GREMLIN Database
YKTB - UPF0637 protein YktB
UniProt: Q45498 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 212 (202)
Sequences: 319 (265)
Seq/√Len: 18.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V188_F6.4891.00
188_F192_I4.0981.00
150_D153_Q3.3961.00
143_V174_Q3.2170.99
173_I195_A2.9540.99
46_S52_E2.5780.97
34_L57_V2.5240.97
10_D33_K2.5030.97
78_S84_K2.4800.96
118_E162_Q2.3850.96
78_S85_L2.2690.94
5_R185_N2.2670.94
136_A157_L2.2500.94
173_I191_R2.2490.94
179_E182_N2.2300.94
27_K31_R2.1600.93
94_E141_P2.0380.90
12_N177_K1.9460.88
180_V183_M1.9460.88
118_E159_E1.9400.88
37_L41_F1.9220.87
176_Q179_E1.9060.87
31_R34_L1.9040.87
96_H174_Q1.8900.86
55_P73_V1.8760.86
134_W169_L1.8180.84
26_L57_V1.7360.81
26_L71_S1.7320.81
41_F73_V1.6960.79
131_S173_I1.6940.79
34_L101_F1.6880.79
101_F113_Y1.6680.78
90_I188_F1.6470.77
113_Y117_L1.6180.76
180_V187_E1.6140.76
6_F71_S1.6040.75
176_Q184_N1.6040.75
175_L191_R1.5910.75
14_F70_D1.5890.75
176_Q180_V1.5870.75
90_I160_R1.5740.74
89_Q160_R1.5720.74
118_E163_T1.5420.72
146_Q171_C1.5280.72
155_K159_E1.4870.70
53_M77_N1.4770.69
95_S161_L1.4740.69
16_I25_V1.4640.68
128_I146_Q1.4440.67
133_V174_Q1.4430.67
13_T64_S1.4230.66
26_L30_V1.4130.65
77_N85_L1.4130.65
27_K30_V1.4110.65
120_N123_T1.3910.64
99_V173_I1.3850.64
79_K195_A1.3820.64
42_A55_P1.3740.63
13_T16_I1.3520.62
48_L197_K1.3420.61
31_R35_T1.3360.61
70_D92_L1.3270.60
180_V184_N1.3030.59
179_E183_M1.3000.59
78_S153_Q1.2290.54
31_R57_V1.2290.54
119_V123_T1.2100.53
153_Q156_T1.2090.53
27_K139_T1.2050.53
39_E99_V1.1960.52
159_E163_T1.1940.52
89_Q104_I1.1740.51
64_S93_W1.1690.51
128_I200_A1.1330.48
84_K108_P1.1240.48
106_E110_K1.1210.48
182_N187_E1.1210.48
13_T29_T1.1200.48
71_S167_A1.1090.47
100_W170_L1.1080.47
61_A65_V1.0950.46
26_L76_A1.0900.46
85_L170_L1.0890.46
70_D93_W1.0850.45
35_T39_E1.0750.45
90_I196_F1.0750.45
99_V192_I1.0740.45
47_A52_E1.0690.44
67_P106_E1.0690.44
138_H168_E1.0620.44
184_N187_E1.0610.44
26_L31_R1.0610.44
61_A106_E1.0600.44
103_I206_T1.0550.44
25_V97_V1.0500.43
182_N188_F1.0450.43
61_A170_L1.0410.43
134_W146_Q1.0360.42
15_T175_L1.0200.41
93_W141_P1.0100.41
91_G98_F1.0060.41
37_L196_F0.9970.40
44_T193_D0.9890.40
119_V147_S0.9890.40
55_P75_F0.9880.40
37_L73_V0.9850.39
18_G89_Q0.9700.38
101_F107_S0.9670.38
30_V65_V0.9670.38
30_V57_V0.9660.38
77_N84_K0.9660.38
160_R164_V0.9500.37
118_E158_F0.9380.37
10_D170_L0.9360.36
115_K162_Q0.9300.36
99_V175_L0.9270.36
114_G162_Q0.9240.36
84_K100_W0.9230.36
10_D106_E0.9230.36
49_T200_A0.9220.36
96_H104_I0.9190.35
8_E177_K0.9130.35
152_E159_E0.8940.34
66_N106_E0.8920.34
13_T20_D0.8890.34
31_R38_G0.8820.33
95_S141_P0.8740.33
159_E162_Q0.8730.33
51_D204_R0.8700.33
115_K119_V0.8680.33
108_P166_K0.8660.33
114_G158_F0.8630.32
113_Y161_L0.8620.32
28_E44_T0.8610.32
59_K196_F0.8580.32
101_F201_F0.8570.32
125_T128_I0.8560.32
38_G73_V0.8500.32
70_D84_K0.8450.31
149_M197_K0.8360.31
142_G147_S0.8340.31
12_N183_M0.8290.31
178_E183_M0.8280.30
31_R73_V0.8200.30
97_V192_I0.8170.30
70_D78_S0.8150.30
66_N70_D0.8080.29
191_R194_D0.8080.29
75_F90_I0.8070.29
34_L134_W0.8030.29
38_G75_F0.7970.29
86_P102_A0.7860.28
134_W173_I0.7850.28
187_E190_Q0.7780.28
27_K55_P0.7770.28
66_N99_V0.7740.28
18_G104_I0.7720.28
5_R53_M0.7650.27
107_S161_L0.7630.27
44_T197_K0.7620.27
41_F75_F0.7610.27
158_F169_L0.7580.27
88_F110_K0.7540.27
158_F195_A0.7540.27
12_N15_T0.7510.27
134_W171_C0.7510.27
34_L55_P0.7490.26
51_D77_N0.7460.26
7_T185_N0.7450.26
109_I116_L0.7440.26
5_R192_I0.7440.26
61_A102_A0.7360.26
19_L168_E0.7290.25
103_I161_L0.7290.25
4_M126_K0.7260.25
127_N154_L0.7220.25
90_I193_D0.7220.25
123_T127_N0.7130.25
19_L138_H0.7120.25
59_K86_P0.7080.24
181_L184_N0.7050.24
134_W158_F0.7020.24
36_A52_E0.7020.24
175_L182_N0.7000.24
102_A170_L0.6990.24
27_K35_T0.6990.24
30_V157_L0.6970.24
33_K106_E0.6970.24
150_D202_L0.6900.24
99_V109_I0.6890.24
20_D127_N0.6890.24
16_I21_A0.6810.23
90_I97_V0.6800.23
104_I114_G0.6780.23
14_F78_S0.6780.23
17_E112_E0.6750.23
190_Q194_D0.6730.23
76_A79_K0.6610.22
117_L166_K0.6590.22
146_Q169_L0.6580.22
10_D91_G0.6570.22
37_L55_P0.6560.22
31_R89_Q0.6550.22
85_L143_V0.6540.22
104_I161_L0.6530.22
41_F90_I0.6520.22
132_F198_Q0.6520.22
98_F106_E0.6510.22
14_F17_E0.6500.22
10_D59_K0.6470.22
92_L174_Q0.6460.22
145_K155_K0.6430.22
107_S141_P0.6410.22
141_P161_L0.6410.22
38_G55_P0.6410.22
103_I107_S0.6370.21
8_E39_E0.6350.21
8_E181_L0.6330.21
197_K204_R0.6300.21
202_L205_L0.6280.21
28_E115_K0.6260.21
33_K105_Y0.6260.21
33_K170_L0.6240.21
16_I44_T0.6220.21
34_L102_A0.6170.21
15_T94_E0.6170.21
115_K122_E0.6160.20
70_D106_E0.6130.20
179_E184_N0.6130.20
35_T73_V0.6110.20
96_H141_P0.6100.20
119_V126_K0.6090.20
183_M192_I0.6090.20
154_L204_R0.6050.20
39_E131_S0.6030.20
64_S69_A0.6030.20
101_F161_L0.6020.20
65_V69_A0.6020.20
23_M88_F0.6010.20
90_I192_I0.5990.20
36_A69_A0.5990.20
48_L53_M0.5980.20
158_F171_C0.5980.20
25_V114_G0.5940.20
128_I195_A0.5930.20
10_D61_A0.5910.19
145_K163_T0.5890.19
105_Y110_K0.5880.19
13_T35_T0.5850.19
35_T100_W0.5850.19
104_I172_G0.5830.19
49_T84_K0.5820.19
38_G204_R0.5780.19
4_M123_T0.5780.19
160_R167_A0.5770.19
8_E117_L0.5770.19
27_K59_K0.5730.19
134_W157_L0.5730.19
55_P84_K0.5720.19
111_E120_N0.5710.19
17_E150_D0.5710.19
40_H124_I0.5680.19
92_L97_V0.5680.19
96_H170_L0.5660.19
112_E193_D0.5590.18
100_W166_K0.5580.18
123_T183_M0.5560.18
9_E169_L0.5530.18
39_E155_K0.5510.18
31_R104_I0.5490.18
130_D133_V0.5470.18
31_R101_F0.5470.18
15_T184_N0.5440.18
26_L120_N0.5440.18
126_K190_Q0.5400.18
92_L160_R0.5390.18
12_N29_T0.5390.18
47_A75_F0.5370.17
121_Q152_E0.5350.17
12_N122_E0.5340.17
135_S164_V0.5330.17
144_H167_A0.5290.17
120_N153_Q0.5280.17
30_V45_L0.5280.17
31_R55_P0.5270.17
57_V163_T0.5270.17
57_V94_E0.5240.17
178_E198_Q0.5230.17
86_P170_L0.5200.17
192_I201_F0.5190.17
53_M103_I0.5180.17
120_N205_L0.5180.17
12_N167_A0.5160.17
178_E187_E0.5110.17
86_P138_H0.5090.16
19_L86_P0.5080.16
73_V103_I0.5070.16
132_F182_N0.5050.16
44_T53_M0.5050.16
84_K170_L0.5040.16
181_L194_D0.5020.16
95_S122_E0.5010.16
33_K59_K0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a8eA 1 0.9906 100 0.047 Contact Map
3mqzA 1 0.9245 100 0.144 Contact Map
1lypA 1 0.1509 29.5 0.965 Contact Map
2bmmA 1 0.5189 27.5 0.966 Contact Map
2qrwA 7 0.5236 20.9 0.968 Contact Map
2xykA 1 0.5425 18.8 0.968 Contact Map
3aq9A 1 0.5094 17.7 0.969 Contact Map
1o6dA 2 0.6179 15.5 0.97 Contact Map
3j7ya 1 0.1792 12 0.971 Contact Map
4h7wA 1 0.5094 10.3 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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