GREMLIN Database
YKRA - Putative phosphatase YkrA
UniProt: Q45494 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 257 (251)
Sequences: 11007 (9101)
Seq/√Len: 574.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_K248_Y4.0731.00
17_H242_D3.6451.00
203_A217_V3.1291.00
240_P243_E3.0351.00
214_I220_G2.9991.00
4_K200_D2.7701.00
22_P244_D2.7451.00
24_S244_D2.6851.00
191_I201_T2.6081.00
24_S251_K2.5221.00
8_F39_V2.4611.00
228_P232_E2.4561.00
16_D20_N2.4101.00
43_S50_V2.3621.00
215_E233_I2.2331.00
188_K216_Y2.1561.00
182_S212_Q2.0061.00
198_I216_Y2.0021.00
23_E27_K1.9761.00
211_L230_L1.9221.00
31_E34_R1.8971.00
211_L233_I1.8431.00
208_L229_E1.8311.00
239_K243_E1.8301.00
222_A234_A1.8241.00
78_Y189_K1.7901.00
5_L40_F1.7891.00
31_E251_K1.7881.00
228_P231_K1.7821.00
26_R56_E1.7721.00
3_S202_Y1.7691.00
208_L227_V1.7681.00
220_G235_D1.7651.00
7_F187_I1.7501.00
188_K192_E1.7411.00
31_E35_Q1.7151.00
29_V39_V1.7131.00
197_D200_D1.7121.00
83_P86_A1.7041.00
32_L37_H1.6951.00
72_F75_Q1.6731.00
230_L233_I1.6511.00
33_Q60_H1.6101.00
189_K192_E1.6101.00
221_V249_A1.5901.00
86_A163_E1.5871.00
219_T235_D1.5841.00
3_S37_H1.5831.00
236_F253_L1.5771.00
8_F204_F1.5621.00
10_I15_Y1.5581.00
22_P25_T1.5501.00
219_T236_F1.5491.00
187_I213_M1.5291.00
89_R163_E1.5241.00
184_A216_Y1.5121.00
189_K193_R1.5031.00
80_N189_K1.5011.00
185_E188_K1.4941.00
204_F246_I1.4821.00
95_D112_T1.4681.00
38_H194_L1.4601.00
25_T244_D1.4341.00
27_K31_E1.4221.00
94_A148_L1.4171.00
236_F249_A1.4091.00
203_A213_M1.4081.00
3_S219_T1.4061.00
222_A226_A1.3581.00
3_S200_D1.3521.00
199_G218_G1.3511.00
224_G240_P1.3471.00
26_R30_A1.3301.00
24_S248_Y1.3241.00
214_I230_L1.3031.00
79_K142_E1.2921.00
155_E159_A1.2851.00
204_F249_A1.2811.00
86_A89_R1.2641.00
7_F42_A1.2631.00
17_H241_V1.2571.00
198_I201_T1.2561.00
84_E88_R1.2391.00
156_K160_A1.2371.00
229_E232_E1.2361.00
28_T247_A1.2351.00
86_A164_F1.2321.00
191_I198_I1.2291.00
165_D212_Q1.2281.00
236_F252_E1.2191.00
211_L215_E1.2141.00
6_I32_L1.2001.00
76_V79_K1.1961.00
16_D242_D1.1921.00
202_Y253_L1.1821.00
6_I250_V1.1781.00
30_A34_R1.1711.00
93_Q97_G1.1701.00
69_F76_V1.1641.00
5_L191_I1.1601.00
249_A253_L1.1571.00
238_T245_G1.1551.00
165_D180_G1.1541.00
24_S28_T1.1511.00
201_T217_V1.1501.00
80_N178_P1.1451.00
7_F201_T1.1391.00
203_A214_I1.1261.00
231_K237_V1.1251.00
246_I250_V1.1221.00
225_N241_V1.1191.00
5_L196_F1.1181.00
40_F190_V1.1181.00
28_T251_K1.1041.00
238_T249_A1.1031.00
79_K144_F1.1001.00
145_Q175_D1.0991.00
163_E179_H1.0971.00
217_V220_G1.0821.00
63_I186_G1.0631.00
23_E26_R1.0551.00
167_V177_L1.0521.00
5_L201_T1.0511.00
178_P181_G1.0471.00
70_V189_K1.0471.00
198_I218_G1.0471.00
10_I53_I1.0441.00
223_M245_G1.0441.00
227_V230_L1.0211.00
6_I37_H1.0181.00
207_G227_V1.0161.00
191_I216_Y1.0131.00
239_K245_G1.0081.00
30_A33_Q1.0061.00
187_I217_V1.0061.00
247_A251_K0.9961.00
221_V238_T0.9921.00
92_K96_E0.9911.00
120_L124_G0.9911.00
182_S185_E0.9891.00
202_Y219_T0.9831.00
88_R92_K0.9781.00
155_E158_Y0.9781.00
190_V194_L0.9771.00
14_I25_T0.9761.00
14_I29_V0.9741.00
191_I218_G0.9721.00
221_V236_F0.9661.00
202_Y221_V0.9621.00
47_P64_S0.9601.00
224_G231_K0.9551.00
30_A58_G0.9531.00
70_V78_Y0.9531.00
248_Y252_E0.9531.00
226_A231_K0.9531.00
184_A212_Q0.9471.00
202_Y249_A0.9341.00
80_N180_G0.9261.00
223_M238_T0.9181.00
191_I196_F0.9181.00
51_K74_N0.9181.00
71_V76_V0.9111.00
222_A230_L0.9111.00
68_Q181_G0.9101.00
89_R92_K0.9101.00
97_G156_K0.9051.00
79_K106_E0.8991.00
201_T218_G0.8961.00
32_L39_V0.8961.00
8_F246_I0.8961.00
27_K30_A0.8861.00
93_Q96_E0.8851.00
156_K159_A0.8841.00
249_A252_E0.8841.00
224_G239_K0.8841.00
188_K198_I0.8831.00
63_I190_V0.8781.00
248_Y251_K0.8771.00
40_F61_S0.8761.00
177_L182_S0.8721.00
51_K55_E0.8701.00
208_L211_L0.8621.00
82_L178_P0.8601.00
43_S64_S0.8591.00
224_G243_E0.8551.00
70_V186_G0.8491.00
7_F40_F0.8471.00
214_I233_I0.8291.00
81_P142_E0.8291.00
85_N89_R0.8261.00
64_S69_F0.8251.00
25_T247_A0.8191.00
77_I193_R0.8191.00
166_L176_V0.8171.00
71_V74_N0.8121.00
37_H202_Y0.8041.00
42_A63_I0.8031.00
201_T216_Y0.7961.00
218_G235_D0.7861.00
8_F14_I0.7861.00
25_T28_T0.7841.00
93_Q160_A0.7821.00
32_L250_V0.7781.00
239_K252_E0.7781.00
229_E233_I0.7761.00
41_I50_V0.7761.00
16_D22_P0.7751.00
96_E160_A0.7671.00
162_P179_H0.7661.00
203_A220_G0.7641.00
37_H254_G0.7641.00
165_D182_S0.7621.00
93_Q161_F0.7601.00
28_T31_E0.7551.00
75_Q193_R0.7521.00
226_A230_L0.7511.00
81_P144_F0.7511.00
12_G223_M0.7491.00
47_P71_V0.7481.00
206_D226_A0.7441.00
46_S65_Y0.7431.00
69_F144_F0.7401.00
6_I202_Y0.7391.00
250_V254_G0.7351.00
89_R93_Q0.7321.00
214_I234_A0.7301.00
18_D242_D0.7301.00
187_I203_A0.7251.00
32_L254_G0.7251.00
24_S247_A0.7251.00
10_I41_I0.7241.00
84_E142_E0.7231.00
14_I21_I0.7221.00
206_D223_M0.7221.00
108_T131_P0.7201.00
223_M226_A0.7181.00
64_S71_V0.7161.00
220_G230_L0.7141.00
68_Q178_P0.7101.00
50_V62_F0.7091.00
50_V64_S0.7081.00
16_D241_V0.7071.00
158_Y161_F0.7031.00
132_E135_D0.7021.00
200_D218_G0.7011.00
66_N175_D0.6961.00
147_L175_D0.6961.00
139_E142_E0.6921.00
95_D101_V0.6901.00
251_K254_G0.6831.00
91_L95_D0.6811.00
134_D137_F0.6791.00
14_I241_V0.6771.00
181_G185_E0.6771.00
188_K191_I0.6761.00
97_G160_A0.6761.00
157_A161_F0.6711.00
118_H122_G0.6581.00
236_F239_K0.6571.00
236_F248_Y0.6541.00
165_D179_H0.6531.00
105_A143_I0.6531.00
42_A213_M0.6491.00
129_D132_E0.6481.00
185_E189_K0.6461.00
89_R160_A0.6451.00
38_H60_H0.6441.00
118_H121_E0.6441.00
145_Q169_W0.6441.00
5_L190_V0.6401.00
132_E137_F0.6361.00
165_D177_L0.6321.00
212_Q215_E0.6321.00
47_P51_K0.6281.00
204_F221_V0.6281.00
204_F238_T0.6221.00
220_G234_A0.6201.00
225_N231_K0.6201.00
121_E125_S0.6191.00
85_N88_R0.6181.00
87_I143_I0.6161.00
122_G126_L0.6151.00
37_H200_D0.6131.00
122_G125_S0.6111.00
10_I50_V0.6111.00
222_A233_I0.6111.00
10_I14_I0.6081.00
219_T249_A0.6071.00
238_T248_Y0.6041.00
24_S27_K0.6001.00
244_D247_A0.6001.00
91_L103_F0.5991.00
208_L230_L0.5971.00
170_H207_G0.5971.00
21_I45_R0.5961.00
121_E124_G0.5931.00
123_I127_K0.5901.00
249_A254_G0.5891.00
239_K249_A0.5891.00
88_R139_E0.5871.00
87_I91_L0.5861.00
196_F218_G0.5851.00
102_V147_L0.5851.00
76_V106_E0.5841.00
70_V193_R0.5831.00
89_R161_F0.5821.00
14_I41_I0.5811.00
131_P134_D0.5811.00
15_Y241_V0.5791.00
184_A188_K0.5781.00
83_P163_E0.5741.00
130_Y133_T0.5731.00
105_A108_T0.5690.99
106_E142_E0.5680.99
150_C153_E0.5650.99
196_F201_T0.5650.99
147_L173_S0.5630.99
29_V250_V0.5600.99
84_E140_G0.5600.99
72_F77_I0.5590.99
119_V122_G0.5570.99
211_L214_I0.5570.99
22_P247_A0.5560.99
69_F106_E0.5540.99
204_F250_V0.5520.99
32_L247_A0.5510.99
65_Y175_D0.5500.99
28_T32_L0.5490.99
41_I54_L0.5480.99
150_C154_E0.5470.99
124_G127_K0.5450.99
52_P55_E0.5440.99
50_V53_I0.5420.99
230_L234_A0.5420.99
8_F32_L0.5400.99
221_V235_D0.5390.99
166_L174_T0.5380.99
155_E168_R0.5370.99
223_M241_V0.5370.99
72_F193_R0.5360.99
21_I26_R0.5350.99
106_E141_K0.5350.99
65_Y68_Q0.5340.99
54_L62_F0.5330.99
106_E144_F0.5320.99
225_N240_P0.5320.99
91_L101_V0.5320.99
25_T29_V0.5300.99
6_I204_F0.5290.99
3_S6_I0.5280.99
105_A141_K0.5240.99
70_V190_V0.5240.99
244_D248_Y0.5240.99
54_L61_S0.5230.99
247_A250_V0.5210.99
65_Y173_S0.5210.99
29_V33_Q0.5200.99
103_F143_I0.5190.99
42_A66_N0.5190.99
4_K37_H0.5180.99
99_H148_L0.5180.99
38_H196_F0.5170.99
94_A101_V0.5170.99
219_T253_L0.5170.99
180_G185_E0.5150.99
168_R173_S0.5140.99
3_S38_H0.5110.99
16_D244_D0.5110.99
27_K251_K0.5110.99
49_L173_S0.5100.99
33_Q58_G0.5050.99
133_T136_L0.5050.99
227_V231_K0.5040.99
101_V146_L0.5030.99
203_A218_G0.5010.99
33_Q39_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pq0A 1 0.9961 100 0.215 Contact Map
1nrwA 1 0.9805 100 0.233 Contact Map
3l7yA 1 0.9883 100 0.243 Contact Map
3pgvA 3 0.9689 100 0.244 Contact Map
2rbkA 1 0.9844 100 0.247 Contact Map
2b30A 2 0.9883 100 0.247 Contact Map
4qjbA 1 0.9922 100 0.253 Contact Map
3daoA 1 0.9844 100 0.253 Contact Map
3fzqA 2 0.9883 100 0.254 Contact Map
1rkqA 1 0.9922 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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