GREMLIN Database
COTJC - Protein CotJC
UniProt: Q45538 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (182)
Sequences: 828 (268)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_Y156_D5.0371.00
126_A140_A4.4611.00
43_L61_G3.7971.00
145_L158_L3.2971.00
114_T117_Y2.9440.99
15_S153_D2.8940.99
2_W66_A2.7810.99
88_R93_G2.7670.99
18_N21_L2.7360.98
39_A65_F2.7340.98
37_A113_F2.5280.97
177_E180_K2.4970.97
107_N111_V2.4910.97
56_L175_A2.3720.96
74_M157_S2.3260.96
113_F118_I2.1210.93
29_Y75_V2.0890.92
71_I87_L1.8970.88
24_Y93_G1.8840.88
41_R130_E1.8560.87
37_A117_Y1.8440.87
149_S155_N1.7380.83
61_G66_A1.7360.83
156_D159_R1.7190.82
53_V178_I1.6730.81
46_R58_T1.6560.80
146_I155_N1.6230.79
83_T86_Q1.6070.78
33_D119_Q1.5950.77
78_L154_L1.5900.77
14_V77_K1.5850.77
25_L74_M1.5710.76
122_G127_D1.4940.72
130_E137_K1.4830.72
150_D155_N1.4810.72
29_Y72_A1.4660.71
23_K109_A1.4450.70
165_E172_F1.4300.69
21_L149_S1.4230.69
68_L72_A1.4180.68
132_I173_R1.3830.66
90_A94_D1.3640.65
99_H104_F1.3600.65
85_E88_R1.3530.65
111_V116_S1.3260.63
27_E97_V1.3140.62
36_L40_L1.3130.62
29_Y71_I1.2480.58
12_V70_M1.2410.58
29_Y155_N1.2390.58
28_Q142_Y1.2380.58
97_V148_I1.2230.57
34_G75_V1.2230.57
84_P88_R1.2220.57
23_K91_G1.2190.56
138_A165_E1.2180.56
72_A103_L1.2070.56
52_K180_K1.2030.55
43_L46_R1.2030.55
113_F157_S1.2020.55
68_L105_Y1.2010.55
112_P116_S1.1990.55
139_R162_R1.1930.55
125_I176_V1.1850.54
145_L149_S1.1730.53
27_E75_V1.1710.53
38_A134_A1.1690.53
29_Y68_L1.1690.53
49_I60_I1.1660.53
38_A172_F1.1460.52
33_D121_K1.1360.51
102_A120_A1.1320.51
2_W43_L1.1310.51
85_E89_E1.1310.51
68_L71_I1.1240.50
37_A114_T1.1100.49
129_Y169_S1.1090.49
74_M154_L1.1090.49
26_I75_V1.1080.49
18_N25_L1.1010.49
38_A165_E1.1010.49
14_V153_D1.1000.49
27_E98_N1.0920.48
155_N159_R1.0870.48
6_K59_D1.0830.48
53_V182_E1.0790.47
106_H118_I1.0650.46
47_Y76_Y1.0360.45
81_D101_S1.0320.44
100_D144_W1.0310.44
146_I158_L1.0210.44
28_Q38_A1.0170.43
175_A179_L1.0150.43
4_Y41_R1.0120.43
48_T76_Y1.0110.43
26_I98_N1.0100.43
176_V181_E0.9920.42
44_N103_L0.9870.41
36_L150_D0.9770.41
97_V140_A0.9730.41
47_Y58_T0.9500.39
31_G35_E0.9500.39
68_L103_L0.9430.39
54_I68_L0.9420.39
27_E34_G0.9410.39
104_F118_I0.9370.38
93_G102_A0.9370.38
28_Q36_L0.9280.38
143_Q162_R0.9230.38
21_L25_L0.9170.37
56_L85_E0.9160.37
76_Y93_G0.9140.37
5_E70_M0.9120.37
39_A114_T0.9110.37
52_K72_A0.9090.37
129_Y132_I0.8870.35
86_Q89_E0.8830.35
3_V7_K0.8770.35
28_Q141_T0.8690.34
150_D159_R0.8670.34
94_D108_A0.8640.34
40_L105_Y0.8580.34
106_H109_A0.8540.33
14_V74_M0.8540.33
4_Y130_E0.8450.33
142_Y165_E0.8400.33
43_L66_A0.8390.33
15_S77_K0.8370.32
20_T23_K0.8360.32
51_D182_E0.8280.32
17_C21_L0.8240.32
12_V73_T0.8220.32
82_A90_A0.8210.32
84_P93_G0.8140.31
55_G156_D0.7990.30
169_S180_K0.7980.30
46_R61_G0.7900.30
159_R163_E0.7890.30
139_R167_V0.7860.30
40_L104_F0.7850.30
102_A127_D0.7800.29
121_K141_T0.7600.28
29_Y44_N0.7570.28
74_M158_L0.7570.28
176_V179_L0.7530.28
18_N149_S0.7510.28
34_G68_L0.7500.28
21_L145_L0.7410.27
12_V124_P0.7380.27
13_K77_K0.7370.27
66_A119_Q0.7350.27
38_A142_Y0.7320.27
169_S173_R0.7150.26
94_D107_N0.7140.26
30_G35_E0.7110.26
51_D177_E0.7100.26
99_H120_A0.7100.26
132_I136_E0.7060.26
142_Y172_F0.7030.25
60_I171_R0.7010.25
177_E181_E0.7010.25
17_C92_L0.6980.25
120_A126_A0.6970.25
13_K102_A0.6940.25
44_N104_F0.6920.25
21_L155_N0.6900.25
13_K16_T0.6850.25
19_P132_I0.6850.25
119_Q137_K0.6840.24
32_A117_Y0.6840.24
100_D107_N0.6820.24
79_T95_H0.6820.24
53_V96_Y0.6810.24
13_K53_V0.6790.24
151_D156_D0.6770.24
147_D177_E0.6770.24
30_G34_G0.6770.24
153_D157_S0.6750.24
2_W62_T0.6740.24
161_L164_R0.6740.24
44_N105_Y0.6740.24
16_T178_I0.6730.24
19_P82_A0.6720.24
130_E133_A0.6700.24
143_Q158_L0.6670.24
1_M8_L0.6670.24
23_K92_L0.6640.24
111_V126_A0.6620.23
82_A100_D0.6600.23
107_N116_S0.6570.23
18_N150_D0.6570.23
21_L154_L0.6570.23
56_L71_I0.6560.23
107_N117_Y0.6550.23
39_A68_L0.6520.23
21_L24_Y0.6480.23
136_E180_K0.6470.23
125_I180_K0.6450.23
138_A142_Y0.6420.23
38_A138_A0.6360.22
27_E32_A0.6360.22
41_R137_K0.6320.22
63_E164_R0.6260.22
13_K75_V0.6250.22
138_A172_F0.6240.22
143_Q146_I0.6200.22
25_L39_A0.6190.22
11_P115_A0.6140.21
44_N120_A0.6120.21
53_V181_E0.6100.21
113_F149_S0.6090.21
4_Y11_P0.6080.21
25_L149_S0.6040.21
152_P156_D0.6040.21
144_W157_S0.5990.21
128_L175_A0.5970.21
82_A143_Q0.5900.20
47_Y72_A0.5890.20
60_I128_L0.5830.20
170_M173_R0.5830.20
48_T114_T0.5810.20
87_L93_G0.5810.20
40_L70_M0.5800.20
56_L60_I0.5790.20
9_Q62_T0.5760.20
82_A158_L0.5740.20
104_F116_S0.5680.19
106_H149_S0.5670.19
138_A161_L0.5670.19
62_T66_A0.5670.19
36_L73_T0.5670.19
25_L89_E0.5650.19
22_A78_L0.5640.19
132_I176_V0.5610.19
153_D159_R0.5580.19
129_Y180_K0.5580.19
18_N151_D0.5580.19
157_S177_E0.5560.19
76_Y129_Y0.5490.19
54_I104_F0.5450.18
135_E168_H0.5430.18
103_L120_A0.5410.18
96_Y104_F0.5400.18
98_N141_T0.5390.18
87_L92_L0.5370.18
33_D133_A0.5370.18
102_A119_Q0.5350.18
96_Y140_A0.5320.18
56_L161_L0.5310.18
61_G65_F0.5310.18
39_A161_L0.5260.18
72_A118_I0.5250.18
106_H116_S0.5200.17
82_A87_L0.5190.17
111_V114_T0.5150.17
63_E110_G0.5150.17
37_A41_R0.5150.17
9_Q66_A0.5140.17
36_L116_S0.5130.17
49_I56_L0.5120.17
113_F128_L0.5100.17
15_S72_A0.5100.17
14_V107_N0.5090.17
113_F117_Y0.5090.17
28_Q71_I0.5090.17
175_A178_I0.5080.17
43_L65_F0.5080.17
115_A124_P0.5070.17
58_T61_G0.5030.17
19_P52_K0.5030.17
133_A142_Y0.5030.17
25_L148_I0.5010.17
21_L158_L0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v8tA 5 1 100 0.29 Contact Map
1o9iA 6 0.9841 100 0.293 Contact Map
2fzfA 2 0.8254 99.1 0.839 Contact Map
4di0A 2 0.6984 99 0.849 Contact Map
1nfvA 7 0.7672 99 0.849 Contact Map
4tofA 6 0.7566 98.9 0.852 Contact Map
4cvrA 2 0.7566 98.9 0.852 Contact Map
2qqyA 6 0.6984 98.9 0.853 Contact Map
3fvbA 6 0.7566 98.8 0.856 Contact Map
1jgcA 6 0.7566 98.7 0.86 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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