GREMLIN Database
DEF2 - Peptide deformylase 2
UniProt: Q45495 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (154)
Sequences: 5848 (3633)
Seq/√Len: 292.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_R159_N3.6231.00
131_G139_I2.9421.00
73_I155_I2.5711.00
38_I86_S2.5581.00
133_T137_E2.5581.00
130_K138_N2.5511.00
93_K130_K2.4591.00
16_R165_D2.3631.00
128_R140_D2.3071.00
130_K140_D2.2521.00
64_P69_K1.9661.00
35_A134_L1.9521.00
106_S149_I1.9331.00
132_T138_N1.9201.00
34_L88_A1.9001.00
143_L151_F1.8731.00
19_A69_K1.8191.00
26_P30_E1.8001.00
24_L27_T1.7991.00
8_V14_A1.7711.00
19_A64_P1.7271.00
95_V130_K1.7251.00
34_L134_L1.7251.00
128_R142_R1.6911.00
126_R142_R1.6701.00
7_I56_R1.6671.00
124_Y152_Q1.6501.00
88_A134_L1.5691.00
8_V12_H1.5691.00
97_H124_Y1.5591.00
33_Q68_I1.5591.00
5_E66_I1.5561.00
107_G120_Y1.5491.00
126_R144_K1.5451.00
98_S126_R1.5381.00
59_V146_F1.5331.00
96_S128_R1.5191.00
133_T139_I1.5101.00
77_A150_V1.5031.00
8_V67_N1.4761.00
155_I159_N1.4241.00
125_A145_G1.4231.00
31_K135_E1.4111.00
73_I89_L1.4101.00
34_L72_M1.3921.00
18_T21_P1.3891.00
143_L147_P1.3851.00
5_E36_D1.3821.00
21_P71_R1.3751.00
9_R114_D1.3561.00
31_K134_L1.3561.00
33_Q72_M1.3341.00
32_Q36_D1.3011.00
38_I88_A1.2511.00
89_L131_G1.2461.00
87_Y141_I1.2461.00
17_E69_K1.2451.00
33_Q66_I1.2271.00
89_L151_F1.2241.00
28_D31_K1.1981.00
34_L38_I1.1761.00
26_P132_T1.1751.00
161_V166_H1.1741.00
21_P93_K1.1721.00
119_G163_F1.1691.00
76_H86_S1.1671.00
141_I151_F1.1631.00
80_A84_L1.1311.00
14_A69_K1.1231.00
23_E26_P1.1161.00
18_T159_N1.1081.00
20_E69_K1.1051.00
36_D40_F1.1021.00
29_A70_K1.0831.00
101_K124_Y1.0681.00
4_M40_F1.0541.00
113_V162_M1.0471.00
34_L90_F1.0471.00
27_T30_E1.0451.00
72_M90_F1.0371.00
101_K122_P1.0361.00
169_K173_F1.0211.00
22_V72_M1.0131.00
26_P31_K1.0091.00
95_V128_R1.0051.00
101_K125_A0.9721.00
131_G141_I0.9701.00
14_A67_N0.9611.00
89_L139_I0.9501.00
146_F150_V0.9451.00
10_D113_V0.9261.00
102_S122_P0.9151.00
122_P168_D0.9121.00
59_V150_V0.9031.00
38_I74_A0.8981.00
75_V87_Y0.8961.00
78_E81_S0.8911.00
40_F66_I0.8851.00
156_D166_H0.8821.00
168_D171_N0.8821.00
10_D164_Y0.8701.00
151_F155_I0.8641.00
95_V140_D0.8511.00
94_I97_H0.8511.00
75_V150_V0.8451.00
129_V141_I0.8401.00
12_H67_N0.8361.00
10_D162_M0.8351.00
92_P158_L0.8311.00
4_M39_E0.8221.00
94_I155_I0.8211.00
161_V165_D0.8201.00
87_Y147_P0.8161.00
19_A71_R0.8141.00
23_E91_N0.8121.00
118_P163_F0.8121.00
117_I175_E0.8111.00
132_T136_G0.8101.00
59_V77_A0.8071.00
156_D161_V0.8000.99
147_P151_F0.7930.99
171_N174_K0.7920.99
129_V151_F0.7880.99
35_A39_E0.7860.99
96_S99_V0.7860.99
125_A144_K0.7800.99
17_E20_E0.7710.99
20_E23_E0.7700.99
102_S125_A0.7700.99
100_E122_P0.7690.99
58_G111_L0.7640.99
117_I163_F0.7600.99
107_G118_P0.7580.99
30_E72_M0.7550.99
4_M36_D0.7480.99
5_E68_I0.7470.99
77_A146_F0.7460.99
41_V74_A0.7420.99
18_T71_R0.7390.99
5_E32_Q0.7380.99
89_L129_V0.7320.99
30_E70_K0.7290.99
127_I143_L0.7280.99
41_V58_G0.7230.99
121_V163_F0.7200.99
73_I151_F0.7190.99
41_V60_G0.7120.99
10_D16_R0.7090.99
89_L141_I0.7070.99
20_E70_K0.7050.99
99_V102_S0.6970.99
102_S149_I0.6970.99
141_I147_P0.6960.99
77_A147_P0.6900.98
36_D39_E0.6890.98
100_E125_A0.6860.98
113_V164_Y0.6860.98
174_K177_E0.6850.98
109_G118_P0.6790.98
6_N9_R0.6790.98
129_V143_L0.6770.98
28_D32_Q0.6760.98
33_Q37_M0.6740.98
78_E84_L0.6720.98
119_G174_K0.6680.98
4_M55_L0.6610.98
41_V56_R0.6580.98
94_I127_I0.6560.98
73_I131_G0.6540.98
31_K34_L0.6510.98
119_G167_I0.6410.98
110_C157_H0.6300.97
173_F177_E0.6300.97
38_I41_V0.6230.97
61_L74_A0.6220.97
41_V76_H0.6190.97
75_V151_F0.6190.97
71_R93_K0.6140.97
30_E33_Q0.6070.97
63_A72_M0.6060.97
94_I124_Y0.6060.97
32_Q35_A0.6050.97
168_D172_P0.6050.97
76_H84_L0.6020.96
96_S124_Y0.6000.96
96_S126_R0.5980.96
5_E40_F0.5970.96
33_Q36_D0.5930.96
37_M72_M0.5930.96
106_S120_Y0.5830.96
137_E140_D0.5830.96
29_A32_Q0.5820.96
30_E132_T0.5760.95
101_K106_S0.5680.95
65_Q157_H0.5680.95
13_P17_E0.5610.95
94_I152_Q0.5580.95
127_I151_F0.5580.95
75_V147_P0.5560.95
90_F132_T0.5540.94
101_K149_I0.5450.94
18_T161_V0.5440.94
172_P176_P0.5400.94
26_P136_G0.5380.94
14_A19_A0.5330.93
37_M41_V0.5330.93
34_L74_A0.5320.93
76_H85_Y0.5300.93
41_V59_V0.5260.93
37_M111_L0.5240.93
26_P90_F0.5230.93
10_D115_E0.5220.92
38_I76_H0.5220.92
22_V30_E0.5210.92
173_F176_P0.5210.92
95_V98_S0.5200.92
23_E27_T0.5170.92
78_E85_Y0.5160.92
65_Q110_C0.5160.92
62_A110_C0.5150.92
80_A85_Y0.5110.92
79_D84_L0.5110.92
75_V89_L0.5100.92
129_V155_I0.5090.92
16_R164_Y0.5040.91
75_V131_G0.5030.91
170_E174_K0.5020.91
102_S120_Y0.5020.91
163_F167_I0.5020.91
37_M61_L0.5010.91
167_I171_N0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u04A 2 0.8967 100 0.077 Contact Map
3l87A 1 0.9891 100 0.077 Contact Map
2oklA 1 1 100 0.078 Contact Map
2os0A 1 0.9728 100 0.079 Contact Map
3svjP 1 0.9891 100 0.081 Contact Map
1n5nA 1 0.8913 100 0.093 Contact Map
3e3uA 1 0.9076 100 0.094 Contact Map
3pn3A 2 0.8913 100 0.097 Contact Map
1lm4A 1 0.9891 100 0.098 Contact Map
4e9aA 1 0.8696 100 0.098 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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