GREMLIN Database
YYCO - Uncharacterized protein YycO
UniProt: Q45607 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (228)
Sequences: 116 (106)
Seq/√Len: 7.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_S205_K6.0181.00
113_Y126_V3.0850.85
144_V182_G3.0730.85
201_K205_K3.0580.85
220_D224_G2.8010.79
224_G227_V2.7190.77
193_R220_D2.7180.77
136_V206_L2.5180.71
124_G177_A2.3190.64
128_M207_L2.3160.64
140_P143_G2.2620.62
193_R223_G2.2340.61
112_Y202_N2.2220.61
138_S176_W2.1980.60
224_G231_D2.1680.59
220_D227_V2.1240.57
189_F226_G2.1180.57
138_S201_K2.1140.57
223_G231_D2.0700.55
206_L215_A2.0330.54
112_Y154_V1.9710.51
232_I235_S1.9700.51
123_H202_N1.9080.49
207_L241_I1.8800.48
139_V143_G1.8720.47
27_A31_T1.8490.46
186_S201_K1.8480.46
154_V202_N1.8040.45
129_Y228_Y1.8040.45
12_V15_T1.7110.41
170_K211_F1.7070.41
126_V202_N1.7020.41
226_G232_I1.6340.38
143_G182_G1.6270.38
128_M173_A1.6210.38
222_N231_D1.6050.37
126_V232_I1.5970.37
177_A185_Y1.5910.37
99_G135_I1.5770.36
121_Y226_G1.5550.36
180_K201_K1.5540.36
109_G125_H1.5360.35
125_H203_C1.5120.34
118_T123_H1.5100.34
21_F26_K1.5060.34
203_C229_P1.4870.33
107_A110_N1.4750.33
220_D223_G1.4750.33
15_T73_K1.4720.33
201_K209_S1.4600.32
114_T186_S1.4590.32
138_S185_Y1.4480.32
112_Y126_V1.4320.31
22_V26_K1.4290.31
103_L215_A1.4210.31
127_G154_V1.4000.30
222_N227_V1.3980.30
45_T48_E1.3920.30
138_S206_L1.3860.30
10_F26_K1.3770.30
37_I72_Y1.3630.29
11_L21_F1.3600.29
202_N228_Y1.3480.29
107_A170_K1.3450.29
117_Y120_Y1.3290.28
129_Y202_N1.3230.28
180_K183_D1.3150.28
173_A207_L1.3100.27
162_T241_I1.3070.27
112_Y129_Y1.3020.27
25_A31_T1.3020.27
129_Y215_A1.2970.27
183_D209_S1.2860.27
160_V241_I1.2850.27
109_G203_C1.2780.27
137_E206_L1.2730.26
151_A202_N1.2710.26
130_S134_K1.2710.26
161_Q240_T1.2340.25
185_Y210_A1.2320.25
178_V219_I1.2270.25
176_W181_V1.2260.25
138_S188_N1.2190.25
173_A204_S1.2180.25
11_L25_A1.1930.24
129_Y149_Y1.1850.24
16_M19_G1.1800.24
20_L68_L1.1760.24
140_P144_V1.1750.24
211_F217_I1.1630.23
190_V228_Y1.1630.23
127_G176_W1.1590.23
113_Y230_R1.1550.23
109_G173_A1.1530.23
12_V31_T1.1500.23
188_N195_T1.1500.23
125_H229_P1.1430.23
110_N241_I1.1420.23
18_G29_K1.1400.23
53_A68_L1.1400.23
110_N128_M1.1290.22
217_I235_S1.1250.22
208_W229_P1.1210.22
149_Y232_I1.1110.22
68_L172_A1.1070.22
110_N211_F1.1040.22
108_K175_D1.1030.22
11_L17_C1.0990.21
129_Y176_W1.0970.21
154_V226_G1.0910.21
125_H185_Y1.0780.21
229_P232_I1.0720.21
118_T202_N1.0550.20
109_G208_W1.0540.20
144_V201_K1.0530.20
205_K209_S1.0460.20
165_V211_F1.0430.20
227_V231_D1.0390.20
60_Q78_D1.0060.19
165_V217_I0.9980.19
157_N207_L0.9920.19
127_G210_A0.9900.19
15_T20_L0.9860.19
27_A33_Y0.9840.19
203_C208_W0.9790.19
127_G202_N0.9730.18
112_Y124_G0.9730.18
10_F18_G0.9650.18
18_G22_V0.9640.18
114_T205_K0.9610.18
173_A177_A0.9540.18
218_D223_G0.9540.18
176_W205_K0.9530.18
140_P214_K0.9430.18
137_E208_W0.9380.18
182_G201_K0.9350.18
173_A208_W0.9320.17
67_I164_S0.9250.17
110_N170_K0.9220.17
84_R166_S0.9120.17
10_F19_G0.9080.17
88_E121_Y0.9070.17
202_N226_G0.9060.17
46_P111_I0.9030.17
218_D231_D0.9000.17
143_G180_K0.8970.17
112_Y228_Y0.8950.17
72_Y222_N0.8940.17
185_Y208_W0.8900.17
19_G35_E0.8840.16
12_V22_V0.8810.16
109_G229_P0.8800.16
107_A211_F0.8790.16
112_Y159_I0.8790.16
218_D222_N0.8760.16
172_A200_A0.8760.16
146_Q209_S0.8720.16
23_T55_Q0.8680.16
10_F25_A0.8670.16
14_L30_T0.8660.16
136_V193_R0.8660.16
125_H204_S0.8610.16
148_A194_N0.8610.16
41_Q205_K0.8600.16
151_A216_G0.8590.16
149_Y154_V0.8550.16
10_F76_T0.8490.16
204_S210_A0.8490.16
78_D82_G0.8470.16
203_C211_F0.8400.16
113_Y147_I0.8340.15
56_I93_I0.8320.15
154_V192_N0.8210.15
200_A206_L0.8160.15
193_R224_G0.8160.15
124_G135_I0.8120.15
149_Y152_R0.8100.15
59_Q174_A0.8100.15
112_Y170_K0.8000.15
138_S200_A0.8000.15
116_S189_F0.7970.15
31_T47_E0.7960.15
218_D227_V0.7860.14
185_Y203_C0.7850.14
20_L27_A0.7830.14
85_L164_S0.7750.14
147_I160_V0.7750.14
104_P165_V0.7660.14
196_G209_S0.7650.14
109_G185_Y0.7640.14
128_M209_S0.7630.14
18_G43_G0.7520.14
177_A210_A0.7520.14
150_N194_N0.7510.14
47_E51_K0.7510.14
16_M23_T0.7500.14
163_V238_T0.7460.14
41_Q114_T0.7450.14
138_S193_R0.7360.14
122_N138_S0.7350.14
159_I231_D0.7340.14
121_Y209_S0.7330.13
223_G227_V0.7320.13
167_S171_T0.7310.13
107_A162_T0.7300.13
19_G32_N0.7290.13
119_A158_S0.7280.13
27_A40_L0.7260.13
173_A210_A0.7230.13
29_K66_V0.7160.13
111_I235_S0.7140.13
37_I58_K0.7120.13
136_V201_K0.7120.13
77_A210_A0.7050.13
14_L24_P0.7050.13
107_A241_I0.7030.13
74_E228_Y0.7000.13
98_S131_A0.6930.13
14_L26_K0.6900.13
185_Y229_P0.6890.13
192_N202_N0.6880.13
57_A96_G0.6850.13
17_C21_F0.6840.13
176_W241_I0.6830.13
124_G206_L0.6820.13
11_L19_G0.6790.13
22_V25_A0.6710.12
208_W220_D0.6700.12
129_Y216_G0.6690.12
128_M177_A0.6670.12
140_P201_K0.6660.12
177_A207_L0.6660.12
176_W209_S0.6650.12
45_T66_V0.6650.12
183_D231_D0.6630.12
40_L45_T0.6590.12
124_G216_G0.6560.12
124_G136_V0.6520.12
138_S232_I0.6500.12
36_E43_G0.6460.12
218_D224_G0.6440.12
116_S150_N0.6410.12
144_V180_K0.6410.12
23_T32_N0.6400.12
204_S229_P0.6400.12
109_G207_L0.6370.12
18_G21_F0.6320.12
129_Y170_K0.6320.12
203_C210_A0.6320.12
65_D81_E0.6300.12
12_V18_G0.6280.12
192_N208_W0.6270.12
161_Q235_S0.6250.12
165_V170_K0.6240.12
13_A19_G0.6210.12
232_I237_Y0.6210.12
57_A112_Y0.6200.12
122_N165_V0.6190.12
21_F111_I0.6180.12
138_S209_S0.6180.12
107_A127_G0.6160.12
203_C207_L0.6150.12
73_K153_D0.6150.12
15_T55_Q0.6110.11
24_P156_D0.6090.11
76_T89_S0.6080.11
15_T52_S0.6020.11
149_Y201_K0.5980.11
158_S182_G0.5980.11
69_K194_N0.5970.11
21_F25_A0.5970.11
114_T147_I0.5960.11
165_V169_Q0.5950.11
69_K179_S0.5950.11
11_L166_S0.5930.11
126_V241_I0.5890.11
41_Q117_Y0.5860.11
19_G27_A0.5850.11
218_D229_P0.5850.11
23_T29_K0.5840.11
113_Y152_R0.5830.11
13_A25_A0.5830.11
28_V50_M0.5810.11
15_T21_F0.5790.11
12_V165_V0.5780.11
13_A65_D0.5760.11
35_E38_A0.5750.11
15_T47_E0.5730.11
98_S118_T0.5720.11
204_S208_W0.5720.11
76_T171_T0.5700.11
54_S101_K0.5700.11
138_S180_K0.5700.11
49_I171_T0.5700.11
17_C30_T0.5690.11
140_P182_G0.5640.11
123_H154_V0.5620.11
28_V44_T0.5600.11
45_T137_E0.5600.11
113_Y222_N0.5590.11
125_H173_A0.5580.11
28_V39_A0.5570.11
122_N129_Y0.5570.11
16_M29_K0.5560.11
115_N122_N0.5540.11
25_A29_K0.5540.11
110_N196_G0.5530.11
143_G224_G0.5530.11
124_G185_Y0.5510.11
52_S181_V0.5510.11
109_G204_S0.5510.11
73_K171_T0.5480.10
223_G226_G0.5470.10
53_A56_I0.5460.10
184_P187_F0.5460.10
18_G27_A0.5440.10
23_T28_V0.5420.10
180_K206_L0.5390.10
151_A160_V0.5390.10
196_G231_D0.5370.10
121_Y166_S0.5360.10
122_N202_N0.5340.10
114_T232_I0.5300.10
151_A166_S0.5280.10
52_S71_F0.5280.10
83_D110_N0.5250.10
33_Y40_L0.5220.10
125_H208_W0.5220.10
52_S239_T0.5220.10
176_W235_S0.5210.10
136_V174_A0.5200.10
62_V111_I0.5160.10
114_T124_G0.5150.10
39_A45_T0.5120.10
17_C28_V0.5100.10
78_D120_Y0.5070.10
161_Q197_H0.5070.10
203_C227_V0.5060.10
104_P238_T0.5060.10
110_N176_W0.5050.10
190_V193_R0.5020.10
138_S210_A0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2if6A 1 0.551 99.9 0.671 Contact Map
3kw0A 3 0.6531 99.9 0.675 Contact Map
4dotA 1 0.3714 97.7 0.882 Contact Map
2lktA 1 0.4082 97 0.896 Contact Map
4q95A 3 0.4408 96.8 0.898 Contact Map
4dpzX 1 0.3755 96.5 0.902 Contact Map
2k1gA 1 0.5102 95.6 0.909 Contact Map
3pbiA 1 0.5673 93.5 0.919 Contact Map
4lj1A 1 0.3102 91.5 0.924 Contact Map
2k3aA 1 0.6082 90.4 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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