GREMLIN Database
YBBP - Uncharacterized protein YbbP
UniProt: Q45589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (249)
Sequences: 1522 (1074)
Seq/√Len: 68.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_A220_I7.3531.00
159_L174_V5.4741.00
151_N180_E5.1991.00
210_I218_T4.3861.00
183_A186_C3.8481.00
135_E177_K3.7881.00
121_N228_V3.5851.00
143_Y175_I3.5471.00
133_T210_I3.0281.00
23_Y27_K2.9851.00
112_T154_V2.8961.00
116_I134_I2.8791.00
128_I165_P2.8741.00
211_S218_T2.7581.00
241_T244_A2.7331.00
27_K30_M2.7151.00
191_S196_I2.7101.00
75_L79_I2.7001.00
161_N167_T2.6431.00
231_A236_L2.5921.00
11_Y14_N2.5231.00
114_E246_K2.4741.00
173_A188_L2.4671.00
134_I219_I2.3311.00
17_D21_V2.1141.00
190_L202_T2.1031.00
200_L238_R2.0561.00
122_Y160_I2.0371.00
237_H248_M1.9391.00
152_A158_L1.9221.00
120_I219_I1.9041.00
133_T188_L1.8691.00
119_A123_M1.8691.00
177_K182_A1.8581.00
124_A225_T1.8231.00
191_S208_V1.7381.00
196_I208_V1.7111.00
54_S63_Q1.6941.00
232_K252_E1.6931.00
219_I245_L1.6540.99
133_T218_T1.6020.99
117_T245_L1.6010.99
75_L78_I1.5990.99
199_E238_R1.5970.99
40_L85_L1.5910.99
20_L62_L1.5700.99
120_I132_L1.5310.99
164_I167_T1.5100.99
120_I124_A1.4850.99
153_K180_E1.4730.99
130_A221_V1.4680.99
71_T75_L1.4640.99
10_Q15_A1.4500.98
230_V248_M1.4410.98
118_K156_S1.4070.98
120_I228_V1.4030.98
248_M251_A1.3750.98
128_I164_I1.3730.98
10_Q14_N1.3460.97
120_I245_L1.3400.97
187_Y202_T1.3360.97
110_Q250_E1.3270.97
132_L176_M1.3260.97
24_V62_L1.3210.97
161_N166_N1.2920.97
43_G93_G1.2860.97
117_T246_K1.2740.96
113_I250_E1.2480.96
117_T242_E1.2250.96
143_Y213_V1.2190.95
13_G59_L1.2180.95
121_N242_E1.2130.95
148_I157_E1.2010.95
218_T231_A1.1980.95
220_I231_A1.1890.95
143_Y214_T1.1860.95
160_I164_I1.1810.95
136_R217_L1.1770.94
113_I253_F1.1730.94
211_S234_G1.1530.94
227_G239_E1.1390.93
36_K90_E1.1250.93
174_V184_A1.1140.93
154_V176_M1.1080.92
57_L119_A1.1040.92
116_I219_I1.1010.92
40_L90_E1.0990.92
42_K90_E1.0960.92
244_A247_E1.0950.92
208_V236_L1.0890.92
72_W75_L1.0880.92
12_L16_V1.0840.92
39_Q42_K1.0800.92
39_Q138_T1.0730.91
16_V57_L1.0630.91
178_N230_V1.0620.91
115_A118_K1.0560.91
118_K157_E1.0540.90
29_I72_W1.0460.90
85_L95_G1.0440.90
134_I253_F1.0360.90
161_N164_I1.0350.90
119_A160_I1.0280.89
115_A156_S1.0250.89
69_A74_F1.0250.89
27_K71_T1.0220.89
148_I198_K1.0200.89
152_A181_I1.0150.89
50_V53_A1.0070.88
148_I185_A1.0030.88
66_M104_P1.0020.88
35_T43_G1.0010.88
187_Y218_T1.0000.88
52_M55_Q0.9990.88
120_I123_M0.9960.88
36_K43_G0.9830.87
217_L252_E0.9780.87
72_W84_E0.9780.87
217_L232_K0.9760.87
143_Y157_E0.9750.87
191_S212_E0.9730.87
149_P182_A0.9710.86
78_I85_L0.9680.86
11_Y58_G0.9620.86
246_K250_E0.9390.85
90_E94_R0.9390.85
113_I249_L0.9360.84
122_Y128_I0.9340.84
161_N168_P0.9320.84
31_V37_A0.9090.83
47_I127_R0.9070.82
210_I216_S0.9040.82
14_N73_G0.8930.81
122_Y126_R0.8890.81
144_I182_A0.8860.81
69_A72_W0.8860.81
14_N22_W0.8770.80
208_V211_S0.8740.80
188_L202_T0.8730.80
61_T64_W0.8720.80
46_V62_L0.8690.80
174_V181_I0.8680.80
116_I120_I0.8650.79
22_W72_W0.8640.79
111_K115_A0.8620.79
54_S91_Q0.8530.78
41_L45_V0.8520.78
13_G16_V0.8480.78
83_P90_E0.8480.78
24_V97_F0.8470.78
134_I176_M0.8470.78
133_T173_A0.8430.78
34_G139_G0.8430.78
90_E142_D0.8420.78
81_F89_L0.8220.76
125_K191_S0.8210.76
21_V73_G0.8180.75
112_T179_N0.8180.75
250_E254_K0.8120.75
179_N210_I0.8090.75
39_Q139_G0.8080.75
25_I29_I0.8080.75
200_L236_L0.8070.74
13_G58_G0.8040.74
50_V66_M0.8030.74
85_L184_A0.8020.74
50_V62_L0.8010.74
150_L180_E0.7990.74
81_F189_P0.7970.74
136_R253_F0.7840.72
76_A85_L0.7830.72
18_I162_I0.7790.72
73_G78_I0.7760.72
132_L219_I0.7760.72
230_V245_L0.7750.71
169_L184_A0.7720.71
139_G145_E0.7620.70
20_L157_E0.7570.70
55_Q63_Q0.7550.69
121_N240_L0.7550.69
28_L191_S0.7510.69
31_V39_Q0.7460.69
68_Q78_I0.7460.69
45_V49_L0.7420.68
42_K83_P0.7420.68
61_T165_P0.7410.68
118_K242_E0.7350.67
136_R232_K0.7310.67
20_L27_K0.7280.67
128_I160_I0.7230.66
51_R73_G0.7150.65
18_I134_I0.7150.65
126_R160_I0.7130.65
200_L225_T0.7130.65
29_I218_T0.7120.65
146_T186_C0.7100.65
140_M183_A0.7100.65
25_I247_E0.7070.64
244_A248_M0.7050.64
219_I249_L0.7020.64
89_L128_I0.7020.64
79_I141_G0.7020.64
88_A202_T0.6990.64
76_A225_T0.6980.63
44_I79_I0.6980.63
237_H244_A0.6900.63
51_R63_Q0.6900.63
54_S185_A0.6860.62
116_I124_A0.6860.62
112_T116_I0.6850.62
47_I77_I0.6850.62
14_N59_L0.6830.62
87_R188_L0.6810.62
240_L244_A0.6810.62
132_L174_V0.6790.61
162_I174_V0.6710.60
127_R166_N0.6700.60
90_E161_N0.6700.60
105_V256_N0.6690.60
12_L52_M0.6660.60
80_I92_L0.6660.60
40_L87_R0.6650.60
32_I212_E0.6650.60
37_A82_Q0.6650.60
28_L58_G0.6630.59
186_C199_E0.6620.59
76_A84_E0.6610.59
36_K94_R0.6590.59
104_P120_I0.6590.59
148_I167_T0.6580.59
51_R70_I0.6580.59
149_P153_K0.6550.59
227_G238_R0.6550.59
45_V63_Q0.6540.58
35_T84_E0.6500.58
115_A119_A0.6480.58
106_E235_D0.6480.58
147_G186_C0.6430.57
11_Y19_L0.6430.57
34_G37_A0.6430.57
141_G145_E0.6360.56
169_L183_A0.6360.56
29_I210_I0.6350.56
135_E200_L0.6340.56
144_I175_I0.6330.56
59_L165_P0.6320.56
21_V62_L0.6300.56
38_V48_V0.6270.55
48_V55_Q0.6270.55
36_K138_T0.6260.55
21_V25_I0.6230.55
37_A78_I0.6220.55
91_Q95_G0.6220.55
35_T64_W0.6210.55
68_Q71_T0.6170.54
193_S212_E0.6170.54
116_I132_L0.6160.54
119_A208_V0.6160.54
109_Q154_V0.6150.54
70_I77_I0.6150.54
21_V26_Y0.6140.54
150_L184_A0.6130.54
117_T132_L0.6120.53
56_Y60_S0.6110.53
167_T185_A0.6100.53
183_A188_L0.6100.53
131_L193_S0.6080.53
84_E189_P0.6080.53
89_L135_E0.6080.53
14_N18_I0.6040.52
41_L80_I0.6010.52
42_K84_E0.5970.52
233_N240_L0.5970.52
16_V45_V0.5950.51
136_R252_E0.5930.51
17_D62_L0.5930.51
24_V65_L0.5930.51
116_I255_K0.5910.51
119_A150_L0.5910.51
82_Q92_L0.5880.51
139_G214_T0.5860.50
123_M165_P0.5860.50
127_R140_M0.5850.50
17_D31_V0.5850.50
237_H240_L0.5840.50
213_V218_T0.5830.50
29_I61_T0.5800.50
161_N199_E0.5800.50
82_Q87_R0.5800.50
25_I193_S0.5730.49
29_I80_I0.5720.49
103_T106_E0.5710.49
150_L169_L0.5700.48
49_L152_A0.5690.48
56_Y67_D0.5690.48
65_L72_W0.5680.48
124_A239_E0.5660.48
77_I80_I0.5660.48
158_L184_A0.5650.48
219_I230_V0.5640.48
89_L93_G0.5640.48
146_T187_Y0.5620.47
51_R78_I0.5610.47
83_P86_R0.5600.47
43_G81_F0.5600.47
32_I37_A0.5590.47
43_G89_L0.5590.47
184_A210_I0.5580.47
228_V245_L0.5570.47
89_L130_A0.5550.47
127_R161_N0.5520.46
126_R165_P0.5520.46
219_I228_V0.5510.46
146_T225_T0.5510.46
216_S231_A0.5490.46
169_L205_R0.5490.46
151_N182_A0.5480.46
11_Y53_A0.5470.46
45_V216_S0.5470.46
197_S238_R0.5470.46
85_L192_E0.5460.46
116_I241_T0.5450.45
123_M148_I0.5430.45
81_F93_G0.5400.45
22_W61_T0.5390.45
147_G183_A0.5380.45
40_L69_A0.5370.45
227_G240_L0.5320.44
22_W133_T0.5320.44
87_R145_E0.5310.44
55_Q152_A0.5290.44
124_A147_G0.5290.44
241_T257_T0.5280.43
15_A235_D0.5280.43
66_M217_L0.5270.43
248_M252_E0.5260.43
69_A137_D0.5260.43
31_V38_V0.5250.43
140_M214_T0.5250.43
144_I211_S0.5250.43
154_V255_K0.5240.43
88_A190_L0.5230.43
28_L137_D0.5210.43
241_T256_N0.5210.43
116_I176_M0.5190.42
157_E165_P0.5190.42
148_I160_I0.5190.42
24_V96_R0.5190.42
88_A197_S0.5180.42
34_G68_Q0.5180.42
66_M74_F0.5160.42
69_A76_A0.5140.42
145_E156_S0.5140.42
176_M181_I0.5120.42
55_Q58_G0.5110.41
85_L96_R0.5110.41
63_Q66_M0.5110.41
73_G214_T0.5100.41
103_T258_R0.5090.41
46_V49_L0.5090.41
229_S237_H0.5080.41
107_E178_N0.5070.41
123_M149_P0.5070.41
12_L258_R0.5060.41
117_T120_I0.5050.41
71_T139_G0.5050.41
148_I187_Y0.5040.41
32_I35_T0.5040.41
143_Y210_I0.5030.41
69_A73_G0.5020.40
97_F236_L0.5020.40
62_L178_N0.5020.40
166_N193_S0.5020.40
184_A205_R0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rv7A 1 0.5897 100 0.392 Contact Map
2fb5A 3 0.6813 100 0.473 Contact Map
3c1yA 5 0.6154 100 0.531 Contact Map
3k6eA 2 0.5641 24.6 0.968 Contact Map
1yavA 2 0.5018 22.6 0.969 Contact Map
3hzqA 3 0.1429 12.1 0.972 Contact Map
4mewA 1 0.4615 9.3 0.974 Contact Map
4xnvA 1 0.3223 8.7 0.974 Contact Map
2emqA 2 0.4982 8.5 0.974 Contact Map
1vz0A 3 0.4396 7.4 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0086 seconds.