20
61_A268_V0.5070.19
14_F17_L0.5060.19
13_A136_L0.5050.19
40_K154_G0.5050.19
52_I222_V0.5030.19
12_V63_E0.5020.19
103_M125_S0.5010.19
98_V178_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o3oA 2 0.8821 100 0.394 Contact Map
2fgtA 1 0.8607 99.8 0.703 Contact Map
4k90B 1 0.6143 99.4 0.788 Contact Map
3nqzA 1 0.5786 98.3 0.861 Contact Map
4exrA 2 0.5071 95.3 0.91 Contact Map
2gu3A 1 0.4357 92.8 0.919 Contact Map
4ipbA 1 0.45 27.2 0.954 Contact Map
4cbcA 3 0.1 25.8 0.954 Contact Map
2kgyA 1 0.3071 25.4 0.955 Contact Map
1sghB 1 0.0464 22.6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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