GREMLIN Database
LSPA - Lipoprotein signal peptidase
UniProt: Q45479 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (142)
Sequences: 4395 (3249)
Seq/√Len: 272.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_I131_S4.0221.00
17_T112_F3.7151.00
11_I101_I2.7871.00
10_I94_G2.7351.00
44_R108_E2.6361.00
22_V110_V2.5551.00
38_F113_I2.3391.00
20_L24_N2.2661.00
21_V25_M2.1171.00
25_M31_I2.0741.00
50_W123_P2.0641.00
17_T127_I2.0361.00
39_Y114_H2.0281.00
130_S134_V1.9851.00
15_Q101_I1.9171.00
22_V44_R1.8831.00
88_A138_L1.8141.00
39_Y116_I1.7871.00
7_A93_L1.7781.00
133_C137_M1.7511.00
127_I130_S1.7251.00
43_H124_I1.6961.00
30_S39_Y1.6811.00
32_P35_D1.6731.00
46_T54_A1.6141.00
92_M135_G1.6121.00
16_L20_L1.6081.00
71_I93_L1.5791.00
68_I93_L1.5761.00
46_T108_E1.5291.00
106_R110_V1.5221.00
73_Y77_R1.5091.00
127_I131_S1.5001.00
19_W23_K1.4861.00
122_Y133_C1.4381.00
90_G94_G1.4031.00
21_V42_S1.3811.00
68_I96_A1.3641.00
25_M42_S1.3551.00
69_I73_Y1.3531.00
7_A90_G1.3481.00
34_I37_V1.3451.00
21_V40_I1.3361.00
13_A127_I1.2761.00
41_T124_I1.2681.00
30_S41_T1.2351.00
12_A16_L1.2201.00
88_A135_G1.2011.00
64_T100_F1.1991.00
84_L88_A1.1661.00
33_I40_I1.1601.00
130_S133_C1.1561.00
84_L138_L1.1391.00
17_T113_I1.1391.00
32_P39_Y1.1331.00
11_I97_I1.1321.00
41_T114_H1.1281.00
40_I113_I1.1271.00
134_V138_L1.1191.00
88_A139_L1.1051.00
38_F115_V1.0841.00
71_I89_L1.0801.00
6_I10_I1.0791.00
61_Y100_F1.0771.00
88_A142_Q1.0701.00
94_G131_S1.0681.00
66_A70_G1.0571.00
26_E42_S1.0511.00
65_T69_I1.0481.00
114_H117_I1.0451.00
114_H124_I1.0401.00
136_V140_F1.0381.00
113_I130_S1.0361.00
141_I145_L1.0331.00
30_S114_H1.0311.00
62_L66_A1.0101.00
57_M61_Y0.9991.00
26_E29_Q0.9881.00
46_T51_G0.9821.00
42_S110_V0.9751.00
83_R87_V0.9721.00
101_I105_V0.9661.00
33_I38_F0.9651.00
70_G74_Y0.9441.00
61_Y104_A0.9381.00
10_I90_G0.9311.00
22_V106_R0.9141.00
53_L60_F0.9121.00
64_T68_I0.9101.00
48_A60_F0.9051.00
70_G73_Y0.8921.00
53_L56_Q0.8901.00
42_S108_E0.8891.00
51_G54_A0.8821.00
56_Q59_F0.8791.00
25_M29_Q0.8741.00
73_Y76_Q0.8721.00
91_L131_S0.8661.00
137_M141_I0.8621.00
72_V76_Q0.8511.00
10_I91_L0.8481.00
14_D18_K0.8391.00
84_L142_Q0.8361.00
82_Q85_L0.8310.99
35_D39_Y0.8310.99
17_T20_L0.8150.99
11_I15_Q0.8140.99
6_I90_G0.8080.99
85_L142_Q0.8060.99
50_W122_Y0.8050.99
67_V96_A0.8040.99
7_A97_I0.8030.99
75_I86_G0.8020.99
17_T21_V0.7900.99
112_F127_I0.7850.99
142_Q146_D0.7720.99
85_L89_L0.7710.99
133_C140_F0.7700.99
7_A94_G0.7700.99
115_V125_F0.7690.99
32_P36_Q0.7680.99
75_I90_G0.7620.99
48_A52_I0.7580.99
68_I100_F0.7560.99
21_V27_L0.7560.99
64_T103_R0.7390.99
91_L135_G0.7320.99
92_M132_L0.7270.99
6_I87_V0.7250.99
92_M139_L0.7250.99
21_V24_N0.7230.99
44_R110_V0.7210.99
3_Y75_I0.7080.98
43_H51_G0.7060.98
142_Q145_L0.7020.98
137_M140_F0.6980.98
98_G101_I0.6970.98
15_Q105_V0.6930.98
76_Q79_T0.6920.98
78_Y82_Q0.6870.98
5_M9_L0.6800.98
96_A132_L0.6770.98
4_Y76_Q0.6770.98
116_I119_N0.6760.98
15_Q19_W0.6720.98
125_F130_S0.6670.98
79_T82_Q0.6660.98
75_I89_L0.6600.97
10_I127_I0.6550.97
32_P116_I0.6520.97
49_A123_P0.6470.97
86_G90_G0.6460.97
3_Y90_G0.6450.97
100_F104_A0.6440.97
82_Q142_Q0.6400.97
37_V116_I0.6400.97
78_Y81_G0.6380.97
53_L59_F0.6380.97
36_Q39_Y0.6370.97
58_W61_Y0.6360.97
51_G123_P0.6360.97
63_I67_V0.6360.97
22_V42_S0.6340.97
57_M60_F0.6220.96
92_M96_A0.6170.96
11_I94_G0.6060.96
13_A17_T0.6050.96
65_T100_F0.6040.96
61_Y64_T0.6030.96
44_R106_R0.6000.96
140_F143_M0.5960.95
7_A11_I0.5950.95
22_V108_E0.5930.95
3_Y86_G0.5880.95
114_H118_V0.5830.95
134_V137_M0.5810.95
27_L44_R0.5810.95
72_V93_L0.5760.94
91_L138_L0.5750.94
71_I96_A0.5730.94
15_Q106_R0.5690.94
31_I40_I0.5670.94
21_V30_S0.5660.94
37_V113_I0.5540.93
13_A16_L0.5520.93
116_I124_I0.5510.93
66_A69_I0.5510.93
91_L134_V0.5510.93
16_L19_W0.5490.93
46_T53_L0.5480.93
10_I130_S0.5450.93
136_V143_M0.5440.93
102_D110_V0.5440.93
85_L146_D0.5400.92
67_V132_L0.5390.92
21_V112_F0.5370.92
61_Y107_Q0.5370.92
25_M28_G0.5350.92
113_I123_P0.5350.92
113_I124_I0.5330.92
26_E30_S0.5320.92
20_L25_M0.5280.92
118_V122_Y0.5210.91
4_Y8_L0.5210.91
97_I101_I0.5190.91
8_L12_A0.5120.90
122_Y125_F0.5110.90
117_I122_Y0.5100.90
56_Q64_T0.5090.90
58_W62_L0.5070.90
27_L30_S0.5070.90
74_Y89_L0.5010.89
59_F62_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x5mA 2 0.5909 10.5 0.941 Contact Map
4qncA 2 0.526 8 0.944 Contact Map
3qe7A 2 0.9416 5 0.949 Contact Map
2m20A 2 0.2338 4 0.952 Contact Map
2kv5A 1 0.2143 3.8 0.952 Contact Map
4px7A 1 0.8571 3.6 0.953 Contact Map
2kluA 1 0.2143 3.5 0.953 Contact Map
3j01B 1 0.3831 3 0.955 Contact Map
4lz6A 1 0.5649 2.6 0.956 Contact Map
2cfqA 1 0.8571 2.5 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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