GREMLIN Database
YYDG - Putative peptide biosynthesis protein YydG
UniProt: Q45595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (267)
Sequences: 7562 (6048)
Seq/√Len: 370.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_H124_V4.2561.00
16_A89_F3.9201.00
118_E124_V3.5031.00
39_R74_I3.3461.00
121_A124_V3.3261.00
15_N87_N2.9301.00
102_H139_Y2.9301.00
37_Y238_Y2.9281.00
218_E236_E2.8931.00
43_T74_I2.8541.00
134_E166_S2.8071.00
93_S135_H2.7861.00
34_E37_Y2.7711.00
40_E44_E2.6011.00
64_D67_F2.4541.00
69_K103_D2.4401.00
218_E233_T2.3451.00
43_T78_Y2.3301.00
204_L222_C2.3281.00
289_C292_C2.2851.00
126_S162_E2.2671.00
35_K70_E2.1681.00
6_V45_F2.1581.00
155_M158_H2.1511.00
241_S244_R2.1341.00
13_R32_R2.1061.00
120_H123_F2.0611.00
88_G114_I1.9901.00
236_E239_N1.9901.00
240_Q244_R1.9401.00
38_I71_L1.9371.00
135_H138_K1.9211.00
118_E123_F1.8631.00
74_I77_P1.8331.00
76_K110_I1.8271.00
261_E267_L1.7471.00
120_H127_S1.7131.00
39_R70_E1.7111.00
214_H218_E1.7061.00
35_K39_R1.6821.00
37_Y40_E1.6481.00
35_K67_F1.6351.00
73_E103_D1.6341.00
102_H106_S1.6271.00
33_M37_Y1.6001.00
73_E77_P1.6001.00
103_D107_L1.5691.00
44_E241_S1.5451.00
67_F70_E1.5391.00
93_S138_K1.5341.00
74_I78_Y1.5301.00
39_R43_T1.5291.00
119_Y124_V1.5231.00
15_N90_W1.5201.00
128_S131_N1.5171.00
46_A78_Y1.5101.00
251_S255_L1.4861.00
161_E165_D1.4821.00
131_N135_H1.4791.00
85_I113_T1.4631.00
56_F82_I1.4611.00
64_D71_L1.4611.00
101_F135_H1.4611.00
33_M38_I1.4591.00
32_R64_D1.4531.00
214_H220_Y1.4521.00
134_E138_K1.4511.00
163_L166_S1.4471.00
105_N139_Y1.4351.00
20_H117_D1.4281.00
219_I245_T1.3921.00
127_S131_N1.3811.00
93_S139_Y1.3751.00
62_F84_L1.3601.00
131_N134_E1.3591.00
114_I133_L1.3401.00
162_E166_S1.3351.00
158_H161_E1.3081.00
118_E121_A1.3011.00
103_D106_S1.2811.00
8_I38_I1.2761.00
261_E264_K1.2731.00
76_K107_L1.2581.00
70_E73_E1.2561.00
134_E137_R1.2531.00
243_E247_E1.2531.00
190_E202_D1.2451.00
264_K267_L1.2431.00
75_I82_I1.2381.00
42_V75_I1.2381.00
252_N255_L1.2191.00
72_M109_V1.2171.00
112_L136_S1.2161.00
120_H155_M1.2051.00
129_I132_I1.1921.00
12_S215_H1.1871.00
222_C274_N1.1861.00
146_L163_L1.1741.00
119_Y123_F1.1721.00
220_Y233_T1.1721.00
76_K82_I1.1661.00
135_H139_Y1.1541.00
114_I136_S1.1511.00
100_Y104_M1.1471.00
15_N60_E1.1461.00
72_M107_L1.1371.00
114_I132_I1.1291.00
244_R248_K1.1281.00
252_N256_F1.1131.00
130_K134_E1.1121.00
11_D32_R1.1091.00
68_L72_M1.0991.00
62_F90_W1.0931.00
10_L56_F1.0891.00
45_F54_I1.0861.00
54_I75_I1.0851.00
92_L100_Y1.0721.00
15_N89_F1.0611.00
126_S130_K1.0611.00
40_E238_Y1.0611.00
73_E107_L1.0591.00
84_L104_M1.0541.00
91_G101_F1.0471.00
146_L169_G1.0441.00
6_V211_I1.0411.00
66_K69_K1.0401.00
49_K52_Q1.0391.00
22_C57_T1.0281.00
41_L213_Y1.0281.00
67_F71_L1.0261.00
148_M159_I1.0171.00
93_S102_H1.0151.00
60_E87_N1.0151.00
116_Y146_L1.0121.00
62_F68_L1.0091.00
148_M172_I1.0041.00
113_T147_N1.0031.00
123_F155_M0.9891.00
132_I136_S0.9881.00
56_F75_I0.9851.00
101_F139_Y0.9791.00
94_K102_H0.9781.00
240_Q245_T0.9761.00
16_A125_K0.9681.00
69_K73_E0.9641.00
249_L253_L0.9631.00
240_Q248_K0.9501.00
9_N215_H0.9461.00
161_E164_G0.9411.00
10_L64_D0.9411.00
115_S149_A0.9391.00
69_K106_S0.9381.00
255_L258_L0.9361.00
160_L164_G0.9271.00
203_S207_P0.9171.00
211_I242_F0.9171.00
44_E243_E0.9121.00
128_S132_I0.9091.00
263_F267_L0.9041.00
53_V83_T0.9001.00
42_V78_Y0.8961.00
82_I109_V0.8931.00
235_R245_T0.8931.00
130_K166_S0.8881.00
259_R262_G0.8871.00
130_K162_E0.8841.00
246_V255_L0.8801.00
8_I41_L0.8761.00
31_T216_D0.8761.00
11_D64_D0.8711.00
261_E270_L0.8691.00
250_N253_L0.8591.00
279_F282_P0.8591.00
137_R168_L0.8571.00
84_L112_L0.8551.00
157_N161_E0.8541.00
203_S209_Y0.8471.00
9_N57_T0.8391.00
40_E43_T0.8361.00
118_E155_M0.8301.00
105_N142_I0.8271.00
119_Y122_P0.8161.00
31_T215_H0.8151.00
33_M41_L0.8131.00
65_Y100_Y0.8041.00
10_L71_L0.8031.00
285_F289_C0.8011.00
70_E74_I0.7991.00
75_I78_Y0.7961.00
151_T154_K0.7951.00
35_K64_D0.7901.00
137_R144_I0.7891.00
112_L142_I0.7851.00
57_T223_C0.7841.00
53_V81_Q0.7821.00
116_Y126_S0.7801.00
132_I135_H0.7781.00
101_F132_I0.7781.00
57_T85_I0.7771.00
258_L264_K0.7741.00
121_A127_S0.7731.00
35_K71_L0.7721.00
183_A186_R0.7711.00
254_L258_L0.7681.00
146_L172_I0.7681.00
69_K72_M0.7671.00
177_M183_A0.7651.00
254_L257_I0.7631.00
116_Y129_I0.7631.00
267_L273_N0.7611.00
87_N90_W0.7611.00
242_F246_V0.7591.00
15_N63_L0.7571.00
235_R240_Q0.7551.00
44_E47_K0.7541.00
211_I246_V0.7521.00
9_N212_V0.7491.00
249_L252_N0.7451.00
261_E266_F0.7421.00
119_Y155_M0.7421.00
105_N141_D0.7401.00
101_F136_S0.7391.00
85_I147_N0.7381.00
101_F105_N0.7381.00
7_S210_D0.7371.00
71_L75_I0.7351.00
137_R170_V0.7341.00
39_R78_Y0.7331.00
273_N276_I0.7331.00
10_L68_L0.7321.00
175_F178_I0.7301.00
267_L271_K0.7301.00
133_L144_I0.7271.00
253_L256_F0.7271.00
69_K107_L0.7251.00
278_E289_C0.7241.00
124_V129_I0.7231.00
122_P153_D0.7191.00
259_R263_F0.7191.00
60_E63_L0.7181.00
46_A80_K0.7181.00
136_S142_I0.7171.00
143_D170_V0.7141.00
162_E165_D0.7120.99
125_K129_I0.7110.99
219_I242_F0.7090.99
60_E86_S0.7080.99
111_A145_S0.7050.99
14_C21_C0.7020.99
288_I292_C0.6980.99
18_C21_C0.6970.99
43_T47_K0.6960.99
65_Y69_K0.6940.99
11_D59_G0.6940.99
133_L146_L0.6920.99
55_S85_I0.6920.99
155_M159_I0.6900.99
205_H209_Y0.6880.99
116_Y130_K0.6850.99
72_M103_D0.6850.99
264_K273_N0.6830.99
262_G267_L0.6820.99
14_C18_C0.6810.99
260_K263_F0.6780.99
35_K74_I0.6750.99
230_T233_T0.6740.99
55_S83_T0.6720.99
166_S169_G0.6710.99
118_E122_P0.6690.99
102_H105_N0.6680.99
37_Y41_L0.6660.99
136_S144_I0.6630.99
204_L207_P0.6580.99
89_F132_I0.6580.99
6_V213_Y0.6580.99
54_I82_I0.6580.99
13_R30_T0.6560.99
206_C222_C0.6520.99
253_L257_I0.6520.99
181_G184_K0.6510.99
38_I64_D0.6500.99
265_W268_N0.6490.99
42_V54_I0.6470.99
62_F100_Y0.6470.99
76_K108_N0.6460.99
42_V80_K0.6460.99
68_L84_L0.6450.99
248_K252_N0.6450.99
113_T145_S0.6440.99
119_Y162_E0.6430.99
39_R77_P0.6410.99
139_Y142_I0.6380.99
282_P287_S0.6380.99
62_F132_I0.6360.99
159_I163_L0.6360.99
286_S289_C0.6330.99
64_D70_E0.6310.99
9_N23_F0.6300.99
91_G132_I0.6290.99
217_G237_E0.6240.99
64_D68_L0.6240.99
36_E39_R0.6140.99
288_I291_V0.6130.99
16_A117_D0.6130.99
221_P232_I0.6120.98
250_N254_L0.6110.98
133_L169_G0.6100.98
127_S130_K0.6090.98
51_I80_K0.6050.98
275_K278_E0.6050.98
284_E287_S0.6020.98
213_Y219_I0.6020.98
86_S114_I0.6010.98
36_E40_E0.6010.98
94_K103_D0.5980.98
9_N214_H0.5970.98
287_S290_G0.5950.98
23_F57_T0.5930.98
221_P234_L0.5900.98
282_P285_F0.5860.98
85_I224_S0.5860.98
91_G104_M0.5850.98
213_Y237_E0.5830.98
85_I223_C0.5800.98
150_V174_K0.5750.98
281_I285_F0.5730.98
60_E88_G0.5720.98
217_G236_E0.5710.98
9_N12_S0.5700.98
20_H23_F0.5690.98
246_V249_L0.5690.98
89_F128_S0.5660.98
233_T236_E0.5660.98
278_E282_P0.5630.97
212_V223_C0.5600.97
221_P225_P0.5600.97
246_V250_N0.5590.97
7_S223_C0.5570.97
58_G212_V0.5570.97
238_Y241_S0.5560.97
58_G61_V0.5550.97
251_S254_L0.5540.97
91_G114_I0.5530.97
241_S245_T0.5530.97
38_I42_V0.5520.97
122_P155_M0.5510.97
156_S160_L0.5510.97
25_S182_A0.5510.97
10_L38_I0.5500.97
56_F71_L0.5490.97
83_T111_A0.5490.97
117_D148_M0.5480.97
117_D149_A0.5450.97
84_L109_V0.5450.97
20_H57_T0.5440.97
35_K38_I0.5430.97
263_F266_F0.5420.97
42_V56_F0.5390.97
44_E238_Y0.5380.97
42_V74_I0.5370.97
17_S24_S0.5360.97
44_E48_N0.5320.96
23_F212_V0.5320.96
46_A79_E0.5310.96
180_V183_A0.5310.96
38_I41_L0.5310.96
38_I56_F0.5300.96
57_T113_T0.5290.96
45_F51_I0.5290.96
285_F288_I0.5270.96
123_F151_T0.5260.96
54_I80_K0.5260.96
47_K243_E0.5260.96
132_I137_R0.5250.96
72_M82_I0.5240.96
137_R169_G0.5240.96
266_F270_L0.5240.96
221_P224_S0.5230.96
41_L237_E0.5220.96
147_N175_F0.5210.96
75_I80_K0.5190.96
248_K251_S0.5180.96
72_M75_I0.5160.96
114_I129_I0.5120.96
56_F72_M0.5120.96
203_S208_G0.5090.95
73_E76_K0.5090.95
206_C209_Y0.5070.95
90_W132_I0.5050.95
234_L251_S0.5050.95
91_G136_S0.5040.95
66_K71_L0.5040.95
253_L258_L0.5030.95
41_L45_F0.5020.95
8_I33_M0.5020.95
85_I117_D0.5010.95
174_K177_M0.5010.95
57_T147_N0.5010.95
52_Q81_Q0.5000.95
147_N223_C0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9498 100 0.368 Contact Map
4m7tA 1 0.7241 100 0.44 Contact Map
1tv8A 2 0.7774 100 0.517 Contact Map
4rtbA 2 0.8621 99.9 0.597 Contact Map
3c8fA 1 0.6301 99.9 0.604 Contact Map
4wcxA 1 0.9467 99.9 0.639 Contact Map
2a5hA 4 0.8809 99.9 0.64 Contact Map
2yx0A 1 0.6991 99.9 0.643 Contact Map
2z2uA 1 0.6238 99.9 0.654 Contact Map
3rfaA 1 0.6646 99.9 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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