YYCR - BACSU - GREMLIN Contacts

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YYCR - Uncharacterized zinc-type alcohol dehydrogenase-like protein YycR

UniProt:	Q45604	Sequences: MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVNRKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGDIVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYADFQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAHSAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDCVGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIRFGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFDKGAAKKFVIDPHGTLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	408 (321)
Sequences:	38620 (25590)
Seq/√Len:	1428.3

ECOLI - YBDR YPHC YGGP GATD FRMA YDJL RSPB ADHP YDJJ YJJN TDH AHR YAHK IDND QOR1 YCJQ CURA ACUI
BACSU - YYCR ADHB YJMD DHSO TDH ADHA YOGA BDHA YFMJ YHFP
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HR85 Q9HQS8
SULSO - Q97YT7 Q97ZV3 ADH Q97VV5 Q97XR4 Q7LXK1 Q97VW0 Q97V32 Q97WA1 Q97TZ4 Q97YM2 GLCD2 GLCD1 GLCD3 Q97W06 Q97VB8 Q97UW5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
383_D	386_K	3.165	1.00
54_K	89_I	3.050	1.00
56_I	87_E	2.975	1.00
56_I	173_L	2.947	1.00
51_V	163_L	2.767	1.00
52_I	89_I	2.763	1.00
260_Q	263_Q	2.619	1.00
102_D	165_V	2.565	1.00
171_Q	175_K	2.539	1.00
84_I	149_G	2.484	1.00
379_I	390_D	2.398	1.00
54_K	87_E	2.364	1.00
99_K	102_D	2.285	1.00
48_E	93_R	2.276	1.00
43_V	153_Y	2.271	1.00
174_E	378_V	2.252	1.00
238_L	242_R	2.250	1.00
103_I	166_F	2.246	1.00
49_H	94_D	2.224	1.00
378_V	402_D	2.224	1.00
380_S	383_D	2.215	1.00
54_K	153_Y	2.184	1.00
203_T	226_S	2.178	1.00
361_K	365_S	2.150	1.00
204_V	220_A	2.127	1.00
239_A	243_S	2.119	1.00
389_S	393_K	2.108	1.00
48_E	94_D	2.084	1.00
97_F	158_Y	2.080	1.00
209_A	230_V	2.068	1.00
169_K	364_L	2.048	1.00
171_Q	174_E	2.040	1.00
199_Q	202_S	2.038	1.00
69_R	392_D	2.030	1.00
376_A	390_D	1.988	1.00
239_A	242_R	1.975	1.00
45_R	90_E	1.946	1.00
47_C	50_G	1.939	1.00
205_Y	270_V	1.932	1.00
302_T	308_L	1.930	1.00
194_Y	223_L	1.886	1.00
254_H	260_Q	1.884	1.00
194_Y	358_N	1.882	1.00
84_I	106_V	1.876	1.00
217_A	246_C	1.861	1.00
386_K	389_S	1.859	1.00
89_I	153_Y	1.852	1.00
235_E	239_A	1.850	1.00
205_Y	231_G	1.816	1.00
85_T	173_L	1.809	1.00
307_S	344_T	1.803	1.00
271_D	303_Q	1.802	1.00
52_I	155_M	1.794	1.00
232_D	238_L	1.757	1.00
247_E	264_I	1.731	1.00
229_I	270_V	1.715	1.00
186_F	215_A	1.714	1.00
390_D	395_A	1.703	1.00
238_L	248_T	1.697	1.00
235_E	250_N	1.691	1.00
103_I	173_L	1.684	1.00
240_Q	243_S	1.661	1.00
386_K	390_D	1.647	1.00
379_I	387_G	1.641	1.00
91_T	100_K	1.616	1.00
92_G	95_V	1.599	1.00
307_S	346_V	1.588	1.00
235_E	253_K	1.583	1.00
98_I	165_V	1.576	1.00
90_E	100_K	1.564	1.00
273_A	302_T	1.561	1.00
31_I	39_P	1.556	1.00
31_I	37_G	1.554	1.00
250_N	253_K	1.542	1.00
55_V	84_I	1.541	1.00
46_K	155_M	1.535	1.00
28_P	39_P	1.525	1.00
302_T	343_H	1.525	1.00
103_I	168_D	1.521	1.00
52_I	153_Y	1.516	1.00
385_P	389_S	1.506	1.00
50_G	157_P	1.498	1.00
46_K	52_I	1.492	1.00
202_S	307_S	1.489	1.00
222_L	367_R	1.485	1.00
98_I	102_D	1.476	1.00
233_L	251_V	1.469	1.00
174_E	402_D	1.465	1.00
50_G	155_M	1.462	1.00
273_A	298_I	1.460	1.00
49_H	157_P	1.450	1.00
88_V	98_I	1.431	1.00
166_F	173_L	1.429	1.00
196_A	272_A	1.427	1.00
207_A	298_I	1.421	1.00
226_S	247_E	1.414	1.00
166_F	176_I	1.405	1.00
87_E	173_L	1.396	1.00
87_E	103_I	1.396	1.00
31_I	35_G	1.394	1.00
259_E	263_Q	1.383	1.00
217_A	230_V	1.366	1.00
57_T	402_D	1.360	1.00
51_V	98_I	1.352	1.00
203_T	229_I	1.344	1.00
150_Q	388_Y	1.338	1.00
43_V	52_I	1.328	1.00
361_K	364_L	1.324	1.00
375_N	390_D	1.323	1.00
302_T	306_G	1.319	1.00
57_T	174_E	1.316	1.00
260_Q	264_I	1.283	1.00
98_I	163_L	1.283	1.00
216_A	274_V	1.274	1.00
52_I	90_E	1.264	1.00
242_R	248_T	1.262	1.00
68_V	388_Y	1.258	1.00
175_K	371_A	1.256	1.00
255_D	259_E	1.240	1.00
49_H	158_Y	1.224	1.00
238_L	250_N	1.216	1.00
235_E	238_L	1.202	1.00
198_V	225_A	1.197	1.00
277_V	282_S	1.181	1.00
26_G	39_P	1.180	1.00
381_L	403_P	1.167	1.00
233_L	252_Q	1.160	1.00
207_A	231_G	1.158	1.00
195_T	344_T	1.156	1.00
46_K	50_G	1.152	1.00
203_T	271_D	1.151	1.00
175_K	369_Q	1.131	1.00
384_A	401_I	1.118	1.00
55_V	154_V	1.116	1.00
56_I	103_I	1.112	1.00
300_D	337_L	1.110	1.00
60_I	387_G	1.110	1.00
222_L	362_A	1.109	1.00
218_H	369_Q	1.106	1.00
89_I	100_K	1.105	1.00
38_V	382_D	1.084	1.00
380_S	402_D	1.077	1.00
53_L	104_V	1.071	1.00
53_L	86_G	1.069	1.00
198_V	202_S	1.068	1.00
58_T	149_G	1.065	1.00
230_V	246_C	1.065	1.00
209_A	232_D	1.056	1.00
189_G	216_A	1.055	1.00
194_Y	355_Y	1.048	1.00
296_N	300_D	1.044	1.00
150_Q	384_A	1.043	1.00
56_I	85_T	1.038	1.00
205_Y	301_V	1.034	1.00
196_A	309_G	1.027	1.00
28_P	37_G	1.026	1.00
220_A	225_A	1.025	1.00
202_S	271_D	1.024	1.00
127_L	304_V	1.014	1.00
150_Q	401_I	1.011	1.00
32_L	35_G	1.011	1.00
265_L	269_T	1.006	1.00
242_R	247_E	1.003	1.00
217_A	228_V	1.002	1.00
156_V	163_L	0.990	1.00
189_G	219_S	0.989	1.00
338_G	345_F	0.987	1.00
358_N	361_K	0.984	1.00
231_G	251_V	0.979	1.00
206_I	220_A	0.978	1.00
57_T	173_L	0.975	1.00
43_V	90_E	0.975	1.00
78_L	147_V	0.974	1.00
357_R	361_K	0.973	1.00
389_S	392_D	0.971	1.00
41_A	147_V	0.968	1.00
233_L	238_L	0.965	1.00
202_S	272_A	0.961	1.00
362_A	367_R	0.959	1.00
191_H	355_Y	0.956	1.00
258_G	300_D	0.956	1.00
57_T	400_V	0.956	1.00
57_T	403_P	0.949	1.00
41_A	79_V	0.949	1.00
229_I	247_E	0.949	1.00
219_S	359_L	0.946	1.00
192_G	311_P	0.943	1.00
186_F	359_L	0.943	1.00
190_F	194_Y	0.939	1.00
236_D	239_A	0.938	1.00
230_V	241_A	0.935	1.00
379_I	383_D	0.934	1.00
253_K	260_Q	0.931	1.00
229_I	264_I	0.931	1.00
43_V	89_I	0.930	1.00
258_G	262_E	0.924	1.00
54_K	152_E	0.919	1.00
258_G	297_S	0.918	1.00
58_T	150_Q	0.913	1.00
209_A	217_A	0.907	1.00
261_I	270_V	0.901	1.00
91_T	95_V	0.897	1.00
159_A	162_Q	0.897	1.00
376_A	379_I	0.895	1.00
275_D	278_G	0.892	1.00
99_K	165_V	0.890	1.00
203_T	270_V	0.888	1.00
390_D	399_F	0.886	1.00
232_D	248_T	0.885	1.00
240_Q	396_A	0.884	1.00
68_V	392_D	0.874	1.00
298_I	308_L	0.873	1.00
28_P	384_A	0.872	1.00
234_N	237_R	0.871	1.00
209_A	241_A	0.868	1.00
247_E	250_N	0.858	1.00
96_E	158_Y	0.855	1.00
337_L	341_K	0.850	1.00
234_N	250_N	0.848	1.00
84_I	154_V	0.847	1.00
49_H	93_R	0.846	1.00
207_A	273_A	0.843	1.00
241_A	246_C	0.842	1.00
29_E	39_P	0.841	1.00
45_R	52_I	0.839	1.00
59_N	83_E	0.838	1.00
49_H	92_G	0.837	1.00
206_I	216_A	0.833	1.00
55_V	403_P	0.832	1.00
189_G	212_V	0.828	1.00
61_C	83_E	0.825	1.00
47_C	155_M	0.823	1.00
61_C	82_H	0.821	1.00
106_V	156_V	0.821	1.00
334_R	337_L	0.820	1.00
305_G	342_A	0.815	1.00
91_T	99_K	0.812	1.00
279_F	282_S	0.809	1.00
297_S	300_D	0.809	1.00
46_K	92_G	0.805	1.00
229_I	249_V	0.804	1.00
255_D	258_G	0.799	1.00
229_I	261_I	0.796	1.00
258_G	301_V	0.795	1.00
60_I	150_Q	0.794	1.00
195_T	346_V	0.794	1.00
255_D	260_Q	0.791	1.00
189_G	215_A	0.791	1.00
104_V	163_L	0.789	1.00
38_V	381_L	0.783	1.00
190_F	358_N	0.782	1.00
103_I	169_K	0.779	1.00
270_V	273_A	0.778	1.00
354_T	357_R	0.778	1.00
243_S	369_Q	0.776	1.00
190_F	359_L	0.774	1.00
338_G	343_H	0.774	1.00
170_E	176_I	0.771	1.00
354_T	358_N	0.770	1.00
221_Q	228_V	0.769	1.00
338_G	347_T	0.769	1.00
95_V	158_Y	0.768	1.00
273_A	308_L	0.766	1.00
191_H	342_A	0.765	1.00
25_I	38_V	0.762	1.00
167_P	364_L	0.761	1.00
166_F	180_T	0.761	1.00
220_A	228_V	0.761	1.00
193_A	220_A	0.761	1.00
26_G	40_K	0.761	1.00
318_D	331_L	0.759	1.00
358_N	362_A	0.758	1.00
65_Q	391_F	0.756	1.00
206_I	230_V	0.755	1.00
257_L	297_S	0.753	1.00
149_G	154_V	0.752	1.00
259_E	262_E	0.749	1.00
379_I	401_I	0.746	1.00
379_I	399_F	0.746	1.00
26_G	29_E	0.740	1.00
362_A	366_G	0.739	1.00
376_A	386_K	0.736	1.00
25_I	28_P	0.735	1.00
198_V	272_A	0.735	1.00
225_A	228_V	0.734	1.00
182_L	363_I	0.733	1.00
168_D	364_L	0.726	1.00
46_K	90_E	0.726	1.00
102_D	168_D	0.723	1.00
53_L	106_V	0.720	1.00
63_S	82_H	0.719	1.00
164_L	356_N	0.716	1.00
192_G	216_A	0.714	1.00
255_D	297_S	0.713	1.00
237_R	396_A	0.711	1.00
164_L	357_R	0.705	1.00
51_V	158_Y	0.704	1.00
391_F	399_F	0.700	1.00
310_I	345_F	0.695	1.00
376_A	399_F	0.694	1.00
317_E	332_K	0.693	1.00
390_D	393_K	0.691	1.00
261_I	301_V	0.690	1.00
189_G	193_A	0.690	1.00
107_P	164_L	0.687	1.00
232_D	241_A	0.685	1.00
60_I	391_F	0.685	1.00
197_G	344_T	0.683	1.00
27_Y	30_L	0.682	1.00
207_A	282_S	0.682	1.00
164_L	360_M	0.681	1.00
317_E	334_R	0.680	1.00
247_E	260_Q	0.680	1.00
58_T	403_P	0.680	1.00
187_P	355_Y	0.680	1.00
197_G	307_S	0.679	1.00
61_C	64_D	0.670	1.00
221_Q	246_C	0.669	1.00
265_L	268_P	0.668	1.00
25_I	381_L	0.668	1.00
304_V	341_K	0.666	1.00
204_V	225_A	0.665	1.00
34_D	389_S	0.658	1.00
219_S	362_A	0.658	1.00
214_L	240_Q	0.653	1.00
197_G	346_V	0.653	1.00
27_Y	35_G	0.649	1.00
272_A	309_G	0.648	1.00
51_V	88_V	0.647	1.00
232_D	251_V	0.645	1.00
44_N	153_Y	0.642	1.00
275_D	308_L	0.642	1.00
273_A	301_V	0.641	1.00
53_L	163_L	0.641	1.00
136_S	146_W	0.641	1.00
374_V	378_V	0.640	1.00
25_I	384_A	0.638	1.00
190_F	362_A	0.638	1.00
223_L	358_N	0.635	1.00
362_A	365_S	0.632	1.00
57_T	378_V	0.631	1.00
192_G	274_V	0.631	1.00
62_G	66_H	0.628	1.00
44_N	155_M	0.626	1.00
97_F	165_V	0.626	1.00
26_G	382_D	0.624	1.00
280_E	296_N	0.622	1.00
127_L	268_P	0.621	1.00
201_G	226_S	0.621	1.00
218_H	244_F	0.620	1.00
318_D	332_K	0.620	1.00
170_E	363_I	0.619	1.00
26_G	152_E	0.619	1.00
105_S	183_S	0.618	1.00
217_A	241_A	0.618	1.00
125_V	342_A	0.618	1.00
85_T	103_I	0.617	1.00
337_L	340_A	0.616	1.00
31_I	34_D	0.615	1.00
49_H	159_A	0.615	1.00
29_E	37_G	0.613	1.00
360_M	364_L	0.612	1.00
85_T	166_F	0.612	1.00
268_P	303_Q	0.610	1.00
249_V	264_I	0.609	1.00
262_E	265_L	0.609	1.00
188_T	212_V	0.608	1.00
388_Y	392_D	0.606	1.00
216_A	311_P	0.606	1.00
74_A	78_L	0.605	1.00
44_N	52_I	0.605	1.00
194_Y	219_S	0.604	1.00
217_A	244_F	0.603	1.00
270_V	301_V	0.603	1.00
225_A	272_A	0.599	1.00
105_S	166_F	0.597	1.00
375_N	397_K	0.596	1.00
231_G	249_V	0.596	1.00
226_S	229_I	0.596	1.00
38_V	384_A	0.595	1.00
56_I	402_D	0.594	1.00
272_A	307_S	0.593	1.00
218_H	368_A	0.592	1.00
65_Q	392_D	0.590	1.00
57_T	85_T	0.590	1.00
82_H	184_D	0.590	1.00
266_G	269_T	0.585	1.00
110_I	162_Q	0.583	1.00
96_E	99_K	0.583	1.00
105_S	360_M	0.582	1.00
97_F	100_K	0.582	1.00
184_D	188_T	0.581	1.00
238_L	251_V	0.580	1.00
249_V	257_L	0.580	1.00
249_V	260_Q	0.579	1.00
203_T	265_L	0.578	1.00
376_A	396_A	0.578	1.00
296_N	332_K	0.575	1.00
181_M	400_V	0.575	1.00
275_D	312_G	0.574	1.00
204_V	272_A	0.574	1.00
83_E	184_D	0.572	1.00
196_A	307_S	0.571	1.00
313_L	339_W	0.569	1.00
26_G	30_L	0.567	1.00
106_V	163_L	0.566	1.00
200_T	224_G	0.565	1.00
193_A	219_S	0.563	1.00
26_G	41_A	0.562	1.00
188_T	311_P	0.561	1.00
81_G	150_Q	0.560	1.00
298_I	302_T	0.560	1.00
276_C	311_P	0.559	1.00
363_I	370_I	0.556	1.00
366_G	369_Q	0.555	1.00
206_I	217_A	0.553	1.00
91_T	102_D	0.553	1.00
309_G	346_V	0.548	1.00
185_I	211_P	0.546	1.00
229_I	248_T	0.546	1.00
85_T	180_T	0.545	1.00
232_D	250_N	0.544	1.00
61_C	184_D	0.543	1.00
262_E	269_T	0.543	1.00
277_V	312_G	0.543	1.00
309_G	348_G	0.541	1.00
337_L	343_H	0.540	1.00
43_V	46_K	0.540	1.00
190_F	355_Y	0.538	1.00
27_Y	31_I	0.537	1.00
58_T	401_I	0.536	1.00
296_N	337_L	0.535	1.00
46_K	49_H	0.534	1.00
173_L	176_I	0.530	1.00
75_P	78_L	0.530	1.00
35_G	385_P	0.528	1.00
399_F	402_D	0.527	1.00
42_N	45_R	0.526	1.00
165_V	168_D	0.525	1.00
185_I	215_A	0.525	1.00
204_V	274_V	0.524	1.00
257_L	261_I	0.524	1.00
91_T	98_I	0.523	1.00
297_S	301_V	0.521	1.00
55_V	58_T	0.520	1.00
36_P	388_Y	0.520	1.00
265_L	270_V	0.519	1.00
215_A	218_H	0.519	1.00
355_Y	358_N	0.517	1.00
63_S	66_H	0.516	1.00
61_C	185_I	0.516	1.00
295_L	308_L	0.515	1.00
36_P	385_P	0.515	1.00
28_P	31_I	0.515	1.00
233_L	250_N	0.514	1.00
249_V	254_H	0.513	1.00
268_P	271_D	0.513	1.00
66_H	313_L	0.511	1.00
232_D	237_R	0.510	1.00
65_Q	69_R	0.510	1.00
61_C	398_K	0.510	1.00
98_I	158_Y	0.509	1.00
219_S	223_L	0.509	1.00
50_G	146_W	0.509	1.00
205_Y	273_A	0.509	1.00
215_A	219_S	0.509	1.00
106_V	149_G	0.508	1.00
353_M	357_R	0.507	1.00
46_K	94_D	0.507	1.00
185_I	398_K	0.507	1.00
356_N	360_M	0.506	1.00
222_L	368_A	0.506	1.00
205_Y	261_I	0.505	1.00
263_Q	266_G	0.504	1.00
238_L	241_A	0.504	1.00
216_A	276_C	0.503	1.00
211_P	398_K	0.503	1.00
55_V	106_V	0.501	1.00
336_G	339_W	0.501	1.00
203_T	268_P	0.500	1.00
281_A	297_S	0.500	1.00
197_G	202_S	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1kolA	4	0.9314	100	0.254	Contact Map
2dphA	4	0.9314	100	0.26	Contact Map
4ej6A	1	0.8284	100	0.277	Contact Map
4cpdA	2	0.8407	100	0.278	Contact Map
3ukoA	4	0.8725	100	0.279	Contact Map
1f8fA	4	0.8529	100	0.284	Contact Map
4ilkA	2	0.8186	100	0.285	Contact Map
1cdoA	2	0.8578	100	0.288	Contact Map
3m6iA	4	0.8309	100	0.289	Contact Map
1vj0A	4	0.8505	100	0.289	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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