SYI - BACSU - GREMLIN Contacts

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SYI - Isoleucine--tRNA ligase

UniProt:	Q45477	Sequences: MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERTKDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIETALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEYEAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDGKGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASACGFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDFIIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHSYPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDWCISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFTHPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSLSTAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSVDYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLIKLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSMQTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEKFDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVSELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEIVEKYYQK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	921 (863)
Sequences:	4843 (2806)
Seq/√Len:	95.5

ECOLI - SYI SYV
BACSU - SYI SYV SYL
HALSA - SYI SYV SYL
SULSO - SYI SYV SYL2 SYL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_D	38_R	5.717	1.00
256_A	282_E	5.703	1.00
251_E	288_K	5.180	1.00
29_K	33_E	4.992	1.00
266_S	286_T	4.911	1.00
81_K	86_Y	4.801	1.00
32_E	141_K	4.088	1.00
253_S	266_S	3.925	1.00
427_K	437_E	3.906	1.00
364_M	372_A	3.841	1.00
134_E	137_R	3.786	1.00
361_F	376_Q	3.775	1.00
39_L	776_Q	3.624	1.00
170_E	173_K	3.587	1.00
337_G	342_L	3.442	1.00
84_S	692_K	3.338	1.00
251_E	266_S	3.291	1.00
293_E	310_L	3.258	1.00
480_E	484_E	3.242	1.00
678_Q	792_S	3.223	1.00
228_I	308_V	3.211	1.00
250_L	316_T	3.137	1.00
212_A	260_D	3.080	1.00
593_R	599_I	2.979	1.00
251_E	286_T	2.941	1.00
187_S	399_T	2.850	1.00
244_I	322_C	2.845	1.00
749_L	753_K	2.814	1.00
124_L	127_E	2.814	1.00
42_E	45_K	2.807	1.00
549_D	579_K	2.778	1.00
104_A	107_K	2.717	1.00
611_Q	634_D	2.698	1.00
44_T	47_R	2.685	1.00
430_K	580_G	2.628	1.00
360_G	376_Q	2.612	1.00
313_H	336_I	2.602	1.00
690_K	706_S	2.594	1.00
590_G	635_A	2.580	1.00
30_K	34_E	2.538	1.00
755_S	763_A	2.535	1.00
253_S	269_V	2.535	1.00
293_E	340_Y	2.530	1.00
30_K	768_S	2.516	1.00
268_L	271_N	2.507	1.00
425_A	428_E	2.484	1.00
669_A	672_D	2.481	1.00
261_R	284_T	2.438	1.00
420_S	424_D	2.435	1.00
313_H	325_T	2.427	1.00
651_F	766_L	2.381	1.00
79_R	760_P	2.366	1.00
117_S	120_E	2.342	1.00
421_D	574_G	2.310	1.00
309_M	336_I	2.305	1.00
376_Q	380_K	2.303	1.00
28_Q	761_H	2.285	1.00
137_R	141_K	2.282	1.00
137_R	150_E	2.266	1.00
228_I	322_C	2.254	1.00
19_N	22_N	2.247	1.00
133_I	154_V	2.240	1.00
267_A	316_T	2.226	1.00
50_F	698_Y	2.225	1.00
693_K	697_E	2.221	1.00
187_S	190_S	2.221	1.00
148_D	151_N	2.204	1.00
166_R	487_R	2.160	1.00
123_K	127_E	2.151	1.00
334_F	338_Q	2.131	1.00
682_I	796_E	2.131	1.00
203_D	392_S	2.123	1.00
692_K	783_M	2.120	1.00
41_Q	87_N	2.115	1.00
48_P	86_Y	2.115	1.00
349_D	353_V	2.115	1.00
467_A	470_G	2.112	1.00
244_I	297_A	2.108	1.00
680_M	747_T	2.100	1.00
550_L	582_L	2.097	1.00
205_R	390_T	2.084	1.00
39_L	42_E	2.074	1.00
375_Q	379_E	2.067	1.00
775_E	781_T	2.053	1.00
607_K	611_Q	2.043	1.00
365_F	368_D	2.038	1.00
311_G	336_I	2.037	1.00
203_D	390_T	2.032	1.00
256_A	261_R	2.027	1.00
62_D	135_G	2.012	1.00
80_Y	696_D	2.010	1.00
424_D	427_K	2.009	1.00
332_D	335_I	1.988	1.00
550_L	580_G	1.980	1.00
190_S	399_T	1.980	1.00
254_V	285_R	1.974	1.00
372_A	375_Q	1.969	1.00
296_I	305_D	1.963	1.00
414_S	417_D	1.958	1.00
687_L	706_S	1.947	1.00
166_R	483_S	1.938	1.00
272_V	276_C	1.934	1.00
356_S	362_E	1.930	1.00
497_K	501_D	1.930	1.00
468_E	518_T	1.928	1.00
243_G	309_M	1.922	1.00
228_I	244_I	1.918	1.00
46_D	87_N	1.906	1.00
254_V	261_R	1.900	1.00
421_D	424_D	1.897	1.00
76_F	622_S	1.895	1.00
245_S	325_T	1.888	1.00
686_K	796_E	1.883	1.00
285_R	291_D	1.875	1.00
689_D	693_K	1.864	1.00
214_G	382_A	1.855	1.00
213_F	241_N	1.849	1.00
227_R	260_D	1.847	1.00
62_D	139_Q	1.844	1.00
288_K	291_D	1.843	1.00
424_D	428_E	1.841	1.00
80_Y	84_S	1.839	1.00
684_L	750_A	1.834	1.00
689_D	788_T	1.826	1.00
245_S	336_I	1.816	1.00
173_K	476_D	1.801	1.00
26_D	29_K	1.799	1.00
83_M	756_A	1.797	1.00
431_W	581_V	1.797	1.00
108_N	131_K	1.795	1.00
270_E	274_S	1.785	1.00
836_K	840_E	1.778	1.00
38_R	42_E	1.775	1.00
375_Q	378_D	1.774	1.00
63_I	143_L	1.772	1.00
257_V	260_D	1.769	1.00
230_I	244_I	1.758	1.00
160_Y	533_S	1.755	1.00
108_N	124_L	1.749	1.00
475_T	478_T	1.747	1.00
49_K	87_N	1.733	1.00
112_N	115_E	1.732	1.00
255_I	269_V	1.730	1.00
247_H	250_L	1.728	1.00
81_K	696_D	1.723	1.00
692_K	696_D	1.721	1.00
214_G	227_R	1.716	1.00
253_S	283_V	1.707	1.00
216_K	296_I	1.699	1.00
165_I	486_F	1.697	1.00
169_G	173_K	1.696	1.00
214_G	298_E	1.690	1.00
170_E	174_R	1.689	1.00
238_I	301_L	1.686	1.00
56_P	160_Y	1.684	1.00
253_S	286_T	1.682	1.00
22_N	25_P	1.669	1.00
130_W	156_L	1.667	1.00
590_G	633_S	1.657	1.00
78_V	88_A	1.656	1.00
843_A	846_K	1.652	1.00
96_T	156_L	1.640	1.00
205_R	388_F	1.625	1.00
688_I	750_A	1.606	1.00
680_M	715_L	1.600	1.00
839_K	843_A	1.599	1.00
607_K	610_K	1.593	1.00
229_I	262_F	1.592	1.00
813_L	853_F	1.588	1.00
81_K	84_S	1.574	1.00
539_E	543_D	1.574	1.00
425_A	570_V	1.572	1.00
216_K	298_E	1.570	1.00
179_K	466_Y	1.569	1.00
829_N	857_E	1.561	1.00
256_A	259_E	1.556	1.00
777_S	780_L	1.552	1.00
264_V	272_V	1.550	1.00
273_A	281_Y	1.550	1.00
22_N	26_D	1.546	1.00
224_N	256_A	1.545	1.00
226_E	254_V	1.542	1.00
695_Y	703_V	1.542	1.00
753_K	781_T	1.538	1.00
171_M	571_A	1.535	1.00
29_K	32_E	1.534	1.00
30_K	764_D	1.531	1.00
275_A	387_E	1.527	1.00
209_I	238_I	1.522	1.00
426_I	444_V	1.515	1.00
245_S	311_G	1.512	1.00
246_V	322_C	1.503	1.00
23_R	26_D	1.501	1.00
427_K	441_H	1.499	1.00
246_V	308_V	1.497	1.00
154_V	157_K	1.494	1.00
248_P	310_L	1.494	1.00
855_V	858_L	1.484	1.00
169_G	479_I	1.482	1.00
190_S	396_D	1.481	1.00
254_V	287_V	1.477	1.00
364_M	369_A	1.474	1.00
675_E	798_K	1.470	1.00
212_A	227_R	1.466	1.00
730_E	736_D	1.466	1.00
229_I	384_V	1.465	1.00
215_V	295_I	1.461	1.00
142_R	610_K	1.455	1.00
752_V	766_L	1.455	1.00
34_E	776_Q	1.445	1.00
688_I	754_L	1.443	1.00
830_L	859_T	1.442	1.00
400_K	598_S	1.439	1.00
90_Y	147_G	1.435	1.00
225_G	261_R	1.435	1.00
223_E	226_E	1.433	1.00
301_L	376_Q	1.425	1.00
431_W	440_L	1.422	1.00
36_I	146_R	1.422	1.00
144_G	761_H	1.420	0.99
376_Q	379_E	1.419	0.99
65_M	602_V	1.419	0.99
764_D	777_S	1.415	0.99
798_K	844_S	1.408	0.99
328_G	347_P	1.408	0.99
310_L	340_Y	1.406	0.99
829_N	859_T	1.404	0.99
695_Y	758_I	1.396	0.99
189_S	399_T	1.392	0.99
120_E	123_K	1.390	0.99
544_L	547_P	1.385	0.99
489_H	493_I	1.380	0.99
699_E	702_V	1.369	0.99
467_A	513_P	1.367	0.99
831_K	861_S	1.367	0.99
73_L	552_L	1.361	0.99
432_V	580_G	1.359	0.99
355_T	358_A	1.356	0.99
292_L	295_I	1.349	0.99
607_K	634_D	1.346	0.99
840_E	843_A	1.340	0.99
608_V	637_L	1.327	0.99
171_M	568_T	1.326	0.99
422_L	567_S	1.320	0.99
84_S	696_D	1.319	0.99
353_V	368_D	1.315	0.99
415_I	418_F	1.310	0.99
748_L	770_L	1.308	0.99
269_V	273_A	1.307	0.99
160_Y	536_A	1.304	0.99
249_D	290_K	1.297	0.99
207_A	369_A	1.297	0.99
486_F	503_L	1.289	0.99
255_I	283_V	1.289	0.99
489_H	496_E	1.288	0.99
816_A	821_I	1.288	0.99
587_A	630_V	1.287	0.99
364_M	368_D	1.277	0.99
266_S	283_V	1.275	0.99
743_V	747_T	1.273	0.99
311_G	335_I	1.264	0.99
325_T	337_G	1.263	0.99
249_D	288_K	1.260	0.99
187_S	396_D	1.258	0.99
546_R	573_T	1.255	0.99
474_I	485_L	1.255	0.99
493_I	497_K	1.255	0.99
685_N	688_I	1.253	0.99
242_L	345_L	1.252	0.99
287_V	291_D	1.251	0.99
801_R	841_L	1.249	0.99
867_P	870_A	1.248	0.99
38_R	150_E	1.247	0.99
361_F	372_A	1.247	0.99
245_S	309_M	1.245	0.99
371_K	386_L	1.245	0.99
430_K	697_E	1.239	0.99
65_M	608_V	1.235	0.99
654_L	657_N	1.233	0.99
228_I	263_V	1.230	0.99
163_Q	166_R	1.227	0.99
444_V	563_N	1.224	0.98
207_A	386_L	1.224	0.98
534_H	568_T	1.224	0.98
216_K	305_D	1.223	0.98
425_A	576_A	1.217	0.98
498_E	501_D	1.214	0.98
367_D	370_N	1.214	0.98
44_T	82_S	1.213	0.98
185_N	405_F	1.212	0.98
563_N	567_S	1.210	0.98
546_R	575_K	1.204	0.98
358_A	362_E	1.204	0.98
347_P	355_T	1.202	0.98
468_E	516_T	1.201	0.98
566_L	577_P	1.197	0.98
311_G	325_T	1.196	0.98
532_S	568_T	1.196	0.98
371_K	375_Q	1.192	0.98
756_A	779_Q	1.192	0.98
24_E	614_A	1.190	0.98
692_K	785_E	1.188	0.98
27_I	768_S	1.188	0.98
672_D	735_P	1.182	0.98
247_H	312_E	1.180	0.98
120_E	124_L	1.180	0.98
726_I	740_M	1.179	0.98
599_I	602_V	1.177	0.98
606_A	610_K	1.176	0.98
470_G	512_S	1.171	0.98
884_E	891_S	1.170	0.98
541_R	544_L	1.168	0.98
331_E	335_I	1.166	0.98
703_V	758_I	1.166	0.98
526_V	529_D	1.164	0.98
45_K	48_P	1.161	0.98
802_F	852_L	1.159	0.98
297_A	306_S	1.158	0.98
240_A	354_M	1.153	0.98
226_E	261_R	1.153	0.98
348_V	366_Y	1.146	0.98
71_K	140_F	1.143	0.98
359_P	362_E	1.141	0.98
169_G	477_E	1.141	0.98
265_A	268_L	1.137	0.98
752_V	763_A	1.132	0.97
159_E	487_R	1.130	0.97
246_V	292_L	1.130	0.97
485_L	493_I	1.129	0.97
245_S	313_H	1.129	0.97
191_E	351_K	1.127	0.97
650_T	720_L	1.126	0.97
887_M	890_R	1.124	0.97
53_H	533_S	1.120	0.97
504_P	516_T	1.117	0.97
283_V	286_T	1.113	0.97
77_I	700_F	1.110	0.97
839_K	862_E	1.105	0.97
441_H	445_R	1.104	0.97
246_V	310_L	1.101	0.97
43_R	782_D	1.100	0.97
214_G	225_G	1.099	0.97
661_F	742_T	1.097	0.97
44_T	782_D	1.094	0.97
238_I	380_K	1.094	0.97
182_K	451_C	1.090	0.97
688_I	786_T	1.086	0.97
483_S	487_R	1.084	0.97
413_A	452_I	1.084	0.97
378_D	386_L	1.084	0.97
242_L	304_R	1.080	0.97
477_E	481_H	1.080	0.97
167_V	572_V	1.080	0.97
353_V	365_F	1.077	0.97
681_L	746_E	1.073	0.97
199_I	403_T	1.070	0.96
361_F	364_M	1.070	0.96
480_E	483_S	1.069	0.96
243_G	337_G	1.065	0.96
470_G	513_P	1.063	0.96
30_K	36_I	1.063	0.96
328_G	344_V	1.062	0.96
366_Y	404_I	1.058	0.96
134_E	138_E	1.058	0.96
166_R	480_E	1.057	0.96
434_E	437_E	1.056	0.96
552_L	584_H	1.055	0.96
512_S	515_G	1.049	0.96
673_L	743_V	1.047	0.96
257_V	262_F	1.046	0.96
254_V	263_V	1.046	0.96
287_V	292_L	1.045	0.96
793_E	797_E	1.044	0.96
655_H	659_F	1.044	0.96
624_V	630_V	1.042	0.96
809_V	830_L	1.041	0.96
440_L	581_V	1.039	0.96
575_K	579_K	1.039	0.96
210_Y	275_A	1.038	0.96
438_Q	442_N	1.038	0.96
863_E	866_A	1.035	0.96
670_V	673_L	1.034	0.96
179_K	409_A	1.034	0.96
580_G	698_Y	1.032	0.96
187_S	470_G	1.030	0.96
676_V	723_A	1.030	0.96
750_A	754_L	1.030	0.96
325_T	336_I	1.029	0.96
673_L	681_L	1.025	0.95
539_E	573_T	1.025	0.95
335_I	338_Q	1.020	0.95
489_H	497_K	1.017	0.95
164_Q	524_M	1.015	0.95
248_P	290_K	1.015	0.95
792_S	795_T	1.014	0.95
167_V	528_F	1.012	0.95
354_M	358_A	1.011	0.95
668_V	673_L	1.009	0.95
730_E	734_H	1.008	0.95
850_S	858_L	1.007	0.95
130_W	133_I	1.007	0.95
290_K	293_E	1.006	0.95
870_A	873_F	1.005	0.95
394_P	405_F	1.005	0.95
687_L	710_F	1.001	0.95
849_L	858_L	1.001	0.95
119_A	123_K	1.000	0.95
273_A	278_F	0.999	0.95
34_E	777_S	0.998	0.95
63_I	67_H	0.996	0.95
888_C	892_R	0.996	0.95
662_D	666_N	0.994	0.95
148_D	543_D	0.993	0.95
242_L	343_D	0.992	0.95
538_L	548_A	0.992	0.95
484_E	487_R	0.990	0.95
755_S	759_L	0.989	0.94
691_V	754_L	0.989	0.94
868_N	871_Q	0.989	0.94
212_A	262_F	0.988	0.94
467_A	517_F	0.988	0.94
829_N	881_E	0.987	0.94
467_A	471_E	0.986	0.94
84_S	783_M	0.986	0.94
683_K	800_D	0.986	0.94
666_N	733_D	0.986	0.94
887_M	892_R	0.984	0.94
171_M	413_A	0.984	0.94
209_I	374_T	0.984	0.94
569_A	573_T	0.980	0.94
215_V	228_I	0.980	0.94
437_E	441_H	0.979	0.94
151_N	157_K	0.977	0.94
346_C	350_E	0.976	0.94
752_V	778_V	0.976	0.94
251_E	267_A	0.976	0.94
192_S	399_T	0.973	0.94
349_D	355_T	0.973	0.94
146_R	779_Q	0.970	0.94
168_F	177_I	0.970	0.94
296_I	307_L	0.969	0.94
399_T	470_G	0.966	0.94
611_Q	638_K	0.966	0.94
65_M	632_V	0.965	0.94
238_I	373_I	0.964	0.94
686_K	793_E	0.963	0.94
374_T	386_L	0.963	0.94
718_F	803_M	0.961	0.94
272_V	384_V	0.960	0.94
294_N	340_Y	0.959	0.94
884_E	896_K	0.957	0.93
65_M	587_A	0.953	0.93
888_C	891_S	0.953	0.93
632_V	637_L	0.948	0.93
813_L	822_I	0.947	0.93
694_A	702_V	0.946	0.93
241_N	306_S	0.945	0.93
240_A	347_P	0.945	0.93
604_V	607_K	0.945	0.93
256_A	284_T	0.944	0.93
312_E	339_K	0.944	0.93
423_L	445_R	0.942	0.93
737_R	741_Q	0.941	0.93
400_K	599_I	0.940	0.93
673_L	739_S	0.940	0.93
176_Y	418_F	0.939	0.93
878_I	882_K	0.937	0.93
684_L	747_T	0.936	0.93
423_L	441_H	0.936	0.93
294_N	307_L	0.933	0.93
849_L	853_F	0.933	0.93
396_D	399_T	0.933	0.93
513_P	517_F	0.931	0.93
349_D	356_S	0.929	0.92
83_M	779_Q	0.928	0.92
782_D	785_E	0.926	0.92
372_A	376_Q	0.926	0.92
467_A	512_S	0.925	0.92
329_H	346_C	0.925	0.92
40_V	82_S	0.924	0.92
455_Q	522_D	0.924	0.92
883_A	894_I	0.923	0.92
608_V	617_L	0.922	0.92
45_K	87_N	0.922	0.92
172_A	177_I	0.920	0.92
83_M	783_M	0.919	0.92
688_I	784_P	0.914	0.92
566_L	576_A	0.912	0.92
26_D	765_E	0.910	0.92
207_A	388_F	0.909	0.92
846_K	850_S	0.909	0.92
749_L	774_E	0.908	0.92
881_E	884_E	0.908	0.92
866_A	869_D	0.902	0.91
275_A	385_K	0.901	0.91
635_A	638_K	0.899	0.91
680_M	710_F	0.898	0.91
867_P	873_F	0.897	0.91
810_L	814_E	0.897	0.91
202_Q	400_K	0.895	0.91
39_L	780_L	0.895	0.91
215_V	226_E	0.895	0.91
869_D	872_S	0.894	0.91
421_D	425_A	0.894	0.91
653_F	657_N	0.893	0.91
750_A	753_K	0.891	0.91
167_V	535_Q	0.891	0.91
682_I	791_N	0.890	0.91
812_A	816_A	0.889	0.91
138_E	141_K	0.887	0.91
651_F	769_H	0.886	0.91
655_H	660_D	0.884	0.90
831_K	859_T	0.882	0.90
823_G	826_L	0.882	0.90
635_A	639_Q	0.882	0.90
429_T	576_A	0.882	0.90
476_D	480_E	0.882	0.90
265_A	316_T	0.881	0.90
83_M	753_K	0.881	0.90
690_K	702_V	0.879	0.90
209_I	383_L	0.879	0.90
440_L	444_V	0.878	0.90
79_R	779_Q	0.877	0.90
673_L	742_T	0.876	0.90
801_R	838_N	0.875	0.90
683_K	686_K	0.874	0.90
465_F	503_L	0.873	0.90
869_D	873_F	0.873	0.90
189_S	401_K	0.873	0.90
248_P	293_E	0.872	0.90
217_D	296_I	0.871	0.90
707_I	755_S	0.870	0.90
476_D	485_L	0.869	0.90
230_I	322_C	0.869	0.90
36_I	780_L	0.868	0.90
297_A	308_V	0.868	0.90
51_V	545_V	0.867	0.90
481_H	485_L	0.867	0.90
554_G	584_H	0.867	0.90
135_G	139_Q	0.866	0.90
689_D	786_T	0.866	0.90
799_F	802_F	0.866	0.90
345_L	348_V	0.866	0.90
163_Q	540_E	0.866	0.90
465_F	499_A	0.865	0.89
815_T	819_E	0.865	0.89
227_R	262_F	0.864	0.89
315_T	318_A	0.864	0.89
771_T	774_E	0.862	0.89
79_R	146_R	0.862	0.89
654_L	658_L	0.862	0.89
49_K	545_V	0.861	0.89
243_G	307_L	0.861	0.89
590_G	634_D	0.861	0.89
243_G	342_L	0.861	0.89
127_E	131_K	0.860	0.89
106_T	121_F	0.858	0.89
539_E	542_D	0.857	0.89
767_W	781_T	0.855	0.89
250_L	265_A	0.854	0.89
794_A	798_K	0.854	0.89
587_A	602_V	0.854	0.89
109_K	112_N	0.852	0.89
130_W	134_E	0.851	0.89
431_W	437_E	0.850	0.89
656_G	659_F	0.849	0.89
746_E	784_P	0.849	0.89
54_D	71_K	0.849	0.89
657_N	660_D	0.847	0.88
851_Q	893_V	0.846	0.88
347_P	357_E	0.846	0.88
889_E	893_V	0.846	0.88
255_I	264_V	0.844	0.88
109_K	114_K	0.842	0.88
80_Y	692_K	0.841	0.88
469_N	516_T	0.841	0.88
230_I	300_P	0.841	0.88
546_R	569_A	0.841	0.88
481_H	484_E	0.840	0.88
187_S	467_A	0.840	0.88
656_G	660_D	0.840	0.88
847_E	850_S	0.840	0.88
483_S	489_H	0.839	0.88
368_D	371_K	0.839	0.88
464_V	473_V	0.836	0.88
866_A	870_A	0.835	0.88
348_V	404_I	0.835	0.88
655_H	661_F	0.834	0.88
867_P	871_Q	0.833	0.88
293_E	339_K	0.832	0.88
119_A	496_E	0.831	0.88
746_E	749_L	0.828	0.87
558_Y	583_S	0.826	0.87
475_T	479_I	0.823	0.87
228_I	297_A	0.821	0.87
756_A	763_A	0.820	0.87
426_I	431_W	0.819	0.87
731_H	734_H	0.819	0.87
682_I	686_K	0.819	0.87
347_P	354_M	0.818	0.87
258_G	280_Q	0.818	0.87
309_M	340_Y	0.816	0.87
756_A	778_V	0.816	0.87
423_L	427_K	0.812	0.86
694_A	706_S	0.809	0.86
876_G	879_A	0.809	0.86
760_P	779_Q	0.808	0.86
174_R	421_D	0.808	0.86
551_Y	565_S	0.808	0.86
353_V	356_S	0.804	0.86
309_M	342_L	0.804	0.86
422_L	563_N	0.803	0.86
336_I	340_Y	0.803	0.86
658_L	661_F	0.802	0.86
193_A	455_Q	0.802	0.86
226_E	263_V	0.800	0.85
39_L	777_S	0.800	0.85
685_N	689_D	0.799	0.85
374_T	388_F	0.798	0.85
399_T	467_A	0.798	0.85
429_T	566_L	0.797	0.85
363_G	366_Y	0.797	0.85
65_M	604_V	0.795	0.85
694_A	703_V	0.795	0.85
168_F	524_M	0.793	0.85
853_F	858_L	0.793	0.85
797_E	837_E	0.793	0.85
415_I	447_R	0.793	0.85
657_N	661_F	0.790	0.85
673_L	746_E	0.790	0.85
486_F	491_S	0.789	0.85
863_E	867_P	0.786	0.84
739_S	743_V	0.786	0.84
828_A	855_V	0.786	0.84
328_G	346_C	0.786	0.84
827_E	882_K	0.785	0.84
797_E	800_D	0.784	0.84
830_L	833_Y	0.784	0.84
139_Q	604_V	0.783	0.84
128_Y	132_Q	0.783	0.84
131_K	135_G	0.783	0.84
41_Q	82_S	0.782	0.84
134_E	141_K	0.781	0.84
354_M	369_A	0.778	0.84
693_K	696_D	0.777	0.84
355_T	362_E	0.777	0.84
25_P	610_K	0.776	0.84
835_N	838_N	0.775	0.84
240_A	329_H	0.775	0.84
278_F	281_Y	0.773	0.83
42_E	46_D	0.772	0.83
309_M	313_H	0.772	0.83
668_V	735_P	0.771	0.83
723_A	740_M	0.771	0.83
881_E	885_G	0.770	0.83
428_E	575_K	0.770	0.83
228_I	246_V	0.770	0.83
670_V	678_Q	0.770	0.83
442_N	445_R	0.768	0.83
126_E	130_W	0.767	0.83
667_A	742_T	0.767	0.83
752_V	770_L	0.766	0.83
657_N	744_F	0.765	0.83
794_A	797_E	0.765	0.83
668_V	742_T	0.765	0.83
812_A	815_T	0.764	0.83
540_E	544_L	0.764	0.83
213_F	244_I	0.763	0.83
685_N	791_N	0.760	0.82
82_S	88_A	0.760	0.82
309_M	337_G	0.760	0.82
271_N	274_S	0.759	0.82
595_M	601_N	0.758	0.82
564_S	578_Y	0.756	0.82
356_S	359_P	0.755	0.82
688_I	692_K	0.755	0.82
299_H	302_Y	0.754	0.82
686_K	690_K	0.753	0.82
116_M	121_F	0.753	0.82
171_M	177_I	0.752	0.82
122_R	495_F	0.752	0.82
866_A	873_F	0.752	0.82
787_I	790_P	0.751	0.82
208_S	389_I	0.751	0.82
838_N	841_L	0.750	0.82
263_V	287_V	0.750	0.82
47_R	782_D	0.749	0.82
207_A	370_N	0.747	0.81
619_L	704_Y	0.746	0.81
174_R	574_G	0.744	0.81
276_C	384_V	0.744	0.81
344_V	347_P	0.743	0.81
94_W	137_R	0.743	0.81
298_E	303_G	0.741	0.81
837_E	840_E	0.740	0.81
682_I	790_P	0.740	0.81
468_E	514_N	0.738	0.81
555_S	558_Y	0.738	0.81
705_H	709_N	0.738	0.81
426_I	440_L	0.737	0.80
263_V	308_V	0.737	0.80
830_L	857_E	0.736	0.80
470_G	517_F	0.735	0.80
467_A	516_T	0.734	0.80
208_S	387_E	0.734	0.80
420_S	423_L	0.734	0.80
685_N	790_P	0.733	0.80
118_V	121_F	0.732	0.80
110_K	114_K	0.731	0.80
28_Q	142_R	0.731	0.80
684_L	688_I	0.731	0.80
485_L	489_H	0.731	0.80
785_E	788_T	0.731	0.80
254_V	284_T	0.730	0.80
135_G	138_E	0.729	0.80
470_G	473_V	0.727	0.80
307_L	340_Y	0.726	0.79
244_I	308_V	0.725	0.79
667_A	746_E	0.725	0.79
647_I	755_S	0.724	0.79
242_L	342_L	0.724	0.79
213_F	306_S	0.724	0.79
797_E	801_R	0.724	0.79
829_N	885_G	0.724	0.79
116_M	124_L	0.723	0.79
73_L	584_H	0.723	0.79
188_P	365_F	0.723	0.79
862_E	865_E	0.722	0.79
255_I	281_Y	0.722	0.79
831_K	881_E	0.721	0.79
500_K	515_G	0.719	0.79
756_A	777_S	0.718	0.79
255_I	273_A	0.718	0.79
471_E	518_T	0.717	0.79
634_D	638_K	0.716	0.79
225_G	260_D	0.716	0.79
622_S	758_I	0.716	0.79
816_A	880_V	0.714	0.78
465_F	482_V	0.713	0.78
139_Q	606_A	0.713	0.78
419_R	445_R	0.712	0.78
767_W	775_E	0.712	0.78
110_K	113_R	0.712	0.78
115_E	120_E	0.711	0.78
836_K	862_E	0.711	0.78
555_S	586_F	0.710	0.78
668_V	672_D	0.709	0.78
132_Q	135_G	0.708	0.78
250_L	267_A	0.706	0.78
217_D	223_E	0.705	0.77
141_K	150_E	0.705	0.77
266_S	269_V	0.705	0.77
846_K	860_I	0.704	0.77
440_L	558_Y	0.704	0.77
123_K	496_E	0.703	0.77
533_S	537_V	0.703	0.77
447_R	567_S	0.703	0.77
764_D	768_S	0.702	0.77
371_K	374_T	0.702	0.77
722_F	851_Q	0.701	0.77
60_N	67_H	0.701	0.77
126_E	492_N	0.701	0.77
884_E	888_C	0.700	0.77
675_E	678_Q	0.700	0.77
246_V	289_G	0.700	0.77
480_E	489_H	0.700	0.77
86_Y	696_D	0.700	0.77
345_L	358_A	0.700	0.77
25_P	29_K	0.700	0.77
311_G	315_T	0.699	0.77
118_V	122_R	0.699	0.77
868_N	872_S	0.699	0.77
294_N	310_L	0.699	0.77
92_P	149_W	0.698	0.77
36_I	776_Q	0.697	0.77
660_D	663_P	0.696	0.77
498_E	502_L	0.694	0.76
215_V	297_A	0.693	0.76
808_D	812_A	0.693	0.76
309_M	339_K	0.692	0.76
674_R	740_M	0.692	0.76
484_E	488_Q	0.692	0.76
205_R	395_H	0.691	0.76
164_Q	167_V	0.691	0.76
886_E	889_E	0.689	0.76
246_V	293_E	0.688	0.76
215_V	308_V	0.688	0.76
690_K	693_K	0.688	0.76
59_A	96_T	0.688	0.76
542_D	545_V	0.688	0.76
190_S	401_K	0.687	0.76
866_A	877_K	0.686	0.76
822_I	828_A	0.686	0.76
749_L	752_V	0.686	0.76
258_G	282_E	0.686	0.76
866_A	871_Q	0.685	0.75
348_V	352_G	0.685	0.75
642_E	645_R	0.685	0.75
361_F	373_I	0.684	0.75
383_L	386_L	0.684	0.75
137_R	149_W	0.684	0.75
187_S	401_K	0.683	0.75
227_R	382_A	0.683	0.75
109_K	113_R	0.683	0.75
422_L	425_A	0.682	0.75
729_I	734_H	0.682	0.75
169_G	480_E	0.679	0.75
213_F	230_I	0.678	0.75
415_I	448_G	0.677	0.75
861_S	864_N	0.676	0.74
497_K	502_L	0.674	0.74
410_Q	451_C	0.674	0.74
668_V	671_E	0.673	0.74
158_P	479_I	0.673	0.74
513_P	516_T	0.672	0.74
603_V	608_V	0.672	0.74
535_Q	573_T	0.671	0.74
603_V	634_D	0.670	0.74
297_A	322_C	0.670	0.74
71_K	92_P	0.670	0.74
169_G	483_S	0.670	0.74
817_R	823_G	0.669	0.74
104_A	132_Q	0.669	0.74
663_P	745_Y	0.669	0.74
861_S	865_E	0.666	0.73
253_S	287_V	0.666	0.73
429_T	577_P	0.665	0.73
58_Y	71_K	0.664	0.73
48_P	81_K	0.664	0.73
893_V	897_D	0.664	0.73
273_A	277_G	0.663	0.73
605_P	608_V	0.663	0.73
36_I	39_L	0.663	0.73
539_E	544_L	0.663	0.73
418_F	571_A	0.662	0.73
857_E	884_E	0.662	0.73
675_E	799_F	0.662	0.73
740_M	743_V	0.660	0.73
444_V	567_S	0.659	0.73
772_F	775_E	0.658	0.72
825_S	854_I	0.658	0.72
868_N	873_F	0.658	0.72
655_H	658_L	0.658	0.72
642_E	646_K	0.658	0.72
414_S	449_D	0.657	0.72
118_V	497_K	0.657	0.72
836_K	839_K	0.657	0.72
788_T	791_N	0.656	0.72
466_Y	473_V	0.656	0.72
133_I	137_R	0.655	0.72
306_S	345_L	0.654	0.72
793_E	796_E	0.653	0.72
660_D	741_Q	0.653	0.72
677_D	726_I	0.653	0.72
391_H	394_P	0.651	0.72
216_K	225_G	0.651	0.72
763_A	778_V	0.650	0.72
676_V	722_F	0.650	0.72
429_T	581_V	0.649	0.71
68_A	72_I	0.649	0.71
242_L	306_S	0.649	0.71
23_R	27_I	0.648	0.71
548_A	565_S	0.647	0.71
839_K	860_I	0.647	0.71
889_E	892_R	0.647	0.71
735_P	739_S	0.646	0.71
313_H	318_A	0.646	0.71
602_V	608_V	0.645	0.71
165_I	463_P	0.645	0.71
375_Q	386_L	0.645	0.71
210_Y	229_I	0.643	0.71
65_M	603_V	0.643	0.71
40_V	146_R	0.642	0.71
826_L	856_S	0.642	0.71
249_D	312_E	0.641	0.71
798_K	845_I	0.640	0.70
241_N	324_H	0.640	0.70
738_R	742_T	0.639	0.70
620_W	636_I	0.639	0.70
224_N	254_V	0.638	0.70
586_F	594_K	0.638	0.70
345_L	349_D	0.638	0.70
269_V	283_V	0.638	0.70
58_Y	101_I	0.638	0.70
137_R	152_P	0.638	0.70
425_A	575_K	0.637	0.70
833_Y	861_S	0.636	0.70
80_Y	783_M	0.636	0.70
250_L	315_T	0.636	0.70
345_L	357_E	0.636	0.70
301_L	377_L	0.634	0.70
27_I	764_D	0.634	0.70
681_L	743_V	0.634	0.70
857_E	883_A	0.633	0.70
885_G	889_E	0.633	0.70
140_F	149_W	0.632	0.69
834_P	842_L	0.632	0.69
47_R	87_N	0.631	0.69
809_V	813_L	0.631	0.69
466_Y	520_E	0.629	0.69
348_V	354_M	0.629	0.69
131_K	134_E	0.629	0.69
140_F	145_V	0.628	0.69
670_V	789_V	0.628	0.69
795_T	798_K	0.627	0.69
885_G	894_I	0.627	0.69
542_D	547_P	0.626	0.69
684_L	754_L	0.626	0.69
163_Q	487_R	0.625	0.69
176_Y	417_D	0.625	0.69
684_L	710_F	0.624	0.68
674_R	736_D	0.623	0.68
40_V	779_Q	0.623	0.68
525_D	528_F	0.623	0.68
746_E	787_I	0.623	0.68
126_E	156_L	0.622	0.68
674_R	735_P	0.622	0.68
588_L	629_D	0.622	0.68
841_L	844_S	0.622	0.68
683_K	796_E	0.621	0.68
481_H	502_L	0.620	0.68
248_P	313_H	0.618	0.68
302_Y	306_S	0.618	0.68
217_D	224_N	0.618	0.68
726_I	730_E	0.617	0.68
553_E	557_Q	0.616	0.67
811_K	815_T	0.616	0.67
46_D	49_K	0.616	0.67
49_K	543_D	0.616	0.67
778_V	781_T	0.615	0.67
680_M	743_V	0.614	0.67
670_V	790_P	0.614	0.67
171_M	572_V	0.613	0.67
158_P	161_E	0.612	0.67
603_V	630_V	0.612	0.67
482_V	503_L	0.611	0.67
499_A	519_K	0.611	0.67
206_S	393_Y	0.610	0.67
313_H	332_D	0.610	0.67
83_M	781_T	0.610	0.67
359_P	376_Q	0.610	0.67
887_M	894_I	0.609	0.67
35_D	42_E	0.609	0.67
481_H	504_P	0.609	0.67
223_E	261_R	0.609	0.67
30_K	33_E	0.608	0.66
668_V	739_S	0.607	0.66
885_G	896_K	0.607	0.66
554_G	586_F	0.607	0.66
65_M	72_I	0.607	0.66
590_G	631_R	0.606	0.66
811_K	818_N	0.605	0.66
69_L	630_V	0.605	0.66
480_E	487_R	0.605	0.66
277_G	280_Q	0.605	0.66
877_K	882_K	0.604	0.66
344_V	350_E	0.604	0.66
302_Y	360_G	0.603	0.66
212_A	384_V	0.603	0.66
622_S	695_Y	0.602	0.66
361_F	379_E	0.601	0.66
117_S	496_E	0.600	0.65
298_E	302_Y	0.600	0.65
49_K	544_L	0.599	0.65
253_S	264_V	0.598	0.65
504_P	518_T	0.598	0.65
92_P	140_F	0.598	0.65
81_K	692_K	0.598	0.65
76_F	758_I	0.598	0.65
354_M	361_F	0.597	0.65
727_V	744_F	0.597	0.65
814_E	817_R	0.596	0.65
71_K	145_V	0.596	0.65
103_T	121_F	0.595	0.65
612_L	637_L	0.594	0.65
329_H	347_P	0.593	0.65
393_Y	405_F	0.593	0.65
595_M	602_V	0.593	0.65
211_V	238_I	0.593	0.65
36_I	777_S	0.593	0.65
48_P	87_N	0.592	0.64
416_K	420_S	0.592	0.64
86_Y	89_P	0.591	0.64
468_E	515_G	0.591	0.64
130_W	154_V	0.591	0.64
53_H	548_A	0.591	0.64
298_E	305_D	0.591	0.64
846_K	857_E	0.591	0.64
654_L	659_F	0.590	0.64
238_I	299_H	0.590	0.64
829_N	884_E	0.590	0.64
659_F	741_Q	0.590	0.64
50_F	77_I	0.589	0.64
264_V	273_A	0.589	0.64
362_E	366_Y	0.588	0.64
579_K	599_I	0.588	0.64
103_T	107_K	0.587	0.64
34_E	768_S	0.587	0.64
759_L	763_A	0.586	0.64
49_K	89_P	0.586	0.64
685_N	746_E	0.586	0.64
211_V	230_I	0.585	0.64
695_Y	700_F	0.585	0.64
691_V	707_I	0.584	0.63
334_F	407_A	0.584	0.63
104_A	108_N	0.584	0.63
187_S	513_P	0.584	0.63
14_F	769_H	0.584	0.63
726_I	736_D	0.584	0.63
878_I	888_C	0.584	0.63
229_I	272_V	0.583	0.63
725_D	729_I	0.583	0.63
127_E	130_W	0.583	0.63
59_A	67_H	0.582	0.63
768_S	771_T	0.582	0.63
240_A	358_A	0.582	0.63
66_G	70_N	0.582	0.63
23_R	765_E	0.582	0.63
162_A	487_R	0.581	0.63
569_A	575_K	0.581	0.63
145_V	149_W	0.580	0.63
345_L	354_M	0.580	0.63
15_P	18_G	0.580	0.63
467_A	472_P	0.579	0.63
661_F	741_Q	0.579	0.63
651_F	752_V	0.579	0.63
34_E	38_R	0.578	0.63
647_I	711_C	0.578	0.63
369_A	373_I	0.578	0.63
371_K	388_F	0.578	0.63
499_A	502_L	0.577	0.62
346_C	354_M	0.577	0.62
32_E	138_E	0.577	0.62
655_H	663_P	0.576	0.62
247_H	316_T	0.576	0.62
61_G	67_H	0.575	0.62
215_V	263_V	0.574	0.62
882_K	889_E	0.574	0.62
55_G	74_K	0.574	0.62
170_E	572_V	0.572	0.62
83_M	782_D	0.572	0.62
746_E	750_A	0.572	0.62
584_H	626_Y	0.571	0.62
776_Q	780_L	0.571	0.62
62_D	132_Q	0.571	0.62
493_I	496_E	0.570	0.62
695_Y	783_M	0.570	0.62
205_R	386_L	0.570	0.62
207_A	371_K	0.569	0.61
748_L	766_L	0.569	0.61
690_K	694_A	0.569	0.61
173_K	477_E	0.569	0.61
768_S	772_F	0.568	0.61
111_V	114_K	0.567	0.61
426_I	437_E	0.567	0.61
43_R	780_L	0.566	0.61
21_P	610_K	0.566	0.61
217_D	295_I	0.566	0.61
877_K	892_R	0.565	0.61
644_Y	759_L	0.565	0.61
273_A	384_V	0.565	0.61
78_V	82_S	0.565	0.61
41_Q	46_D	0.564	0.61
63_I	604_V	0.564	0.61
92_P	152_P	0.564	0.61
865_E	879_A	0.564	0.61
244_I	300_P	0.564	0.61
255_I	262_F	0.564	0.61
264_V	269_V	0.563	0.61
711_C	751_L	0.563	0.61
73_L	77_I	0.563	0.61
26_D	30_K	0.562	0.60
865_E	871_Q	0.562	0.60
425_A	429_T	0.562	0.60
654_L	661_F	0.562	0.60
315_T	325_T	0.561	0.60
35_D	39_L	0.561	0.60
15_P	769_H	0.560	0.60
845_I	848_N	0.559	0.60
272_V	275_A	0.559	0.60
167_V	171_M	0.558	0.60
331_E	405_F	0.558	0.60
64_H	70_N	0.558	0.60
228_I	292_L	0.557	0.60
447_R	563_N	0.557	0.60
514_N	518_T	0.557	0.60
271_N	275_A	0.557	0.60
535_Q	572_V	0.557	0.60
541_R	545_V	0.557	0.60
438_Q	441_H	0.557	0.60
674_R	723_A	0.557	0.60
677_D	739_S	0.557	0.60
332_D	336_I	0.556	0.60
160_Y	532_S	0.556	0.60
159_E	163_Q	0.555	0.59
673_L	678_Q	0.555	0.59
273_A	280_Q	0.555	0.59
764_D	772_F	0.555	0.59
661_F	745_Y	0.555	0.59
44_T	48_P	0.554	0.59
808_D	811_K	0.554	0.59
67_H	588_L	0.554	0.59
186_W	586_F	0.553	0.59
679_Y	683_K	0.553	0.59
185_N	403_T	0.553	0.59
123_K	126_E	0.553	0.59
360_G	379_E	0.553	0.59
206_S	391_H	0.553	0.59
687_L	691_V	0.552	0.59
202_Q	395_H	0.552	0.59
54_D	58_Y	0.552	0.59
527_W	530_S	0.551	0.59
377_L	382_A	0.551	0.59
161_E	447_R	0.551	0.59
63_I	602_V	0.551	0.59
123_K	492_N	0.550	0.59
41_Q	44_T	0.550	0.59
20_L	644_Y	0.549	0.59
419_R	423_L	0.549	0.59
116_M	120_E	0.549	0.59
78_V	83_M	0.549	0.59
53_H	551_Y	0.548	0.59
193_A	451_C	0.548	0.59
759_L	762_T	0.548	0.59
18_G	21_P	0.547	0.58
522_D	526_V	0.547	0.58
816_A	820_K	0.546	0.58
702_V	706_S	0.546	0.58
27_I	30_K	0.545	0.58
53_H	565_S	0.545	0.58
204_K	395_H	0.544	0.58
353_V	366_Y	0.544	0.58
661_F	738_R	0.544	0.58
674_R	739_S	0.543	0.58
882_K	885_G	0.543	0.58
694_A	697_E	0.543	0.58
520_E	523_I	0.543	0.58
423_L	426_I	0.542	0.58
857_E	894_I	0.542	0.58
37_Y	40_V	0.542	0.58
76_F	695_Y	0.542	0.58
833_Y	840_E	0.541	0.58
865_E	869_D	0.541	0.58
264_V	390_T	0.541	0.58
261_R	282_E	0.541	0.58
415_I	567_S	0.541	0.58
72_I	621_V	0.540	0.57
57_P	61_G	0.540	0.57
556_D	586_F	0.540	0.57
469_N	472_P	0.540	0.57
51_V	89_P	0.539	0.57
423_L	444_V	0.539	0.57
65_M	68_A	0.539	0.57
242_L	337_G	0.539	0.57
464_V	520_E	0.538	0.57
24_E	142_R	0.538	0.57
68_A	143_L	0.538	0.57
857_E	896_K	0.538	0.57
835_N	842_L	0.538	0.57
347_P	369_A	0.537	0.57
476_D	479_I	0.536	0.57
794_A	837_E	0.536	0.57
141_K	149_W	0.536	0.57
682_I	685_N	0.536	0.57
229_I	264_V	0.536	0.57
878_I	881_E	0.535	0.57
532_S	536_A	0.534	0.57
266_S	270_E	0.534	0.57
142_R	614_A	0.534	0.57
602_V	605_P	0.534	0.57
846_K	858_L	0.533	0.56
602_V	632_V	0.533	0.56
103_T	190_S	0.533	0.56
171_M	578_Y	0.532	0.56
467_A	514_N	0.531	0.56
346_C	357_E	0.531	0.56
76_F	700_F	0.531	0.56
47_R	84_S	0.531	0.56
432_V	440_L	0.531	0.56
626_Y	700_F	0.530	0.56
489_H	502_L	0.530	0.56
49_K	86_Y	0.530	0.56
738_R	741_Q	0.529	0.56
164_Q	460_V	0.529	0.56
160_Y	164_Q	0.528	0.56
879_A	882_K	0.527	0.56
207_A	374_T	0.527	0.56
394_P	398_R	0.527	0.56
122_R	492_N	0.526	0.55
524_M	528_F	0.526	0.55
497_K	500_K	0.525	0.55
857_E	860_I	0.524	0.55
84_S	785_E	0.523	0.55
270_E	286_T	0.523	0.55
552_L	582_L	0.523	0.55
217_D	225_G	0.523	0.55
274_S	288_K	0.523	0.55
718_F	722_F	0.523	0.55
191_E	350_E	0.522	0.55
143_L	617_L	0.522	0.55
865_E	868_N	0.522	0.55
474_I	517_F	0.521	0.55
327_P	337_G	0.521	0.55
587_A	632_V	0.521	0.55
63_I	139_Q	0.521	0.55
478_T	481_H	0.520	0.55
38_R	41_Q	0.520	0.55
708_H	712_T	0.519	0.54
197_A	200_E	0.519	0.54
18_G	23_R	0.519	0.54
694_A	699_E	0.518	0.54
691_V	703_V	0.518	0.54
555_S	629_D	0.518	0.54
833_Y	863_E	0.517	0.54
880_V	888_C	0.517	0.54
469_N	515_G	0.517	0.54
101_I	129_A	0.517	0.54
512_S	517_F	0.517	0.54
685_N	792_S	0.517	0.54
650_T	715_L	0.516	0.54
829_N	883_A	0.516	0.54
721_D	854_I	0.516	0.54
118_V	495_F	0.516	0.54
809_V	812_A	0.516	0.54
680_M	739_S	0.516	0.54
215_V	224_N	0.515	0.54
242_L	327_P	0.515	0.54
269_V	281_Y	0.515	0.54
369_A	372_A	0.514	0.54
670_V	674_R	0.514	0.54
70_N	554_G	0.514	0.54
880_V	883_A	0.514	0.54
887_M	891_S	0.514	0.54
103_T	189_S	0.514	0.54
472_P	513_P	0.513	0.54
310_L	313_H	0.513	0.54
816_A	819_E	0.513	0.54
648_R	762_T	0.513	0.54
25_P	142_R	0.513	0.54
190_S	470_G	0.513	0.54
862_E	868_N	0.513	0.54
304_R	345_L	0.513	0.54
410_Q	586_F	0.512	0.53
63_I	136_Q	0.512	0.53
833_Y	842_L	0.511	0.53
343_D	350_E	0.511	0.53
268_L	272_V	0.511	0.53
184_V	193_A	0.511	0.53
276_C	385_K	0.511	0.53
877_K	888_C	0.510	0.53
138_E	610_K	0.510	0.53
609_M	614_A	0.510	0.53
745_Y	749_L	0.510	0.53
681_L	790_P	0.510	0.53
489_H	492_N	0.509	0.53
550_L	626_Y	0.508	0.53
54_D	92_P	0.508	0.53
703_V	713_I	0.508	0.53
472_P	512_S	0.508	0.53
765_E	769_H	0.508	0.53
842_L	860_I	0.508	0.53
111_V	116_M	0.508	0.53
876_G	881_E	0.507	0.53
270_E	273_A	0.507	0.53
207_A	247_H	0.507	0.53
435_W	438_Q	0.507	0.53
262_F	278_F	0.506	0.53
422_L	447_R	0.506	0.53
187_S	438_Q	0.506	0.53
728_Y	741_Q	0.506	0.53
181_L	328_G	0.506	0.53
276_C	279_D	0.505	0.53
243_G	325_T	0.505	0.53
723_A	727_V	0.505	0.53
222_L	263_V	0.505	0.53
542_D	546_R	0.504	0.52
335_I	339_K	0.504	0.52
808_D	878_I	0.504	0.52
831_K	879_A	0.504	0.52
750_A	786_T	0.504	0.52
707_I	751_L	0.503	0.52
371_K	378_D	0.503	0.52
595_M	603_V	0.503	0.52
178_Y	414_S	0.503	0.52
813_L	828_A	0.503	0.52
392_S	395_H	0.502	0.52
820_K	823_G	0.502	0.52
357_E	362_E	0.502	0.52
763_A	766_L	0.502	0.52
217_D	222_L	0.501	0.52
417_D	420_S	0.501	0.52
709_N	712_T	0.501	0.52
294_N	341_G	0.501	0.52
91_V	152_P	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ffyA	1	0.9913	100	0.136	Contact Map
1gaxA	1	0.8893	100	0.324	Contact Map
1ileA	1	0.8643	100	0.332	Contact Map
1wz2A	1	0.9088	100	0.348	Contact Map
1wkbA	1	0.7731	100	0.415	Contact Map
2v0cA	1	0.7264	100	0.464	Contact Map
4arcA	1	0.7503	100	0.483	Contact Map
3ziuA	1	0.6265	100	0.589	Contact Map
1rqgA	2	0.5798	100	0.675	Contact Map
4qreA	1	0.5418	100	0.681	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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