GREMLIN Database
CSBB - Putative glycosyltransferase CsbB
UniProt: Q45539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 329 (278)
Sequences: 16243 (12914)
Seq/√Len: 774.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_G49_D5.0201.00
43_N68_S4.4521.00
163_R167_N4.1201.00
49_D52_Q3.4111.00
7_S88_G3.4011.00
116_Y191_K3.0791.00
54_I66_Y3.0011.00
7_S38_E2.8391.00
51_L68_S2.6891.00
90_A112_Y2.5891.00
111_G114_E2.5821.00
38_E65_K2.5721.00
51_L55_K2.5671.00
20_K56_D2.5591.00
12_S50_T2.4971.00
5_L89_E2.4281.00
43_N46_S2.4131.00
42_I82_G2.3661.00
20_K53_Q2.3351.00
20_K24_E2.2931.00
92_I160_L2.2371.00
165_A188_F2.2351.00
111_G191_K2.2131.00
41_F54_I2.2121.00
51_L66_Y2.1771.00
23_H57_L2.0751.00
5_L87_Q2.0661.00
90_A160_L2.0031.00
52_Q56_D1.9751.00
112_Y160_L1.9491.00
117_D162_S1.9351.00
53_Q56_D1.9331.00
107_E110_K1.9131.00
5_L36_D1.9001.00
38_E88_G1.8841.00
111_G193_V1.8821.00
24_E57_L1.8581.00
49_D53_Q1.8571.00
6_I109_I1.8561.00
107_E195_Y1.8501.00
15_E96_A1.8481.00
92_I105_L1.8391.00
168_A188_F1.8211.00
75_K79_I1.8161.00
90_A109_I1.8141.00
69_F81_A1.8061.00
178_F182_L1.7951.00
7_S86_V1.7761.00
14_N47_V1.7611.00
56_D60_T1.7571.00
7_S40_F1.7551.00
144_N147_V1.7541.00
110_K114_E1.7451.00
108_F160_L1.6931.00
168_A186_I1.6861.00
55_K68_S1.6751.00
33_I106_K1.6501.00
21_L24_E1.6211.00
9_I82_G1.5931.00
129_S132_R1.5911.00
23_H61_C1.5601.00
112_Y162_S1.5541.00
117_D188_F1.5411.00
13_Y72_N1.5351.00
24_E28_K1.5151.00
9_I42_I1.4971.00
83_F91_V1.4891.00
33_I36_D1.4841.00
14_N46_S1.4471.00
83_F166_V1.4431.00
24_E60_T1.4411.00
91_V166_V1.4351.00
141_K144_N1.4311.00
79_I93_V1.4191.00
10_I22_I1.4131.00
67_I85_H1.4061.00
27_K61_C1.4041.00
25_S103_Y1.3791.00
12_S96_A1.3721.00
23_H41_F1.3691.00
43_N51_L1.3641.00
81_A85_H1.3571.00
118_Q190_Q1.3531.00
5_L88_G1.3491.00
38_E87_Q1.3401.00
205_S208_S1.3391.00
164_Q168_A1.3371.00
118_Q183_F1.3041.00
103_Y107_E1.2901.00
42_I78_A1.2761.00
125_R128_D1.2531.00
86_V163_R1.2371.00
6_I105_L1.2371.00
16_G53_Q1.2301.00
211_S214_N1.2281.00
25_S100_H1.2131.00
56_D59_A1.2111.00
141_K145_K1.2031.00
122_Q194_F1.1951.00
211_S215_Y1.1721.00
52_Q55_K1.1701.00
40_F65_K1.1631.00
21_L201_K1.1511.00
10_I96_A1.1231.00
130_F133_S1.1191.00
132_R135_L1.1121.00
21_L25_S1.1081.00
8_I105_L1.0991.00
44_D72_N1.0941.00
19_V53_Q1.0901.00
44_D74_G1.0861.00
82_G86_V1.0801.00
162_S165_A1.0741.00
12_S41_F1.0721.00
91_V163_R1.0641.00
84_E170_L1.0531.00
25_S99_Q1.0521.00
65_K85_H1.0491.00
100_H197_N1.0471.00
8_I92_I1.0411.00
224_N227_P1.0401.00
130_F134_L1.0381.00
165_A183_F1.0341.00
81_A84_E1.0251.00
108_F121_A1.0231.00
154_G159_R1.0161.00
193_V196_E1.0141.00
53_Q57_L1.0021.00
100_H104_L1.0001.00
23_H64_V0.9951.00
94_M100_H0.9951.00
22_I26_L0.9881.00
27_K63_R0.9871.00
37_Y63_R0.9861.00
164_Q167_N0.9841.00
168_A171_K0.9821.00
248_A252_K0.9801.00
212_L215_Y0.9731.00
90_A162_S0.9691.00
35_Y113_E0.9681.00
20_K60_T0.9631.00
131_V135_L0.9621.00
109_I113_E0.9611.00
134_L138_M0.9611.00
111_G119_V0.9471.00
67_I81_A0.9421.00
88_G163_R0.9401.00
123_R157_D0.9311.00
75_K95_D0.9251.00
235_G239_L0.9211.00
20_K57_L0.9151.00
110_K113_E0.9121.00
23_H27_K0.9081.00
174_E177_R0.9071.00
239_L242_S0.9071.00
29_E106_K0.9061.00
200_R203_G0.9031.00
104_L107_E0.9021.00
143_I147_V0.9011.00
83_F93_V0.8951.00
104_L158_F0.8901.00
252_K256_N0.8851.00
28_K102_T0.8801.00
139_Y143_I0.8791.00
161_L183_F0.8781.00
25_S198_V0.8771.00
138_M141_K0.8731.00
215_Y219_G0.8731.00
232_F235_G0.8721.00
133_S136_S0.8681.00
40_F86_V0.8661.00
58_A64_V0.8621.00
215_Y218_D0.8591.00
25_S28_K0.8531.00
12_S15_E0.8491.00
217_M221_V0.8451.00
13_Y47_V0.8371.00
216_G219_G0.8361.00
18_N201_K0.8331.00
161_L166_V0.8321.00
21_L99_Q0.8291.00
80_L84_E0.8281.00
25_S29_E0.8241.00
144_N148_E0.8221.00
41_F64_V0.8211.00
132_R136_S0.8191.00
140_Y143_I0.8141.00
65_K87_Q0.8131.00
251_V255_T0.8091.00
275_G278_L0.8051.00
120_I123_R0.8021.00
57_L61_C0.8021.00
262_G265_T0.7991.00
19_V41_F0.7971.00
10_I41_F0.7961.00
10_I26_L0.7931.00
8_I26_L0.7931.00
38_E86_V0.7921.00
106_K110_K0.7921.00
89_E164_Q0.7901.00
218_D221_V0.7891.00
15_E18_N0.7871.00
117_D164_Q0.7861.00
271_L275_G0.7861.00
133_S137_S0.7811.00
271_L274_G0.7801.00
121_A158_F0.7791.00
226_K229_R0.7771.00
281_L285_G0.7731.00
5_L38_E0.7701.00
273_L277_Q0.7691.00
18_N22_I0.7681.00
256_N259_S0.7651.00
231_C235_G0.7641.00
269_A273_L0.7591.00
124_N127_G0.7471.00
14_N48_D0.7451.00
225_H229_R0.7411.00
183_F188_F0.7411.00
39_I64_V0.7411.00
111_G115_G0.7341.00
29_E33_I0.7341.00
12_S19_V0.7331.00
107_E111_G0.7301.00
19_V50_T0.7281.00
7_S87_Q0.7281.00
37_Y105_L0.7271.00
272_F276_V0.7271.00
131_V134_L0.7261.00
7_S163_R0.7251.00
46_S50_T0.7241.00
22_I96_A0.7221.00
58_A61_C0.7221.00
33_I37_Y0.7201.00
22_I25_S0.7181.00
214_N218_D0.7171.00
61_C64_V0.7131.00
178_F181_G0.7121.00
26_L39_I0.7101.00
142_F146_A0.7091.00
98_L200_R0.7081.00
223_F227_P0.7081.00
249_T252_K0.7021.00
135_L138_M0.7011.00
224_N228_L0.6991.00
162_S188_F0.6981.00
253_I256_N0.6971.00
108_F196_E0.6961.00
141_K147_V0.6951.00
55_K59_A0.6941.00
34_H37_Y0.6921.00
86_V91_V0.6911.00
92_I104_L0.6901.00
19_V54_I0.6891.00
112_Y119_V0.6871.00
212_L216_G0.6871.00
142_F147_V0.6851.00
225_H228_L0.6841.00
55_K58_A0.6831.00
141_K146_A0.6811.00
69_F72_N0.6811.00
10_I94_M0.6771.00
222_S225_H0.6731.00
140_Y144_N0.6691.00
10_I39_I0.6661.00
240_L244_I0.6661.00
275_G285_G0.6651.00
9_I86_V0.6621.00
75_K156_G0.6601.00
109_I160_L0.6601.00
274_G278_L0.6591.00
246_I249_T0.6581.00
16_G48_D0.6531.00
98_L198_V0.6521.00
245_Y249_T0.6521.00
276_V280_S0.6511.00
281_L284_I0.6501.00
36_D63_R0.6501.00
54_I58_A0.6501.00
111_G116_Y0.6491.00
222_S226_K0.6491.00
239_L243_I0.6481.00
13_Y45_G0.6481.00
242_S272_F0.6471.00
139_Y146_A0.6471.00
83_F86_V0.6461.00
276_V279_L0.6421.00
261_P264_F0.6401.00
129_S136_S0.6391.00
6_I35_Y0.6371.00
16_G52_Q0.6361.00
191_K194_F0.6361.00
124_N196_E0.6331.00
19_V57_L0.6321.00
213_F217_M0.6311.00
58_A66_Y0.6271.00
268_S271_L0.6261.00
73_F77_A0.6261.00
272_F279_L0.6251.00
108_F158_F0.6251.00
211_S218_D0.6201.00
209_F212_L0.6161.00
70_S73_F0.6161.00
19_V24_E0.6161.00
76_E80_L0.6151.00
27_K64_V0.6111.00
236_I240_L0.6091.00
165_A168_A0.6071.00
256_N260_V0.6061.00
89_E163_R0.6061.00
101_P104_L0.6061.00
209_F213_F0.6021.00
272_F275_G0.6001.00
270_V273_L0.5991.00
116_Y119_V0.5981.00
138_M147_V0.5981.00
266_I269_A0.5971.00
70_S81_A0.5971.00
106_K109_I0.5961.00
222_S229_R0.5951.00
15_E50_T0.5951.00
132_R137_S0.5941.00
5_L37_Y0.5931.00
51_L54_I0.5931.00
93_V159_R0.5901.00
122_Q192_I0.5901.00
117_D189_D0.5881.00
107_E193_V0.5881.00
279_L282_G0.5861.00
8_I94_M0.5841.00
258_I261_P0.5841.00
173_S178_F0.5831.00
14_N50_T0.5791.00
268_S272_F0.5791.00
57_L60_T0.5781.00
26_L100_H0.5771.00
229_R232_F0.5751.00
233_Y236_I0.5741.00
134_L137_S0.5741.00
103_Y106_K0.5731.00
230_L235_G0.5711.00
247_I251_V0.5711.00
143_I148_E0.5681.00
34_H109_I0.5671.00
19_V96_A0.5661.00
277_Q281_L0.5651.00
264_F268_S0.5651.00
18_N96_A0.5641.00
74_G97_D0.5641.00
116_Y189_D0.5641.00
238_I242_S0.5611.00
275_G279_L0.5601.00
131_V136_S0.5591.00
50_T96_A0.5591.00
222_S227_P0.5581.00
44_D95_D0.5581.00
89_E162_S0.5561.00
120_I190_Q0.5541.00
173_S182_L0.5521.00
274_G277_Q0.5511.00
184_C190_Q0.5501.00
105_L160_L0.5501.00
139_Y144_N0.5481.00
15_E75_K0.5461.00
169_L183_F0.5451.00
224_N229_R0.5451.00
11_P78_A0.5451.00
140_Y148_E0.5441.00
129_S134_L0.5421.00
263_Y267_I0.5421.00
55_K66_Y0.5421.00
227_P230_L0.5401.00
174_E178_F0.5401.00
282_G285_G0.5381.00
120_I192_I0.5381.00
255_T258_I0.5371.00
244_I248_A0.5361.00
100_H158_F0.5361.00
139_Y142_F0.5361.00
104_L108_F0.5351.00
143_I146_A0.5341.00
223_F226_K0.5321.00
261_P265_T0.5311.00
145_K148_E0.5311.00
69_F73_F0.5311.00
108_F112_Y0.5301.00
14_N43_N0.5301.00
130_F135_L0.5301.00
119_V193_V0.5281.00
25_S98_L0.5281.00
231_C234_T0.5281.00
40_F85_H0.5271.00
50_T54_I0.5261.00
131_V137_S0.5221.00
13_Y43_N0.5201.00
45_G72_N0.5201.00
266_I270_V0.5181.00
212_L219_G0.5161.00
5_L35_Y0.5141.00
210_S213_F0.5141.00
40_F82_G0.5131.00
80_L173_S0.5131.00
233_Y237_F0.5121.00
92_I108_F0.5111.00
145_K149_V0.5111.00
271_L279_L0.5101.00
17_Y53_Q0.5101.00
141_K148_E0.5101.00
139_Y147_V0.5081.00
269_A282_G0.5081.00
210_S214_N0.5071.00
234_T238_I0.5061.00
142_F145_K0.5051.00
8_I37_Y0.5051.00
179_S183_F0.5031.00
138_M146_A0.5021.00
273_L276_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9605 100 0.45 Contact Map
2z86A 2 0.7325 100 0.478 Contact Map
3bcvA 2 0.5258 100 0.486 Contact Map
2d7iA 1 0.8663 100 0.497 Contact Map
1qg8A 1 0.6383 100 0.502 Contact Map
1xhbA 1 0.9544 100 0.504 Contact Map
3l7iA 4 0.0912 100 0.505 Contact Map
3ckjA 2 0.7538 100 0.519 Contact Map
2bo4A 4 0.8632 100 0.521 Contact Map
4fixA 3 0.9605 100 0.521 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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