GREMLIN Database
YBEC - Probable amino acid-proton symporter YbeC
UniProt: Q45577 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 539 (422)
Sequences: 22601 (14285)
Seq/√Len: 695.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_I344_Q4.3641.00
147_F350_L4.1141.00
387_T391_T3.4891.00
379_I412_F3.1571.00
49_M248_T3.1251.00
334_K344_Q3.0961.00
234_K238_I2.9931.00
9_G230_K2.8341.00
231_N234_K2.7931.00
336_H339_Y2.7881.00
229_A235_S2.6651.00
73_V325_N2.6571.00
323_E333_G2.6291.00
331_I334_K2.5861.00
179_L257_A2.5821.00
140_S354_F2.4851.00
336_H343_R2.4821.00
89_G322_M2.4811.00
14_M242_G2.4031.00
10_T242_G2.3861.00
291_W295_V2.3521.00
177_G181_F2.2711.00
382_P411_G2.2221.00
227_G324_K2.2201.00
77_Q85_G2.2081.00
61_E389_R2.2031.00
433_I437_G2.1581.00
320_Y324_K2.1231.00
144_L354_F2.0951.00
147_F346_M2.0951.00
148_L152_W2.0841.00
151_Y343_R2.0811.00
10_T235_S2.0441.00
140_S357_L2.0431.00
155_N159_K2.0391.00
347_F351_I2.0381.00
13_L229_A2.0341.00
409_P413_I2.0221.00
282_D285_I2.0201.00
77_Q82_S1.9801.00
263_N266_D1.9671.00
228_E317_R1.9561.00
166_I170_I1.9531.00
238_I242_G1.9371.00
332_F348_F1.9251.00
139_A357_L1.8881.00
80_H387_T1.8871.00
50_V54_F1.8711.00
9_G12_S1.8631.00
58_S382_P1.8631.00
10_T14_M1.8611.00
439_P443_Y1.8601.00
93_W349_N1.8281.00
326_K330_S1.8221.00
144_L350_L1.8161.00
14_M246_V1.8111.00
266_D286_A1.7981.00
406_V410_L1.7841.00
33_A41_A1.7551.00
431_L435_L1.7441.00
80_H383_I1.7311.00
282_D286_A1.7281.00
76_T88_A1.7121.00
88_A380_T1.7121.00
170_I174_L1.7021.00
437_G440_I1.6991.00
446_A449_K1.6901.00
12_S162_S1.6841.00
51_V414_F1.6781.00
387_T390_R1.6721.00
100_I353_S1.6641.00
17_G243_S1.6521.00
231_N235_S1.6371.00
4_L335_L1.6351.00
8_M12_S1.6221.00
54_F410_L1.6151.00
241_V245_F1.6001.00
151_Y347_F1.5971.00
104_A308_G1.5961.00
276_F282_D1.5941.00
5_H340_G1.5781.00
383_I412_F1.5661.00
50_V410_L1.5611.00
143_L353_S1.5511.00
140_S144_L1.5501.00
403_G407_I1.5461.00
339_Y343_R1.5371.00
413_I417_L1.5331.00
111_M138_F1.5291.00
134_E137_A1.5221.00
90_W437_G1.5211.00
344_Q348_F1.5191.00
315_T349_N1.5001.00
245_F249_V1.4961.00
150_N309_I1.4931.00
330_S333_G1.4911.00
133_G137_A1.4731.00
205_T209_T1.4651.00
81_G84_I1.4471.00
147_F347_F1.4401.00
200_W203_V1.4371.00
285_I293_V1.4231.00
404_L408_A1.4151.00
152_W339_Y1.4151.00
443_Y447_K1.4041.00
442_F446_A1.4011.00
107_S142_L1.4011.00
48_G212_I1.3931.00
143_L350_L1.3821.00
330_S334_K1.3801.00
56_A244_L1.3781.00
40_A203_V1.3761.00
444_Y448_A1.3701.00
56_A240_V1.3671.00
176_I253_L1.3651.00
104_A143_L1.3641.00
66_F78_Y1.3601.00
235_S238_I1.3591.00
334_K343_R1.3581.00
58_S408_A1.3551.00
79_S384_T1.3511.00
80_H84_I1.3501.00
169_I173_G1.3491.00
294_I298_A1.3401.00
42_I256_I1.3351.00
202_S206_A1.3351.00
316_S346_M1.3221.00
171_I299_D1.3181.00
12_S158_S1.3161.00
438_L442_F1.3151.00
319_I345_A1.3151.00
383_I387_T1.3081.00
146_Y308_G1.3061.00
249_V253_L1.3031.00
427_T430_V1.3001.00
440_I443_Y1.2981.00
231_N238_I1.2911.00
278_S282_D1.2871.00
225_M313_A1.2861.00
180_L257_A1.2831.00
69_A227_G1.2781.00
199_G202_S1.2771.00
320_Y335_L1.2701.00
390_R393_K1.2621.00
426_L430_V1.2581.00
276_F279_P1.2571.00
440_I444_Y1.2521.00
107_S301_F1.2501.00
432_F436_I1.2491.00
83_F444_Y1.2391.00
136_L140_S1.2361.00
40_A196_A1.2271.00
21_M247_A1.2251.00
285_I290_N1.2201.00
10_T238_I1.2101.00
435_L439_P1.2081.00
405_N409_P1.2021.00
8_M158_S1.2021.00
76_T380_T1.1971.00
55_I382_P1.1931.00
202_S205_T1.1911.00
57_L241_V1.1901.00
344_Q347_F1.1871.00
44_S206_A1.1831.00
386_M409_P1.1761.00
319_I328_M1.1731.00
336_H341_V1.1691.00
16_V225_M1.1681.00
393_K397_R1.1651.00
324_K333_G1.1621.00
28_F106_A1.1591.00
428_G432_F1.1591.00
426_L429_Q1.1551.00
392_G395_L1.1461.00
7_R230_K1.1431.00
181_F185_H1.1421.00
230_K235_S1.1381.00
103_E307_T1.1261.00
160_A164_I1.1241.00
232_P237_P1.1241.00
13_L239_A1.1221.00
385_V408_A1.1191.00
430_V434_I1.1161.00
74_K78_Y1.1111.00
379_I416_S1.1091.00
406_V409_P1.1081.00
76_T84_I1.0991.00
205_T208_A1.0981.00
411_G415_A1.0971.00
201_A205_T1.0971.00
203_V208_A1.0931.00
149_L160_A1.0921.00
175_T179_L1.0861.00
46_V252_V1.0851.00
65_M395_L1.0811.00
444_Y447_K1.0771.00
426_L433_I1.0771.00
8_M13_L1.0761.00
334_K337_P1.0761.00
179_L261_A1.0751.00
417_L421_W1.0751.00
11_F15_M1.0701.00
445_Q449_K1.0671.00
63_G75_Y1.0591.00
78_Y392_G1.0581.00
93_W319_I1.0581.00
59_Y72_M1.0541.00
203_V207_V1.0531.00
68_E74_K1.0511.00
173_G177_G1.0421.00
86_F90_W1.0411.00
263_N286_A1.0411.00
390_R405_N1.0371.00
204_L207_V1.0341.00
17_G222_P1.0341.00
443_Y446_A1.0281.00
187_E190_T1.0281.00
174_L178_A1.0271.00
65_M397_R1.0251.00
18_L246_V1.0231.00
200_W204_L1.0231.00
186_G190_T1.0131.00
351_I355_I1.0111.00
437_G441_Y1.0061.00
412_F416_S1.0011.00
161_N309_I1.0011.00
379_I415_A1.0011.00
399_L402_K1.0001.00
108_V138_F0.9991.00
111_M115_P0.9941.00
427_T431_L0.9941.00
193_Q196_A0.9821.00
11_F162_S0.9801.00
141_V145_I0.9791.00
403_G408_A0.9771.00
335_L340_G0.9771.00
403_G406_V0.9761.00
137_A141_V0.9751.00
408_A412_F0.9731.00
428_G431_L0.9701.00
164_I306_G0.9691.00
429_Q432_F0.9681.00
15_M162_S0.9671.00
432_F435_L0.9651.00
382_P412_F0.9651.00
279_P283_L0.9641.00
154_V313_A0.9621.00
7_R155_N0.9621.00
144_L148_L0.9591.00
416_S420_Y0.9591.00
73_V321_G0.9581.00
184_F260_G0.9531.00
217_N374_T0.9461.00
415_A418_V0.9401.00
394_D397_R0.9401.00
22_I25_G0.9391.00
312_T350_L0.9381.00
392_G397_R0.9341.00
159_K162_S0.9341.00
147_F151_Y0.9321.00
49_M216_F0.9321.00
159_K163_L0.9281.00
242_G246_V0.9281.00
68_E78_Y0.9251.00
176_I180_L0.9231.00
204_L208_A0.9221.00
151_Y341_V0.9191.00
379_I383_I0.9171.00
426_L437_G0.9151.00
12_S159_K0.9141.00
372_V430_V0.9091.00
83_F438_L0.9081.00
290_N294_I0.9071.00
261_A283_L0.9061.00
180_L184_F0.9041.00
420_Y424_W0.9001.00
64_S398_P0.8971.00
386_M405_N0.8931.00
226_A236_I0.8931.00
433_I440_I0.8921.00
143_L357_L0.8911.00
248_T252_V0.8911.00
61_E64_S0.8891.00
343_R347_F0.8891.00
203_V206_A0.8881.00
18_L247_A0.8881.00
111_M301_F0.8881.00
102_V367_A0.8831.00
34_A41_A0.8831.00
145_I305_S0.8801.00
221_S314_T0.8791.00
288_N292_L0.8771.00
220_Q224_N0.8731.00
55_I415_A0.8681.00
169_I250_I0.8671.00
427_T441_Y0.8651.00
77_Q325_N0.8631.00
83_F87_I0.8631.00
275_N279_P0.8581.00
332_F344_Q0.8531.00
278_S281_A0.8511.00
427_T440_I0.8491.00
84_I380_T0.8461.00
404_L407_I0.8441.00
412_F415_A0.8411.00
415_A419_L0.8411.00
54_F407_I0.8371.00
148_L151_Y0.8311.00
431_L434_I0.8311.00
350_L354_F0.8281.00
188_N192_G0.8271.00
289_I292_L0.8221.00
138_F141_V0.8221.00
389_R393_K0.8201.00
70_G74_K0.8181.00
256_I260_G0.8171.00
386_M408_A0.8161.00
107_S305_S0.8131.00
176_I257_A0.8121.00
107_S304_P0.8111.00
436_I440_I0.8071.00
275_N278_S0.8071.00
14_M239_A0.8051.00
10_T239_A0.8001.00
62_L385_V0.7951.00
194_S197_P0.7941.00
319_I348_F0.7861.00
237_P240_V0.7851.00
4_L320_Y0.7851.00
369_I373_A0.7801.00
233_G398_P0.7801.00
112_S135_G0.7761.00
90_W328_M0.7741.00
433_I436_I0.7721.00
108_V139_A0.7721.00
417_L420_Y0.7671.00
186_G189_F0.7671.00
76_T384_T0.7661.00
175_T284_A0.7651.00
11_F159_K0.7651.00
419_L422_A0.7641.00
196_A203_V0.7631.00
395_L398_P0.7621.00
146_Y309_I0.7611.00
26_W254_L0.7601.00
41_A255_Q0.7591.00
393_K396_Y0.7581.00
146_Y312_T0.7571.00
7_R154_V0.7551.00
53_L57_L0.7551.00
189_F259_I0.7551.00
53_L241_V0.7531.00
23_G27_L0.7511.00
386_M390_R0.7501.00
401_L407_I0.7471.00
42_I259_I0.7471.00
97_V352_V0.7461.00
328_M332_F0.7441.00
390_R394_D0.7441.00
291_W294_I0.7441.00
436_I439_P0.7421.00
168_K303_S0.7421.00
431_L437_G0.7411.00
190_T194_S0.7401.00
43_I46_V0.7351.00
158_S162_S0.7341.00
434_I438_L0.7331.00
405_N408_A0.7281.00
439_P442_F0.7271.00
428_G433_I0.7261.00
81_G445_Q0.7241.00
20_S310_T0.7221.00
95_A374_T0.7211.00
39_P259_I0.7201.00
70_G73_V0.7171.00
136_L357_L0.7161.00
438_L441_Y0.7141.00
284_A287_L0.7141.00
384_T388_L0.7141.00
54_F58_S0.7141.00
102_V214_F0.7111.00
332_F345_A0.7111.00
30_A255_Q0.7061.00
58_S401_L0.7041.00
99_V370_I0.7041.00
22_I168_K0.7041.00
140_S358_F0.7031.00
441_Y445_Q0.7011.00
430_V433_I0.6991.00
404_L409_P0.6991.00
99_V102_V0.6991.00
105_V366_L0.6981.00
426_L431_L0.6971.00
52_I219_F0.6961.00
51_V54_F0.6931.00
151_Y336_H0.6931.00
62_L75_Y0.6921.00
418_V422_A0.6921.00
411_G414_F0.6921.00
43_I203_V0.6921.00
92_N96_I0.6891.00
279_P282_D0.6881.00
427_T444_Y0.6861.00
351_I354_F0.6851.00
46_V50_V0.6851.00
113_S297_Y0.6831.00
189_F260_G0.6821.00
152_W156_L0.6811.00
176_I254_L0.6801.00
316_S345_A0.6791.00
22_I27_L0.6791.00
430_V437_G0.6781.00
186_G260_G0.6751.00
242_G245_F0.6741.00
101_P366_L0.6731.00
280_F284_A0.6701.00
142_L308_G0.6691.00
442_F445_Q0.6671.00
136_L139_A0.6671.00
199_G203_V0.6651.00
194_S198_N0.6651.00
19_G165_T0.6621.00
32_R364_G0.6621.00
420_Y423_R0.6621.00
42_I46_V0.6611.00
427_T433_I0.6611.00
167_F171_I0.6601.00
59_Y381_G0.6591.00
151_Y339_Y0.6591.00
98_S369_I0.6571.00
42_I252_V0.6571.00
253_L257_A0.6561.00
54_F411_G0.6531.00
43_I47_I0.6531.00
192_G196_A0.6521.00
114_W298_A0.6521.00
63_G223_I0.6511.00
29_G367_A0.6511.00
433_I441_Y0.6501.00
206_A209_T0.6501.00
180_L253_L0.6501.00
429_Q433_I0.6501.00
73_V77_Q0.6491.00
108_V135_G0.6481.00
217_N378_Y0.6461.00
432_F439_P0.6451.00
108_V111_M0.6441.00
7_R11_F0.6431.00
437_G444_Y0.6431.00
231_N237_P0.6431.00
429_Q435_L0.6421.00
408_A415_A0.6391.00
408_A411_G0.6381.00
337_P340_G0.6381.00
20_S311_Y0.6381.00
132_T135_G0.6371.00
53_L245_F0.6371.00
80_H384_T0.6371.00
44_S203_V0.6351.00
167_F299_D0.6341.00
323_E332_F0.6341.00
355_I358_F0.6331.00
427_T437_G0.6331.00
342_P345_A0.6321.00
40_A195_I0.6301.00
181_F184_F0.6291.00
91_A377_S0.6291.00
445_Q448_A0.6281.00
408_A425_P0.6281.00
101_P356_F0.6281.00
281_A285_I0.6251.00
150_N346_M0.6251.00
199_G206_A0.6251.00
411_G422_A0.6231.00
279_P284_A0.6231.00
49_M54_F0.6211.00
331_I348_F0.6211.00
441_Y447_K0.6201.00
18_L165_T0.6201.00
56_A219_F0.6181.00
435_L438_L0.6171.00
201_A204_L0.6171.00
223_I240_V0.6151.00
427_T434_I0.6151.00
233_G396_Y0.6141.00
79_S387_T0.6111.00
48_G213_V0.6101.00
57_L407_I0.6091.00
441_Y446_A0.6091.00
13_L225_M0.6091.00
312_T316_S0.6081.00
227_G320_Y0.6071.00
21_M243_S0.6061.00
69_A320_Y0.6061.00
65_M398_P0.6061.00
428_G442_F0.6051.00
146_Y305_S0.6051.00
407_I411_G0.6051.00
224_N314_T0.6041.00
317_R320_Y0.6031.00
388_L392_G0.6011.00
284_A289_I0.6001.00
298_A302_V0.5991.00
364_G367_A0.5991.00
430_V435_L0.5971.00
171_I295_V0.5971.00
96_I311_Y0.5961.00
295_V299_D0.5961.00
79_S388_L0.5961.00
246_V250_I0.5931.00
430_V440_I0.5911.00
373_A377_S0.5911.00
114_W297_Y0.5871.00
65_M393_K0.5851.00
437_G442_F0.5841.00
147_F312_T0.5821.00
385_V389_R0.5811.00
30_A33_A0.5811.00
192_G265_S0.5811.00
151_Y346_M0.5801.00
426_L442_F0.5791.00
434_I437_G0.5781.00
280_F283_L0.5771.00
398_P402_K0.5751.00
144_L147_F0.5741.00
111_M142_L0.5741.00
220_Q378_Y0.5731.00
101_P353_S0.5721.00
62_L79_S0.5711.00
433_I438_L0.5691.00
153_T156_L0.5691.00
374_T377_S0.5691.00
276_F280_F0.5681.00
315_T319_I0.5651.00
402_K406_V0.5641.00
103_E308_G0.5631.00
396_Y400_R0.5631.00
440_I445_Q0.5621.00
178_A289_I0.5621.00
33_A37_A0.5611.00
81_G85_G0.5611.00
156_L159_K0.5611.00
426_L441_Y0.5611.00
431_L440_I0.5601.00
409_P412_F0.5601.00
204_L417_L0.5601.00
428_G437_G0.5601.00
45_W215_A0.5591.00
72_M224_N0.5591.00
246_V253_L0.5571.00
170_I173_G0.5551.00
17_G21_M0.5541.00
65_M392_G0.5541.00
72_M381_G0.5531.00
408_A422_A0.5531.00
431_L446_A0.5511.00
428_G441_Y0.5481.00
150_N313_A0.5481.00
444_Y449_K0.5471.00
83_F441_Y0.5471.00
421_W425_P0.5461.00
257_A260_G0.5461.00
48_G216_F0.5451.00
441_Y444_Y0.5451.00
61_E402_K0.5451.00
60_S64_S0.5451.00
72_M220_Q0.5441.00
183_G260_G0.5411.00
6_R230_K0.5411.00
11_F14_M0.5401.00
11_F166_I0.5401.00
62_L388_L0.5371.00
73_V85_G0.5351.00
18_L21_M0.5351.00
97_V349_N0.5351.00
99_V103_E0.5341.00
91_A376_I0.5331.00
36_I205_T0.5321.00
254_L280_F0.5321.00
303_S306_G0.5321.00
73_V89_G0.5311.00
22_I250_I0.5301.00
427_T432_F0.5301.00
97_V101_P0.5291.00
431_L438_L0.5271.00
167_F302_V0.5271.00
32_R35_Q0.5271.00
233_G238_I0.5271.00
432_F443_Y0.5271.00
254_L258_F0.5241.00
294_I297_Y0.5241.00
331_I335_L0.5231.00
143_L354_F0.5221.00
110_Y300_A0.5221.00
14_M17_G0.5221.00
37_A44_S0.5221.00
408_A419_L0.5221.00
336_H340_G0.5211.00
201_A208_A0.5211.00
234_K237_P0.5211.00
156_L160_A0.5201.00
42_I45_W0.5201.00
15_M165_T0.5201.00
145_I149_L0.5191.00
363_W367_A0.5181.00
165_T168_K0.5171.00
9_G155_N0.5171.00
95_A373_A0.5160.99
375_L415_A0.5160.99
192_G197_P0.5150.99
408_A424_W0.5150.99
432_F437_G0.5140.99
57_L402_K0.5140.99
27_L168_K0.5140.99
428_G435_L0.5120.99
98_S370_I0.5110.99
158_S309_I0.5110.99
246_V249_V0.5070.99
379_I419_L0.5070.99
389_R404_L0.5070.99
163_L167_F0.5070.99
112_S116_W0.5060.99
201_A206_A0.5050.99
417_L424_W0.5050.99
104_A146_Y0.5050.99
103_E304_P0.5040.99
142_L305_S0.5040.99
106_A110_Y0.5040.99
36_I39_P0.5030.99
217_N370_I0.5020.99
316_S349_N0.5010.99
8_M154_V0.5000.99
141_V144_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.7737 100 0.375 Contact Map
3giaA 1 0.7941 100 0.407 Contact Map
4djkA 2 0.7811 100 0.43 Contact Map
2jlnA 1 0.7755 99 0.871 Contact Map
3dh4A 3 0.8349 98.6 0.892 Contact Map
2xq2A 2 0.7681 98.5 0.893 Contact Map
4wgvA 2 0.6809 98.2 0.903 Contact Map
4us3A 1 0.7384 96.4 0.929 Contact Map
2a65A 2 0.8089 95.9 0.932 Contact Map
4xp4A 1 0.8275 94.7 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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