GREMLIN Database
COTJA - Protein CotJA
UniProt: Q45536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 82 (68)
Sequences: 139 (101)
Seq/√Len: 12.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K38_Y5.1941.00
11_K33_T3.2100.97
9_P66_D2.5240.90
39_M63_D2.2860.85
53_E57_K2.2140.83
50_S56_R1.9170.72
33_T37_L1.9050.72
17_H27_G1.7780.66
47_E62_K1.7120.63
11_K37_L1.5960.58
62_K69_E1.5820.57
32_R36_N1.5130.53
29_K35_P1.4900.52
10_V32_R1.4890.52
17_H37_L1.4770.52
33_T71_P1.3630.46
10_V67_F1.3520.45
26_I29_K1.2970.42
14_T28_K1.2750.41
65_Y74_G1.2690.41
52_M56_R1.2360.39
19_R47_E1.2160.39
8_T11_K1.1860.37
46_M49_F1.1620.36
50_S53_E1.1460.35
66_D73_R1.0940.33
69_E73_R1.0860.32
16_F19_R1.0850.32
50_S57_K1.0690.32
14_T24_P1.0650.32
38_Y56_R1.0140.29
47_E74_G1.0110.29
13_Y28_K1.0030.29
41_F45_H0.9910.28
9_P62_K0.9880.28
10_V30_Y0.9870.28
33_T38_Y0.9740.28
12_S75_G0.9740.28
17_H28_K0.9170.25
17_H67_F0.9150.25
40_T63_D0.9080.25
31_Y38_Y0.8990.25
18_S52_M0.8960.25
45_H51_P0.8870.24
47_E63_D0.8850.24
8_T13_Y0.8840.24
45_H57_K0.8820.24
13_Y37_L0.8770.24
8_T33_T0.8640.23
30_Y69_E0.8550.23
9_P67_F0.8490.23
40_T64_L0.8430.23
41_F44_E0.8310.22
20_F63_D0.8010.21
12_S30_Y0.7940.21
27_G41_F0.7930.21
14_T27_G0.7820.21
8_T16_F0.7810.21
39_M46_M0.7640.20
32_R66_D0.7250.19
15_P43_P0.7220.19
69_E72_Y0.7190.19
46_M61_W0.7140.18
66_D70_N0.7100.18
49_F70_N0.7080.18
27_G32_R0.7010.18
31_Y70_N0.6860.18
8_T14_T0.6850.18
40_T71_P0.6810.17
8_T44_E0.6750.17
9_P64_L0.6720.17
16_F70_N0.6660.17
9_P27_G0.6560.17
24_P39_M0.6520.17
30_Y67_F0.6520.17
57_K64_L0.6500.17
24_P47_E0.6420.16
32_R72_Y0.6370.16
55_L59_T0.6300.16
44_E49_F0.6200.16
15_P55_L0.6170.16
16_F57_K0.6030.15
27_G67_F0.6020.15
12_S49_F0.5990.15
15_P39_M0.5920.15
20_F62_K0.5900.15
12_S28_K0.5810.15
27_G30_Y0.5640.14
32_R39_M0.5550.14
34_P71_P0.5550.14
34_P73_R0.5540.14
12_S66_D0.5490.14
19_R63_D0.5450.14
14_T47_E0.5450.14
10_V27_G0.5310.13
12_S40_T0.5230.13
11_K45_H0.5180.13
9_P38_Y0.5170.13
51_P72_Y0.5080.13
8_T38_Y0.5070.13
59_T71_P0.5050.13
50_S65_Y0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hcjA 1 0.878 2.3 0.953 Contact Map
1l2lA 1 0.2683 2.1 0.954 Contact Map
1t3cA 2 0.7927 1.8 0.956 Contact Map
4hjzA 1 0.8293 1.7 0.956 Contact Map
3maoA 1 0.5976 1.5 0.958 Contact Map
3ffzA 1 0.8049 1.4 0.958 Contact Map
2fpqA 1 0.7805 1.2 0.959 Contact Map
3qr0A 1 0.378 1.2 0.959 Contact Map
2qn0A 1 0.7805 1.2 0.959 Contact Map
2a97A 1 0.7927 1.2 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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