COTJC - BACSU - GREMLIN Contacts

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COTJC - Protein CotJC

UniProt:	Q45538	Sequences: MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLNQRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSALFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRFLREREIVHSMRFREAVEILKEERDKKKIF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	189 (182)
Sequences:	828 (268)
Seq/√Len:	19.9

BACSU - COTJC YJQC MCAT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_Y	156_D	5.037	1.00
126_A	140_A	4.461	1.00
43_L	61_G	3.797	1.00
145_L	158_L	3.297	1.00
114_T	117_Y	2.944	0.99
15_S	153_D	2.894	0.99
2_W	66_A	2.781	0.99
88_R	93_G	2.767	0.99
18_N	21_L	2.736	0.98
39_A	65_F	2.734	0.98
37_A	113_F	2.528	0.97
177_E	180_K	2.497	0.97
107_N	111_V	2.491	0.97
56_L	175_A	2.372	0.96
74_M	157_S	2.326	0.96
113_F	118_I	2.121	0.93
29_Y	75_V	2.089	0.92
71_I	87_L	1.897	0.88
24_Y	93_G	1.884	0.88
41_R	130_E	1.856	0.87
37_A	117_Y	1.844	0.87
149_S	155_N	1.738	0.83
61_G	66_A	1.736	0.83
156_D	159_R	1.719	0.82
53_V	178_I	1.673	0.81
46_R	58_T	1.656	0.80
146_I	155_N	1.623	0.79
83_T	86_Q	1.607	0.78
33_D	119_Q	1.595	0.77
78_L	154_L	1.590	0.77
14_V	77_K	1.585	0.77
25_L	74_M	1.571	0.76
122_G	127_D	1.494	0.72
130_E	137_K	1.483	0.72
150_D	155_N	1.481	0.72
29_Y	72_A	1.466	0.71
23_K	109_A	1.445	0.70
165_E	172_F	1.430	0.69
21_L	149_S	1.423	0.69
68_L	72_A	1.418	0.68
132_I	173_R	1.383	0.66
90_A	94_D	1.364	0.65
99_H	104_F	1.360	0.65
85_E	88_R	1.353	0.65
111_V	116_S	1.326	0.63
27_E	97_V	1.314	0.62
36_L	40_L	1.313	0.62
29_Y	71_I	1.248	0.58
12_V	70_M	1.241	0.58
29_Y	155_N	1.239	0.58
28_Q	142_Y	1.238	0.58
97_V	148_I	1.223	0.57
34_G	75_V	1.223	0.57
84_P	88_R	1.222	0.57
23_K	91_G	1.219	0.56
138_A	165_E	1.218	0.56
72_A	103_L	1.207	0.56
52_K	180_K	1.203	0.55
43_L	46_R	1.203	0.55
113_F	157_S	1.202	0.55
68_L	105_Y	1.201	0.55
112_P	116_S	1.199	0.55
139_R	162_R	1.193	0.55
125_I	176_V	1.185	0.54
145_L	149_S	1.173	0.53
27_E	75_V	1.171	0.53
38_A	134_A	1.169	0.53
29_Y	68_L	1.169	0.53
49_I	60_I	1.166	0.53
38_A	172_F	1.146	0.52
33_D	121_K	1.136	0.51
102_A	120_A	1.132	0.51
2_W	43_L	1.131	0.51
85_E	89_E	1.131	0.51
68_L	71_I	1.124	0.50
37_A	114_T	1.110	0.49
129_Y	169_S	1.109	0.49
74_M	154_L	1.109	0.49
26_I	75_V	1.108	0.49
18_N	25_L	1.101	0.49
38_A	165_E	1.101	0.49
14_V	153_D	1.100	0.49
27_E	98_N	1.092	0.48
155_N	159_R	1.087	0.48
6_K	59_D	1.083	0.48
53_V	182_E	1.079	0.47
106_H	118_I	1.065	0.46
47_Y	76_Y	1.036	0.45
81_D	101_S	1.032	0.44
100_D	144_W	1.031	0.44
146_I	158_L	1.021	0.44
28_Q	38_A	1.017	0.43
175_A	179_L	1.015	0.43
4_Y	41_R	1.012	0.43
48_T	76_Y	1.011	0.43
26_I	98_N	1.010	0.43
176_V	181_E	0.992	0.42
44_N	103_L	0.987	0.41
36_L	150_D	0.977	0.41
97_V	140_A	0.973	0.41
47_Y	58_T	0.950	0.39
31_G	35_E	0.950	0.39
68_L	103_L	0.943	0.39
54_I	68_L	0.942	0.39
27_E	34_G	0.941	0.39
104_F	118_I	0.937	0.38
93_G	102_A	0.937	0.38
28_Q	36_L	0.928	0.38
143_Q	162_R	0.923	0.38
21_L	25_L	0.917	0.37
56_L	85_E	0.916	0.37
76_Y	93_G	0.914	0.37
5_E	70_M	0.912	0.37
39_A	114_T	0.911	0.37
52_K	72_A	0.909	0.37
129_Y	132_I	0.887	0.35
86_Q	89_E	0.883	0.35
3_V	7_K	0.877	0.35
28_Q	141_T	0.869	0.34
150_D	159_R	0.867	0.34
94_D	108_A	0.864	0.34
40_L	105_Y	0.858	0.34
106_H	109_A	0.854	0.33
14_V	74_M	0.854	0.33
4_Y	130_E	0.845	0.33
142_Y	165_E	0.840	0.33
43_L	66_A	0.839	0.33
15_S	77_K	0.837	0.32
20_T	23_K	0.836	0.32
51_D	182_E	0.828	0.32
17_C	21_L	0.824	0.32
12_V	73_T	0.822	0.32
82_A	90_A	0.821	0.32
84_P	93_G	0.814	0.31
55_G	156_D	0.799	0.30
169_S	180_K	0.798	0.30
46_R	61_G	0.790	0.30
159_R	163_E	0.789	0.30
139_R	167_V	0.786	0.30
40_L	104_F	0.785	0.30
102_A	127_D	0.780	0.29
121_K	141_T	0.760	0.28
29_Y	44_N	0.757	0.28
74_M	158_L	0.757	0.28
176_V	179_L	0.753	0.28
18_N	149_S	0.751	0.28
34_G	68_L	0.750	0.28
21_L	145_L	0.741	0.27
12_V	124_P	0.738	0.27
13_K	77_K	0.737	0.27
66_A	119_Q	0.735	0.27
38_A	142_Y	0.732	0.27
169_S	173_R	0.715	0.26
94_D	107_N	0.714	0.26
30_G	35_E	0.711	0.26
51_D	177_E	0.710	0.26
99_H	120_A	0.710	0.26
132_I	136_E	0.706	0.26
142_Y	172_F	0.703	0.25
60_I	171_R	0.701	0.25
177_E	181_E	0.701	0.25
17_C	92_L	0.698	0.25
120_A	126_A	0.697	0.25
13_K	102_A	0.694	0.25
44_N	104_F	0.692	0.25
21_L	155_N	0.690	0.25
13_K	16_T	0.685	0.25
19_P	132_I	0.685	0.25
119_Q	137_K	0.684	0.24
32_A	117_Y	0.684	0.24
100_D	107_N	0.682	0.24
79_T	95_H	0.682	0.24
53_V	96_Y	0.681	0.24
13_K	53_V	0.679	0.24
151_D	156_D	0.677	0.24
147_D	177_E	0.677	0.24
30_G	34_G	0.677	0.24
153_D	157_S	0.675	0.24
2_W	62_T	0.674	0.24
161_L	164_R	0.674	0.24
44_N	105_Y	0.674	0.24
16_T	178_I	0.673	0.24
19_P	82_A	0.672	0.24
130_E	133_A	0.670	0.24
143_Q	158_L	0.667	0.24
1_M	8_L	0.667	0.24
23_K	92_L	0.664	0.24
111_V	126_A	0.662	0.23
82_A	100_D	0.660	0.23
107_N	116_S	0.657	0.23
18_N	150_D	0.657	0.23
21_L	154_L	0.657	0.23
56_L	71_I	0.656	0.23
107_N	117_Y	0.655	0.23
39_A	68_L	0.652	0.23
21_L	24_Y	0.648	0.23
136_E	180_K	0.647	0.23
125_I	180_K	0.645	0.23
138_A	142_Y	0.642	0.23
38_A	138_A	0.636	0.22
27_E	32_A	0.636	0.22
41_R	137_K	0.632	0.22
63_E	164_R	0.626	0.22
13_K	75_V	0.625	0.22
138_A	172_F	0.624	0.22
143_Q	146_I	0.620	0.22
25_L	39_A	0.619	0.22
11_P	115_A	0.614	0.21
44_N	120_A	0.612	0.21
53_V	181_E	0.610	0.21
113_F	149_S	0.609	0.21
4_Y	11_P	0.608	0.21
25_L	149_S	0.604	0.21
152_P	156_D	0.604	0.21
144_W	157_S	0.599	0.21
128_L	175_A	0.597	0.21
82_A	143_Q	0.590	0.20
47_Y	72_A	0.589	0.20
60_I	128_L	0.583	0.20
170_M	173_R	0.583	0.20
48_T	114_T	0.581	0.20
87_L	93_G	0.581	0.20
40_L	70_M	0.580	0.20
56_L	60_I	0.579	0.20
9_Q	62_T	0.576	0.20
82_A	158_L	0.574	0.20
104_F	116_S	0.568	0.19
106_H	149_S	0.567	0.19
138_A	161_L	0.567	0.19
62_T	66_A	0.567	0.19
36_L	73_T	0.567	0.19
25_L	89_E	0.565	0.19
22_A	78_L	0.564	0.19
132_I	176_V	0.561	0.19
153_D	159_R	0.558	0.19
129_Y	180_K	0.558	0.19
18_N	151_D	0.558	0.19
157_S	177_E	0.556	0.19
76_Y	129_Y	0.549	0.19
54_I	104_F	0.545	0.18
135_E	168_H	0.543	0.18
103_L	120_A	0.541	0.18
96_Y	104_F	0.540	0.18
98_N	141_T	0.539	0.18
87_L	92_L	0.537	0.18
33_D	133_A	0.537	0.18
102_A	119_Q	0.535	0.18
96_Y	140_A	0.532	0.18
56_L	161_L	0.531	0.18
61_G	65_F	0.531	0.18
39_A	161_L	0.526	0.18
72_A	118_I	0.525	0.18
106_H	116_S	0.520	0.17
82_A	87_L	0.519	0.17
111_V	114_T	0.515	0.17
63_E	110_G	0.515	0.17
37_A	41_R	0.515	0.17
9_Q	66_A	0.514	0.17
36_L	116_S	0.513	0.17
49_I	56_L	0.512	0.17
113_F	128_L	0.510	0.17
15_S	72_A	0.510	0.17
14_V	107_N	0.509	0.17
113_F	117_Y	0.509	0.17
28_Q	71_I	0.509	0.17
175_A	178_I	0.508	0.17
43_L	65_F	0.508	0.17
115_A	124_P	0.507	0.17
58_T	61_G	0.503	0.17
19_P	52_K	0.503	0.17
133_A	142_Y	0.503	0.17
25_L	148_I	0.501	0.17
21_L	158_L	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2v8tA	5	1	100	0.29	Contact Map
1o9iA	6	0.9841	100	0.293	Contact Map
2fzfA	2	0.8254	99.1	0.839	Contact Map
4di0A	2	0.6984	99	0.849	Contact Map
1nfvA	7	0.7672	99	0.849	Contact Map
4tofA	6	0.7566	98.9	0.852	Contact Map
4cvrA	2	0.7566	98.9	0.852	Contact Map
2qqyA	6	0.6984	98.9	0.853	Contact Map
3fvbA	6	0.7566	98.8	0.856	Contact Map
1jgcA	6	0.7566	98.7	0.86	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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