GREMLIN Database
SAPB - Protein SapB
UniProt: Q45514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (211)
Sequences: 1839 (1472)
Seq/√Len: 101.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_A49_C5.2471.00
51_L113_G4.3391.00
22_G45_A4.3171.00
79_I116_L4.2871.00
50_M129_S4.1361.00
118_T126_A3.2371.00
110_G133_I3.1301.00
52_T116_L3.0831.00
21_I118_T2.8421.00
23_M38_L2.4901.00
21_I130_L2.4811.00
19_T42_I2.3731.00
12_L128_A2.3261.00
78_Q81_S2.2641.00
157_I161_M2.2321.00
47_S110_G2.1781.00
71_D74_R2.1431.00
56_I61_H2.1101.00
14_K121_G2.0941.00
21_I126_A2.0841.00
25_I111_A2.0101.00
135_I139_F2.0001.00
51_L75_L1.9341.00
43_V47_S1.8561.00
48_S112_A1.7711.00
21_I127_F1.7681.00
11_I125_E1.7211.00
41_C107_M1.7091.00
23_M42_I1.6981.00
49_C118_T1.6961.00
52_T120_A1.6921.00
158_R161_M1.6611.00
12_L16_G1.6601.00
114_L130_L1.6551.00
70_M73_L1.6121.00
58_A73_L1.5981.00
42_I136_S1.5951.00
10_D14_K1.5631.00
22_G111_A1.5601.00
46_V132_F1.5431.00
11_I14_K1.5301.00
122_F125_E1.5261.00
179_R217_D1.4871.00
77_A81_S1.4861.00
14_K123_Y1.4791.00
114_L133_I1.4491.00
75_L80_I1.4351.00
8_D124_K1.4231.00
51_L80_I1.4191.00
54_V120_A1.4161.00
217_D221_I1.3941.00
9_P13_L1.3780.99
76_P113_G1.3680.99
90_V108_I1.3570.99
47_S112_A1.3550.99
88_A92_L1.3520.99
93_R96_N1.3500.99
199_M203_V1.3440.99
24_V134_L1.3160.99
155_K161_M1.3140.99
41_C111_A1.3020.99
17_I127_F1.2690.99
16_G20_L1.2540.99
10_D123_Y1.2420.99
76_P80_I1.2410.99
103_T137_V1.2240.99
59_A73_L1.2170.99
41_C137_V1.2020.99
86_I91_I1.1970.99
75_L122_F1.1910.99
74_R83_V1.1850.98
128_A131_L1.1810.98
90_V116_L1.1800.98
19_T46_V1.1720.98
19_T132_F1.1720.98
55_S76_P1.1620.98
178_R217_D1.1590.98
80_I112_A1.1550.98
59_A70_M1.1530.98
15_L132_F1.1440.98
38_L42_I1.1360.98
47_S83_V1.1110.98
166_K170_T1.1060.98
175_E179_R1.1030.98
95_S98_V1.1000.98
43_V110_G1.0710.97
54_V117_A1.0700.97
52_T76_P1.0650.97
127_F131_L1.0630.97
216_Y220_A1.0620.97
82_G112_A1.0610.97
107_M137_V1.0580.97
19_T136_S1.0570.97
14_K53_I1.0340.96
216_Y219_K1.0320.96
213_D216_Y1.0230.96
34_K78_Q1.0210.96
46_V110_G1.0000.96
52_T119_G0.9980.96
56_I120_A0.9960.96
59_A72_P0.9890.95
71_D78_Q0.9840.95
80_I113_G0.9660.95
22_G49_C0.9650.95
51_L81_S0.9650.95
139_F146_K0.9640.95
34_K94_K0.9630.95
76_P116_L0.9590.94
30_E137_V0.9590.94
52_T79_I0.9500.94
31_L43_V0.9480.94
21_I114_L0.9460.94
44_I107_M0.9430.94
162_S225_V0.9420.94
39_K42_I0.9400.94
169_M199_M0.9360.94
54_V75_L0.9330.94
92_L96_N0.9320.94
30_E38_L0.9290.94
47_S78_Q0.9230.93
17_I123_Y0.9210.93
168_K171_E0.9210.93
30_E148_G0.9040.93
9_P20_L0.9040.93
94_K100_S0.9040.93
59_A94_K0.9020.92
22_G93_R0.9020.92
51_L116_L0.9000.92
81_S113_G0.8990.92
17_I118_T0.8940.92
59_A122_F0.8850.92
16_G132_F0.8820.92
103_T116_L0.8810.92
82_G105_S0.8810.92
23_M140_L0.8760.91
99_I134_L0.8630.91
44_I108_I0.8590.91
56_I92_L0.8560.90
176_M181_I0.8510.90
38_L137_V0.8350.89
72_P78_Q0.8240.89
55_S78_Q0.8240.89
52_T70_M0.8230.89
36_L108_I0.8220.89
175_E178_R0.8210.88
111_A137_V0.8200.88
34_K108_I0.8140.88
104_T108_I0.8090.88
55_S120_A0.8050.87
58_A93_R0.8020.87
34_K90_V0.8020.87
173_L183_A0.7960.87
174_K177_K0.7960.87
18_A22_G0.7930.87
137_V141_P0.7900.86
136_S140_L0.7890.86
90_V93_R0.7860.86
30_E84_G0.7810.86
126_A169_M0.7810.86
53_I57_N0.7750.85
30_E141_P0.7740.85
25_I176_M0.7730.85
210_Y213_D0.7720.85
38_L144_V0.7720.85
21_I137_V0.7680.85
36_L47_S0.7660.85
189_D200_E0.7650.85
75_L116_L0.7600.84
142_W147_I0.7570.84
50_M76_P0.7550.84
18_A45_A0.7540.84
13_L123_Y0.7470.83
27_L79_I0.7440.83
36_L43_V0.7440.83
59_A71_D0.7390.83
124_K128_A0.7330.82
69_M75_L0.7320.82
43_V137_V0.7290.82
196_F213_D0.7280.82
179_R213_D0.7250.81
85_F89_G0.7250.81
167_D171_E0.7250.81
79_I112_A0.7220.81
212_T215_Y0.7200.81
99_I187_R0.7160.81
21_I56_I0.7120.80
72_P76_P0.7040.79
83_V112_A0.7020.79
224_V227_V0.6980.79
34_K54_V0.6970.79
23_M123_Y0.6950.79
34_K95_S0.6940.79
44_I86_I0.6940.79
44_I90_V0.6930.78
172_I218_I0.6890.78
36_L107_M0.6870.78
51_L69_M0.6860.78
32_K49_C0.6840.78
177_K182_K0.6820.77
77_A80_I0.6810.77
118_T123_Y0.6790.77
160_R200_E0.6780.77
150_D203_V0.6770.77
168_K172_I0.6760.77
78_Q82_G0.6720.76
139_F158_R0.6670.76
79_I142_W0.6640.75
20_L23_M0.6640.75
18_A148_G0.6630.75
32_K35_P0.6610.75
174_K178_R0.6570.75
131_L198_I0.6510.74
36_L104_T0.6490.74
56_I59_A0.6490.74
54_V78_Q0.6480.74
94_K98_V0.6470.74
43_V133_I0.6460.73
88_A132_F0.6440.73
87_G112_A0.6430.73
54_V116_L0.6420.73
88_A140_L0.6410.73
167_D170_T0.6400.73
191_L196_F0.6380.72
58_A70_M0.6370.72
48_S132_F0.6370.72
154_E178_R0.6370.72
206_H209_R0.6330.72
60_Y68_I0.6280.71
45_A111_A0.6260.71
12_L130_L0.6240.71
74_R85_F0.6240.71
41_C141_P0.6230.71
14_K57_N0.6220.71
61_H73_L0.6200.70
9_P164_S0.6200.70
181_I206_H0.6180.70
11_I119_G0.6170.70
70_M122_F0.6130.69
72_P75_L0.6110.69
177_K194_K0.6080.69
34_K39_K0.6050.68
51_L118_T0.6040.68
43_V96_N0.6040.68
108_I141_P0.5960.67
33_N110_G0.5960.67
171_E206_H0.5960.67
102_L112_A0.5950.67
42_I100_S0.5940.67
131_L146_K0.5840.66
192_G195_D0.5800.65
146_K149_P0.5790.65
73_L78_Q0.5790.65
137_V144_V0.5760.65
110_G113_G0.5760.65
35_P83_V0.5750.65
15_L128_A0.5740.64
31_L136_S0.5720.64
113_G118_T0.5710.64
193_E222_E0.5640.63
45_A122_F0.5620.63
30_E144_V0.5610.63
45_A144_V0.5610.63
146_K150_D0.5590.62
221_I224_V0.5580.62
133_I137_V0.5570.62
217_D220_A0.5540.62
90_V137_V0.5540.62
42_I140_L0.5540.62
53_I121_G0.5520.61
19_T32_K0.5510.61
25_I181_I0.5510.61
58_A76_P0.5490.61
114_L149_P0.5460.61
73_L122_F0.5450.60
142_W146_K0.5450.60
84_G89_G0.5450.60
84_G126_A0.5410.60
187_R200_E0.5410.60
124_K177_K0.5400.60
127_F186_V0.5360.59
43_V100_S0.5360.59
162_S222_E0.5360.59
28_E98_V0.5360.59
107_M111_A0.5350.59
54_V122_F0.5350.59
74_R89_G0.5340.59
176_M201_V0.5340.59
43_V106_A0.5330.59
215_Y227_V0.5320.59
205_V223_G0.5320.59
55_S77_A0.5290.58
43_V95_S0.5280.58
198_I202_K0.5270.58
176_M180_D0.5260.58
124_K135_I0.5250.58
181_I205_V0.5230.57
24_V213_D0.5220.57
32_K80_I0.5210.57
58_A61_H0.5210.57
57_N122_F0.5200.57
194_K221_I0.5200.57
25_I114_L0.5190.57
61_H70_M0.5170.57
39_K130_L0.5160.56
170_T177_K0.5130.56
54_V119_G0.5120.56
172_I202_K0.5110.56
160_R214_V0.5090.55
165_D168_K0.5070.55
216_Y224_V0.5070.55
129_S219_K0.5050.55
79_I93_R0.5020.54
41_C130_L0.5020.54
54_V133_I0.5010.54
166_K197_P0.5000.54
176_M222_E0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ko1A 2 0.3448 95.3 0.912 Contact Map
2pc6A 2 0.3405 95.1 0.914 Contact Map
2f1fA 4 0.3362 95 0.914 Contact Map
1y7pA 5 0.3448 93.9 0.918 Contact Map
2lqjA 1 0.3621 93.8 0.919 Contact Map
2lvwA 2 0.3664 93.3 0.92 Contact Map
1zpvA 3 0.3405 92.6 0.922 Contact Map
2fgcA 2 0.3362 85.7 0.932 Contact Map
3w7bA 3 0.3448 54.6 0.947 Contact Map
1u0sA 1 0.3448 51.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0082 seconds.