GREMLIN Database
YYDB - Uncharacterized metallophosphoesterase-like protein YydB
UniProt: Q45600 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 481 (414)
Sequences: 185 (173)
Seq/√Len: 8.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_F269_F6.2511.00
269_F286_Y5.5141.00
46_T202_I4.6960.99
177_A214_E3.8370.97
381_F386_E3.6010.96
30_F286_Y3.5140.95
84_N234_H3.3940.94
49_I60_V3.3920.94
381_F388_F3.3250.93
5_F272_V3.2400.93
381_F390_V2.9890.89
5_F44_L2.8600.87
10_D236_H2.7650.85
257_G268_E2.7570.85
45_L64_L2.6430.82
204_H233_G2.6050.81
10_D47_G2.5790.80
10_D48_D2.5790.80
12_H48_D2.5440.79
12_H47_G2.5440.79
9_S12_H2.4580.77
381_F387_Y2.4560.77
83_G233_G2.4130.75
83_G204_H2.4130.75
204_H236_H2.3750.74
233_G236_H2.3750.74
85_H204_H2.3660.74
85_H233_G2.3660.74
387_Y390_V2.3480.73
48_D204_H2.3140.72
47_G233_G2.3140.72
48_D233_G2.3140.72
47_G204_H2.3140.72
60_V63_Y2.2650.70
63_Y67_I2.2410.70
160_N205_H2.2150.69
157_L227_I2.1840.67
83_G236_H2.1660.67
7_Q46_T2.1590.67
11_L349_E2.1380.66
85_H236_H2.1200.65
48_D83_G2.1140.65
47_G83_G2.1140.65
86_D204_H2.0970.64
86_D233_G2.0970.64
47_G236_H2.0740.63
48_D236_H2.0740.63
386_E390_V2.0690.63
47_G85_H2.0670.63
48_D85_H2.0670.63
84_N204_H2.0560.63
84_N233_G2.0560.63
10_D204_H1.9820.60
10_D233_G1.9820.60
188_M256_S1.9460.58
12_H233_G1.9370.58
12_H204_H1.9370.58
4_R273_D1.8790.55
83_G86_D1.8510.54
421_H426_N1.8470.54
155_N199_N1.8340.53
86_D236_H1.8110.52
44_L202_I1.8000.52
81_V158_S1.7950.52
84_N236_H1.7670.51
10_D83_G1.7620.50
47_G86_D1.7600.50
48_D86_D1.7600.50
48_D84_N1.7420.49
47_G84_N1.7420.49
204_H234_H1.7380.49
12_H83_G1.7160.48
10_D85_H1.7140.48
148_L157_L1.7100.48
82_P160_N1.7080.48
82_P205_H1.7040.48
12_H236_H1.6770.47
162_C205_H1.6760.47
12_H85_H1.6680.46
44_L156_V1.6450.45
404_D408_L1.6430.45
198_L274_V1.6260.45
174_L206_T1.6250.45
238_S269_F1.6140.44
391_I399_S1.6010.44
180_K286_Y1.6010.44
154_Y268_E1.5970.43
9_S47_G1.5280.41
9_S48_D1.5280.41
65_N69_K1.5210.40
26_K327_D1.5050.40
386_E389_G1.5010.39
80_L271_S1.5010.39
6_L46_T1.4670.38
83_G234_H1.4630.38
234_H387_Y1.4550.38
79_H156_V1.4380.37
82_P89_R1.4310.37
85_H234_H1.4280.37
386_E391_I1.4220.36
48_D234_H1.4150.36
47_G234_H1.4150.36
13_F259_I1.4120.36
13_F43_L1.4120.36
7_Q60_V1.4090.36
5_F202_I1.3730.34
19_D156_V1.3700.34
44_L87_I1.3630.34
78_V170_E1.3590.34
51_H257_G1.3580.34
10_D86_D1.3570.34
10_D84_N1.3410.33
426_N430_I1.3320.33
12_H86_D1.3210.32
12_H84_N1.3060.32
84_N206_T1.2970.32
46_T214_E1.2930.31
174_L382_D1.2860.31
94_T256_S1.2830.31
80_L287_I1.2800.31
394_I397_S1.2690.31
381_F389_G1.2620.30
245_N249_N1.2610.30
356_S360_N1.2410.30
206_T234_H1.2400.30
80_L161_T1.2340.29
28_L210_I1.2290.29
45_L50_A1.2260.29
257_G269_F1.2250.29
156_V242_I1.2240.29
4_R8_I1.2060.28
56_Y270_I1.1930.28
128_F206_T1.1750.27
231_L379_R1.1730.27
388_F391_I1.1720.27
5_F295_W1.1690.27
62_E313_K1.1580.27
6_L160_N1.1560.27
9_S80_L1.1490.26
413_I420_F1.1410.26
7_Q27_L1.1360.26
277_D344_F1.1350.26
164_L288_W1.1340.26
381_F391_I1.1330.26
146_H150_Q1.1310.26
159_I315_N1.1250.26
46_T298_N1.1240.26
386_E392_N1.1210.26
224_D249_N1.1170.25
235_V255_V1.1110.25
7_Q232_A1.1090.25
151_S398_T1.1060.25
424_Y427_G1.0990.25
343_D357_N1.0990.25
219_K255_V1.0880.24
165_S242_I1.0780.24
148_L187_K1.0770.24
7_Q231_L1.0700.24
80_L344_F1.0700.24
9_S204_H1.0690.24
9_S233_G1.0690.24
395_M416_K1.0620.24
272_V295_W1.0500.23
174_L229_L1.0450.23
128_F313_K1.0410.23
31_I319_S1.0410.23
64_L90_D1.0380.23
69_K356_S1.0370.23
80_L217_S1.0370.23
28_L238_S1.0320.23
31_I107_S1.0280.23
40_F78_V1.0260.23
165_S214_E1.0220.22
345_H350_S1.0210.22
131_F387_Y1.0180.22
154_Y224_D1.0160.22
244_A277_D1.0140.22
8_I161_T1.0100.22
31_I70_S1.0100.22
157_L163_L1.0010.22
86_D234_H1.0000.22
159_I267_P0.9990.22
384_Y388_F0.9960.22
52_K56_Y0.9920.22
161_T203_G0.9860.21
10_D234_H0.9860.21
295_W301_G0.9860.21
113_L130_D0.9830.21
27_L283_V0.9830.21
44_L295_W0.9810.21
246_T345_H0.9780.21
57_N131_F0.9750.21
125_Q129_F0.9750.21
181_L360_N0.9750.21
348_R395_M0.9740.21
8_I415_D0.9730.21
160_N226_F0.9720.21
3_V387_Y0.9720.21
82_P196_K0.9700.21
45_L274_V0.9700.21
65_N347_Y0.9690.21
7_Q11_L0.9690.21
82_P85_H0.9680.21
30_F295_W0.9650.21
8_I276_L0.9640.21
84_N388_F0.9630.21
101_M201_A0.9620.21
357_N385_S0.9620.21
334_E343_D0.9610.21
12_H234_H0.9610.21
84_N387_Y0.9590.21
150_Q287_I0.9510.20
9_S83_G0.9500.20
53_G234_H0.9480.20
258_A312_Y0.9460.20
409_I413_I0.9410.20
424_Y429_E0.9350.20
335_D346_E0.9350.20
27_L52_K0.9340.20
133_E341_I0.9300.20
174_L177_A0.9280.20
318_E373_S0.9250.20
6_L22_V0.9250.20
98_D377_F0.9210.20
6_L27_L0.9190.20
206_T269_F0.9170.20
7_Q67_I0.9160.19
186_R205_H0.9150.19
88_S202_I0.9130.19
416_K427_G0.9110.19
165_S168_K0.9110.19
80_L401_V0.9100.19
85_H205_H0.9090.19
56_Y209_C0.9070.19
177_A180_K0.9030.19
5_F270_I0.9000.19
413_I419_E0.8930.19
366_K389_G0.8870.19
269_F283_V0.8860.19
425_N430_I0.8860.19
11_L24_R0.8860.19
368_F371_M0.8820.19
379_R388_F0.8730.18
218_I349_E0.8730.18
163_L214_E0.8720.18
405_K413_I0.8720.18
254_L270_I0.8720.18
230_Y269_F0.8700.18
261_K270_I0.8700.18
50_A57_N0.8670.18
201_A222_F0.8650.18
357_N388_F0.8640.18
202_I322_E0.8630.18
163_L209_C0.8610.18
234_H388_F0.8590.18
147_F316_R0.8580.18
128_F173_T0.8560.18
50_A267_P0.8560.18
81_V257_G0.8560.18
231_L258_A0.8530.18
222_F331_K0.8520.18
20_T23_M0.8510.18
89_R165_S0.8510.18
164_L254_L0.8490.18
57_N286_Y0.8460.18
8_I12_H0.8450.18
313_K330_D0.8430.18
186_R190_K0.8430.18
46_T162_C0.8420.18
11_L45_L0.8370.17
50_A117_A0.8370.17
371_M378_K0.8370.17
69_K92_T0.8360.17
82_P256_S0.8350.17
30_F230_Y0.8340.17
54_D210_I0.8340.17
58_E348_R0.8330.17
315_N335_D0.8330.17
7_Q44_L0.8310.17
234_H390_V0.8290.17
210_I237_D0.8290.17
67_I160_N0.8270.17
107_S116_K0.8270.17
80_L116_K0.8270.17
423_Q430_I0.8250.17
81_V231_L0.8240.17
12_H53_G0.8230.17
406_K420_F0.8220.17
407_E413_I0.8210.17
8_I11_L0.8200.17
317_L329_D0.8190.17
101_M396_D0.8160.17
128_F354_F0.8150.17
186_R406_K0.8140.17
160_N233_G0.8120.17
160_N204_H0.8120.17
5_F81_V0.8120.17
186_R374_G0.8120.17
274_V423_Q0.8100.17
7_Q160_N0.8030.17
19_D264_Y0.8020.17
174_L386_E0.8020.17
125_Q269_F0.7940.16
78_V313_K0.7920.16
27_L237_D0.7910.16
174_L283_V0.7900.16
109_M273_D0.7890.16
59_D128_F0.7890.16
4_R41_D0.7880.16
165_S205_H0.7870.16
8_I61_K0.7840.16
218_I256_S0.7820.16
124_G155_N0.7820.16
9_S205_H0.7810.16
366_K379_R0.7790.16
34_L62_E0.7790.16
51_H57_N0.7790.16
16_Q43_L0.7760.16
62_E332_I0.7730.16
228_D231_L0.7710.16
82_P233_G0.7710.16
82_P204_H0.7710.16
209_C381_F0.7700.16
31_I353_T0.7700.16
161_T205_H0.7700.16
132_Y227_I0.7670.16
89_R160_N0.7650.16
87_I125_Q0.7640.16
356_S361_Q0.7640.16
339_S414_V0.7590.16
402_S405_K0.7570.16
27_L265_A0.7570.16
155_N227_I0.7550.16
192_K254_L0.7530.16
248_E259_I0.7520.15
79_H148_L0.7510.15
218_I323_K0.7460.15
163_L227_I0.7450.15
407_E430_I0.7450.15
395_M401_V0.7440.15
5_F154_Y0.7430.15
79_H234_H0.7420.15
206_T235_V0.7390.15
176_T210_I0.7390.15
155_N272_V0.7390.15
201_A227_I0.7380.15
274_V287_I0.7380.15
70_S249_N0.7350.15
412_T425_N0.7350.15
98_D309_K0.7330.15
3_V339_S0.7310.15
403_A406_K0.7300.15
367_K391_I0.7290.15
84_N386_E0.7290.15
147_F426_N0.7280.15
189_N303_R0.7270.15
126_R362_I0.7270.15
272_V370_D0.7260.15
201_A276_L0.7260.15
184_A315_N0.7260.15
147_F240_F0.7230.15
6_L60_V0.7220.15
250_P295_W0.7190.15
387_Y391_I0.7170.15
5_F76_N0.7160.15
42_F289_N0.7150.15
311_N356_S0.7150.15
190_K229_L0.7140.15
104_P300_Q0.7130.15
124_G158_S0.7100.15
422_N427_G0.7080.15
181_L274_V0.7070.15
106_P379_R0.7070.15
407_E429_E0.7060.15
31_I318_E0.7060.15
114_D208_G0.7060.15
168_K205_H0.7030.14
359_D378_K0.7020.14
205_H233_G0.7020.14
53_G210_I0.6970.14
228_D388_F0.6920.14
6_L257_G0.6910.14
413_I422_N0.6900.14
32_E367_K0.6890.14
159_I166_D0.6880.14
139_K201_A0.6870.14
212_S235_V0.6860.14
7_Q12_H0.6850.14
198_L201_A0.6840.14
153_K334_E0.6830.14
98_D378_K0.6830.14
55_V248_E0.6830.14
411_E420_F0.6810.14
203_G230_Y0.6800.14
318_E363_G0.6800.14
200_I205_H0.6780.14
13_F267_P0.6760.14
44_L95_L0.6740.14
248_E304_R0.6700.14
171_E258_A0.6690.14
67_I206_T0.6690.14
248_E400_Y0.6680.14
342_I345_H0.6680.14
256_S281_T0.6660.14
348_R364_L0.6660.14
29_D210_I0.6640.14
41_D184_A0.6620.14
177_A298_N0.6620.14
9_S236_H0.6620.14
45_L268_E0.6610.14
205_H214_E0.6610.14
82_P161_T0.6600.14
157_L184_A0.6590.14
81_V205_H0.6590.14
163_L387_Y0.6570.14
86_D200_I0.6560.13
4_R78_V0.6560.13
242_I343_D0.6470.13
309_K375_E0.6430.13
4_R40_F0.6420.13
324_E335_D0.6420.13
262_D283_V0.6410.13
154_Y367_K0.6410.13
162_C209_C0.6410.13
200_I306_Q0.6390.13
114_D120_I0.6390.13
48_D53_G0.6370.13
47_G53_G0.6370.13
361_Q380_K0.6370.13
163_L268_E0.6360.13
282_E305_L0.6350.13
109_M401_V0.6350.13
44_L174_L0.6340.13
9_S85_H0.6340.13
182_Y271_S0.6320.13
87_I158_S0.6320.13
8_I48_D0.6320.13
8_I47_G0.6320.13
61_K274_V0.6300.13
341_I365_D0.6290.13
365_D372_K0.6290.13
340_F351_Y0.6280.13
343_D348_R0.6260.13
157_L387_Y0.6260.13
150_Q202_I0.6250.13
155_N295_W0.6250.13
60_V160_N0.6220.13
107_S347_Y0.6220.13
160_N208_G0.6210.13
405_K408_L0.6210.13
186_R381_F0.6200.13
65_N377_F0.6170.13
157_L199_N0.6160.13
184_A250_P0.6140.13
57_N209_C0.6140.13
82_P162_C0.6130.13
5_F158_S0.6130.13
412_T416_K0.6130.13
408_L420_F0.6120.13
232_A336_E0.6120.13
378_K386_E0.6080.13
98_D120_I0.6080.13
404_D420_F0.6070.13
363_G373_S0.6070.13
87_I96_L0.6060.13
11_L51_H0.6050.13
222_F274_V0.6030.12
412_T418_L0.6030.12
345_H369_Y0.6030.12
172_G205_H0.6020.12
45_L354_F0.6000.12
24_R67_I0.5980.12
22_V147_F0.5970.12
205_H230_Y0.5960.12
209_C258_A0.5960.12
373_S378_K0.5960.12
127_K379_R0.5950.12
160_N164_L0.5950.12
241_N254_L0.5940.12
127_K248_E0.5930.12
396_D399_S0.5930.12
166_D170_E0.5920.12
209_C267_P0.5900.12
57_N381_F0.5870.12
129_F161_T0.5870.12
75_K136_M0.5870.12
46_T231_L0.5860.12
97_I101_M0.5850.12
81_V128_F0.5850.12
304_R341_I0.5840.12
7_Q202_I0.5840.12
208_G215_R0.5820.12
70_S222_F0.5810.12
84_N390_V0.5810.12
297_K353_T0.5790.12
7_Q63_Y0.5780.12
142_E250_P0.5780.12
188_M224_D0.5770.12
177_A208_G0.5760.12
299_N306_Q0.5760.12
49_I256_S0.5750.12
108_E338_K0.5750.12
185_I188_M0.5750.12
155_N163_L0.5750.12
183_K191_E0.5740.12
68_I313_K0.5740.12
33_V373_S0.5730.12
245_N288_W0.5730.12
128_F187_K0.5710.12
245_N276_L0.5710.12
7_Q82_P0.5690.12
117_A222_F0.5690.12
88_S209_C0.5670.12
147_F183_K0.5670.12
34_L324_E0.5660.12
409_I417_Y0.5660.12
420_F426_N0.5640.12
50_A174_L0.5640.12
13_F206_T0.5640.12
5_F249_N0.5640.12
66_G406_K0.5630.12
359_D398_T0.5630.12
43_L147_F0.5620.12
44_L168_K0.5620.12
124_G180_K0.5610.12
30_F297_K0.5610.12
82_P297_K0.5600.12
280_E382_D0.5600.12
128_F406_K0.5580.12
343_D390_V0.5580.12
182_Y311_N0.5570.12
81_V254_L0.5570.12
50_A177_A0.5570.12
26_K337_F0.5570.12
6_L67_I0.5560.12
303_R368_F0.5550.12
220_A369_Y0.5550.12
9_S419_E0.5550.12
367_K371_M0.5550.12
404_D410_A0.5510.12
86_D205_H0.5510.12
252_L320_L0.5490.12
403_A412_T0.5490.12
363_G382_D0.5470.11
345_H348_R0.5470.11
368_F386_E0.5460.11
82_P172_G0.5450.11
33_V181_L0.5440.11
343_D350_S0.5430.11
53_G85_H0.5420.11
40_F121_L0.5420.11
157_L270_I0.5410.11
100_I125_Q0.5410.11
82_P231_L0.5400.11
43_L206_T0.5380.11
59_D63_Y0.5380.11
128_F414_V0.5380.11
163_L386_E0.5370.11
135_F251_F0.5370.11
82_P86_D0.5360.11
24_R222_F0.5360.11
156_V412_T0.5360.11
3_V192_K0.5360.11
134_D248_E0.5360.11
174_L313_K0.5350.11
196_K268_E0.5350.11
83_G128_F0.5330.11
42_F64_L0.5330.11
269_F347_Y0.5320.11
389_G393_H0.5310.11
167_K170_E0.5300.11
162_C387_Y0.5280.11
129_F174_L0.5270.11
159_I390_V0.5260.11
176_T383_S0.5260.11
191_E240_F0.5250.11
416_K419_E0.5250.11
5_F231_L0.5250.11
50_A209_C0.5250.11
133_E378_K0.5250.11
419_E423_Q0.5230.11
124_G208_G0.5220.11
53_G222_F0.5220.11
35_R314_I0.5220.11
154_Y361_Q0.5210.11
27_L223_D0.5200.11
248_E309_K0.5200.11
25_D281_T0.5200.11
307_E369_Y0.5190.11
6_L63_Y0.5180.11
3_V364_L0.5180.11
223_D288_W0.5170.11
40_F271_S0.5160.11
46_T131_F0.5160.11
356_S412_T0.5160.11
404_D414_V0.5160.11
179_M353_T0.5150.11
163_L206_T0.5150.11
289_N332_I0.5130.11
411_E422_N0.5130.11
382_D398_T0.5110.11
325_I332_I0.5110.11
145_L378_K0.5100.11
112_K282_E0.5100.11
408_L416_K0.5090.11
259_I427_G0.5090.11
230_Y363_G0.5090.11
162_C394_I0.5070.11
199_N227_I0.5070.11
79_H118_T0.5060.11
158_S295_W0.5060.11
93_R114_D0.5060.11
24_R147_F0.5050.11
234_H275_N0.5040.11
183_K257_G0.5040.11
8_I283_V0.5030.11
123_E364_L0.5030.11
56_Y262_D0.5020.11
245_N296_S0.5010.11
308_G318_E0.5000.11
240_F264_Y0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ib7A 2 0.5343 100 0.734 Contact Map
3d03A 5 0.5135 100 0.736 Contact Map
2yvtA 1 0.4595 99.9 0.742 Contact Map
1uteA 1 0.5426 99.9 0.746 Contact Map
2nxfA 1 0.5198 99.9 0.747 Contact Map
2xmoA 1 0.7277 99.9 0.747 Contact Map
3tghA 1 0.5925 99.9 0.76 Contact Map
3av0A 1 0.7006 99.9 0.779 Contact Map
4nzvA 1 0.605 99.9 0.782 Contact Map
4fbwA 2 0.7069 99.9 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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