YKRA - BACSU - GREMLIN Contacts

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YKRA - Putative phosphatase YkrA

UniProt:	Q45494	Sequences: MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASGRSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVVFMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAAFPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVGTGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	257 (251)
Sequences:	11007 (9101)
Seq/√Len:	574.4

ECOLI - SUPH YBJI YIDA YBHA YIGL COF MPGP
BACSU - YKRA YHAX YWPJ YWTE YXEH YITU YCSE NTDB
HALSA - PGP
SULSO - PGP1 PGP2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_K	248_Y	4.073	1.00
17_H	242_D	3.645	1.00
203_A	217_V	3.129	1.00
240_P	243_E	3.035	1.00
214_I	220_G	2.999	1.00
4_K	200_D	2.770	1.00
22_P	244_D	2.745	1.00
24_S	244_D	2.685	1.00
191_I	201_T	2.608	1.00
24_S	251_K	2.522	1.00
8_F	39_V	2.461	1.00
228_P	232_E	2.456	1.00
16_D	20_N	2.410	1.00
43_S	50_V	2.362	1.00
215_E	233_I	2.233	1.00
188_K	216_Y	2.156	1.00
182_S	212_Q	2.006	1.00
198_I	216_Y	2.002	1.00
23_E	27_K	1.976	1.00
211_L	230_L	1.922	1.00
31_E	34_R	1.897	1.00
211_L	233_I	1.843	1.00
208_L	229_E	1.831	1.00
239_K	243_E	1.830	1.00
222_A	234_A	1.824	1.00
78_Y	189_K	1.790	1.00
5_L	40_F	1.789	1.00
31_E	251_K	1.788	1.00
228_P	231_K	1.782	1.00
26_R	56_E	1.772	1.00
3_S	202_Y	1.769	1.00
208_L	227_V	1.768	1.00
220_G	235_D	1.765	1.00
7_F	187_I	1.750	1.00
188_K	192_E	1.741	1.00
31_E	35_Q	1.715	1.00
29_V	39_V	1.713	1.00
197_D	200_D	1.712	1.00
83_P	86_A	1.704	1.00
32_L	37_H	1.695	1.00
72_F	75_Q	1.673	1.00
230_L	233_I	1.651	1.00
33_Q	60_H	1.610	1.00
189_K	192_E	1.610	1.00
221_V	249_A	1.590	1.00
86_A	163_E	1.587	1.00
219_T	235_D	1.584	1.00
3_S	37_H	1.583	1.00
236_F	253_L	1.577	1.00
8_F	204_F	1.562	1.00
10_I	15_Y	1.558	1.00
22_P	25_T	1.550	1.00
219_T	236_F	1.549	1.00
187_I	213_M	1.529	1.00
89_R	163_E	1.524	1.00
184_A	216_Y	1.512	1.00
189_K	193_R	1.503	1.00
80_N	189_K	1.501	1.00
185_E	188_K	1.494	1.00
204_F	246_I	1.482	1.00
95_D	112_T	1.468	1.00
38_H	194_L	1.460	1.00
25_T	244_D	1.434	1.00
27_K	31_E	1.422	1.00
94_A	148_L	1.417	1.00
236_F	249_A	1.409	1.00
203_A	213_M	1.408	1.00
3_S	219_T	1.406	1.00
222_A	226_A	1.358	1.00
3_S	200_D	1.352	1.00
199_G	218_G	1.351	1.00
224_G	240_P	1.347	1.00
26_R	30_A	1.330	1.00
24_S	248_Y	1.324	1.00
214_I	230_L	1.303	1.00
79_K	142_E	1.292	1.00
155_E	159_A	1.285	1.00
204_F	249_A	1.281	1.00
86_A	89_R	1.264	1.00
7_F	42_A	1.263	1.00
17_H	241_V	1.257	1.00
198_I	201_T	1.256	1.00
84_E	88_R	1.239	1.00
156_K	160_A	1.237	1.00
229_E	232_E	1.236	1.00
28_T	247_A	1.235	1.00
86_A	164_F	1.232	1.00
191_I	198_I	1.229	1.00
165_D	212_Q	1.228	1.00
236_F	252_E	1.219	1.00
211_L	215_E	1.214	1.00
6_I	32_L	1.200	1.00
76_V	79_K	1.196	1.00
16_D	242_D	1.192	1.00
202_Y	253_L	1.182	1.00
6_I	250_V	1.178	1.00
30_A	34_R	1.171	1.00
93_Q	97_G	1.170	1.00
69_F	76_V	1.164	1.00
5_L	191_I	1.160	1.00
249_A	253_L	1.157	1.00
238_T	245_G	1.155	1.00
165_D	180_G	1.154	1.00
24_S	28_T	1.151	1.00
201_T	217_V	1.150	1.00
80_N	178_P	1.145	1.00
7_F	201_T	1.139	1.00
203_A	214_I	1.126	1.00
231_K	237_V	1.125	1.00
246_I	250_V	1.122	1.00
225_N	241_V	1.119	1.00
5_L	196_F	1.118	1.00
40_F	190_V	1.118	1.00
28_T	251_K	1.104	1.00
238_T	249_A	1.103	1.00
79_K	144_F	1.100	1.00
145_Q	175_D	1.099	1.00
163_E	179_H	1.097	1.00
217_V	220_G	1.082	1.00
63_I	186_G	1.063	1.00
23_E	26_R	1.055	1.00
167_V	177_L	1.052	1.00
5_L	201_T	1.051	1.00
178_P	181_G	1.047	1.00
70_V	189_K	1.047	1.00
198_I	218_G	1.047	1.00
10_I	53_I	1.044	1.00
223_M	245_G	1.044	1.00
227_V	230_L	1.021	1.00
6_I	37_H	1.018	1.00
207_G	227_V	1.016	1.00
191_I	216_Y	1.013	1.00
239_K	245_G	1.008	1.00
30_A	33_Q	1.006	1.00
187_I	217_V	1.006	1.00
247_A	251_K	0.996	1.00
221_V	238_T	0.992	1.00
92_K	96_E	0.991	1.00
120_L	124_G	0.991	1.00
182_S	185_E	0.989	1.00
202_Y	219_T	0.983	1.00
88_R	92_K	0.978	1.00
155_E	158_Y	0.978	1.00
190_V	194_L	0.977	1.00
14_I	25_T	0.976	1.00
14_I	29_V	0.974	1.00
191_I	218_G	0.972	1.00
221_V	236_F	0.966	1.00
202_Y	221_V	0.962	1.00
47_P	64_S	0.960	1.00
224_G	231_K	0.955	1.00
30_A	58_G	0.953	1.00
70_V	78_Y	0.953	1.00
248_Y	252_E	0.953	1.00
226_A	231_K	0.953	1.00
184_A	212_Q	0.947	1.00
202_Y	249_A	0.934	1.00
80_N	180_G	0.926	1.00
223_M	238_T	0.918	1.00
191_I	196_F	0.918	1.00
51_K	74_N	0.918	1.00
71_V	76_V	0.911	1.00
222_A	230_L	0.911	1.00
68_Q	181_G	0.910	1.00
89_R	92_K	0.910	1.00
97_G	156_K	0.905	1.00
79_K	106_E	0.899	1.00
201_T	218_G	0.896	1.00
32_L	39_V	0.896	1.00
8_F	246_I	0.896	1.00
27_K	30_A	0.886	1.00
93_Q	96_E	0.885	1.00
156_K	159_A	0.884	1.00
249_A	252_E	0.884	1.00
224_G	239_K	0.884	1.00
188_K	198_I	0.883	1.00
63_I	190_V	0.878	1.00
248_Y	251_K	0.877	1.00
40_F	61_S	0.876	1.00
177_L	182_S	0.872	1.00
51_K	55_E	0.870	1.00
208_L	211_L	0.862	1.00
82_L	178_P	0.860	1.00
43_S	64_S	0.859	1.00
224_G	243_E	0.855	1.00
70_V	186_G	0.849	1.00
7_F	40_F	0.847	1.00
214_I	233_I	0.829	1.00
81_P	142_E	0.829	1.00
85_N	89_R	0.826	1.00
64_S	69_F	0.825	1.00
25_T	247_A	0.819	1.00
77_I	193_R	0.819	1.00
166_L	176_V	0.817	1.00
71_V	74_N	0.812	1.00
37_H	202_Y	0.804	1.00
42_A	63_I	0.803	1.00
201_T	216_Y	0.796	1.00
218_G	235_D	0.786	1.00
8_F	14_I	0.786	1.00
25_T	28_T	0.784	1.00
93_Q	160_A	0.782	1.00
32_L	250_V	0.778	1.00
239_K	252_E	0.778	1.00
229_E	233_I	0.776	1.00
41_I	50_V	0.776	1.00
16_D	22_P	0.775	1.00
96_E	160_A	0.767	1.00
162_P	179_H	0.766	1.00
203_A	220_G	0.764	1.00
37_H	254_G	0.764	1.00
165_D	182_S	0.762	1.00
93_Q	161_F	0.760	1.00
28_T	31_E	0.755	1.00
75_Q	193_R	0.752	1.00
226_A	230_L	0.751	1.00
81_P	144_F	0.751	1.00
12_G	223_M	0.749	1.00
47_P	71_V	0.748	1.00
206_D	226_A	0.744	1.00
46_S	65_Y	0.743	1.00
69_F	144_F	0.740	1.00
6_I	202_Y	0.739	1.00
250_V	254_G	0.735	1.00
89_R	93_Q	0.732	1.00
214_I	234_A	0.730	1.00
18_D	242_D	0.730	1.00
187_I	203_A	0.725	1.00
32_L	254_G	0.725	1.00
24_S	247_A	0.725	1.00
10_I	41_I	0.724	1.00
84_E	142_E	0.723	1.00
14_I	21_I	0.722	1.00
206_D	223_M	0.722	1.00
108_T	131_P	0.720	1.00
223_M	226_A	0.718	1.00
64_S	71_V	0.716	1.00
220_G	230_L	0.714	1.00
68_Q	178_P	0.710	1.00
50_V	62_F	0.709	1.00
50_V	64_S	0.708	1.00
16_D	241_V	0.707	1.00
158_Y	161_F	0.703	1.00
132_E	135_D	0.702	1.00
200_D	218_G	0.701	1.00
66_N	175_D	0.696	1.00
147_L	175_D	0.696	1.00
139_E	142_E	0.692	1.00
95_D	101_V	0.690	1.00
251_K	254_G	0.683	1.00
91_L	95_D	0.681	1.00
134_D	137_F	0.679	1.00
14_I	241_V	0.677	1.00
181_G	185_E	0.677	1.00
188_K	191_I	0.676	1.00
97_G	160_A	0.676	1.00
157_A	161_F	0.671	1.00
118_H	122_G	0.658	1.00
236_F	239_K	0.657	1.00
236_F	248_Y	0.654	1.00
165_D	179_H	0.653	1.00
105_A	143_I	0.653	1.00
42_A	213_M	0.649	1.00
129_D	132_E	0.648	1.00
185_E	189_K	0.646	1.00
89_R	160_A	0.645	1.00
38_H	60_H	0.644	1.00
118_H	121_E	0.644	1.00
145_Q	169_W	0.644	1.00
5_L	190_V	0.640	1.00
132_E	137_F	0.636	1.00
165_D	177_L	0.632	1.00
212_Q	215_E	0.632	1.00
47_P	51_K	0.628	1.00
204_F	221_V	0.628	1.00
204_F	238_T	0.622	1.00
220_G	234_A	0.620	1.00
225_N	231_K	0.620	1.00
121_E	125_S	0.619	1.00
85_N	88_R	0.618	1.00
87_I	143_I	0.616	1.00
122_G	126_L	0.615	1.00
37_H	200_D	0.613	1.00
122_G	125_S	0.611	1.00
10_I	50_V	0.611	1.00
222_A	233_I	0.611	1.00
10_I	14_I	0.608	1.00
219_T	249_A	0.607	1.00
238_T	248_Y	0.604	1.00
24_S	27_K	0.600	1.00
244_D	247_A	0.600	1.00
91_L	103_F	0.599	1.00
208_L	230_L	0.597	1.00
170_H	207_G	0.597	1.00
21_I	45_R	0.596	1.00
121_E	124_G	0.593	1.00
123_I	127_K	0.590	1.00
249_A	254_G	0.589	1.00
239_K	249_A	0.589	1.00
88_R	139_E	0.587	1.00
87_I	91_L	0.586	1.00
196_F	218_G	0.585	1.00
102_V	147_L	0.585	1.00
76_V	106_E	0.584	1.00
70_V	193_R	0.583	1.00
89_R	161_F	0.582	1.00
14_I	41_I	0.581	1.00
131_P	134_D	0.581	1.00
15_Y	241_V	0.579	1.00
184_A	188_K	0.578	1.00
83_P	163_E	0.574	1.00
130_Y	133_T	0.573	1.00
105_A	108_T	0.569	0.99
106_E	142_E	0.568	0.99
150_C	153_E	0.565	0.99
196_F	201_T	0.565	0.99
147_L	173_S	0.563	0.99
29_V	250_V	0.560	0.99
84_E	140_G	0.560	0.99
72_F	77_I	0.559	0.99
119_V	122_G	0.557	0.99
211_L	214_I	0.557	0.99
22_P	247_A	0.556	0.99
69_F	106_E	0.554	0.99
204_F	250_V	0.552	0.99
32_L	247_A	0.551	0.99
65_Y	175_D	0.550	0.99
28_T	32_L	0.549	0.99
41_I	54_L	0.548	0.99
150_C	154_E	0.547	0.99
124_G	127_K	0.545	0.99
52_P	55_E	0.544	0.99
50_V	53_I	0.542	0.99
230_L	234_A	0.542	0.99
8_F	32_L	0.540	0.99
221_V	235_D	0.539	0.99
166_L	174_T	0.538	0.99
155_E	168_R	0.537	0.99
223_M	241_V	0.537	0.99
72_F	193_R	0.536	0.99
21_I	26_R	0.535	0.99
106_E	141_K	0.535	0.99
65_Y	68_Q	0.534	0.99
54_L	62_F	0.533	0.99
106_E	144_F	0.532	0.99
225_N	240_P	0.532	0.99
91_L	101_V	0.532	0.99
25_T	29_V	0.530	0.99
6_I	204_F	0.529	0.99
3_S	6_I	0.528	0.99
105_A	141_K	0.524	0.99
70_V	190_V	0.524	0.99
244_D	248_Y	0.524	0.99
54_L	61_S	0.523	0.99
247_A	250_V	0.521	0.99
65_Y	173_S	0.521	0.99
29_V	33_Q	0.520	0.99
103_F	143_I	0.519	0.99
42_A	66_N	0.519	0.99
4_K	37_H	0.518	0.99
99_H	148_L	0.518	0.99
38_H	196_F	0.517	0.99
94_A	101_V	0.517	0.99
219_T	253_L	0.517	0.99
180_G	185_E	0.515	0.99
168_R	173_S	0.514	0.99
3_S	38_H	0.511	0.99
16_D	244_D	0.511	0.99
27_K	251_K	0.511	0.99
49_L	173_S	0.510	0.99
33_Q	58_G	0.505	0.99
133_T	136_L	0.505	0.99
227_V	231_K	0.504	0.99
101_V	146_L	0.503	0.99
203_A	218_G	0.501	0.99
33_Q	39_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2pq0A	1	0.9961	100	0.215	Contact Map
1nrwA	1	0.9805	100	0.233	Contact Map
3l7yA	1	0.9883	100	0.243	Contact Map
3pgvA	3	0.9689	100	0.244	Contact Map
2rbkA	1	0.9844	100	0.247	Contact Map
2b30A	2	0.9883	100	0.247	Contact Map
4qjbA	1	0.9922	100	0.253	Contact Map
3daoA	1	0.9844	100	0.253	Contact Map
3fzqA	2	0.9883	100	0.254	Contact Map
1rkqA	1	0.9922	100	0.259	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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