SAPB - BACSU - GREMLIN Contacts

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SAPB - Protein SapB

UniProt:	Q45514	Sequences: MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVIAVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGLTTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIRMSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDIKAIEGVVGVKCDTL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	232 (211)
Sequences:	1839 (1472)
Seq/√Len:	101.3

ECOLI - YHID
BACSU - SAPB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
18_A	49_C	5.247	1.00
51_L	113_G	4.339	1.00
22_G	45_A	4.317	1.00
79_I	116_L	4.287	1.00
50_M	129_S	4.136	1.00
118_T	126_A	3.237	1.00
110_G	133_I	3.130	1.00
52_T	116_L	3.083	1.00
21_I	118_T	2.842	1.00
23_M	38_L	2.490	1.00
21_I	130_L	2.481	1.00
19_T	42_I	2.373	1.00
12_L	128_A	2.326	1.00
78_Q	81_S	2.264	1.00
157_I	161_M	2.232	1.00
47_S	110_G	2.178	1.00
71_D	74_R	2.143	1.00
56_I	61_H	2.110	1.00
14_K	121_G	2.094	1.00
21_I	126_A	2.084	1.00
25_I	111_A	2.010	1.00
135_I	139_F	2.000	1.00
51_L	75_L	1.934	1.00
43_V	47_S	1.856	1.00
48_S	112_A	1.771	1.00
21_I	127_F	1.768	1.00
11_I	125_E	1.721	1.00
41_C	107_M	1.709	1.00
23_M	42_I	1.698	1.00
49_C	118_T	1.696	1.00
52_T	120_A	1.692	1.00
158_R	161_M	1.661	1.00
12_L	16_G	1.660	1.00
114_L	130_L	1.655	1.00
70_M	73_L	1.612	1.00
58_A	73_L	1.598	1.00
42_I	136_S	1.595	1.00
10_D	14_K	1.563	1.00
22_G	111_A	1.560	1.00
46_V	132_F	1.543	1.00
11_I	14_K	1.530	1.00
122_F	125_E	1.526	1.00
179_R	217_D	1.487	1.00
77_A	81_S	1.486	1.00
14_K	123_Y	1.479	1.00
114_L	133_I	1.449	1.00
75_L	80_I	1.435	1.00
8_D	124_K	1.423	1.00
51_L	80_I	1.419	1.00
54_V	120_A	1.416	1.00
217_D	221_I	1.394	1.00
9_P	13_L	1.378	0.99
76_P	113_G	1.368	0.99
90_V	108_I	1.357	0.99
47_S	112_A	1.355	0.99
88_A	92_L	1.352	0.99
93_R	96_N	1.350	0.99
199_M	203_V	1.344	0.99
24_V	134_L	1.316	0.99
155_K	161_M	1.314	0.99
41_C	111_A	1.302	0.99
17_I	127_F	1.269	0.99
16_G	20_L	1.254	0.99
10_D	123_Y	1.242	0.99
76_P	80_I	1.241	0.99
103_T	137_V	1.224	0.99
59_A	73_L	1.217	0.99
41_C	137_V	1.202	0.99
86_I	91_I	1.197	0.99
75_L	122_F	1.191	0.99
74_R	83_V	1.185	0.98
128_A	131_L	1.181	0.98
90_V	116_L	1.180	0.98
19_T	46_V	1.172	0.98
19_T	132_F	1.172	0.98
55_S	76_P	1.162	0.98
178_R	217_D	1.159	0.98
80_I	112_A	1.155	0.98
59_A	70_M	1.153	0.98
15_L	132_F	1.144	0.98
38_L	42_I	1.136	0.98
47_S	83_V	1.111	0.98
166_K	170_T	1.106	0.98
175_E	179_R	1.103	0.98
95_S	98_V	1.100	0.98
43_V	110_G	1.071	0.97
54_V	117_A	1.070	0.97
52_T	76_P	1.065	0.97
127_F	131_L	1.063	0.97
216_Y	220_A	1.062	0.97
82_G	112_A	1.061	0.97
107_M	137_V	1.058	0.97
19_T	136_S	1.057	0.97
14_K	53_I	1.034	0.96
216_Y	219_K	1.032	0.96
213_D	216_Y	1.023	0.96
34_K	78_Q	1.021	0.96
46_V	110_G	1.000	0.96
52_T	119_G	0.998	0.96
56_I	120_A	0.996	0.96
59_A	72_P	0.989	0.95
71_D	78_Q	0.984	0.95
80_I	113_G	0.966	0.95
22_G	49_C	0.965	0.95
51_L	81_S	0.965	0.95
139_F	146_K	0.964	0.95
34_K	94_K	0.963	0.95
76_P	116_L	0.959	0.94
30_E	137_V	0.959	0.94
52_T	79_I	0.950	0.94
31_L	43_V	0.948	0.94
21_I	114_L	0.946	0.94
44_I	107_M	0.943	0.94
162_S	225_V	0.942	0.94
39_K	42_I	0.940	0.94
169_M	199_M	0.936	0.94
54_V	75_L	0.933	0.94
92_L	96_N	0.932	0.94
30_E	38_L	0.929	0.94
47_S	78_Q	0.923	0.93
17_I	123_Y	0.921	0.93
168_K	171_E	0.921	0.93
30_E	148_G	0.904	0.93
9_P	20_L	0.904	0.93
94_K	100_S	0.904	0.93
59_A	94_K	0.902	0.92
22_G	93_R	0.902	0.92
51_L	116_L	0.900	0.92
81_S	113_G	0.899	0.92
17_I	118_T	0.894	0.92
59_A	122_F	0.885	0.92
16_G	132_F	0.882	0.92
103_T	116_L	0.881	0.92
82_G	105_S	0.881	0.92
23_M	140_L	0.876	0.91
99_I	134_L	0.863	0.91
44_I	108_I	0.859	0.91
56_I	92_L	0.856	0.90
176_M	181_I	0.851	0.90
38_L	137_V	0.835	0.89
72_P	78_Q	0.824	0.89
55_S	78_Q	0.824	0.89
52_T	70_M	0.823	0.89
36_L	108_I	0.822	0.89
175_E	178_R	0.821	0.88
111_A	137_V	0.820	0.88
34_K	108_I	0.814	0.88
104_T	108_I	0.809	0.88
55_S	120_A	0.805	0.87
58_A	93_R	0.802	0.87
34_K	90_V	0.802	0.87
173_L	183_A	0.796	0.87
174_K	177_K	0.796	0.87
18_A	22_G	0.793	0.87
137_V	141_P	0.790	0.86
136_S	140_L	0.789	0.86
90_V	93_R	0.786	0.86
30_E	84_G	0.781	0.86
126_A	169_M	0.781	0.86
53_I	57_N	0.775	0.85
30_E	141_P	0.774	0.85
25_I	176_M	0.773	0.85
210_Y	213_D	0.772	0.85
38_L	144_V	0.772	0.85
21_I	137_V	0.768	0.85
36_L	47_S	0.766	0.85
189_D	200_E	0.765	0.85
75_L	116_L	0.760	0.84
142_W	147_I	0.757	0.84
50_M	76_P	0.755	0.84
18_A	45_A	0.754	0.84
13_L	123_Y	0.747	0.83
27_L	79_I	0.744	0.83
36_L	43_V	0.744	0.83
59_A	71_D	0.739	0.83
124_K	128_A	0.733	0.82
69_M	75_L	0.732	0.82
43_V	137_V	0.729	0.82
196_F	213_D	0.728	0.82
179_R	213_D	0.725	0.81
85_F	89_G	0.725	0.81
167_D	171_E	0.725	0.81
79_I	112_A	0.722	0.81
212_T	215_Y	0.720	0.81
99_I	187_R	0.716	0.81
21_I	56_I	0.712	0.80
72_P	76_P	0.704	0.79
83_V	112_A	0.702	0.79
224_V	227_V	0.698	0.79
34_K	54_V	0.697	0.79
23_M	123_Y	0.695	0.79
34_K	95_S	0.694	0.79
44_I	86_I	0.694	0.79
44_I	90_V	0.693	0.78
172_I	218_I	0.689	0.78
36_L	107_M	0.687	0.78
51_L	69_M	0.686	0.78
32_K	49_C	0.684	0.78
177_K	182_K	0.682	0.77
77_A	80_I	0.681	0.77
118_T	123_Y	0.679	0.77
160_R	200_E	0.678	0.77
150_D	203_V	0.677	0.77
168_K	172_I	0.676	0.77
78_Q	82_G	0.672	0.76
139_F	158_R	0.667	0.76
79_I	142_W	0.664	0.75
20_L	23_M	0.664	0.75
18_A	148_G	0.663	0.75
32_K	35_P	0.661	0.75
174_K	178_R	0.657	0.75
131_L	198_I	0.651	0.74
36_L	104_T	0.649	0.74
56_I	59_A	0.649	0.74
54_V	78_Q	0.648	0.74
94_K	98_V	0.647	0.74
43_V	133_I	0.646	0.73
88_A	132_F	0.644	0.73
87_G	112_A	0.643	0.73
54_V	116_L	0.642	0.73
88_A	140_L	0.641	0.73
167_D	170_T	0.640	0.73
191_L	196_F	0.638	0.72
58_A	70_M	0.637	0.72
48_S	132_F	0.637	0.72
154_E	178_R	0.637	0.72
206_H	209_R	0.633	0.72
60_Y	68_I	0.628	0.71
45_A	111_A	0.626	0.71
12_L	130_L	0.624	0.71
74_R	85_F	0.624	0.71
41_C	141_P	0.623	0.71
14_K	57_N	0.622	0.71
61_H	73_L	0.620	0.70
9_P	164_S	0.620	0.70
181_I	206_H	0.618	0.70
11_I	119_G	0.617	0.70
70_M	122_F	0.613	0.69
72_P	75_L	0.611	0.69
177_K	194_K	0.608	0.69
34_K	39_K	0.605	0.68
51_L	118_T	0.604	0.68
43_V	96_N	0.604	0.68
108_I	141_P	0.596	0.67
33_N	110_G	0.596	0.67
171_E	206_H	0.596	0.67
102_L	112_A	0.595	0.67
42_I	100_S	0.594	0.67
131_L	146_K	0.584	0.66
192_G	195_D	0.580	0.65
146_K	149_P	0.579	0.65
73_L	78_Q	0.579	0.65
137_V	144_V	0.576	0.65
110_G	113_G	0.576	0.65
35_P	83_V	0.575	0.65
15_L	128_A	0.574	0.64
31_L	136_S	0.572	0.64
113_G	118_T	0.571	0.64
193_E	222_E	0.564	0.63
45_A	122_F	0.562	0.63
30_E	144_V	0.561	0.63
45_A	144_V	0.561	0.63
146_K	150_D	0.559	0.62
221_I	224_V	0.558	0.62
133_I	137_V	0.557	0.62
217_D	220_A	0.554	0.62
90_V	137_V	0.554	0.62
42_I	140_L	0.554	0.62
53_I	121_G	0.552	0.61
19_T	32_K	0.551	0.61
25_I	181_I	0.551	0.61
58_A	76_P	0.549	0.61
114_L	149_P	0.546	0.61
73_L	122_F	0.545	0.60
142_W	146_K	0.545	0.60
84_G	89_G	0.545	0.60
84_G	126_A	0.541	0.60
187_R	200_E	0.541	0.60
124_K	177_K	0.540	0.60
127_F	186_V	0.536	0.59
43_V	100_S	0.536	0.59
162_S	222_E	0.536	0.59
28_E	98_V	0.536	0.59
107_M	111_A	0.535	0.59
54_V	122_F	0.535	0.59
74_R	89_G	0.534	0.59
176_M	201_V	0.534	0.59
43_V	106_A	0.533	0.59
215_Y	227_V	0.532	0.59
205_V	223_G	0.532	0.59
55_S	77_A	0.529	0.58
43_V	95_S	0.528	0.58
198_I	202_K	0.527	0.58
176_M	180_D	0.526	0.58
124_K	135_I	0.525	0.58
181_I	205_V	0.523	0.57
24_V	213_D	0.522	0.57
32_K	80_I	0.521	0.57
58_A	61_H	0.521	0.57
57_N	122_F	0.520	0.57
194_K	221_I	0.520	0.57
25_I	114_L	0.519	0.57
61_H	70_M	0.517	0.57
39_K	130_L	0.516	0.56
170_T	177_K	0.513	0.56
54_V	119_G	0.512	0.56
172_I	202_K	0.511	0.56
160_R	214_V	0.509	0.55
165_D	168_K	0.507	0.55
216_Y	224_V	0.507	0.55
129_S	219_K	0.505	0.55
79_I	93_R	0.502	0.54
41_C	130_L	0.502	0.54
54_V	133_I	0.501	0.54
166_K	197_P	0.500	0.54
176_M	222_E	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ko1A	2	0.3448	95.3	0.912	Contact Map
2pc6A	2	0.3405	95.1	0.914	Contact Map
2f1fA	4	0.3362	95	0.914	Contact Map
1y7pA	5	0.3448	93.9	0.918	Contact Map
2lqjA	1	0.3621	93.8	0.919	Contact Map
2lvwA	2	0.3664	93.3	0.92	Contact Map
1zpvA	3	0.3405	92.6	0.922	Contact Map
2fgcA	2	0.3362	85.7	0.932	Contact Map
3w7bA	3	0.3448	54.6	0.947	Contact Map
1u0sA	1	0.3448	51.6	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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