GREMLIN Database
RSIW - Anti-sigma-W factor RsiW
UniProt: Q45588 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (198)
Sequences: 184 (148)
Seq/√Len: 10.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_M23_D3.9050.99
62_D66_N3.3690.97
141_V148_L2.9830.94
138_K155_D2.7090.90
18_D177_I2.4720.85
159_T163_G2.4490.84
63_F67_V2.3980.83
18_D77_R2.3650.82
22_K150_I2.2730.79
9_Q189_Y2.2620.79
10_L23_D2.2270.78
142_T157_D2.1940.77
46_K52_R2.1750.76
148_L154_I2.1670.76
45_E54_T2.1410.75
114_F148_L2.1360.75
137_V140_D2.0320.71
36_K109_H1.9820.69
74_E82_R1.9610.68
10_L13_M1.9520.67
57_V181_N1.9320.67
6_Q111_D1.9120.66
11_M41_F1.9040.65
43_E59_A1.8520.63
114_F159_T1.8440.63
7_I11_M1.8160.62
150_I165_K1.7860.60
117_S143_V1.7550.59
147_K164_E1.6930.56
23_D80_V1.6800.55
113_N142_T1.6590.54
28_N98_I1.6510.54
48_I51_V1.6440.54
18_D187_T1.6260.53
114_F181_N1.5600.50
108_W186_W1.5400.49
24_E137_V1.5260.48
48_I60_P1.5200.48
42_Y191_M1.5140.48
128_T149_I1.4970.47
46_K127_H1.4930.47
52_R56_H1.4780.46
12_H161_V1.4750.46
63_F99_L1.4580.45
118_K184_F1.4390.44
11_M145_N1.4290.44
39_K180_I1.4170.43
136_T153_K1.4170.43
18_D184_F1.4140.43
118_K122_L1.4090.43
94_A126_N1.3910.42
153_K172_Q1.3800.41
183_L190_K1.3600.40
1_M117_S1.3410.40
111_D150_I1.3380.39
24_E28_N1.3370.39
160_V163_G1.3370.39
49_A177_I1.3050.38
33_T106_N1.2840.37
62_D65_A1.2780.37
1_M116_V1.2770.37
115_S124_V1.2750.37
52_R57_V1.2570.36
12_H15_L1.2310.35
9_Q116_V1.2190.34
173_V184_F1.2150.34
123_V150_I1.2110.34
17_G193_S1.2100.34
64_T108_W1.2010.33
164_E170_A1.1960.33
95_V191_M1.1860.33
67_V192_K1.1830.33
22_K161_V1.1830.33
61_A193_S1.1810.33
52_R176_Q1.1780.32
86_T130_T1.1680.32
65_A69_A1.1650.32
23_D180_I1.1580.32
95_V99_L1.1540.31
70_K189_Y1.1490.31
164_E171_G1.1380.31
17_G122_L1.1340.31
7_I181_N1.1250.30
178_E194_A1.1210.30
46_K49_A1.1180.30
11_M113_N1.1170.30
19_I122_L1.1120.30
127_H157_D1.1070.30
25_H50_L1.0950.29
27_L128_T1.0880.29
60_P179_E1.0790.29
67_V173_V1.0770.28
119_Q123_V1.0720.28
170_A173_V1.0640.28
134_G179_E1.0600.28
97_I127_H1.0560.28
38_R91_A1.0470.27
7_I130_T1.0420.27
20_L191_M1.0400.27
38_R176_Q1.0320.27
115_S160_V1.0310.27
87_H186_W1.0300.27
114_F182_Q1.0290.27
17_G142_T1.0180.26
74_E78_A1.0150.26
94_A105_F1.0140.26
180_I187_T1.0090.26
140_D182_Q1.0030.26
140_D195_G1.0030.26
41_F47_S0.9830.25
22_K100_M0.9800.25
133_E197_S0.9710.25
26_V29_E0.9710.25
176_Q182_Q0.9690.24
135_E166_Y0.9670.24
94_A137_V0.9540.24
104_F109_H0.9380.23
82_R174_T0.9380.23
150_I164_E0.9370.23
52_R142_T0.9280.23
116_V181_N0.9260.23
85_R153_K0.9240.23
126_N190_K0.9210.23
30_H37_C0.9210.23
106_N127_H0.9170.23
131_V158_V0.9150.23
109_H178_E0.9140.23
100_M118_K0.9130.23
67_V99_L0.9110.23
94_A110_N0.9090.22
18_D197_S0.9030.22
12_H171_G0.9030.22
14_H176_Q0.9020.22
49_A103_G0.9020.22
34_C37_C0.8970.22
17_G141_V0.8970.22
4_P19_I0.8910.22
94_A145_N0.8880.22
62_D106_N0.8870.22
75_K136_T0.8830.22
95_V114_F0.8830.22
22_K59_A0.8810.22
53_S56_H0.8730.21
75_K97_I0.8710.21
30_H34_C0.8580.21
7_I124_V0.8540.21
42_Y185_D0.8500.21
63_F192_K0.8400.20
7_I141_V0.8340.20
39_K43_E0.8300.20
53_S85_R0.8300.20
125_H172_Q0.8270.20
29_E94_A0.8260.20
116_V124_V0.8250.20
20_L68_M0.8230.20
10_L20_L0.8190.20
63_F184_F0.8160.20
31_L189_Y0.8140.20
46_K55_S0.8100.19
77_R172_Q0.8010.19
55_S144_K0.8010.19
1_M108_W0.8000.19
21_P65_A0.7980.19
72_P88_P0.7930.19
116_V194_A0.7920.19
2_S181_N0.7910.19
22_K131_V0.7870.19
114_F122_L0.7830.19
90_I127_H0.7790.18
19_I163_G0.7790.18
167_M172_Q0.7770.18
84_F127_H0.7740.18
160_V194_A0.7680.18
52_R60_P0.7600.18
58_E61_A0.7590.18
65_A183_L0.7590.18
17_G94_A0.7590.18
83_W87_H0.7550.18
73_K112_H0.7530.18
76_K106_N0.7510.18
83_W168_A0.7510.18
12_H160_V0.7480.18
48_I57_V0.7470.18
65_A89_V0.7430.17
48_I199_L0.7410.17
74_E184_F0.7390.17
165_K174_T0.7380.17
28_N32_E0.7380.17
121_N135_E0.7370.17
75_K164_E0.7370.17
35_E102_G0.7360.17
17_G102_G0.7340.17
13_M97_I0.7300.17
58_E193_S0.7260.17
39_K98_I0.7160.17
25_H111_D0.7100.17
135_E177_I0.7060.17
18_D123_V0.7050.16
114_F174_T0.7010.16
4_P174_T0.6970.16
18_D145_N0.6950.16
168_A188_W0.6930.16
127_H153_K0.6900.16
94_A141_V0.6850.16
66_N89_V0.6850.16
104_F107_S0.6840.16
58_E120_P0.6820.16
136_T187_T0.6770.16
115_S179_E0.6680.16
148_L160_V0.6670.16
33_T98_I0.6660.15
2_S123_V0.6660.15
136_T182_Q0.6580.15
17_G135_E0.6540.15
107_S144_K0.6540.15
12_H30_H0.6520.15
6_Q42_Y0.6510.15
63_F178_E0.6450.15
31_L57_V0.6440.15
75_K198_V0.6430.15
79_S167_M0.6360.15
103_G107_S0.6360.15
3_C12_H0.6300.15
150_I170_A0.6280.15
33_T181_N0.6260.15
19_I23_D0.6200.14
22_K69_A0.6180.14
145_N192_K0.6170.14
63_F147_K0.6160.14
10_L187_T0.6130.14
4_P170_A0.6100.14
72_P188_W0.6090.14
52_R55_S0.6090.14
85_R176_Q0.6070.14
20_L144_K0.6060.14
47_S62_D0.6050.14
123_V159_T0.6050.14
84_F150_I0.6030.14
48_I52_R0.6030.14
44_M50_L0.6000.14
61_A90_I0.5990.14
26_V125_H0.5940.14
111_D119_Q0.5930.14
173_V177_I0.5900.14
126_N187_T0.5890.14
185_D194_A0.5870.14
9_Q107_S0.5860.14
51_V151_K0.5840.14
136_T155_D0.5760.13
64_T170_A0.5710.13
162_N180_I0.5700.13
104_F191_M0.5700.13
120_P125_H0.5700.13
185_D196_K0.5680.13
18_D147_K0.5650.13
162_N170_A0.5650.13
80_V174_T0.5640.13
106_N121_N0.5620.13
6_Q187_T0.5610.13
116_V160_V0.5610.13
50_L75_K0.5600.13
61_A197_S0.5590.13
60_P100_M0.5590.13
190_K198_V0.5540.13
70_K105_F0.5520.13
142_T193_S0.5510.13
18_D103_G0.5480.13
78_A133_E0.5470.13
119_Q157_D0.5430.13
11_M163_G0.5400.13
3_C16_D0.5400.13
38_R42_Y0.5390.13
84_F183_L0.5380.13
31_L97_I0.5380.13
164_E190_K0.5380.13
124_V141_V0.5340.13
63_F140_D0.5330.12
10_L117_S0.5320.12
133_E162_N0.5300.12
76_K87_H0.5290.12
68_M186_W0.5270.12
36_K161_V0.5250.12
15_L44_M0.5210.12
101_G178_E0.5210.12
50_L111_D0.5190.12
41_F60_P0.5190.12
79_S98_I0.5180.12
162_N190_K0.5180.12
50_L76_K0.5160.12
66_N199_L0.5100.12
91_A101_G0.5070.12
124_V166_Y0.5070.12
77_R136_T0.5060.12
43_E167_M0.5030.12
53_S100_M0.5020.12
61_A157_D0.5010.12
69_A187_T0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q1zB 1 0.774 99.4 0.852 Contact Map
3hugB 2 0.2788 99.2 0.865 Contact Map
4nqwB 1 0.3269 99.2 0.869 Contact Map
1or7C 1 0.3173 97.9 0.911 Contact Map
2zxeA 1 0.8413 93.1 0.943 Contact Map
3ixzA 1 0.8654 91.6 0.945 Contact Map
3b8cA 1 0.8173 83.5 0.952 Contact Map
1mhsA 2 0.9663 80.8 0.954 Contact Map
1dbgA 1 0.4375 65.4 0.959 Contact Map
3ar4A 1 0.7933 64.6 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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