GREMLIN Database
SUHB - Inositol-1-monophosphatase
UniProt: Q45499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 265 (246)
Sequences: 10229 (7245)
Seq/√Len: 461.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_L227_G4.1761.00
120_Y127_L3.5521.00
82_V110_E3.2391.00
230_T253_H3.1631.00
131_F134_R3.0601.00
81_G111_N2.9921.00
135_G224_E2.8801.00
219_C223_N2.8331.00
121_D124_H2.7091.00
14_W56_R2.6491.00
157_A202_I2.5711.00
17_E56_R2.4841.00
33_E47_K2.4191.00
21_R52_F2.3421.00
19_G120_Y2.2451.00
113_E132_S2.2441.00
204_A256_I2.1491.00
231_T235_E2.1151.00
83_V109_F2.1101.00
102_F123_V2.0791.00
82_V108_I2.0451.00
44_N48_E2.0371.00
50_E68_G1.9941.00
129_H137_Y1.9901.00
51_K55_D1.9581.00
61_F64_H1.9421.00
25_S45_I1.8941.00
22_I49_T1.8881.00
85_I109_F1.8471.00
56_R59_E1.8441.00
110_E115_K1.8201.00
117_G220_V1.8111.00
128_Y199_A1.7831.00
109_F114_G1.7671.00
54_I58_Q1.7621.00
130_A224_E1.7301.00
64_H82_V1.7201.00
220_V224_E1.6981.00
138_M199_A1.6891.00
15_I106_I1.6621.00
11_A84_W1.6421.00
150_V153_E1.6381.00
137_Y142_K1.6231.00
23_T123_V1.6211.00
54_I66_I1.6011.00
119_I195_A1.5961.00
121_D192_L1.5811.00
52_F56_R1.5811.00
10_I61_F1.5591.00
103_A191_A1.5521.00
10_I60_T1.5481.00
133_G224_E1.5471.00
105_S191_A1.5411.00
10_I14_W1.5341.00
12_K129_H1.5291.00
126_E201_R1.4931.00
26_M102_F1.4831.00
64_H84_W1.4521.00
126_E138_M1.4501.00
43_T96_V1.4491.00
195_A221_L1.4311.00
113_E223_N1.4311.00
81_G110_E1.4301.00
22_I89_I1.4241.00
86_I106_I1.4021.00
13_K60_T1.4011.00
107_G216_A1.3891.00
132_S223_N1.3751.00
84_W108_I1.3621.00
126_E199_A1.3611.00
21_R24_Q1.3601.00
132_S224_E1.3541.00
248_G253_H1.3521.00
55_D59_E1.3411.00
172_S175_A1.3341.00
16_R127_L1.3291.00
53_F86_I1.3291.00
15_I118_L1.3181.00
136_A143_L1.3031.00
23_T102_F1.2941.00
57_I64_H1.2831.00
56_R60_T1.2641.00
53_F106_I1.2591.00
12_K16_R1.2441.00
194_L218_G1.2411.00
22_I102_F1.2251.00
12_K127_L1.2161.00
8_D129_H1.2141.00
48_E51_K1.2071.00
171_Q175_A1.2031.00
51_K71_G1.2011.00
54_I68_G1.2001.00
13_K17_E1.1941.00
228_T254_K1.1921.00
50_E71_G1.1881.00
41_L93_M1.1841.00
156_L204_A1.1621.00
17_E52_F1.1601.00
41_L96_V1.1551.00
22_I45_I1.1351.00
7_I64_H1.1351.00
130_A220_V1.1331.00
196_N201_R1.1261.00
50_E54_I1.1251.00
54_I71_G1.1211.00
223_N236_P1.1021.00
254_K258_E1.0911.00
115_K132_S1.0881.00
219_C229_Y1.0811.00
47_K51_K1.0781.00
154_A252_I1.0621.00
14_W52_F1.0621.00
168_R172_S1.0591.00
99_Q187_Y1.0561.00
85_I216_A1.0531.00
120_Y125_D1.0361.00
77_H80_E1.0311.00
20_A24_Q1.0251.00
146_L203_D1.0241.00
67_L85_I1.0171.00
194_L247_A1.0091.00
107_G114_G1.0031.00
25_S48_E1.0021.00
24_Q28_E0.9941.00
108_I116_I0.9931.00
114_G220_V0.9921.00
21_R25_S0.9921.00
14_W53_F0.9911.00
17_E20_A0.9831.00
168_R175_A0.9781.00
190_A210_L0.9771.00
46_D70_E0.9741.00
21_R48_E0.9691.00
194_L222_L0.9631.00
10_I57_I0.9611.00
13_K56_R0.9611.00
222_L247_A0.9601.00
129_H140_E0.9581.00
192_L196_N0.9571.00
43_T92_T0.9571.00
114_G219_C0.9531.00
255_T258_E0.9521.00
49_T53_F0.9511.00
7_I108_I0.9471.00
7_I61_F0.9411.00
143_L199_A0.9381.00
94_N185_R0.9341.00
136_A221_L0.9331.00
67_L83_V0.9301.00
228_T250_P0.9251.00
11_A118_L0.9201.00
25_S44_N0.9201.00
172_S176_P0.9151.00
228_T253_H0.9121.00
35_K42_V0.9101.00
170_D173_V0.9091.00
136_A224_E0.8911.00
49_T89_I0.8901.00
154_A203_D0.8851.00
82_V115_K0.8831.00
68_G71_G0.8751.00
69_E92_T0.8721.00
8_D131_F0.8681.00
249_N252_I0.8681.00
70_E92_T0.8661.00
7_I82_V0.8621.00
35_K43_T0.8611.00
16_R125_D0.8591.00
26_M123_V0.8511.00
108_I115_K0.8461.00
175_A179_K0.8461.00
101_N196_N0.8451.00
26_M98_Q0.8401.00
238_T241_E0.8391.00
253_H257_F0.8341.00
46_D92_T0.8331.00
138_M141_T0.8221.00
119_I221_L0.8171.00
31_T44_N0.8151.00
57_I61_F0.8071.00
16_R120_Y0.8051.00
67_L213_W0.7941.00
149_T251_S0.7901.00
119_I218_G0.7891.00
128_Y195_A0.7881.00
16_R20_A0.7831.00
21_R49_T0.7821.00
9_E13_K0.7811.00
9_E12_K0.7801.00
18_A52_F0.7741.00
116_I131_F0.7721.00
105_S218_G0.7691.00
8_D118_L0.7661.00
231_T234_G0.7621.00
210_L215_Y0.7611.00
105_S217_A0.7601.00
107_G220_V0.7591.00
155_I159_N0.7591.00
103_A189_S0.7561.00
12_K118_L0.7541.00
30_L44_N0.7481.00
150_V255_T0.7471.00
174_L178_V0.7431.00
18_A49_T0.7421.00
61_F84_W0.7381.00
57_I108_I0.7371.00
65_R83_V0.7331.00
194_L229_Y0.7321.00
155_I183_G0.7311.00
105_S119_I0.7271.00
219_C239_F0.7251.00
23_T125_D0.7251.00
241_E244_S0.7221.00
46_D69_E0.7151.00
22_I95_F0.7131.00
49_T104_I0.7111.00
16_R19_G0.7091.00
46_D87_D0.7061.00
70_E87_D0.7061.00
11_A64_H0.7051.00
87_D92_T0.7051.00
113_E236_P0.7041.00
177_L256_I0.7041.00
197_V202_I0.7041.00
132_S220_V0.7021.00
222_L229_Y0.7011.00
155_I160_A0.7001.00
110_E113_E0.6951.00
135_G142_K0.6951.00
18_A104_I0.6901.00
44_N47_K0.6901.00
156_L160_A0.6881.00
130_A136_A0.6871.00
45_I49_T0.6871.00
8_D116_I0.6861.00
129_H139_N0.6861.00
97_H182_R0.6851.00
130_A221_L0.6851.00
109_F216_A0.6821.00
15_I104_I0.6821.00
106_I118_L0.6801.00
107_G117_G0.6801.00
198_A221_L0.6781.00
218_G221_L0.6781.00
103_A121_D0.6771.00
132_S135_G0.6731.00
138_M201_R0.6731.00
126_E139_N0.6731.00
45_I95_F0.6731.00
189_S192_L0.6721.00
32_I96_V0.6691.00
250_P254_K0.6671.00
246_L257_F0.6671.00
50_E72_Q0.6671.00
252_I255_T0.6651.00
76_I80_E0.6611.00
158_I161_T0.6611.00
121_D128_Y0.6591.00
186_S193_E0.6581.00
157_A193_E0.6551.00
146_L149_T0.6511.00
148_E154_A0.6461.00
126_E196_N0.6451.00
103_A192_L0.6451.00
130_A135_G0.6431.00
190_A207_T0.6401.00
145_P227_G0.6391.00
69_E214_D0.6381.00
154_A160_A0.6371.00
223_N228_T0.6371.00
144_A147_K0.6320.99
25_S28_E0.6320.99
48_E52_F0.6310.99
154_A159_N0.6300.99
248_G252_I0.6280.99
170_D174_L0.6270.99
169_I172_S0.6230.99
185_R188_G0.6220.99
36_S40_D0.6220.99
16_R139_N0.6200.99
164_T167_R0.6200.99
165_E168_R0.6190.99
69_E87_D0.6190.99
13_K16_R0.6170.99
166_N170_D0.6160.99
151_I154_A0.6130.99
21_R45_I0.6120.99
121_D126_E0.6090.99
215_Y237_F0.6080.99
14_W18_A0.6060.99
25_S95_F0.6040.99
42_V50_E0.6010.99
52_F55_D0.5990.99
54_I72_Q0.5930.99
250_P253_H0.5890.99
11_A15_I0.5890.99
57_I84_W0.5890.99
173_V176_P0.5880.99
94_N193_E0.5870.99
8_D12_K0.5850.99
41_L182_R0.5810.99
25_S89_I0.5800.99
205_Y210_L0.5790.99
145_P225_V0.5780.99
148_E203_D0.5770.99
93_M97_H0.5770.99
14_W60_T0.5760.99
84_W116_I0.5760.99
46_D214_D0.5750.99
70_E214_D0.5710.99
85_I107_G0.5690.99
234_G257_F0.5690.99
24_Q27_H0.5650.99
93_M155_I0.5640.99
19_G23_T0.5630.99
188_G207_T0.5620.99
189_S193_E0.5600.99
119_I217_A0.5600.99
215_Y219_C0.5580.99
232_I244_S0.5570.99
103_A119_I0.5570.99
151_I255_T0.5570.99
18_A22_I0.5560.99
143_L225_V0.5560.99
11_A116_I0.5550.99
10_I56_R0.5530.99
20_A23_T0.5500.99
85_I114_G0.5500.99
101_N192_L0.5490.99
246_L249_N0.5480.99
134_R224_E0.5470.98
194_L197_V0.5450.98
49_T52_F0.5420.98
90_D214_D0.5400.98
173_V206_I0.5400.98
170_D206_I0.5390.98
28_E44_N0.5350.98
69_E88_P0.5340.98
19_G127_L0.5340.98
15_I120_Y0.5320.98
109_F212_P0.5320.98
223_N229_Y0.5290.98
117_G217_A0.5290.98
65_R78_S0.5280.98
83_V112_G0.5260.98
26_M45_I0.5260.98
167_R170_D0.5260.98
65_R80_E0.5250.98
161_T164_T0.5240.98
94_N188_G0.5140.98
100_R124_H0.5140.98
34_T38_P0.5130.98
70_E88_P0.5130.98
14_W17_E0.5130.98
193_E205_Y0.5120.98
173_V177_L0.5100.98
15_I19_G0.5100.98
207_T210_L0.5080.98
229_Y247_A0.5070.98
230_T234_G0.5070.98
47_K71_G0.5070.98
92_T214_D0.5050.97
156_L159_N0.5040.97
152_E180_R0.5040.97
169_I173_V0.5030.97
26_M100_R0.5030.97
22_I104_I0.5020.97
88_P92_T0.5020.97
146_L249_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n81A 2 0.9509 100 0.093 Contact Map
2pcrA 3 0.9057 100 0.105 Contact Map
2q74A 2 0.8868 100 0.113 Contact Map
2bjiA 2 0.9925 100 0.113 Contact Map
2fvzA 2 0.9057 100 0.115 Contact Map
4i3yA 2 0.9698 100 0.116 Contact Map
3lv0A 2 0.9623 100 0.119 Contact Map
3t0jA 3 0.9623 100 0.12 Contact Map
2p3nA 4 0.9472 100 0.125 Contact Map
2qflA 1 0.9774 100 0.13 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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