GREMLIN Database
YYCR - Uncharacterized zinc-type alcohol dehydrogenase-like protein YycR
UniProt: Q45604 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (321)
Sequences: 38620 (25590)
Seq/√Len: 1428.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
383_D386_K3.1651.00
54_K89_I3.0501.00
56_I87_E2.9751.00
56_I173_L2.9471.00
51_V163_L2.7671.00
52_I89_I2.7631.00
260_Q263_Q2.6191.00
102_D165_V2.5651.00
171_Q175_K2.5391.00
84_I149_G2.4841.00
379_I390_D2.3981.00
54_K87_E2.3641.00
99_K102_D2.2851.00
48_E93_R2.2761.00
43_V153_Y2.2711.00
174_E378_V2.2521.00
238_L242_R2.2501.00
103_I166_F2.2461.00
49_H94_D2.2241.00
378_V402_D2.2241.00
380_S383_D2.2151.00
54_K153_Y2.1841.00
203_T226_S2.1781.00
361_K365_S2.1501.00
204_V220_A2.1271.00
239_A243_S2.1191.00
389_S393_K2.1081.00
48_E94_D2.0841.00
97_F158_Y2.0801.00
209_A230_V2.0681.00
169_K364_L2.0481.00
171_Q174_E2.0401.00
199_Q202_S2.0381.00
69_R392_D2.0301.00
376_A390_D1.9881.00
239_A242_R1.9751.00
45_R90_E1.9461.00
47_C50_G1.9391.00
205_Y270_V1.9321.00
302_T308_L1.9301.00
194_Y223_L1.8861.00
254_H260_Q1.8841.00
194_Y358_N1.8821.00
84_I106_V1.8761.00
217_A246_C1.8611.00
386_K389_S1.8591.00
89_I153_Y1.8521.00
235_E239_A1.8501.00
205_Y231_G1.8161.00
85_T173_L1.8091.00
307_S344_T1.8031.00
271_D303_Q1.8021.00
52_I155_M1.7941.00
232_D238_L1.7571.00
247_E264_I1.7311.00
229_I270_V1.7151.00
186_F215_A1.7141.00
390_D395_A1.7031.00
238_L248_T1.6971.00
235_E250_N1.6911.00
103_I173_L1.6841.00
240_Q243_S1.6611.00
386_K390_D1.6471.00
379_I387_G1.6411.00
91_T100_K1.6161.00
92_G95_V1.5991.00
307_S346_V1.5881.00
235_E253_K1.5831.00
98_I165_V1.5761.00
90_E100_K1.5641.00
273_A302_T1.5611.00
31_I39_P1.5561.00
31_I37_G1.5541.00
250_N253_K1.5421.00
55_V84_I1.5411.00
46_K155_M1.5351.00
28_P39_P1.5251.00
302_T343_H1.5251.00
103_I168_D1.5211.00
52_I153_Y1.5161.00
385_P389_S1.5061.00
50_G157_P1.4981.00
46_K52_I1.4921.00
202_S307_S1.4891.00
222_L367_R1.4851.00
98_I102_D1.4761.00
233_L251_V1.4691.00
174_E402_D1.4651.00
50_G155_M1.4621.00
273_A298_I1.4601.00
49_H157_P1.4501.00
88_V98_I1.4311.00
166_F173_L1.4291.00
196_A272_A1.4271.00
207_A298_I1.4211.00
226_S247_E1.4141.00
166_F176_I1.4051.00
87_E173_L1.3961.00
87_E103_I1.3961.00
31_I35_G1.3941.00
259_E263_Q1.3831.00
217_A230_V1.3661.00
57_T402_D1.3601.00
51_V98_I1.3521.00
203_T229_I1.3441.00
150_Q388_Y1.3381.00
43_V52_I1.3281.00
361_K364_L1.3241.00
375_N390_D1.3231.00
302_T306_G1.3191.00
57_T174_E1.3161.00
260_Q264_I1.2831.00
98_I163_L1.2831.00
216_A274_V1.2741.00
52_I90_E1.2641.00
242_R248_T1.2621.00
68_V388_Y1.2581.00
175_K371_A1.2561.00
255_D259_E1.2401.00
49_H158_Y1.2241.00
238_L250_N1.2161.00
235_E238_L1.2021.00
198_V225_A1.1971.00
277_V282_S1.1811.00
26_G39_P1.1801.00
381_L403_P1.1671.00
233_L252_Q1.1601.00
207_A231_G1.1581.00
195_T344_T1.1561.00
46_K50_G1.1521.00
203_T271_D1.1511.00
175_K369_Q1.1311.00
384_A401_I1.1181.00
55_V154_V1.1161.00
56_I103_I1.1121.00
300_D337_L1.1101.00
60_I387_G1.1101.00
222_L362_A1.1091.00
218_H369_Q1.1061.00
89_I100_K1.1051.00
38_V382_D1.0841.00
380_S402_D1.0771.00
53_L104_V1.0711.00
53_L86_G1.0691.00
198_V202_S1.0681.00
58_T149_G1.0651.00
230_V246_C1.0651.00
209_A232_D1.0561.00
189_G216_A1.0551.00
194_Y355_Y1.0481.00
296_N300_D1.0441.00
150_Q384_A1.0431.00
56_I85_T1.0381.00
205_Y301_V1.0341.00
196_A309_G1.0271.00
28_P37_G1.0261.00
220_A225_A1.0251.00
202_S271_D1.0241.00
127_L304_V1.0141.00
150_Q401_I1.0111.00
32_L35_G1.0111.00
265_L269_T1.0061.00
242_R247_E1.0031.00
217_A228_V1.0021.00
156_V163_L0.9901.00
189_G219_S0.9891.00
338_G345_F0.9871.00
358_N361_K0.9841.00
231_G251_V0.9791.00
206_I220_A0.9781.00
57_T173_L0.9751.00
43_V90_E0.9751.00
78_L147_V0.9741.00
357_R361_K0.9731.00
389_S392_D0.9711.00
41_A147_V0.9681.00
233_L238_L0.9651.00
202_S272_A0.9611.00
362_A367_R0.9591.00
191_H355_Y0.9561.00
258_G300_D0.9561.00
57_T400_V0.9561.00
57_T403_P0.9491.00
41_A79_V0.9491.00
229_I247_E0.9491.00
219_S359_L0.9461.00
192_G311_P0.9431.00
186_F359_L0.9431.00
190_F194_Y0.9391.00
236_D239_A0.9381.00
230_V241_A0.9351.00
379_I383_D0.9341.00
253_K260_Q0.9311.00
229_I264_I0.9311.00
43_V89_I0.9301.00
258_G262_E0.9241.00
54_K152_E0.9191.00
258_G297_S0.9181.00
58_T150_Q0.9131.00
209_A217_A0.9071.00
261_I270_V0.9011.00
91_T95_V0.8971.00
159_A162_Q0.8971.00
376_A379_I0.8951.00
275_D278_G0.8921.00
99_K165_V0.8901.00
203_T270_V0.8881.00
390_D399_F0.8861.00
232_D248_T0.8851.00
240_Q396_A0.8841.00
68_V392_D0.8741.00
298_I308_L0.8731.00
28_P384_A0.8721.00
234_N237_R0.8711.00
209_A241_A0.8681.00
247_E250_N0.8581.00
96_E158_Y0.8551.00
337_L341_K0.8501.00
234_N250_N0.8481.00
84_I154_V0.8471.00
49_H93_R0.8461.00
207_A273_A0.8431.00
241_A246_C0.8421.00
29_E39_P0.8411.00
45_R52_I0.8391.00
59_N83_E0.8381.00
49_H92_G0.8371.00
206_I216_A0.8331.00
55_V403_P0.8321.00
189_G212_V0.8281.00
61_C83_E0.8251.00
47_C155_M0.8231.00
61_C82_H0.8211.00
106_V156_V0.8211.00
334_R337_L0.8201.00
305_G342_A0.8151.00
91_T99_K0.8121.00
279_F282_S0.8091.00
297_S300_D0.8091.00
46_K92_G0.8051.00
229_I249_V0.8041.00
255_D258_G0.7991.00
229_I261_I0.7961.00
258_G301_V0.7951.00
60_I150_Q0.7941.00
195_T346_V0.7941.00
255_D260_Q0.7911.00
189_G215_A0.7911.00
104_V163_L0.7891.00
38_V381_L0.7831.00
190_F358_N0.7821.00
103_I169_K0.7791.00
270_V273_A0.7781.00
354_T357_R0.7781.00
243_S369_Q0.7761.00
190_F359_L0.7741.00
338_G343_H0.7741.00
170_E176_I0.7711.00
354_T358_N0.7701.00
221_Q228_V0.7691.00
338_G347_T0.7691.00
95_V158_Y0.7681.00
273_A308_L0.7661.00
191_H342_A0.7651.00
25_I38_V0.7621.00
167_P364_L0.7611.00
166_F180_T0.7611.00
220_A228_V0.7611.00
193_A220_A0.7611.00
26_G40_K0.7611.00
318_D331_L0.7591.00
358_N362_A0.7581.00
65_Q391_F0.7561.00
206_I230_V0.7551.00
257_L297_S0.7531.00
149_G154_V0.7521.00
259_E262_E0.7491.00
379_I401_I0.7461.00
379_I399_F0.7461.00
26_G29_E0.7401.00
362_A366_G0.7391.00
376_A386_K0.7361.00
25_I28_P0.7351.00
198_V272_A0.7351.00
225_A228_V0.7341.00
182_L363_I0.7331.00
168_D364_L0.7261.00
46_K90_E0.7261.00
102_D168_D0.7231.00
53_L106_V0.7201.00
63_S82_H0.7191.00
164_L356_N0.7161.00
192_G216_A0.7141.00
255_D297_S0.7131.00
237_R396_A0.7111.00
164_L357_R0.7051.00
51_V158_Y0.7041.00
391_F399_F0.7001.00
310_I345_F0.6951.00
376_A399_F0.6941.00
317_E332_K0.6931.00
390_D393_K0.6911.00
261_I301_V0.6901.00
189_G193_A0.6901.00
107_P164_L0.6871.00
232_D241_A0.6851.00
60_I391_F0.6851.00
197_G344_T0.6831.00
27_Y30_L0.6821.00
207_A282_S0.6821.00
164_L360_M0.6811.00
317_E334_R0.6801.00
247_E260_Q0.6801.00
58_T403_P0.6801.00
187_P355_Y0.6801.00
197_G307_S0.6791.00
61_C64_D0.6701.00
221_Q246_C0.6691.00
265_L268_P0.6681.00
25_I381_L0.6681.00
304_V341_K0.6661.00
204_V225_A0.6651.00
34_D389_S0.6581.00
219_S362_A0.6581.00
214_L240_Q0.6531.00
197_G346_V0.6531.00
27_Y35_G0.6491.00
272_A309_G0.6481.00
51_V88_V0.6471.00
232_D251_V0.6451.00
44_N153_Y0.6421.00
275_D308_L0.6421.00
273_A301_V0.6411.00
53_L163_L0.6411.00
136_S146_W0.6411.00
374_V378_V0.6401.00
25_I384_A0.6381.00
190_F362_A0.6381.00
223_L358_N0.6351.00
362_A365_S0.6321.00
57_T378_V0.6311.00
192_G274_V0.6311.00
62_G66_H0.6281.00
44_N155_M0.6261.00
97_F165_V0.6261.00
26_G382_D0.6241.00
280_E296_N0.6221.00
127_L268_P0.6211.00
201_G226_S0.6211.00
218_H244_F0.6201.00
318_D332_K0.6201.00
170_E363_I0.6191.00
26_G152_E0.6191.00
105_S183_S0.6181.00
217_A241_A0.6181.00
125_V342_A0.6181.00
85_T103_I0.6171.00
337_L340_A0.6161.00
31_I34_D0.6151.00
49_H159_A0.6151.00
29_E37_G0.6131.00
360_M364_L0.6121.00
85_T166_F0.6121.00
268_P303_Q0.6101.00
249_V264_I0.6091.00
262_E265_L0.6091.00
188_T212_V0.6081.00
388_Y392_D0.6061.00
216_A311_P0.6061.00
74_A78_L0.6051.00
44_N52_I0.6051.00
194_Y219_S0.6041.00
217_A244_F0.6031.00
270_V301_V0.6031.00
225_A272_A0.5991.00
105_S166_F0.5971.00
375_N397_K0.5961.00
231_G249_V0.5961.00
226_S229_I0.5961.00
38_V384_A0.5951.00
56_I402_D0.5941.00
272_A307_S0.5931.00
218_H368_A0.5921.00
65_Q392_D0.5901.00
57_T85_T0.5901.00
82_H184_D0.5901.00
266_G269_T0.5851.00
110_I162_Q0.5831.00
96_E99_K0.5831.00
105_S360_M0.5821.00
97_F100_K0.5821.00
184_D188_T0.5811.00
238_L251_V0.5801.00
249_V257_L0.5801.00
249_V260_Q0.5791.00
203_T265_L0.5781.00
376_A396_A0.5781.00
296_N332_K0.5751.00
181_M400_V0.5751.00
275_D312_G0.5741.00
204_V272_A0.5741.00
83_E184_D0.5721.00
196_A307_S0.5711.00
313_L339_W0.5691.00
26_G30_L0.5671.00
106_V163_L0.5661.00
200_T224_G0.5651.00
193_A219_S0.5631.00
26_G41_A0.5621.00
188_T311_P0.5611.00
81_G150_Q0.5601.00
298_I302_T0.5601.00
276_C311_P0.5591.00
363_I370_I0.5561.00
366_G369_Q0.5551.00
206_I217_A0.5531.00
91_T102_D0.5531.00
309_G346_V0.5481.00
185_I211_P0.5461.00
229_I248_T0.5461.00
85_T180_T0.5451.00
232_D250_N0.5441.00
61_C184_D0.5431.00
262_E269_T0.5431.00
277_V312_G0.5431.00
309_G348_G0.5411.00
337_L343_H0.5401.00
43_V46_K0.5401.00
190_F355_Y0.5381.00
27_Y31_I0.5371.00
58_T401_I0.5361.00
296_N337_L0.5351.00
46_K49_H0.5341.00
173_L176_I0.5301.00
75_P78_L0.5301.00
35_G385_P0.5281.00
399_F402_D0.5271.00
42_N45_R0.5261.00
165_V168_D0.5251.00
185_I215_A0.5251.00
204_V274_V0.5241.00
257_L261_I0.5241.00
91_T98_I0.5231.00
297_S301_V0.5211.00
55_V58_T0.5201.00
36_P388_Y0.5201.00
265_L270_V0.5191.00
215_A218_H0.5191.00
355_Y358_N0.5171.00
63_S66_H0.5161.00
61_C185_I0.5161.00
295_L308_L0.5151.00
36_P385_P0.5151.00
28_P31_I0.5151.00
233_L250_N0.5141.00
249_V254_H0.5131.00
268_P271_D0.5131.00
66_H313_L0.5111.00
232_D237_R0.5101.00
65_Q69_R0.5101.00
61_C398_K0.5101.00
98_I158_Y0.5091.00
219_S223_L0.5091.00
50_G146_W0.5091.00
205_Y273_A0.5091.00
215_A219_S0.5091.00
106_V149_G0.5081.00
353_M357_R0.5071.00
46_K94_D0.5071.00
185_I398_K0.5071.00
356_N360_M0.5061.00
222_L368_A0.5061.00
205_Y261_I0.5051.00
263_Q266_G0.5041.00
238_L241_A0.5041.00
216_A276_C0.5031.00
211_P398_K0.5031.00
55_V106_V0.5011.00
336_G339_W0.5011.00
203_T268_P0.5001.00
281_A297_S0.5001.00
197_G202_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kolA 4 0.9314 100 0.254 Contact Map
2dphA 4 0.9314 100 0.26 Contact Map
4ej6A 1 0.8284 100 0.277 Contact Map
4cpdA 2 0.8407 100 0.278 Contact Map
3ukoA 4 0.8725 100 0.279 Contact Map
1f8fA 4 0.8529 100 0.284 Contact Map
4ilkA 2 0.8186 100 0.285 Contact Map
1cdoA 2 0.8578 100 0.288 Contact Map
3m6iA 4 0.8309 100 0.289 Contact Map
1vj0A 4 0.8505 100 0.289 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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