GREMLIN Database
COTH - Inner spore coat protein H
UniProt: Q45535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 362 (327)
Sequences: 1247 (1141)
Seq/√Len: 63.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_M345_C8.7581.00
216_R295_L7.1281.00
212_D291_S4.6581.00
49_Y55_R3.8981.00
34_A45_I3.6121.00
321_R338_D3.5591.00
281_R284_D3.4541.00
93_K97_D3.3791.00
215_L291_S3.2201.00
86_D91_R3.1131.00
63_H129_S3.0721.00
210_D244_L3.0701.00
300_L356_K2.7651.00
97_D312_K2.7471.00
219_A296_L2.7281.00
290_K294_R2.6911.00
215_L295_L2.5801.00
36_M45_I2.5411.00
175_K178_G2.5141.00
31_P48_A2.5031.00
191_F195_T2.4831.00
59_K327_D2.1821.00
99_F220_G2.1581.00
228_D233_N2.1301.00
204_E207_K2.1211.00
50_R79_H2.1171.00
206_T211_V2.0751.00
90_M111_F2.0721.00
313_I345_C2.0051.00
346_E350_N1.9311.00
112_A126_E1.9041.00
51_G251_D1.8971.00
312_K315_A1.8591.00
295_L298_K1.8501.00
47_I62_Y1.8451.00
48_A63_H1.8421.00
197_P200_Q1.8341.00
221_I226_N1.8331.00
35_V44_D1.7901.00
298_K302_S1.7621.00
184_F188_D1.7571.00
310_E345_C1.7330.99
113_F323_F1.7270.99
96_L107_P1.7010.99
108_K128_E1.6580.99
97_D316_M1.6460.99
76_R133_Y1.6400.99
97_D101_E1.6270.99
100_S106_S1.6190.99
46_D67_Y1.6150.99
165_T169_L1.6080.99
305_T308_Y1.5890.99
93_K109_A1.5820.99
199_A203_S1.5820.99
66_F78_I1.5760.99
50_R81_N1.5660.99
59_K114_V1.5600.99
101_E312_K1.5480.99
282_I288_F1.5460.99
186_L194_N1.5330.99
228_D253_D1.5230.99
80_L112_A1.5130.98
50_R250_W1.5050.98
187_Q191_F1.4960.98
61_S81_N1.4960.98
190_I194_N1.4810.98
123_V320_I1.4810.98
235_A250_W1.4790.98
93_K316_M1.4790.98
83_E125_L1.4720.98
119_K330_K1.4690.98
54_I228_D1.4680.98
58_K84_Y1.4540.98
113_F326_M1.4490.98
79_H129_S1.4470.98
123_V323_F1.4300.98
77_E131_D1.4280.98
62_Y124_Y1.3910.97
296_L356_K1.3770.97
194_N197_P1.3720.97
222_V292_Y1.3710.97
31_P63_H1.3690.97
51_G228_D1.3650.97
282_I289_R1.3550.97
233_N248_I1.3220.96
152_D159_S1.3160.96
95_S256_W1.3100.96
206_T288_F1.3050.96
37_K42_R1.2970.96
314_M318_E1.2960.96
352_S356_K1.2960.96
109_A125_L1.2920.96
54_I82_A1.2910.96
170_E173_Y1.2890.96
91_R257_G1.2810.96
34_A47_I1.2610.95
165_T170_E1.2550.95
81_N250_W1.2400.95
115_K120_N1.2300.95
314_M317_Y1.2220.94
256_W348_I1.2140.94
102_L299_T1.2110.94
88_S344_I1.2060.94
317_Y341_P1.1980.94
206_T291_S1.1970.94
320_I324_V1.1950.94
201_F205_V1.1910.94
72_F75_A1.1880.94
85_K253_D1.1830.93
296_L300_L1.1750.93
93_K125_L1.1750.93
236_L247_V1.1720.93
81_N92_N1.1660.93
189_M194_N1.1650.93
173_Y176_K1.1640.93
198_K281_R1.1630.93
202_K285_E1.1490.92
204_E208_H1.1470.92
214_Y247_V1.1430.92
340_E343_V1.1300.92
171_L174_E1.1230.91
185_Y238_R1.1220.91
101_E308_Y1.1180.91
342_D346_E1.1140.91
209_V214_Y1.1120.91
95_S252_Y1.1100.91
224_T256_W1.1060.91
109_A316_M1.1000.91
134_Y248_I1.0960.90
63_H79_H1.0920.90
104_T216_R1.0910.90
336_R339_R1.0890.90
83_E89_L1.0850.90
59_K82_A1.0770.90
186_L189_M1.0660.89
220_G252_Y1.0660.89
134_Y139_K1.0640.89
63_H77_E1.0630.89
35_V42_R1.0450.88
228_D251_D1.0450.88
242_T330_K1.0420.88
48_A61_S1.0390.88
99_F106_S1.0330.88
90_M313_I1.0240.87
51_G54_I1.0140.87
81_N107_P1.0100.86
54_I61_S1.0080.86
346_E357_D1.0040.86
212_D295_L1.0020.86
45_I50_R1.0010.86
130_V248_I0.9960.86
94_L256_W0.9950.86
144_A148_A0.9940.86
83_E92_N0.9900.85
212_D216_R0.9890.85
219_A295_L0.9890.85
83_E253_D0.9880.85
49_Y60_K0.9840.85
65_S76_R0.9790.85
205_V211_V0.9780.85
91_R258_R0.9730.84
257_G347_Y0.9720.84
99_F249_P0.9700.84
213_K247_V0.9640.84
95_S224_T0.9610.84
353_Q357_D0.9570.83
103_G216_R0.9560.83
155_F159_S0.9550.83
116_M121_E0.9510.83
211_V291_S0.9470.83
283_L289_R0.9470.83
81_N232_H0.9460.83
302_S305_T0.9450.83
25_D28_D0.9450.83
89_L327_D0.9410.82
347_Y351_R0.9260.81
45_I64_I0.9260.81
205_V209_V0.9260.81
339_R342_D0.9260.81
298_K301_Q0.9220.81
114_V124_Y0.9130.80
218_L292_Y0.9120.80
145_I185_Y0.9090.80
294_R342_D0.9070.80
64_I299_T0.9050.80
154_N157_L0.8980.79
98_F102_L0.8970.79
147_Y182_D0.8940.79
92_N233_N0.8940.79
135_L248_I0.8900.79
295_L299_T0.8900.79
90_M214_Y0.8880.78
222_V296_L0.8850.78
155_F172_G0.8850.78
130_V146_F0.8840.78
176_K235_A0.8830.78
111_F123_V0.8800.78
154_N158_M0.8780.78
115_K118_G0.8750.77
130_V250_W0.8700.77
200_Q203_S0.8680.77
52_S61_S0.8670.77
88_S91_R0.8560.76
81_N99_F0.8540.76
225_S347_Y0.8530.76
61_S252_Y0.8500.75
352_S355_L0.8470.75
117_N351_R0.8460.75
65_S77_E0.8460.75
306_I349_K0.8450.75
81_N125_L0.8410.75
165_T168_S0.8370.74
152_D155_F0.8350.74
126_E288_F0.8330.74
350_N353_Q0.8290.74
59_K124_Y0.8280.73
185_Y188_D0.8260.73
297_E301_Q0.8250.73
197_P353_Q0.8240.73
189_M208_H0.8230.73
107_P237_Y0.8220.73
342_D349_K0.8200.73
112_A117_N0.8120.72
52_S55_R0.8110.72
354_Y358_H0.8110.72
112_A253_D0.8080.72
80_L122_G0.8070.72
205_V320_I0.8060.71
50_R92_N0.8050.71
189_M193_I0.8050.71
245_F285_E0.8040.71
107_P250_W0.8030.71
173_Y178_G0.8030.71
65_S70_K0.8020.71
38_V72_F0.7990.71
36_M64_I0.7970.71
210_D246_E0.7970.71
201_F281_R0.7920.70
128_E137_K0.7910.70
216_R219_A0.7910.70
171_L175_K0.7900.70
88_S337_F0.7880.70
29_D48_A0.7840.69
172_G176_K0.7770.69
80_L114_V0.7760.69
113_F120_N0.7750.68
96_L250_W0.7750.68
48_A55_R0.7740.68
342_D353_Q0.7730.68
214_Y282_I0.7730.68
205_V285_E0.7720.68
326_M329_Y0.7710.68
217_W299_T0.7700.68
36_M255_T0.7690.68
98_F309_M0.7680.68
190_I205_V0.7670.68
199_A287_E0.7620.67
346_E353_Q0.7610.67
223_F296_L0.7600.67
99_F104_T0.7580.67
324_V337_F0.7570.67
213_K246_E0.7540.66
249_P252_Y0.7530.66
155_F160_D0.7520.66
254_A258_R0.7450.65
131_D134_Y0.7450.65
188_D207_K0.7440.65
67_Y76_R0.7410.65
102_L304_F0.7400.65
117_N330_K0.7360.64
49_Y81_N0.7330.64
230_F279_T0.7320.64
290_K293_K0.7320.64
120_N323_F0.7310.64
295_L300_L0.7310.64
48_A52_S0.7310.64
134_Y233_N0.7300.64
121_E330_K0.7290.64
303_L308_Y0.7250.63
148_A233_N0.7220.63
180_E184_F0.7210.63
85_K254_A0.7200.63
267_A270_V0.7190.63
86_D122_G0.7190.63
204_E285_E0.7180.62
66_F77_E0.7170.62
315_A318_E0.7160.62
100_S109_A0.7150.62
307_E349_K0.7130.62
185_Y189_M0.7130.62
81_N127_L0.7130.62
322_P325_L0.7120.62
92_N234_Y0.7120.62
198_K201_F0.7110.62
237_Y245_F0.7100.62
217_W226_N0.7100.62
181_E184_F0.7080.61
92_N96_L0.7070.61
304_F309_M0.7070.61
190_I193_I0.7060.61
188_D346_E0.7060.61
100_S108_K0.7060.61
76_R150_D0.7040.61
114_V171_L0.7020.61
102_L220_G0.7000.61
97_D100_S0.7000.61
95_S250_W0.6940.60
309_M348_I0.6930.60
335_E346_E0.6920.60
337_F340_E0.6920.60
95_S309_M0.6900.59
214_Y232_H0.6850.59
311_P315_A0.6820.59
29_D32_V0.6810.58
218_L226_N0.6790.58
62_Y237_Y0.6780.58
128_E292_Y0.6770.58
116_M291_S0.6730.58
81_N249_P0.6710.57
53_H254_A0.6690.57
112_A124_Y0.6690.57
99_F226_N0.6680.57
45_I324_V0.6680.57
93_K111_F0.6680.57
33_P46_D0.6670.57
66_F71_T0.6630.56
96_L127_L0.6610.56
221_I232_H0.6590.56
159_S165_T0.6580.56
333_D336_R0.6570.56
48_A51_G0.6550.55
144_A209_V0.6550.55
342_D345_C0.6520.55
191_F273_Q0.6510.55
215_L288_F0.6480.55
158_M167_T0.6470.55
94_L316_M0.6460.54
166_K169_L0.6460.54
111_F245_F0.6460.54
87_P327_D0.6460.54
130_V149_V0.6450.54
61_S135_L0.6430.54
217_W221_I0.6420.54
188_D208_H0.6400.54
92_N253_D0.6390.54
317_Y321_R0.6370.53
280_A284_D0.6370.53
117_N327_D0.6370.53
317_Y338_D0.6360.53
112_A133_Y0.6350.53
94_L344_I0.6310.53
219_A299_T0.6300.53
49_Y61_S0.6290.53
135_L146_F0.6280.52
75_A114_V0.6270.52
34_A38_V0.6260.52
105_L246_E0.6260.52
108_K111_F0.6250.52
326_M331_K0.6250.52
50_R254_A0.6240.52
222_V278_L0.6220.52
136_A193_I0.6220.52
169_L174_E0.6200.51
64_I78_I0.6180.51
207_K244_L0.6160.51
308_Y311_P0.6160.51
96_L109_A0.6160.51
341_P344_I0.6150.51
195_T198_K0.6110.50
145_I182_D0.6090.50
128_E250_W0.6070.50
134_Y137_K0.6070.50
349_K355_L0.6050.50
113_F123_V0.6030.50
119_K242_T0.6020.49
111_F250_W0.6010.49
48_A69_P0.6000.49
211_V282_I0.5980.49
81_N233_N0.5970.49
59_K66_F0.5930.48
59_K91_R0.5930.48
217_W247_V0.5880.48
188_D192_K0.5870.48
286_S326_M0.5860.48
93_K218_L0.5840.47
144_A237_Y0.5810.47
311_P353_Q0.5800.47
33_P37_K0.5800.47
189_M256_W0.5800.47
132_E263_E0.5790.47
196_V201_F0.5770.47
140_L186_L0.5740.46
179_T182_D0.5720.46
62_Y121_E0.5710.46
116_M199_A0.5710.46
218_L255_T0.5700.46
335_E339_R0.5700.46
62_Y140_L0.5690.46
105_L248_I0.5690.46
51_G233_N0.5680.46
185_Y350_N0.5660.45
89_L123_V0.5620.45
226_N229_G0.5610.45
219_A355_L0.5600.45
215_L348_I0.5600.45
54_I85_K0.5590.44
55_R81_N0.5580.44
268_D313_I0.5580.44
193_I196_V0.5570.44
94_L313_I0.5560.44
55_R222_V0.5550.44
252_Y257_G0.5540.44
95_S227_Y0.5540.44
150_D235_A0.5540.44
264_R318_E0.5540.44
103_G239_S0.5540.44
82_A218_L0.5520.44
310_E314_M0.5520.44
233_N237_Y0.5510.44
60_K251_D0.5510.44
46_D70_K0.5510.44
39_N292_Y0.5510.44
349_K357_D0.5500.43
168_S171_L0.5500.43
201_F278_L0.5500.43
220_G224_T0.5490.43
82_A260_I0.5480.43
128_E134_Y0.5480.43
50_R77_E0.5480.43
269_Y272_I0.5480.43
82_A257_G0.5470.43
105_L213_K0.5440.43
214_Y218_L0.5420.43
57_F125_L0.5400.42
184_F302_S0.5400.42
239_S246_E0.5390.42
199_A264_R0.5390.42
187_Q194_N0.5390.42
236_L296_L0.5380.42
230_F234_Y0.5370.42
136_A203_S0.5370.42
168_S255_T0.5370.42
42_R357_D0.5370.42
25_D29_D0.5370.42
92_N127_L0.5360.42
65_S183_D0.5360.42
170_E174_E0.5350.42
253_D332_N0.5340.42
247_V292_Y0.5320.41
339_R353_Q0.5290.41
157_L160_D0.5290.41
262_G306_I0.5280.41
245_F292_Y0.5270.41
246_E253_D0.5270.41
232_H250_W0.5260.41
239_S242_T0.5260.41
43_L76_R0.5230.40
50_R235_A0.5210.40
120_N142_D0.5210.40
58_K331_K0.5210.40
229_G233_N0.5200.40
172_G175_K0.5190.40
84_Y250_W0.5180.40
32_V49_Y0.5160.40
36_M44_D0.5160.40
68_Q180_E0.5160.40
83_E127_L0.5150.40
228_D250_W0.5140.39
315_A319_R0.5130.39
54_I96_L0.5130.39
130_V134_Y0.5120.39
50_R219_A0.5120.39
48_A65_S0.5100.39
61_S127_L0.5100.39
254_A257_G0.5100.39
184_F353_Q0.5080.39
111_F316_M0.5060.39
165_T263_E0.5050.38
105_L233_N0.5050.38
31_P46_D0.5040.38
154_N159_S0.5040.38
87_P340_E0.5040.38
291_S294_R0.5030.38
61_S82_A0.5030.38
55_R217_W0.5030.38
142_D264_R0.5030.38
48_A156_S0.5020.38
299_T302_S0.5010.38
143_G301_Q0.5000.38
199_A294_R0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3akjA 2 0.6768 98 0.89 Contact Map
4pu5A 1 0.8508 97.9 0.892 Contact Map
3tpdA 1 0.7735 97.4 0.904 Contact Map
1cjaA 1 0.7376 51.5 0.954 Contact Map
4wtvA 1 0.779 26.8 0.961 Contact Map
4n78F 1 0.1906 22.4 0.962 Contact Map
4cg4A 2 0.2072 15.8 0.965 Contact Map
1ez3A 1 0.1961 15.6 0.965 Contact Map
4jehB 1 0.1934 12.6 0.966 Contact Map
4bwcA 1 0.3066 8.9 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.