GREMLIN Database
MURQ - N-acetylmuramic acid 6-phosphate etherase
UniProt: Q45582 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (290)
Sequences: 1859 (1245)
Seq/√Len: 73.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
253_S256_T4.1021.00
55_A166_I3.6021.00
159_R181_D3.5361.00
27_T57_D3.4631.00
34_I199_M3.2081.00
186_V208_I3.2081.00
39_M46_Q2.9821.00
70_I131_I2.7951.00
260_T275_L2.7891.00
62_S164_H2.7441.00
280_D283_Q2.5861.00
82_V110_F2.5471.00
42_A207_M2.4771.00
121_E156_R2.4501.00
92_Y199_M2.4361.00
72_T154_A2.3611.00
133_L139_V2.3281.00
62_S138_T2.3211.00
124_G154_A2.3171.00
157_Y160_K2.2651.00
39_M43_A2.2131.00
31_L56_V2.1811.00
58_C182_H2.1281.00
107_P111_L2.1201.00
56_V215_A2.1101.00
156_R179_D2.0871.00
25_A33_M2.0111.00
127_D150_Y2.0021.00
92_Y193_I1.9891.00
28_L53_K1.9791.00
155_L165_T1.9711.00
240_E254_Y1.9691.00
11_T172_E1.9501.00
59_A212_I1.9241.00
22_I218_V1.8691.00
22_I193_I1.8571.00
240_E244_S1.8411.00
63_F220_I1.7871.00
157_Y161_V1.7761.00
48_V51_D1.7521.00
155_L176_I1.7501.00
31_L49_L1.7351.00
58_C164_H1.6931.00
63_F98_Q1.6891.00
48_V184_I1.6791.00
27_T219_K1.6761.00
69_L99_V1.6671.00
30_I215_A1.6551.00
174_S177_S1.6471.00
141_A151_A1.6321.00
222_K230_D1.6270.99
273_V295_I1.6260.99
28_L32_K1.5980.99
125_A129_R1.5910.99
18_Q40_K1.5880.99
140_I212_I1.5850.99
177_S185_E1.5590.99
28_L49_L1.5440.99
64_Q292_N1.5430.99
267_H270_T1.5400.99
128_L157_Y1.5230.99
259_Y263_Q1.5130.99
65_N136_N1.5110.99
243_I258_R1.5030.99
48_V186_V1.4950.99
88_C94_V1.4940.99
188_V201_A1.4890.99
57_D219_K1.4780.99
52_I208_I1.4710.99
281_Q285_Q1.4650.99
133_L157_Y1.4430.99
26_N29_G1.4360.99
48_V52_I1.4240.99
21_E24_K1.4190.99
19_T33_M1.4190.99
216_V220_I1.4010.98
120_S123_A1.3930.98
126_E130_N1.3850.98
31_L53_K1.3760.98
60_Y219_K1.3720.98
265_D281_Q1.3710.98
252_A257_A1.3690.98
240_E243_I1.3600.98
274_M281_Q1.3590.98
63_F216_V1.3520.98
16_N19_T1.3350.98
123_A127_D1.3330.98
142_I168_L1.3300.98
129_R157_Y1.3210.98
19_T192_A1.3190.98
249_L272_I1.3040.98
80_L209_L1.2930.97
20_V225_E1.2860.97
88_C99_V1.2850.97
72_T124_G1.2770.97
167_A183_S1.2770.97
24_K296_D1.2730.97
72_T102_I1.2670.97
37_E40_K1.2600.97
164_H182_H1.2590.97
69_L140_I1.2580.97
167_A180_A1.2570.97
15_R225_E1.2560.97
159_R179_D1.2530.97
72_T139_V1.2480.97
258_R262_E1.2340.97
70_I100_I1.2190.96
97_D100_I1.2020.96
264_A274_M1.1850.96
126_E129_R1.1840.96
114_A117_I1.1690.95
170_C201_A1.1680.95
53_K57_D1.1660.95
36_N39_M1.1480.95
252_A275_L1.1250.94
246_I272_I1.1250.94
59_A216_V1.1210.94
227_L249_L1.1160.94
270_T281_Q1.1150.94
23_H296_D1.1140.94
125_A160_K1.1120.94
147_R175_A1.1030.94
72_T128_L1.0970.93
100_I131_I1.0960.93
96_P112_Q1.0940.93
170_C204_A1.0900.93
86_V110_F1.0860.93
167_A177_S1.0850.93
55_A212_I1.0700.93
287_L291_A1.0680.92
125_A153_G1.0670.92
52_I184_I1.0620.92
231_V245_I1.0500.92
55_A59_A1.0500.92
42_A45_V1.0480.92
277_T299_I1.0480.92
108_E114_A1.0430.92
35_N42_A1.0390.91
246_I261_L1.0340.91
81_G101_G1.0280.91
33_M192_A1.0260.91
60_Y215_A1.0240.91
133_L161_V1.0230.91
267_H285_Q1.0210.91
227_L248_S1.0200.91
262_E266_H1.0170.91
122_E126_E1.0140.90
30_I218_V1.0120.90
86_V89_P1.0110.90
31_L215_A1.0000.90
242_A268_V0.9960.90
55_A182_H0.9940.90
18_Q36_N0.9930.89
16_N37_E0.9860.89
11_T171_N0.9850.89
247_Q254_Y0.9830.89
133_L163_A0.9790.89
27_T30_I0.9610.88
86_V111_L0.9560.88
202_A205_H0.9550.88
167_A176_I0.9550.88
48_V208_I0.9540.88
94_V98_Q0.9500.87
233_V242_A0.9490.87
79_R115_E0.9470.87
124_G153_G0.9460.87
35_N38_D0.9400.87
43_A46_Q0.9330.86
127_D130_N0.9280.86
168_L208_I0.9230.86
28_L50_P0.9200.86
55_A184_I0.9160.85
32_K49_L0.9160.85
58_C62_S0.9140.85
250_T275_L0.9140.85
32_K36_N0.9130.85
11_T187_V0.9100.85
27_T31_L0.9090.85
60_Y216_V0.9090.85
143_A148_T0.9090.85
56_V212_I0.9070.85
175_A178_K0.9010.84
88_C230_D0.8950.84
15_R194_T0.8920.84
283_Q286_T0.8910.84
243_I254_Y0.8880.83
286_T290_E0.8880.83
49_L211_M0.8820.83
36_N46_Q0.8780.83
143_A234_S0.8730.82
164_H181_D0.8640.82
59_A138_T0.8620.82
108_E112_Q0.8550.81
21_E33_M0.8530.81
128_L133_L0.8530.81
169_T185_E0.8510.81
173_N178_K0.8510.81
140_I168_L0.8500.81
15_R248_S0.8440.80
270_T273_V0.8430.80
52_I211_M0.8400.80
80_L83_M0.8400.80
230_D267_H0.8380.80
22_I92_Y0.8370.80
277_T298_A0.8350.80
29_G32_K0.8350.80
54_T182_H0.8340.79
155_L180_A0.8340.79
169_T177_S0.8260.79
277_T284_A0.8240.79
103_M110_F0.8220.78
38_D207_M0.8200.78
294_F297_K0.8180.78
11_T188_V0.8140.78
34_I192_A0.8140.78
15_R227_L0.8100.77
21_E25_A0.8090.77
120_S126_E0.8070.77
252_A260_T0.8030.77
10_L147_R0.8000.77
15_R19_T0.7990.76
138_T166_I0.7960.76
254_Y257_A0.7890.76
25_A30_I0.7880.75
246_I252_A0.7880.75
283_Q287_L0.7880.75
31_L50_P0.7860.75
21_E296_D0.7860.75
15_R20_V0.7850.75
256_T259_Y0.7840.75
260_T263_Q0.7780.75
193_I199_M0.7770.74
59_A69_L0.7700.74
230_D269_K0.7690.74
166_I184_I0.7690.74
31_L211_M0.7660.73
93_S232_N0.7650.73
32_K46_Q0.7650.73
254_Y258_R0.7640.73
277_T287_L0.7580.73
35_N41_V0.7540.72
270_T279_T0.7520.72
285_Q289_D0.7520.72
166_I212_I0.7500.72
64_Q220_I0.7480.72
252_A256_T0.7480.72
227_L245_I0.7430.71
273_V298_A0.7390.71
236_K240_E0.7390.71
72_T151_A0.7340.70
124_G151_A0.7310.70
51_D54_T0.7300.70
264_A270_T0.7250.69
274_M284_A0.7240.69
265_D285_Q0.7230.69
102_I131_I0.7220.69
138_T164_H0.7210.69
188_V197_T0.7200.69
27_T215_A0.7150.68
63_F213_S0.7150.68
88_C216_V0.7140.68
270_T285_Q0.7140.68
98_Q220_I0.7130.68
164_H216_V0.7100.68
246_I266_H0.7100.68
19_T226_N0.7060.67
279_T287_L0.7030.67
282_K285_Q0.7000.67
158_A163_A0.6980.66
27_T53_K0.6960.66
175_A179_D0.6950.66
170_C205_H0.6930.66
22_I30_I0.6930.66
188_V204_A0.6920.66
273_V287_L0.6910.66
82_V86_V0.6910.66
34_I42_A0.6900.65
270_T284_A0.6880.65
273_V279_T0.6880.65
35_N49_L0.6860.65
156_R160_K0.6850.65
151_A176_I0.6840.65
62_S216_V0.6830.65
193_I214_T0.6810.64
180_A183_S0.6810.64
18_Q37_E0.6800.64
282_K286_T0.6750.64
256_T260_T0.6740.64
256_T275_L0.6730.63
279_T283_Q0.6720.63
59_A166_I0.6670.63
86_V103_M0.6670.63
169_T176_I0.6650.63
76_T115_E0.6650.63
225_E249_L0.6590.62
246_I268_V0.6590.62
261_L266_H0.6570.62
171_N188_V0.6540.61
21_E225_E0.6540.61
43_A47_E0.6530.61
172_E187_V0.6530.61
30_I219_K0.6520.61
86_V101_G0.6510.61
203_T207_M0.6460.60
70_I102_I0.6450.60
41_V207_M0.6430.60
194_T248_S0.6430.60
233_V246_I0.6390.59
245_I268_V0.6380.59
81_G86_V0.6350.59
152_A167_A0.6350.59
69_L88_C0.6340.59
86_V188_V0.6330.59
170_C197_T0.6300.58
239_K242_A0.6300.58
58_C61_E0.6290.58
128_L154_A0.6280.58
88_C140_I0.6270.58
48_V172_E0.6260.58
183_S186_V0.6220.57
229_V272_I0.6220.57
49_L52_I0.6220.57
77_S143_A0.6220.57
12_T295_I0.6190.57
140_I166_I0.6180.57
81_G222_K0.6160.57
93_S234_S0.6150.57
76_T143_A0.6130.56
273_V284_A0.6110.56
229_V269_K0.6050.55
34_I215_A0.6040.55
32_K50_P0.6000.55
113_A234_S0.5980.55
63_F138_T0.5980.55
70_I98_Q0.5930.54
65_N135_S0.5920.54
45_V204_A0.5920.54
247_Q257_A0.5920.54
82_V103_M0.5910.54
74_A104_A0.5900.54
61_E65_N0.5900.54
67_G136_N0.5900.54
53_K215_A0.5880.53
63_F99_V0.5870.53
30_I192_A0.5860.53
10_L171_N0.5840.53
81_G142_I0.5840.53
255_D259_Y0.5840.53
233_V261_L0.5820.53
101_G143_A0.5800.52
155_L167_A0.5770.52
55_A140_I0.5770.52
69_L220_I0.5760.52
93_S205_H0.5750.52
192_A201_A0.5720.51
64_Q294_F0.5700.51
233_V239_K0.5690.51
63_F142_I0.5680.51
193_I218_V0.5680.51
125_A156_R0.5670.51
240_E247_Q0.5650.50
84_D91_T0.5650.50
122_E125_A0.5640.50
233_V266_H0.5630.50
12_T201_A0.5620.50
12_T144_A0.5610.50
168_L186_V0.5600.50
17_S20_V0.5600.50
89_P113_A0.5580.50
239_K266_H0.5570.49
86_V93_S0.5560.49
63_F69_L0.5560.49
168_L205_H0.5560.49
22_I25_A0.5560.49
155_L179_D0.5520.49
123_A126_E0.5500.49
64_Q219_K0.5500.49
33_M36_N0.5480.48
177_S183_S0.5480.48
129_R161_V0.5430.48
69_L138_T0.5430.48
115_E200_K0.5420.48
40_K44_A0.5410.47
18_Q21_E0.5400.47
72_T120_S0.5390.47
42_A46_Q0.5370.47
225_E296_D0.5360.47
130_N160_K0.5360.47
242_A261_L0.5350.47
169_T183_S0.5340.47
82_V201_A0.5330.46
273_V277_T0.5310.46
128_L139_V0.5310.46
142_I213_S0.5290.46
88_C170_C0.5280.46
95_S98_Q0.5260.46
52_I98_Q0.5260.46
88_C98_Q0.5260.46
109_A115_E0.5260.46
117_I234_S0.5240.45
84_D237_K0.5220.45
51_D182_H0.5220.45
69_L98_Q0.5190.45
23_H227_L0.5170.45
79_R113_A0.5170.45
135_S259_Y0.5160.44
174_S185_E0.5150.44
118_E196_S0.5140.44
291_A297_K0.5140.44
111_L114_A0.5140.44
192_A257_A0.5140.44
270_T277_T0.5140.44
189_G200_K0.5130.44
182_H215_A0.5130.44
290_E297_K0.5120.44
76_T82_V0.5120.44
43_A255_D0.5120.44
71_Y84_D0.5110.44
135_S163_A0.5110.44
56_V277_T0.5100.44
143_A194_T0.5100.44
47_E290_E0.5080.43
292_N297_K0.5070.43
59_A142_I0.5070.43
60_Y220_I0.5070.43
243_I247_Q0.5050.43
213_S216_V0.5050.43
264_A271_A0.5040.43
34_I92_Y0.5030.43
169_T174_S0.5030.43
23_H226_N0.5020.43
41_V188_V0.5020.43
59_A63_F0.5000.42
44_A187_V0.5000.42
139_V158_A0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nriA 2 0.8158 100 0.397 Contact Map
4s12A 2 0.9737 100 0.42 Contact Map
3w0lB 1 0.9539 100 0.429 Contact Map
4bb9A 1 0.9934 100 0.455 Contact Map
1tk9A 4 0.6184 99.9 0.804 Contact Map
3trjA 4 0.6151 99.8 0.817 Contact Map
2xblA 4 0.625 99.8 0.824 Contact Map
2yvaA 4 0.625 99.8 0.826 Contact Map
2i2wA 4 0.6217 99.7 0.833 Contact Map
1x92A 4 0.6349 99.7 0.833 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0319 seconds.