GREMLIN Database
YKTD - Putative S-adenosyl-L-methionine-dependent methyltransferase YktD
UniProt: Q45500 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (258)
Sequences: 1945 (1433)
Seq/√Len: 89.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_E117_F5.1001.00
90_S94_K4.2501.00
129_Q158_H4.1441.00
22_R35_K3.7961.00
108_V185_F3.7681.00
96_L184_F3.6291.00
171_D175_D3.1021.00
195_T198_E2.6731.00
183_T210_V2.5411.00
178_F183_T2.4741.00
21_S30_D2.4701.00
187_L202_L2.4631.00
93_E120_R2.4541.00
185_F210_V2.4311.00
274_S277_D2.3321.00
132_E142_K2.2531.00
273_L281_L2.1551.00
107_Y186_S2.1001.00
168_F171_D2.0631.00
117_F188_L2.0611.00
111_G190_V2.0541.00
136_P161_P2.0511.00
251_S255_Y2.0441.00
131_F177_G2.0151.00
143_K159_F1.9961.00
139_Q159_F1.9491.00
133_V162_M1.9231.00
108_V178_F1.8991.00
287_K290_L1.8801.00
26_P30_D1.8541.00
133_V160_V1.8311.00
129_Q156_H1.8191.00
37_L145_K1.7871.00
44_I47_S1.7561.00
200_A265_S1.7251.00
92_C188_L1.7121.00
185_F206_L1.6811.00
276_D282_F1.6791.00
89_A117_F1.6621.00
261_L265_S1.6511.00
112_A132_E1.6431.00
131_F160_V1.6161.00
257_E260_H1.6141.00
174_L180_N1.6071.00
260_H264_S1.6051.00
7_S10_S1.5621.00
98_N101_I1.5471.00
277_D282_F1.5451.00
223_E252_C1.5421.00
20_H23_Y1.5391.00
23_Y26_P1.5141.00
167_T172_P1.5081.00
21_S29_F1.5051.00
247_E252_C1.5021.00
35_K39_N1.4911.00
239_V243_A1.4781.00
139_Q161_P1.4640.99
242_A245_S1.4480.99
283_F287_K1.4350.99
199_N251_S1.4200.99
201_S204_S1.4130.99
198_E202_L1.4110.99
96_L128_L1.4050.99
190_V202_L1.4030.99
241_M245_S1.3930.99
164_F202_L1.3840.99
187_L190_V1.3660.99
240_K244_A1.3450.99
14_A17_R1.3400.99
117_F121_H1.3190.99
278_I282_F1.3130.99
20_H188_L1.3120.99
285_N288_D1.3110.99
122_P154_P1.3090.99
256_Q261_L1.3060.99
7_S135_H1.3050.99
139_Q143_K1.3040.99
140_Q144_N1.2970.99
144_N148_D1.2790.99
119_F157_L1.2710.99
164_F190_V1.2630.98
133_V169_S1.2610.98
170_Y174_L1.2570.98
89_A186_S1.2510.98
178_F210_V1.2310.98
84_T219_D1.2240.98
88_R193_Y1.2130.98
173_L178_F1.2020.98
99_E184_F1.2020.98
238_M242_A1.1990.98
170_Y205_N1.1910.98
275_P279_N1.1900.98
215_S262_L1.1880.98
121_H188_L1.1840.98
106_Q132_E1.1780.98
284_S287_K1.1750.98
108_V131_F1.1720.97
89_A188_L1.1670.97
7_S138_T1.1660.97
21_S32_F1.1640.97
9_T13_S1.1510.97
277_D283_F1.1440.97
100_L107_Y1.1360.97
131_F178_F1.1350.97
13_S16_A1.1340.97
235_V239_V1.1250.97
108_V177_G1.1250.97
169_S187_L1.1160.97
12_I16_A1.1110.97
98_N215_S1.1060.96
106_Q131_F1.1030.96
121_H267_L1.1010.96
84_T238_M1.0960.96
12_I192_Y1.0930.96
114_L141_L1.0900.96
279_N282_F1.0840.96
44_I49_N1.0830.96
223_E248_P1.0490.95
250_K255_Y1.0300.95
169_S214_S1.0290.95
109_I132_E1.0250.95
117_F130_V1.0180.94
277_D281_L1.0180.94
92_C186_S1.0160.94
206_L216_I1.0160.94
96_L186_S1.0080.94
29_F86_L1.0080.94
234_R237_H1.0040.94
276_D280_D1.0020.94
238_M241_M1.0010.94
11_L15_F1.0000.94
106_Q183_T0.9940.94
105_K183_T0.9890.93
16_A19_Y0.9880.93
165_T198_E0.9830.93
77_A81_L0.9800.93
271_E281_L0.9780.93
172_P195_T0.9750.93
228_A234_R0.9690.93
283_F290_L0.9690.93
78_Q192_Y0.9670.93
143_K147_K0.9670.93
81_L238_M0.9660.93
236_E240_K0.9640.93
106_Q182_K0.9590.92
36_D39_N0.9590.92
12_I82_S0.9580.92
96_L107_Y0.9520.92
95_V184_F0.9510.92
273_L277_D0.9510.92
47_S50_M0.9510.92
11_L38_I0.9490.92
24_D33_I0.9400.92
11_L219_D0.9380.91
83_P86_L0.9370.91
37_L112_A0.9340.91
249_M252_C0.9290.91
107_Y128_L0.9180.91
187_L191_S0.9010.90
40_E44_I0.8990.90
111_G202_L0.8960.89
124_L127_S0.8930.89
279_N283_F0.8920.89
141_L145_K0.8910.89
248_P252_C0.8890.89
234_R238_M0.8820.89
136_P162_M0.8780.89
41_K48_K0.8770.88
106_Q178_F0.8760.88
258_I261_L0.8750.88
174_L208_S0.8740.88
247_E250_K0.8720.88
7_S29_F0.8710.88
172_P204_S0.8690.88
38_I42_E0.8670.88
109_I130_V0.8670.88
223_E226_F0.8620.88
36_D149_A0.8560.87
135_H138_T0.8540.87
197_E201_S0.8490.87
29_F47_S0.8470.87
174_L209_H0.8450.87
182_K211_P0.8440.86
17_R89_A0.8360.86
191_S202_L0.8340.86
11_L43_F0.8330.86
80_Q87_A0.8300.86
40_E141_L0.8290.86
221_A226_F0.8210.85
192_Y221_A0.8210.85
279_N284_S0.8150.85
204_S208_S0.8140.84
234_R241_M0.8120.84
158_H161_P0.8080.84
276_D284_S0.8040.84
107_Y130_V0.8030.84
203_I262_L0.7980.83
196_R257_E0.7960.83
92_C117_F0.7960.83
30_D122_P0.7960.83
89_A121_H0.7950.83
146_L151_L0.7870.82
33_I36_D0.7850.82
107_Y184_F0.7780.82
162_M172_P0.7720.81
99_E103_G0.7720.81
204_S265_S0.7710.81
240_K243_A0.7710.81
50_M203_I0.7700.81
152_T264_S0.7650.81
37_L141_L0.7630.80
167_T173_L0.7520.79
243_A246_G0.7500.79
201_S205_N0.7440.79
19_Y186_S0.7400.78
189_G193_Y0.7390.78
251_S261_L0.7370.78
112_A142_K0.7330.78
10_S14_A0.7330.78
81_L112_A0.7230.77
20_H117_F0.7230.77
172_P175_D0.7210.77
20_H28_I0.7200.76
96_L130_V0.7180.76
16_A86_L0.7170.76
89_A93_E0.7160.76
283_F286_R0.7150.76
175_D197_E0.7130.76
108_V173_L0.7130.76
206_L210_V0.7120.76
95_V215_S0.7060.75
99_E119_F0.7050.75
24_D235_V0.7040.75
16_A238_M0.7030.75
23_Y29_F0.7010.75
80_Q192_Y0.7010.75
242_A249_M0.6950.74
286_R289_N0.6940.74
169_S213_G0.6940.74
235_V242_A0.6920.74
271_E274_S0.6910.73
105_K182_K0.6880.73
10_S142_K0.6870.73
76_V80_Q0.6850.73
33_I37_L0.6850.73
15_F18_A0.6820.72
249_M255_Y0.6760.72
25_T32_F0.6720.71
210_V214_S0.6720.71
33_I116_T0.6690.71
100_L105_K0.6690.71
23_Y82_S0.6680.71
227_T234_R0.6630.70
260_H263_E0.6610.70
281_L288_D0.6610.70
273_L283_F0.6610.70
165_T195_T0.6610.70
206_L209_H0.6590.70
21_S25_T0.6590.70
280_D284_S0.6580.70
84_T192_Y0.6560.70
281_L284_S0.6540.69
144_N180_N0.6540.69
97_H101_I0.6510.69
134_D193_Y0.6510.69
94_K98_N0.6490.69
229_K240_K0.6490.69
118_C130_V0.6470.69
93_E188_L0.6460.68
88_R189_G0.6410.68
239_V252_C0.6400.68
19_Y82_S0.6390.68
180_N281_L0.6370.67
177_G214_S0.6370.67
16_A219_D0.6370.67
12_I15_F0.6350.67
235_V241_M0.6340.67
17_R189_G0.6330.67
16_A82_S0.6320.67
259_E272_H0.6320.67
175_D204_S0.6320.67
20_H93_E0.6300.66
20_H25_T0.6290.66
225_L252_C0.6280.66
256_Q280_D0.6280.66
135_H139_Q0.6270.66
106_Q177_G0.6230.66
164_F262_L0.6220.65
164_F209_H0.6220.65
277_D280_D0.6210.65
160_V262_L0.6180.65
7_S16_A0.6180.65
84_T234_R0.6180.65
251_S254_T0.6170.65
226_F229_K0.6170.65
160_V206_L0.6140.64
137_A140_Q0.6130.64
41_K45_D0.6130.64
106_Q109_I0.6120.64
107_Y286_R0.6120.64
228_A238_M0.6100.64
98_N102_L0.6090.64
273_L282_F0.6050.63
127_S156_H0.6050.63
84_T87_A0.6010.63
235_V238_M0.6000.63
11_L261_L0.6000.63
281_L289_N0.5990.63
84_T220_Y0.5990.63
97_H100_L0.5960.62
277_D284_S0.5960.62
283_F288_D0.5870.61
13_S192_Y0.5850.61
113_G134_D0.5850.61
196_R261_L0.5820.60
153_I179_K0.5800.60
250_K254_T0.5800.60
81_L192_Y0.5790.60
22_R32_F0.5780.60
13_S85_P0.5770.60
169_S172_P0.5760.60
204_S207_F0.5760.60
200_A254_T0.5750.59
111_G205_N0.5750.59
191_S199_N0.5720.59
19_Y22_R0.5690.59
192_Y219_D0.5680.59
259_E263_E0.5680.59
91_Y214_S0.5670.58
259_E276_D0.5670.58
200_A261_L0.5640.58
220_Y272_H0.5640.58
187_L203_I0.5620.58
11_L41_K0.5560.57
276_D279_N0.5550.57
32_F51_I0.5530.57
12_I85_P0.5510.56
145_K149_A0.5480.56
6_S9_T0.5470.56
142_K146_L0.5410.55
189_G220_Y0.5400.55
229_K238_M0.5400.55
31_D34_A0.5390.55
144_N158_H0.5390.55
136_P140_Q0.5380.54
211_P214_S0.5360.54
216_I269_I0.5360.54
49_N52_Q0.5340.54
106_Q214_S0.5340.54
77_A242_A0.5330.54
109_I226_F0.5320.54
187_L219_D0.5300.53
252_C255_Y0.5300.53
115_D173_L0.5290.53
81_L85_P0.5280.53
149_A186_S0.5280.53
228_A235_V0.5250.53
44_I48_K0.5240.53
192_Y251_S0.5240.53
89_A92_C0.5220.52
147_K153_I0.5220.52
187_L199_N0.5220.52
285_N289_N0.5210.52
276_D281_L0.5210.52
171_D176_E0.5190.52
39_N261_L0.5180.52
136_P264_S0.5160.51
199_N261_L0.5140.51
160_V172_P0.5130.51
89_A120_R0.5130.51
129_Q177_G0.5130.51
38_I41_K0.5120.51
80_Q235_V0.5120.51
221_A228_A0.5110.51
197_E207_F0.5090.51
124_L153_I0.5080.50
114_L120_R0.5070.50
17_R37_L0.5070.50
76_V240_K0.5060.50
20_H26_P0.5050.50
102_L215_S0.5050.50
177_G209_H0.5050.50
273_L280_D0.5050.50
127_S201_S0.5030.50
16_A23_Y0.5020.50
210_V267_L0.5020.50
242_A247_E0.5000.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ieiA 2 0.8487 100 0.374 Contact Map
1rjdA 1 0.9243 100 0.384 Contact Map
2uyoA 1 0.8586 100 0.385 Contact Map
2zwaA 1 0.9178 100 0.396 Contact Map
3giwA 1 0.8224 99 0.834 Contact Map
2qe6A 2 0.8322 98.8 0.848 Contact Map
2r3sA 4 0.8783 98.1 0.878 Contact Map
3dp7A 2 0.898 98 0.882 Contact Map
2ip2A 2 0.8355 98 0.882 Contact Map
3g2mA 2 0.7039 97.9 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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