SUHB - BACSU - GREMLIN Contacts

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SUHB - Inositol-1-monophosphatase

UniProt:	Q45499	Sequences: MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTNIDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNFAISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINATWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAGCVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	265 (246)
Sequences:	10229 (7245)
Seq/√Len:	461.9

ECOLI - SUHB CYSQ
BACSU - SUHB
HALSA - Q9HQ12
SULSO - Q97W26

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_L	227_G	4.176	1.00
120_Y	127_L	3.552	1.00
82_V	110_E	3.239	1.00
230_T	253_H	3.163	1.00
131_F	134_R	3.060	1.00
81_G	111_N	2.992	1.00
135_G	224_E	2.880	1.00
219_C	223_N	2.833	1.00
121_D	124_H	2.709	1.00
14_W	56_R	2.649	1.00
157_A	202_I	2.571	1.00
17_E	56_R	2.484	1.00
33_E	47_K	2.419	1.00
21_R	52_F	2.342	1.00
19_G	120_Y	2.245	1.00
113_E	132_S	2.244	1.00
204_A	256_I	2.149	1.00
231_T	235_E	2.115	1.00
83_V	109_F	2.110	1.00
102_F	123_V	2.079	1.00
82_V	108_I	2.045	1.00
44_N	48_E	2.037	1.00
50_E	68_G	1.994	1.00
129_H	137_Y	1.990	1.00
51_K	55_D	1.958	1.00
61_F	64_H	1.942	1.00
25_S	45_I	1.894	1.00
22_I	49_T	1.888	1.00
85_I	109_F	1.847	1.00
56_R	59_E	1.844	1.00
110_E	115_K	1.820	1.00
117_G	220_V	1.811	1.00
128_Y	199_A	1.783	1.00
109_F	114_G	1.767	1.00
54_I	58_Q	1.762	1.00
130_A	224_E	1.730	1.00
64_H	82_V	1.720	1.00
220_V	224_E	1.698	1.00
138_M	199_A	1.689	1.00
15_I	106_I	1.662	1.00
11_A	84_W	1.642	1.00
150_V	153_E	1.638	1.00
137_Y	142_K	1.623	1.00
23_T	123_V	1.621	1.00
54_I	66_I	1.601	1.00
119_I	195_A	1.596	1.00
121_D	192_L	1.581	1.00
52_F	56_R	1.581	1.00
10_I	61_F	1.559	1.00
103_A	191_A	1.552	1.00
10_I	60_T	1.548	1.00
133_G	224_E	1.547	1.00
105_S	191_A	1.541	1.00
10_I	14_W	1.534	1.00
12_K	129_H	1.529	1.00
126_E	201_R	1.493	1.00
26_M	102_F	1.483	1.00
64_H	84_W	1.452	1.00
126_E	138_M	1.450	1.00
43_T	96_V	1.449	1.00
195_A	221_L	1.431	1.00
113_E	223_N	1.431	1.00
81_G	110_E	1.430	1.00
22_I	89_I	1.424	1.00
86_I	106_I	1.402	1.00
13_K	60_T	1.401	1.00
107_G	216_A	1.389	1.00
132_S	223_N	1.375	1.00
84_W	108_I	1.362	1.00
126_E	199_A	1.361	1.00
21_R	24_Q	1.360	1.00
132_S	224_E	1.354	1.00
248_G	253_H	1.352	1.00
55_D	59_E	1.341	1.00
172_S	175_A	1.334	1.00
16_R	127_L	1.329	1.00
53_F	86_I	1.329	1.00
15_I	118_L	1.318	1.00
136_A	143_L	1.303	1.00
23_T	102_F	1.294	1.00
57_I	64_H	1.283	1.00
56_R	60_T	1.264	1.00
53_F	106_I	1.259	1.00
12_K	16_R	1.244	1.00
194_L	218_G	1.241	1.00
22_I	102_F	1.225	1.00
12_K	127_L	1.216	1.00
8_D	129_H	1.214	1.00
48_E	51_K	1.207	1.00
171_Q	175_A	1.203	1.00
51_K	71_G	1.201	1.00
54_I	68_G	1.200	1.00
13_K	17_E	1.194	1.00
228_T	254_K	1.192	1.00
50_E	71_G	1.188	1.00
41_L	93_M	1.184	1.00
156_L	204_A	1.162	1.00
17_E	52_F	1.160	1.00
41_L	96_V	1.155	1.00
22_I	45_I	1.135	1.00
7_I	64_H	1.135	1.00
130_A	220_V	1.133	1.00
196_N	201_R	1.126	1.00
50_E	54_I	1.125	1.00
54_I	71_G	1.121	1.00
223_N	236_P	1.102	1.00
254_K	258_E	1.091	1.00
115_K	132_S	1.088	1.00
219_C	229_Y	1.081	1.00
47_K	51_K	1.078	1.00
154_A	252_I	1.062	1.00
14_W	52_F	1.062	1.00
168_R	172_S	1.059	1.00
99_Q	187_Y	1.056	1.00
85_I	216_A	1.053	1.00
120_Y	125_D	1.036	1.00
77_H	80_E	1.031	1.00
20_A	24_Q	1.025	1.00
146_L	203_D	1.024	1.00
67_L	85_I	1.017	1.00
194_L	247_A	1.009	1.00
107_G	114_G	1.003	1.00
25_S	48_E	1.002	1.00
24_Q	28_E	0.994	1.00
108_I	116_I	0.993	1.00
114_G	220_V	0.992	1.00
21_R	25_S	0.992	1.00
14_W	53_F	0.991	1.00
17_E	20_A	0.983	1.00
168_R	175_A	0.978	1.00
190_A	210_L	0.977	1.00
46_D	70_E	0.974	1.00
21_R	48_E	0.969	1.00
194_L	222_L	0.963	1.00
10_I	57_I	0.961	1.00
13_K	56_R	0.961	1.00
222_L	247_A	0.960	1.00
129_H	140_E	0.958	1.00
192_L	196_N	0.957	1.00
43_T	92_T	0.957	1.00
114_G	219_C	0.953	1.00
255_T	258_E	0.952	1.00
49_T	53_F	0.951	1.00
7_I	108_I	0.947	1.00
7_I	61_F	0.941	1.00
143_L	199_A	0.938	1.00
94_N	185_R	0.934	1.00
136_A	221_L	0.933	1.00
67_L	83_V	0.930	1.00
228_T	250_P	0.925	1.00
11_A	118_L	0.920	1.00
25_S	44_N	0.920	1.00
172_S	176_P	0.915	1.00
228_T	253_H	0.912	1.00
35_K	42_V	0.910	1.00
170_D	173_V	0.909	1.00
136_A	224_E	0.891	1.00
49_T	89_I	0.890	1.00
154_A	203_D	0.885	1.00
82_V	115_K	0.883	1.00
68_G	71_G	0.875	1.00
69_E	92_T	0.872	1.00
8_D	131_F	0.868	1.00
249_N	252_I	0.868	1.00
70_E	92_T	0.866	1.00
7_I	82_V	0.862	1.00
35_K	43_T	0.861	1.00
16_R	125_D	0.859	1.00
26_M	123_V	0.851	1.00
108_I	115_K	0.846	1.00
175_A	179_K	0.846	1.00
101_N	196_N	0.845	1.00
26_M	98_Q	0.840	1.00
238_T	241_E	0.839	1.00
253_H	257_F	0.834	1.00
46_D	92_T	0.833	1.00
138_M	141_T	0.822	1.00
119_I	221_L	0.817	1.00
31_T	44_N	0.815	1.00
57_I	61_F	0.807	1.00
16_R	120_Y	0.805	1.00
67_L	213_W	0.794	1.00
149_T	251_S	0.790	1.00
119_I	218_G	0.789	1.00
128_Y	195_A	0.788	1.00
16_R	20_A	0.783	1.00
21_R	49_T	0.782	1.00
9_E	13_K	0.781	1.00
9_E	12_K	0.780	1.00
18_A	52_F	0.774	1.00
116_I	131_F	0.772	1.00
105_S	218_G	0.769	1.00
8_D	118_L	0.766	1.00
231_T	234_G	0.762	1.00
210_L	215_Y	0.761	1.00
105_S	217_A	0.760	1.00
107_G	220_V	0.759	1.00
155_I	159_N	0.759	1.00
103_A	189_S	0.756	1.00
12_K	118_L	0.754	1.00
30_L	44_N	0.748	1.00
150_V	255_T	0.747	1.00
174_L	178_V	0.743	1.00
18_A	49_T	0.742	1.00
61_F	84_W	0.738	1.00
57_I	108_I	0.737	1.00
65_R	83_V	0.733	1.00
194_L	229_Y	0.732	1.00
155_I	183_G	0.731	1.00
105_S	119_I	0.727	1.00
219_C	239_F	0.725	1.00
23_T	125_D	0.725	1.00
241_E	244_S	0.722	1.00
46_D	69_E	0.715	1.00
22_I	95_F	0.713	1.00
49_T	104_I	0.711	1.00
16_R	19_G	0.709	1.00
46_D	87_D	0.706	1.00
70_E	87_D	0.706	1.00
11_A	64_H	0.705	1.00
87_D	92_T	0.705	1.00
113_E	236_P	0.704	1.00
177_L	256_I	0.704	1.00
197_V	202_I	0.704	1.00
132_S	220_V	0.702	1.00
222_L	229_Y	0.701	1.00
155_I	160_A	0.700	1.00
110_E	113_E	0.695	1.00
135_G	142_K	0.695	1.00
18_A	104_I	0.690	1.00
44_N	47_K	0.690	1.00
156_L	160_A	0.688	1.00
130_A	136_A	0.687	1.00
45_I	49_T	0.687	1.00
8_D	116_I	0.686	1.00
129_H	139_N	0.686	1.00
97_H	182_R	0.685	1.00
130_A	221_L	0.685	1.00
109_F	216_A	0.682	1.00
15_I	104_I	0.682	1.00
106_I	118_L	0.680	1.00
107_G	117_G	0.680	1.00
198_A	221_L	0.678	1.00
218_G	221_L	0.678	1.00
103_A	121_D	0.677	1.00
132_S	135_G	0.673	1.00
138_M	201_R	0.673	1.00
126_E	139_N	0.673	1.00
45_I	95_F	0.673	1.00
189_S	192_L	0.672	1.00
32_I	96_V	0.669	1.00
250_P	254_K	0.667	1.00
246_L	257_F	0.667	1.00
50_E	72_Q	0.667	1.00
252_I	255_T	0.665	1.00
76_I	80_E	0.661	1.00
158_I	161_T	0.661	1.00
121_D	128_Y	0.659	1.00
186_S	193_E	0.658	1.00
157_A	193_E	0.655	1.00
146_L	149_T	0.651	1.00
148_E	154_A	0.646	1.00
126_E	196_N	0.645	1.00
103_A	192_L	0.645	1.00
130_A	135_G	0.643	1.00
190_A	207_T	0.640	1.00
145_P	227_G	0.639	1.00
69_E	214_D	0.638	1.00
154_A	160_A	0.637	1.00
223_N	228_T	0.637	1.00
144_A	147_K	0.632	0.99
25_S	28_E	0.632	0.99
48_E	52_F	0.631	0.99
154_A	159_N	0.630	0.99
248_G	252_I	0.628	0.99
170_D	174_L	0.627	0.99
169_I	172_S	0.623	0.99
185_R	188_G	0.622	0.99
36_S	40_D	0.622	0.99
16_R	139_N	0.620	0.99
164_T	167_R	0.620	0.99
165_E	168_R	0.619	0.99
69_E	87_D	0.619	0.99
13_K	16_R	0.617	0.99
166_N	170_D	0.616	0.99
151_I	154_A	0.613	0.99
21_R	45_I	0.612	0.99
121_D	126_E	0.609	0.99
215_Y	237_F	0.608	0.99
14_W	18_A	0.606	0.99
25_S	95_F	0.604	0.99
42_V	50_E	0.601	0.99
52_F	55_D	0.599	0.99
54_I	72_Q	0.593	0.99
250_P	253_H	0.589	0.99
11_A	15_I	0.589	0.99
57_I	84_W	0.589	0.99
173_V	176_P	0.588	0.99
94_N	193_E	0.587	0.99
8_D	12_K	0.585	0.99
41_L	182_R	0.581	0.99
25_S	89_I	0.580	0.99
205_Y	210_L	0.579	0.99
145_P	225_V	0.578	0.99
148_E	203_D	0.577	0.99
93_M	97_H	0.577	0.99
14_W	60_T	0.576	0.99
84_W	116_I	0.576	0.99
46_D	214_D	0.575	0.99
70_E	214_D	0.571	0.99
85_I	107_G	0.569	0.99
234_G	257_F	0.569	0.99
24_Q	27_H	0.565	0.99
93_M	155_I	0.564	0.99
19_G	23_T	0.563	0.99
188_G	207_T	0.562	0.99
189_S	193_E	0.560	0.99
119_I	217_A	0.560	0.99
215_Y	219_C	0.558	0.99
232_I	244_S	0.557	0.99
103_A	119_I	0.557	0.99
151_I	255_T	0.557	0.99
18_A	22_I	0.556	0.99
143_L	225_V	0.556	0.99
11_A	116_I	0.555	0.99
10_I	56_R	0.553	0.99
20_A	23_T	0.550	0.99
85_I	114_G	0.550	0.99
101_N	192_L	0.549	0.99
246_L	249_N	0.548	0.99
134_R	224_E	0.547	0.98
194_L	197_V	0.545	0.98
49_T	52_F	0.542	0.98
90_D	214_D	0.540	0.98
173_V	206_I	0.540	0.98
170_D	206_I	0.539	0.98
28_E	44_N	0.535	0.98
69_E	88_P	0.534	0.98
19_G	127_L	0.534	0.98
15_I	120_Y	0.532	0.98
109_F	212_P	0.532	0.98
223_N	229_Y	0.529	0.98
117_G	217_A	0.529	0.98
65_R	78_S	0.528	0.98
83_V	112_G	0.526	0.98
26_M	45_I	0.526	0.98
167_R	170_D	0.526	0.98
65_R	80_E	0.525	0.98
161_T	164_T	0.524	0.98
94_N	188_G	0.514	0.98
100_R	124_H	0.514	0.98
34_T	38_P	0.513	0.98
70_E	88_P	0.513	0.98
14_W	17_E	0.513	0.98
193_E	205_Y	0.512	0.98
173_V	177_L	0.510	0.98
15_I	19_G	0.510	0.98
207_T	210_L	0.508	0.98
229_Y	247_A	0.507	0.98
230_T	234_G	0.507	0.98
47_K	71_G	0.507	0.98
92_T	214_D	0.505	0.97
156_L	159_N	0.504	0.97
152_E	180_R	0.504	0.97
169_I	173_V	0.503	0.97
26_M	100_R	0.503	0.97
22_I	104_I	0.502	0.97
88_P	92_T	0.502	0.97
146_L	249_N	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4n81A	2	0.9509	100	0.093	Contact Map
2pcrA	3	0.9057	100	0.105	Contact Map
2q74A	2	0.8868	100	0.113	Contact Map
2bjiA	2	0.9925	100	0.113	Contact Map
2fvzA	2	0.9057	100	0.115	Contact Map
4i3yA	2	0.9698	100	0.116	Contact Map
3lv0A	2	0.9623	100	0.119	Contact Map
3t0jA	3	0.9623	100	0.12	Contact Map
2p3nA	4	0.9472	100	0.125	Contact Map
2qflA	1	0.9774	100	0.13	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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