GREMLIN Database
YYDH - Putative peptide zinc metalloprotease protein YydH
UniProt: Q45594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (208)
Sequences: 596 (502)
Seq/√Len: 34.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_F112_Y9.0931.00
39_D115_K4.2391.00
53_S113_S4.2051.00
109_G161_I3.8701.00
156_L208_I3.7631.00
41_Q45_F3.2371.00
43_L115_K2.8981.00
142_E145_M2.4631.00
117_F153_I2.4261.00
113_S153_I2.3901.00
72_Y170_E2.3270.99
105_L161_I2.2640.99
148_R214_S2.2480.99
108_L124_V2.2070.99
114_L119_K2.2040.99
108_L112_Y2.1630.99
144_Y211_A2.1320.99
153_I160_F2.1230.99
172_I176_T2.1090.99
64_T164_L2.1020.99
48_Y51_K2.0340.98
156_L159_L1.9780.98
117_F150_E1.9470.98
38_S42_L1.9410.98
35_N137_Y1.9140.98
162_N202_N1.8940.97
57_F61_L1.8560.97
41_Q112_Y1.8230.97
32_N128_L1.7330.96
119_K142_E1.7250.96
143_T154_V1.7190.95
162_N207_K1.6610.94
199_P205_G1.6590.94
42_L111_I1.6580.94
152_I212_F1.6490.94
42_L124_V1.6160.94
134_P205_G1.6080.93
72_Y83_S1.6040.93
124_V138_V1.5830.93
109_G122_D1.5790.93
46_K49_K1.5700.93
75_L78_L1.5570.92
137_Y205_G1.5470.92
119_K146_L1.5290.92
92_W96_V1.5240.91
42_L121_F1.5230.91
49_K112_Y1.4890.90
159_L165_L1.4620.90
146_L154_V1.4540.89
60_F128_L1.4400.89
141_N145_M1.4390.89
162_N198_I1.4210.88
73_I156_L1.4110.88
172_I175_F1.3890.87
146_L150_E1.3500.85
67_M171_L1.3360.85
111_I138_V1.3350.85
114_L146_L1.3210.84
197_L219_S1.3200.84
32_N101_M1.2960.83
114_L154_V1.2920.83
61_L168_T1.2480.81
155_H211_A1.2450.80
198_I211_A1.2270.79
158_G204_D1.2150.79
106_H204_D1.1930.77
159_L192_T1.1710.76
106_H158_G1.1670.76
138_V196_N1.1350.74
110_H204_D1.1350.74
107_E204_D1.1290.73
123_K137_Y1.1240.73
129_N134_P1.1240.73
110_H158_G1.1080.72
107_E158_G1.1030.72
103_I166_I1.1010.72
207_K211_A1.0990.71
66_L94_I1.0930.71
60_F168_T1.0910.71
106_H110_H1.0870.71
37_L80_N1.0700.69
188_L193_L1.0690.69
150_E153_I1.0620.69
58_Y160_F1.0580.68
82_L86_F1.0480.68
169_L173_N1.0470.68
53_S211_A1.0410.67
190_S207_K1.0380.67
66_L93_I1.0340.67
68_F171_L1.0290.66
92_W205_G1.0260.66
78_L172_I1.0200.66
107_E110_H1.0200.66
61_L64_T1.0190.65
113_S160_F1.0170.65
59_L92_W1.0130.65
38_S135_A0.9700.62
72_Y79_Q0.9690.62
42_L112_Y0.9630.61
213_L216_D0.9560.60
39_D43_L0.9540.60
103_I162_N0.9530.60
68_F174_Q0.9520.60
140_L144_Y0.9440.59
60_F63_F0.9420.59
49_K53_S0.9390.59
144_Y162_N0.9370.59
46_K222_K0.9340.59
162_N217_E0.9300.58
60_F98_Y0.9080.56
68_F167_N0.9050.56
56_F59_L0.9040.56
137_Y199_P0.8970.56
99_F136_F0.8900.55
182_L228_V0.8850.55
228_V232_Q0.8850.55
58_Y150_E0.8840.54
145_M214_S0.8770.54
81_G84_S0.8740.54
129_N201_L0.8730.54
85_V194_L0.8710.53
111_I139_Q0.8710.53
61_L164_L0.8700.53
94_I180_E0.8660.53
219_S223_T0.8630.53
165_L169_L0.8550.52
129_N135_A0.8520.52
123_K139_Q0.8510.52
62_S150_E0.8480.51
24_K28_E0.8460.51
151_K211_A0.8370.50
32_N104_V0.8350.50
197_L205_G0.8290.50
32_N148_R0.8230.49
103_I211_A0.8210.49
147_S192_T0.8180.49
144_Y213_L0.8160.49
127_K135_A0.8150.49
154_V196_N0.8140.48
103_I173_N0.8090.48
86_F200_I0.8070.48
172_I181_A0.8030.48
157_F161_I0.8020.47
68_F139_Q0.8010.47
120_N142_E0.7920.47
51_K57_F0.7920.47
191_S214_S0.7810.46
159_L208_I0.7800.46
129_N155_H0.7780.45
67_M70_L0.7780.45
123_K148_R0.7770.45
120_N186_F0.7730.45
198_I219_S0.7730.45
135_A182_L0.7710.45
85_V227_L0.7670.44
117_F146_L0.7640.44
134_P216_D0.7560.44
138_V203_S0.7560.44
86_F186_F0.7550.43
53_S191_S0.7540.43
40_K43_L0.7540.43
137_Y203_S0.7530.43
60_F93_I0.7500.43
157_F222_K0.7470.43
141_N198_I0.7440.43
100_I132_V0.7430.42
141_N219_S0.7410.42
44_R112_Y0.7400.42
229_L232_Q0.7370.42
119_K154_V0.7360.42
228_V231_I0.7280.41
60_F65_A0.7250.41
60_F64_T0.7230.41
122_D228_V0.7230.41
138_V200_I0.7220.41
131_Y135_A0.7220.41
128_L134_P0.7210.41
162_N222_K0.7200.41
102_N197_L0.7190.40
137_Y196_N0.7140.40
202_N207_K0.7110.40
91_M138_V0.7100.40
39_D52_V0.7060.39
196_N203_S0.7060.39
58_Y66_L0.7040.39
108_L184_M0.7040.39
129_N203_S0.7030.39
101_M153_I0.7020.39
134_P221_F0.7000.39
184_M201_L0.7000.39
122_D207_K0.6990.39
202_N217_E0.6980.39
207_K210_L0.6960.39
126_F201_L0.6950.38
63_F77_K0.6910.38
182_L195_W0.6900.38
111_I145_M0.6890.38
134_P211_A0.6880.38
92_W186_F0.6840.38
59_L67_M0.6840.38
211_A216_D0.6820.37
33_S51_K0.6790.37
109_G145_M0.6770.37
62_S70_L0.6680.36
223_T227_L0.6640.36
165_L205_G0.6640.36
53_S116_F0.6620.36
162_N211_A0.6590.36
65_A70_L0.6570.35
225_H229_L0.6560.35
62_S101_M0.6510.35
37_L124_V0.6510.35
109_G112_Y0.6510.35
55_K73_I0.6490.35
162_N192_T0.6480.35
69_I73_I0.6470.35
114_L135_A0.6460.35
45_F55_K0.6440.34
79_Q185_A0.6430.34
59_L63_F0.6400.34
37_L59_L0.6380.34
48_Y112_Y0.6370.34
110_H206_Y0.6370.34
132_V182_L0.6370.34
76_I80_N0.6320.34
63_F147_S0.6270.33
196_N205_G0.6260.33
39_D119_K0.6250.33
139_Q151_K0.6230.33
80_N84_S0.6170.32
200_I214_S0.6160.32
102_N165_L0.6050.32
66_L220_R0.6040.31
29_Y202_N0.6030.31
77_K170_E0.6030.31
137_Y212_F0.5970.31
43_L49_K0.5970.31
37_L40_K0.5950.31
116_F153_I0.5950.31
182_L187_M0.5930.31
144_Y219_S0.5930.31
144_Y189_F0.5920.31
63_F227_L0.5900.30
149_N176_T0.5900.30
33_S136_F0.5890.30
128_L196_N0.5840.30
94_I172_I0.5820.30
109_G113_S0.5810.30
104_V176_T0.5800.30
37_L67_M0.5740.29
131_Y211_A0.5730.29
24_K29_Y0.5730.29
137_Y173_N0.5720.29
60_F174_Q0.5710.29
160_F212_F0.5710.29
52_V208_I0.5690.29
55_K149_N0.5690.29
143_T211_A0.5680.29
83_S104_V0.5650.29
173_N200_I0.5630.28
175_F195_W0.5620.28
100_I136_F0.5610.28
82_L182_L0.5590.28
183_T188_L0.5580.28
112_Y222_K0.5570.28
94_I229_L0.5570.28
113_S154_V0.5560.28
60_F96_V0.5560.28
62_S187_M0.5560.28
52_V69_I0.5530.28
100_I141_N0.5520.28
162_N201_L0.5520.28
89_W104_V0.5500.28
162_N189_F0.5500.28
62_S66_L0.5490.28
60_F194_L0.5480.27
109_G185_A0.5480.27
192_T196_N0.5460.27
60_F66_L0.5450.27
192_T202_N0.5440.27
63_F174_Q0.5440.27
215_L221_F0.5440.27
129_N198_I0.5440.27
29_Y128_L0.5400.27
57_F141_N0.5390.27
195_W198_I0.5380.27
209_L213_L0.5370.27
192_T195_W0.5360.27
210_L217_E0.5340.27
46_K105_L0.5340.27
190_S194_L0.5310.26
39_D122_D0.5310.26
93_I172_I0.5300.26
49_K160_F0.5290.26
105_L113_S0.5260.26
123_K225_H0.5250.26
51_K55_K0.5240.26
155_H214_S0.5240.26
152_I155_H0.5220.26
203_S211_A0.5190.26
138_V221_F0.5180.25
52_V56_F0.5180.25
76_I108_L0.5170.25
39_D44_R0.5150.25
108_L210_L0.5140.25
128_L213_L0.5130.25
50_E116_F0.5120.25
30_Y203_S0.5070.25
143_T207_K0.5050.25
125_G199_P0.5040.25
139_Q222_K0.5040.25
51_K93_I0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b4rA 2 0.75 99.7 0.721 Contact Map
2di4A 3 0.4722 10.2 0.959 Contact Map
3ilwA 2 0.2381 5.9 0.964 Contact Map
1vx7U 1 0.2302 3.7 0.967 Contact Map
3j39S 1 0.2341 3.6 0.967 Contact Map
4a18X 1 0.2381 3.2 0.968 Contact Map
2inrA 2 0.2421 2.7 0.969 Contact Map
3hsqA 3 0.2381 2.7 0.969 Contact Map
2xf7A 3 0.0913 2.7 0.969 Contact Map
3kvpA 3 0.119 2.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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