GREMLIN Database
COTJB - Protein CotJB
UniProt: Q45537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 87 (80)
Sequences: 484 (409)
Seq/√Len: 45.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_D50_S3.5791.00
26_L42_Q3.1341.00
16_I50_S2.7821.00
50_S54_K2.6191.00
22_V46_Y2.0951.00
14_E18_A2.0791.00
14_E17_Q1.9280.99
16_I53_L1.8660.99
56_Q60_S1.8630.99
27_S66_Q1.8330.99
9_Y57_F1.7870.98
15_Q49_Y1.7740.98
65_L69_N1.7460.98
8_E11_R1.7310.98
58_E68_G1.7180.98
16_I54_K1.6660.98
27_S31_N1.6420.97
24_V27_S1.6400.97
40_L44_N1.6300.97
19_A53_L1.5860.97
8_E60_S1.5740.97
29_Y36_D1.5080.96
49_Y53_L1.4890.95
36_D39_A1.4820.95
19_A46_Y1.4660.95
49_Y52_H1.4590.95
72_A75_D1.4420.94
77_D80_K1.3990.93
54_K58_E1.3830.93
73_G77_D1.3500.92
81_G86_Q1.3390.92
23_L69_N1.3020.91
20_D23_L1.2510.89
47_S51_R1.1360.84
75_D80_K1.0940.81
44_N72_A1.0500.78
38_D41_K1.0280.77
17_Q25_E1.0230.77
13_L64_L1.0160.76
27_S86_Q0.9990.75
36_D83_W0.9850.74
44_N75_D0.9840.74
25_E64_L0.9740.73
51_R73_G0.9520.71
24_V67_F0.9350.70
20_D25_E0.9330.70
9_Y86_Q0.8990.67
12_Q57_F0.8960.67
21_F29_Y0.8520.63
48_G52_H0.8420.62
43_F66_Q0.8370.61
37_E60_S0.8290.61
62_G83_W0.8250.60
29_Y46_Y0.8230.60
25_E69_N0.8040.58
55_R59_S0.7960.57
22_V32_T0.7960.57
22_V33_H0.7940.57
79_G83_W0.7890.57
16_I25_E0.7580.54
46_Y77_D0.7480.53
59_S76_W0.7460.53
31_N86_Q0.7410.52
26_L78_W0.7390.52
10_Y14_E0.7340.51
19_A49_Y0.7140.49
9_Y81_G0.7140.49
8_E37_E0.7000.48
35_H79_G0.6850.47
13_L71_P0.6840.46
20_D67_F0.6740.45
20_D54_K0.6720.45
23_L43_F0.6700.45
26_L53_L0.6680.45
32_T39_A0.6640.45
13_L49_Y0.6580.44
31_N79_G0.6540.44
8_E45_Q0.6530.43
11_R15_Q0.6520.43
24_V50_S0.6440.43
13_L61_Y0.6440.43
55_R58_E0.6380.42
51_R55_R0.6310.41
49_Y86_Q0.6280.41
25_E71_P0.6180.40
48_G59_S0.6170.40
30_L85_W0.6100.39
24_V28_L0.6020.39
37_E40_L0.5940.38
31_N78_W0.5840.37
33_H63_P0.5820.37
20_D24_V0.5770.36
43_F78_W0.5750.36
37_E48_G0.5740.36
15_Q53_L0.5680.36
51_R56_Q0.5560.34
23_L47_S0.5550.34
16_I58_E0.5520.34
7_A13_L0.5510.34
70_S75_D0.5490.34
22_V42_Q0.5460.34
31_N65_L0.5430.33
14_E35_H0.5400.33
12_Q53_L0.5400.33
44_N74_K0.5400.33
11_R18_A0.5390.33
14_E59_S0.5380.33
9_Y61_Y0.5360.33
14_E57_F0.5350.33
16_I26_L0.5340.33
24_V66_Q0.5320.32
46_Y61_Y0.5320.32
82_P85_W0.5290.32
37_E74_K0.5290.32
23_L66_Q0.5250.32
40_L79_G0.5230.32
31_N52_H0.5170.31
24_V29_Y0.5090.30
55_R73_G0.5050.30
46_Y73_G0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ds1A 2 0.5632 21.9 0.916 Contact Map
4v0qA 2 0.954 14.6 0.922 Contact Map
1yo3A 2 0.5747 12.7 0.925 Contact Map
2mnuB 1 0.2299 12.1 0.925 Contact Map
3rjsA 2 0.7356 10 0.928 Contact Map
1hyuA 2 0.9655 7.8 0.931 Contact Map
3rczB 1 0.6552 6.9 0.933 Contact Map
2fbnA 2 0.6092 6.3 0.934 Contact Map
3czqA 3 0.9655 5.8 0.935 Contact Map
3rkvA 1 0.6322 5.7 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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