GREMLIN Database
YLXX - UPF0749 protein YlxX
UniProt: Q45544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 235 (222)
Sequences: 1486 (1097)
Seq/√Len: 73.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_T215_K5.9351.00
150_V154_T4.7721.00
104_V213_E3.9371.00
104_V178_K3.8871.00
124_P158_D3.4971.00
188_H212_S2.9441.00
99_T217_T2.9401.00
147_E178_K2.7531.00
142_H180_L2.4711.00
102_G216_L2.4521.00
148_R166_D2.4141.00
103_I187_L2.2861.00
98_I218_L2.2781.00
97_D220_A2.2651.00
183_D186_M2.2541.00
98_I142_H2.2081.00
132_I145_I2.2001.00
142_H218_L2.1951.00
109_P158_D2.1161.00
151_V221_Y2.0531.00
141_E180_L2.0431.00
178_K216_L1.9711.00
97_D217_T1.9461.00
148_R168_Y1.9301.00
108_S206_A1.9091.00
185_D212_S1.8761.00
109_P124_P1.8691.00
184_P187_L1.8681.00
128_L175_L1.8471.00
103_I179_V1.8351.00
104_V176_T1.8301.00
125_P158_D1.7891.00
59_E62_K1.7631.00
147_E176_T1.7621.00
200_F205_L1.7331.00
210_G213_E1.7191.00
105_I191_V1.7101.00
132_I156_I1.6901.00
106_T210_G1.6731.00
13_L20_M1.6601.00
197_E207_L1.6000.99
98_I180_L1.5910.99
128_L163_T1.5850.99
144_S219_K1.5810.99
98_I141_E1.5550.99
165_I170_L1.5360.99
158_D167_G1.4380.99
83_N87_Q1.4330.99
55_K59_E1.4220.99
146_N175_L1.4200.99
57_L61_N1.4090.99
178_K218_L1.4060.99
144_S147_E1.4010.99
158_D161_G1.3910.98
179_V189_S1.3880.98
65_K69_S1.3870.98
166_D221_Y1.3850.98
183_D187_L1.3770.98
196_L200_F1.3720.98
122_N158_D1.3450.98
227_V230_L1.3430.98
155_V166_D1.3420.98
86_L90_K1.3400.98
103_I184_P1.3280.98
18_G22_S1.3210.98
89_L93_A1.3130.98
131_L177_V1.3120.98
107_I131_L1.3050.98
19_L23_V1.3030.98
41_D45_E1.2950.97
101_S184_P1.2890.97
62_K66_L1.2770.97
157_R164_K1.2760.97
161_G171_D1.2750.97
135_L140_A1.2600.97
19_L22_S1.2490.97
144_S218_L1.2490.97
188_H192_K1.2470.97
122_N161_G1.2350.97
67_L71_S1.2240.96
158_D162_T1.2070.96
114_S120_I1.1960.96
11_S15_V1.1860.96
159_I164_K1.1830.96
125_P157_R1.1760.96
49_E52_K1.1680.95
132_I143_I1.1520.95
200_F207_L1.1510.95
7_F11_S1.1500.95
195_G198_D1.1460.95
6_S11_S1.1370.95
81_A85_T1.1330.95
46_L49_E1.1270.94
91_K96_T1.1140.94
106_T176_T1.0950.94
102_G178_K1.0940.93
20_M25_F1.0840.93
68_N72_Q1.0770.93
93_A96_T1.0450.92
16_I85_T1.0410.92
85_T88_S1.0320.91
15_V22_S1.0320.91
145_I177_V1.0260.91
63_Y67_L1.0200.91
164_K167_G0.9890.89
68_N71_S0.9890.89
197_E200_F0.9870.89
118_E121_E0.9870.89
154_T161_G0.9820.89
85_T89_L0.9760.89
34_R58_A0.9730.89
9_S13_L0.9710.89
13_L25_F0.9590.88
94_G152_N0.9520.88
108_S173_Y0.9470.87
136_N143_I0.9420.87
142_H181_A0.9410.87
156_I165_I0.9400.87
125_P161_G0.9360.87
132_I177_V0.9360.87
109_P160_N0.9340.87
71_S90_K0.9330.87
14_M17_F0.9320.86
105_I209_A0.9160.86
193_G196_L0.9140.85
187_L216_L0.9120.85
94_G151_V0.9120.85
54_E144_S0.9100.85
103_I188_H0.9020.85
141_E181_A0.9020.85
135_L179_V0.9010.85
133_N157_R0.9010.85
139_G181_A0.8950.84
158_D175_L0.8950.84
116_T119_P0.8930.84
110_L158_D0.8900.84
8_I12_V0.8890.84
52_K55_K0.8880.84
6_S10_I0.8790.83
114_S117_G0.8740.83
11_S187_L0.8720.83
28_L31_P0.8670.82
33_V147_E0.8660.82
129_K155_V0.8630.82
162_T169_A0.8620.82
11_S18_G0.8610.82
169_A175_L0.8600.82
136_N151_V0.8580.82
11_S24_Q0.8550.81
117_G121_E0.8480.81
150_V156_I0.8430.80
129_K136_N0.8420.80
134_E195_G0.8350.80
43_R47_T0.8320.80
124_P127_L0.8300.79
103_I183_D0.8270.79
66_L69_S0.8250.79
112_S116_T0.8200.79
62_K80_T0.8100.78
61_N65_K0.8060.77
162_T170_L0.8030.77
125_P170_L0.8030.77
186_M189_S0.8010.77
20_M133_N0.7980.77
38_D46_L0.7930.76
17_F24_Q0.7900.76
192_K201_A0.7840.75
94_G216_L0.7770.75
228_Q231_K0.7770.75
49_E177_V0.7730.74
89_L154_T0.7710.74
70_Y97_D0.7640.73
125_P146_N0.7600.73
213_E216_L0.7570.73
101_S141_E0.7560.73
180_L216_L0.7530.72
112_S120_I0.7500.72
156_I166_D0.7470.72
135_L143_I0.7470.72
124_P162_T0.7460.72
87_Q214_S0.7420.71
117_G120_I0.7420.71
91_K141_E0.7390.71
128_L146_N0.7360.71
151_V225_L0.7350.71
124_P161_G0.7340.70
41_D70_Y0.7340.70
102_G213_E0.7280.70
46_L126_D0.7250.70
159_I169_A0.7240.69
92_T136_N0.7160.69
82_L85_T0.7140.68
24_Q129_K0.7120.68
158_D173_Y0.7100.68
81_A84_N0.7080.68
138_Y194_S0.6900.66
164_K169_A0.6880.65
46_L203_E0.6840.65
44_E48_S0.6840.65
189_S193_G0.6820.65
124_P167_G0.6770.64
107_I207_L0.6750.64
27_S214_S0.6750.64
138_Y190_R0.6740.64
124_P131_L0.6730.64
221_Y225_L0.6720.64
146_N181_A0.6700.63
160_N163_T0.6650.63
13_L17_F0.6640.63
107_I205_L0.6630.63
83_N210_G0.6610.62
68_N223_R0.6590.62
15_V19_L0.6580.62
65_K201_A0.6570.62
9_S20_M0.6570.62
127_L203_E0.6550.62
70_Y82_L0.6550.62
60_I64_D0.6550.62
66_L70_Y0.6540.62
46_L196_L0.6530.61
99_T216_L0.6530.61
178_K213_E0.6490.61
23_V150_V0.6480.61
125_P160_N0.6470.61
144_S166_D0.6430.60
24_Q27_S0.6410.60
87_Q224_P0.6410.60
143_I150_V0.6400.60
84_N87_Q0.6370.60
195_G199_L0.6360.59
73_T79_E0.6350.59
50_Q220_A0.6310.59
107_I158_D0.6280.58
116_T121_E0.6270.58
130_K163_T0.6230.58
123_P208_K0.6200.57
49_E56_L0.6140.57
51_K154_T0.6140.57
60_I83_N0.6140.57
107_I177_V0.6120.57
112_S147_E0.6100.56
21_I66_L0.6100.56
46_L50_Q0.6090.56
97_D219_K0.6090.56
72_Q198_D0.6060.56
19_L35_D0.6040.56
20_M24_Q0.6030.55
28_L154_T0.5990.55
121_E154_T0.5990.55
73_T229_Q0.5960.55
76_M107_I0.5950.54
20_M153_H0.5920.54
53_Q175_L0.5920.54
165_I199_L0.5910.54
127_L204_N0.5910.54
189_S194_S0.5860.53
124_P203_E0.5830.53
156_I209_A0.5830.53
23_V154_T0.5820.53
122_N160_N0.5810.53
79_E84_N0.5810.53
36_T40_W0.5750.52
76_M183_D0.5750.52
74_K191_V0.5740.52
58_A219_K0.5730.52
9_S88_S0.5720.52
122_N162_T0.5710.51
125_P200_F0.5710.51
11_S22_S0.5680.51
125_P163_T0.5670.51
144_S178_K0.5650.51
53_Q56_L0.5650.51
86_L116_T0.5630.50
109_P127_L0.5620.50
127_L155_V0.5610.50
19_L231_K0.5600.50
129_K194_S0.5590.50
190_R193_G0.5590.50
109_P142_H0.5580.50
115_L231_K0.5570.50
144_S220_A0.5550.49
39_M187_L0.5540.49
195_G200_F0.5490.49
40_W231_K0.5480.49
84_N88_S0.5480.49
123_P186_M0.5460.48
55_K87_Q0.5440.48
102_G214_S0.5440.48
146_N161_G0.5400.48
117_G152_N0.5400.48
119_P163_T0.5400.48
83_N156_I0.5390.47
128_L177_V0.5390.47
34_R38_D0.5390.47
109_P122_N0.5380.47
101_S215_K0.5360.47
134_E138_Y0.5360.47
18_G168_Y0.5360.47
176_T213_E0.5340.47
183_D216_L0.5320.47
73_T214_S0.5320.47
226_D231_K0.5310.46
14_M31_P0.5310.46
65_K101_S0.5300.46
145_I187_L0.5290.46
74_K214_S0.5280.46
79_E103_I0.5260.46
130_K205_L0.5220.45
87_Q90_K0.5210.45
142_H150_V0.5210.45
197_E201_A0.5200.45
48_S55_K0.5200.45
162_T166_D0.5190.45
184_P214_S0.5170.45
140_A143_I0.5170.45
150_V223_R0.5170.45
59_E201_A0.5160.45
20_M110_L0.5150.45
33_V36_T0.5150.45
22_S25_F0.5100.44
130_K148_R0.5100.44
146_N156_I0.5080.44
112_S180_L0.5070.44
75_E78_K0.5050.43
178_K181_A0.5050.43
148_R167_G0.5050.43
109_P174_P0.5050.43
136_N218_L0.5020.43
60_I67_L0.5020.43
16_I25_F0.5010.43
63_Y220_A0.5010.43
68_N88_S0.5000.43
23_V27_S0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmgA 2 0.5872 100 0.332 Contact Map
4cbcA 3 0.1191 81.6 0.93 Contact Map
4ltoA 3 0.3149 80.5 0.931 Contact Map
3rvyA 3 0.1191 76.7 0.933 Contact Map
4bgnA 3 0.1745 64 0.939 Contact Map
3layA 5 0.2723 62.5 0.94 Contact Map
2yy0A 6 0.2213 58.7 0.941 Contact Map
3hnwA 2 0.3574 57.6 0.942 Contact Map
1go4E 4 0.3277 51.8 0.944 Contact Map
3pjsK 4 0.3064 46.9 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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