GREMLIN Database
SYI - Isoleucine--tRNA ligase
UniProt: Q45477 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 921 (863)
Sequences: 4843 (2806)
Seq/√Len: 95.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_D38_R5.7171.00
256_A282_E5.7031.00
251_E288_K5.1801.00
29_K33_E4.9921.00
266_S286_T4.9111.00
81_K86_Y4.8011.00
32_E141_K4.0881.00
253_S266_S3.9251.00
427_K437_E3.9061.00
364_M372_A3.8411.00
134_E137_R3.7861.00
361_F376_Q3.7751.00
39_L776_Q3.6241.00
170_E173_K3.5871.00
337_G342_L3.4421.00
84_S692_K3.3381.00
251_E266_S3.2911.00
293_E310_L3.2581.00
480_E484_E3.2421.00
678_Q792_S3.2231.00
228_I308_V3.2111.00
250_L316_T3.1371.00
212_A260_D3.0801.00
593_R599_I2.9791.00
251_E286_T2.9411.00
187_S399_T2.8501.00
244_I322_C2.8451.00
749_L753_K2.8141.00
124_L127_E2.8141.00
42_E45_K2.8071.00
549_D579_K2.7781.00
104_A107_K2.7171.00
611_Q634_D2.6981.00
44_T47_R2.6851.00
430_K580_G2.6281.00
360_G376_Q2.6121.00
313_H336_I2.6021.00
690_K706_S2.5941.00
590_G635_A2.5801.00
30_K34_E2.5381.00
755_S763_A2.5351.00
253_S269_V2.5351.00
293_E340_Y2.5301.00
30_K768_S2.5161.00
268_L271_N2.5071.00
425_A428_E2.4841.00
669_A672_D2.4811.00
261_R284_T2.4381.00
420_S424_D2.4351.00
313_H325_T2.4271.00
651_F766_L2.3811.00
79_R760_P2.3661.00
117_S120_E2.3421.00
421_D574_G2.3101.00
309_M336_I2.3051.00
376_Q380_K2.3031.00
28_Q761_H2.2851.00
137_R141_K2.2821.00
137_R150_E2.2661.00
228_I322_C2.2541.00
19_N22_N2.2471.00
133_I154_V2.2401.00
267_A316_T2.2261.00
50_F698_Y2.2251.00
693_K697_E2.2211.00
187_S190_S2.2211.00
148_D151_N2.2041.00
166_R487_R2.1601.00
123_K127_E2.1511.00
334_F338_Q2.1311.00
682_I796_E2.1311.00
203_D392_S2.1231.00
692_K783_M2.1201.00
41_Q87_N2.1151.00
48_P86_Y2.1151.00
349_D353_V2.1151.00
467_A470_G2.1121.00
244_I297_A2.1081.00
680_M747_T2.1001.00
550_L582_L2.0971.00
205_R390_T2.0841.00
39_L42_E2.0741.00
375_Q379_E2.0671.00
775_E781_T2.0531.00
607_K611_Q2.0431.00
365_F368_D2.0381.00
311_G336_I2.0371.00
203_D390_T2.0321.00
256_A261_R2.0271.00
62_D135_G2.0121.00
80_Y696_D2.0101.00
424_D427_K2.0091.00
332_D335_I1.9881.00
550_L580_G1.9801.00
190_S399_T1.9801.00
254_V285_R1.9741.00
372_A375_Q1.9691.00
296_I305_D1.9631.00
414_S417_D1.9581.00
687_L706_S1.9471.00
166_R483_S1.9381.00
272_V276_C1.9341.00
356_S362_E1.9301.00
497_K501_D1.9301.00
468_E518_T1.9281.00
243_G309_M1.9221.00
228_I244_I1.9181.00
46_D87_N1.9061.00
254_V261_R1.9001.00
421_D424_D1.8971.00
76_F622_S1.8951.00
245_S325_T1.8881.00
686_K796_E1.8831.00
285_R291_D1.8751.00
689_D693_K1.8641.00
214_G382_A1.8551.00
213_F241_N1.8491.00
227_R260_D1.8471.00
62_D139_Q1.8441.00
288_K291_D1.8431.00
424_D428_E1.8411.00
80_Y84_S1.8391.00
684_L750_A1.8341.00
689_D788_T1.8261.00
245_S336_I1.8161.00
173_K476_D1.8011.00
26_D29_K1.7991.00
83_M756_A1.7971.00
431_W581_V1.7971.00
108_N131_K1.7951.00
270_E274_S1.7851.00
836_K840_E1.7781.00
38_R42_E1.7751.00
375_Q378_D1.7741.00
63_I143_L1.7721.00
257_V260_D1.7691.00
230_I244_I1.7581.00
160_Y533_S1.7551.00
108_N124_L1.7491.00
475_T478_T1.7471.00
49_K87_N1.7331.00
112_N115_E1.7321.00
255_I269_V1.7301.00
247_H250_L1.7281.00
81_K696_D1.7231.00
692_K696_D1.7211.00
214_G227_R1.7161.00
253_S283_V1.7071.00
216_K296_I1.6991.00
165_I486_F1.6971.00
169_G173_K1.6961.00
214_G298_E1.6901.00
170_E174_R1.6891.00
238_I301_L1.6861.00
56_P160_Y1.6841.00
253_S286_T1.6821.00
22_N25_P1.6691.00
130_W156_L1.6671.00
590_G633_S1.6571.00
78_V88_A1.6561.00
843_A846_K1.6521.00
96_T156_L1.6401.00
205_R388_F1.6251.00
688_I750_A1.6061.00
680_M715_L1.6001.00
839_K843_A1.5991.00
607_K610_K1.5931.00
229_I262_F1.5921.00
813_L853_F1.5881.00
81_K84_S1.5741.00
539_E543_D1.5741.00
425_A570_V1.5721.00
216_K298_E1.5701.00
179_K466_Y1.5691.00
829_N857_E1.5611.00
256_A259_E1.5561.00
777_S780_L1.5521.00
264_V272_V1.5501.00
273_A281_Y1.5501.00
22_N26_D1.5461.00
224_N256_A1.5451.00
226_E254_V1.5421.00
695_Y703_V1.5421.00
753_K781_T1.5381.00
171_M571_A1.5351.00
29_K32_E1.5341.00
30_K764_D1.5311.00
275_A387_E1.5271.00
209_I238_I1.5221.00
426_I444_V1.5151.00
245_S311_G1.5121.00
246_V322_C1.5031.00
23_R26_D1.5011.00
427_K441_H1.4991.00
246_V308_V1.4971.00
154_V157_K1.4941.00
248_P310_L1.4941.00
855_V858_L1.4841.00
169_G479_I1.4821.00
190_S396_D1.4811.00
254_V287_V1.4771.00
364_M369_A1.4741.00
675_E798_K1.4701.00
212_A227_R1.4661.00
730_E736_D1.4661.00
229_I384_V1.4651.00
215_V295_I1.4611.00
142_R610_K1.4551.00
752_V766_L1.4551.00
34_E776_Q1.4451.00
688_I754_L1.4431.00
830_L859_T1.4421.00
400_K598_S1.4391.00
90_Y147_G1.4351.00
225_G261_R1.4351.00
223_E226_E1.4331.00
301_L376_Q1.4251.00
431_W440_L1.4221.00
36_I146_R1.4221.00
144_G761_H1.4200.99
376_Q379_E1.4190.99
65_M602_V1.4190.99
764_D777_S1.4150.99
798_K844_S1.4080.99
328_G347_P1.4080.99
310_L340_Y1.4060.99
829_N859_T1.4040.99
695_Y758_I1.3960.99
189_S399_T1.3920.99
120_E123_K1.3900.99
544_L547_P1.3850.99
489_H493_I1.3800.99
699_E702_V1.3690.99
467_A513_P1.3670.99
831_K861_S1.3670.99
73_L552_L1.3610.99
432_V580_G1.3590.99
355_T358_A1.3560.99
292_L295_I1.3490.99
607_K634_D1.3460.99
840_E843_A1.3400.99
608_V637_L1.3270.99
171_M568_T1.3260.99
422_L567_S1.3200.99
84_S696_D1.3190.99
353_V368_D1.3150.99
415_I418_F1.3100.99
748_L770_L1.3080.99
269_V273_A1.3070.99
160_Y536_A1.3040.99
249_D290_K1.2970.99
207_A369_A1.2970.99
486_F503_L1.2890.99
255_I283_V1.2890.99
489_H496_E1.2880.99
816_A821_I1.2880.99
587_A630_V1.2870.99
364_M368_D1.2770.99
266_S283_V1.2750.99
743_V747_T1.2730.99
311_G335_I1.2640.99
325_T337_G1.2630.99
249_D288_K1.2600.99
187_S396_D1.2580.99
546_R573_T1.2550.99
474_I485_L1.2550.99
493_I497_K1.2550.99
685_N688_I1.2530.99
242_L345_L1.2520.99
287_V291_D1.2510.99
801_R841_L1.2490.99
867_P870_A1.2480.99
38_R150_E1.2470.99
361_F372_A1.2470.99
245_S309_M1.2450.99
371_K386_L1.2450.99
430_K697_E1.2390.99
65_M608_V1.2350.99
654_L657_N1.2330.99
228_I263_V1.2300.99
163_Q166_R1.2270.99
444_V563_N1.2240.98
207_A386_L1.2240.98
534_H568_T1.2240.98
216_K305_D1.2230.98
425_A576_A1.2170.98
498_E501_D1.2140.98
367_D370_N1.2140.98
44_T82_S1.2130.98
185_N405_F1.2120.98
563_N567_S1.2100.98
546_R575_K1.2040.98
358_A362_E1.2040.98
347_P355_T1.2020.98
468_E516_T1.2010.98
566_L577_P1.1970.98
311_G325_T1.1960.98
532_S568_T1.1960.98
371_K375_Q1.1920.98
756_A779_Q1.1920.98
24_E614_A1.1900.98
692_K785_E1.1880.98
27_I768_S1.1880.98
672_D735_P1.1820.98
247_H312_E1.1800.98
120_E124_L1.1800.98
726_I740_M1.1790.98
599_I602_V1.1770.98
606_A610_K1.1760.98
470_G512_S1.1710.98
884_E891_S1.1700.98
541_R544_L1.1680.98
331_E335_I1.1660.98
703_V758_I1.1660.98
526_V529_D1.1640.98
45_K48_P1.1610.98
802_F852_L1.1590.98
297_A306_S1.1580.98
240_A354_M1.1530.98
226_E261_R1.1530.98
348_V366_Y1.1460.98
71_K140_F1.1430.98
359_P362_E1.1410.98
169_G477_E1.1410.98
265_A268_L1.1370.98
752_V763_A1.1320.97
159_E487_R1.1300.97
246_V292_L1.1300.97
485_L493_I1.1290.97
245_S313_H1.1290.97
191_E351_K1.1270.97
650_T720_L1.1260.97
887_M890_R1.1240.97
53_H533_S1.1200.97
504_P516_T1.1170.97
283_V286_T1.1130.97
77_I700_F1.1100.97
839_K862_E1.1050.97
441_H445_R1.1040.97
246_V310_L1.1010.97
43_R782_D1.1000.97
214_G225_G1.0990.97
661_F742_T1.0970.97
44_T782_D1.0940.97
238_I380_K1.0940.97
182_K451_C1.0900.97
688_I786_T1.0860.97
483_S487_R1.0840.97
413_A452_I1.0840.97
378_D386_L1.0840.97
242_L304_R1.0800.97
477_E481_H1.0800.97
167_V572_V1.0800.97
353_V365_F1.0770.97
681_L746_E1.0730.97
199_I403_T1.0700.96
361_F364_M1.0700.96
480_E483_S1.0690.96
243_G337_G1.0650.96
470_G513_P1.0630.96
30_K36_I1.0630.96
328_G344_V1.0620.96
366_Y404_I1.0580.96
134_E138_E1.0580.96
166_R480_E1.0570.96
434_E437_E1.0560.96
552_L584_H1.0550.96
512_S515_G1.0490.96
673_L743_V1.0470.96
257_V262_F1.0460.96
254_V263_V1.0460.96
287_V292_L1.0450.96
793_E797_E1.0440.96
655_H659_F1.0440.96
624_V630_V1.0420.96
809_V830_L1.0410.96
440_L581_V1.0390.96
575_K579_K1.0390.96
210_Y275_A1.0380.96
438_Q442_N1.0380.96
863_E866_A1.0350.96
670_V673_L1.0340.96
179_K409_A1.0340.96
580_G698_Y1.0320.96
187_S470_G1.0300.96
676_V723_A1.0300.96
750_A754_L1.0300.96
325_T336_I1.0290.96
673_L681_L1.0250.95
539_E573_T1.0250.95
335_I338_Q1.0200.95
489_H497_K1.0170.95
164_Q524_M1.0150.95
248_P290_K1.0150.95
792_S795_T1.0140.95
167_V528_F1.0120.95
354_M358_A1.0110.95
668_V673_L1.0090.95
730_E734_H1.0080.95
850_S858_L1.0070.95
130_W133_I1.0070.95
290_K293_E1.0060.95
870_A873_F1.0050.95
394_P405_F1.0050.95
687_L710_F1.0010.95
849_L858_L1.0010.95
119_A123_K1.0000.95
273_A278_F0.9990.95
34_E777_S0.9980.95
63_I67_H0.9960.95
888_C892_R0.9960.95
662_D666_N0.9940.95
148_D543_D0.9930.95
242_L343_D0.9920.95
538_L548_A0.9920.95
484_E487_R0.9900.95
755_S759_L0.9890.94
691_V754_L0.9890.94
868_N871_Q0.9890.94
212_A262_F0.9880.94
467_A517_F0.9880.94
829_N881_E0.9870.94
467_A471_E0.9860.94
84_S783_M0.9860.94
683_K800_D0.9860.94
666_N733_D0.9860.94
887_M892_R0.9840.94
171_M413_A0.9840.94
209_I374_T0.9840.94
569_A573_T0.9800.94
215_V228_I0.9800.94
437_E441_H0.9790.94
151_N157_K0.9770.94
346_C350_E0.9760.94
752_V778_V0.9760.94
251_E267_A0.9760.94
192_S399_T0.9730.94
349_D355_T0.9730.94
146_R779_Q0.9700.94
168_F177_I0.9700.94
296_I307_L0.9690.94
399_T470_G0.9660.94
611_Q638_K0.9660.94
65_M632_V0.9650.94
238_I373_I0.9640.94
686_K793_E0.9630.94
374_T386_L0.9630.94
718_F803_M0.9610.94
272_V384_V0.9600.94
294_N340_Y0.9590.94
884_E896_K0.9570.93
65_M587_A0.9530.93
888_C891_S0.9530.93
632_V637_L0.9480.93
813_L822_I0.9470.93
694_A702_V0.9460.93
241_N306_S0.9450.93
240_A347_P0.9450.93
604_V607_K0.9450.93
256_A284_T0.9440.93
312_E339_K0.9440.93
423_L445_R0.9420.93
737_R741_Q0.9410.93
400_K599_I0.9400.93
673_L739_S0.9400.93
176_Y418_F0.9390.93
878_I882_K0.9370.93
684_L747_T0.9360.93
423_L441_H0.9360.93
294_N307_L0.9330.93
849_L853_F0.9330.93
396_D399_T0.9330.93
513_P517_F0.9310.93
349_D356_S0.9290.92
83_M779_Q0.9280.92
782_D785_E0.9260.92
372_A376_Q0.9260.92
467_A512_S0.9250.92
329_H346_C0.9250.92
40_V82_S0.9240.92
455_Q522_D0.9240.92
883_A894_I0.9230.92
608_V617_L0.9220.92
45_K87_N0.9220.92
172_A177_I0.9200.92
83_M783_M0.9190.92
688_I784_P0.9140.92
566_L576_A0.9120.92
26_D765_E0.9100.92
207_A388_F0.9090.92
846_K850_S0.9090.92
749_L774_E0.9080.92
881_E884_E0.9080.92
866_A869_D0.9020.91
275_A385_K0.9010.91
635_A638_K0.8990.91
680_M710_F0.8980.91
867_P873_F0.8970.91
810_L814_E0.8970.91
202_Q400_K0.8950.91
39_L780_L0.8950.91
215_V226_E0.8950.91
869_D872_S0.8940.91
421_D425_A0.8940.91
653_F657_N0.8930.91
750_A753_K0.8910.91
167_V535_Q0.8910.91
682_I791_N0.8900.91
812_A816_A0.8890.91
138_E141_K0.8870.91
651_F769_H0.8860.91
655_H660_D0.8840.90
831_K859_T0.8820.90
823_G826_L0.8820.90
635_A639_Q0.8820.90
429_T576_A0.8820.90
476_D480_E0.8820.90
265_A316_T0.8810.90
83_M753_K0.8810.90
690_K702_V0.8790.90
209_I383_L0.8790.90
440_L444_V0.8780.90
79_R779_Q0.8770.90
673_L742_T0.8760.90
801_R838_N0.8750.90
683_K686_K0.8740.90
465_F503_L0.8730.90
869_D873_F0.8730.90
189_S401_K0.8730.90
248_P293_E0.8720.90
217_D296_I0.8710.90
707_I755_S0.8700.90
476_D485_L0.8690.90
230_I322_C0.8690.90
36_I780_L0.8680.90
297_A308_V0.8680.90
51_V545_V0.8670.90
481_H485_L0.8670.90
554_G584_H0.8670.90
135_G139_Q0.8660.90
689_D786_T0.8660.90
799_F802_F0.8660.90
345_L348_V0.8660.90
163_Q540_E0.8660.90
465_F499_A0.8650.89
815_T819_E0.8650.89
227_R262_F0.8640.89
315_T318_A0.8640.89
771_T774_E0.8620.89
79_R146_R0.8620.89
654_L658_L0.8620.89
49_K545_V0.8610.89
243_G307_L0.8610.89
590_G634_D0.8610.89
243_G342_L0.8610.89
127_E131_K0.8600.89
106_T121_F0.8580.89
539_E542_D0.8570.89
767_W781_T0.8550.89
250_L265_A0.8540.89
794_A798_K0.8540.89
587_A602_V0.8540.89
109_K112_N0.8520.89
130_W134_E0.8510.89
431_W437_E0.8500.89
656_G659_F0.8490.89
746_E784_P0.8490.89
54_D71_K0.8490.89
657_N660_D0.8470.88
851_Q893_V0.8460.88
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556_D586_F0.5400.57
469_N472_P0.5400.57
51_V89_P0.5390.57
423_L444_V0.5390.57
65_M68_A0.5390.57
242_L337_G0.5390.57
464_V520_E0.5380.57
24_E142_R0.5380.57
68_A143_L0.5380.57
857_E896_K0.5380.57
835_N842_L0.5380.57
347_P369_A0.5370.57
476_D479_I0.5360.57
794_A837_E0.5360.57
141_K149_W0.5360.57
682_I685_N0.5360.57
229_I264_V0.5360.57
878_I881_E0.5350.57
532_S536_A0.5340.57
266_S270_E0.5340.57
142_R614_A0.5340.57
602_V605_P0.5340.57
846_K858_L0.5330.56
602_V632_V0.5330.56
103_T190_S0.5330.56
171_M578_Y0.5320.56
467_A514_N0.5310.56
346_C357_E0.5310.56
76_F700_F0.5310.56
47_R84_S0.5310.56
432_V440_L0.5310.56
626_Y700_F0.5300.56
489_H502_L0.5300.56
49_K86_Y0.5300.56
738_R741_Q0.5290.56
164_Q460_V0.5290.56
160_Y164_Q0.5280.56
879_A882_K0.5270.56
207_A374_T0.5270.56
394_P398_R0.5270.56
122_R492_N0.5260.55
524_M528_F0.5260.55
497_K500_K0.5250.55
857_E860_I0.5240.55
84_S785_E0.5230.55
270_E286_T0.5230.55
552_L582_L0.5230.55
217_D225_G0.5230.55
274_S288_K0.5230.55
718_F722_F0.5230.55
191_E350_E0.5220.55
143_L617_L0.5220.55
865_E868_N0.5220.55
474_I517_F0.5210.55
327_P337_G0.5210.55
587_A632_V0.5210.55
63_I139_Q0.5210.55
478_T481_H0.5200.55
38_R41_Q0.5200.55
708_H712_T0.5190.54
197_A200_E0.5190.54
18_G23_R0.5190.54
694_A699_E0.5180.54
691_V703_V0.5180.54
555_S629_D0.5180.54
833_Y863_E0.5170.54
880_V888_C0.5170.54
469_N515_G0.5170.54
101_I129_A0.5170.54
512_S517_F0.5170.54
685_N792_S0.5170.54
650_T715_L0.5160.54
829_N883_A0.5160.54
721_D854_I0.5160.54
118_V495_F0.5160.54
809_V812_A0.5160.54
680_M739_S0.5160.54
215_V224_N0.5150.54
242_L327_P0.5150.54
269_V281_Y0.5150.54
369_A372_A0.5140.54
670_V674_R0.5140.54
70_N554_G0.5140.54
880_V883_A0.5140.54
887_M891_S0.5140.54
103_T189_S0.5140.54
472_P513_P0.5130.54
310_L313_H0.5130.54
816_A819_E0.5130.54
648_R762_T0.5130.54
25_P142_R0.5130.54
190_S470_G0.5130.54
862_E868_N0.5130.54
304_R345_L0.5130.54
410_Q586_F0.5120.53
63_I136_Q0.5120.53
833_Y842_L0.5110.53
343_D350_E0.5110.53
268_L272_V0.5110.53
184_V193_A0.5110.53
276_C385_K0.5110.53
877_K888_C0.5100.53
138_E610_K0.5100.53
609_M614_A0.5100.53
745_Y749_L0.5100.53
681_L790_P0.5100.53
489_H492_N0.5090.53
550_L626_Y0.5080.53
54_D92_P0.5080.53
703_V713_I0.5080.53
472_P512_S0.5080.53
765_E769_H0.5080.53
842_L860_I0.5080.53
111_V116_M0.5080.53
876_G881_E0.5070.53
270_E273_A0.5070.53
207_A247_H0.5070.53
435_W438_Q0.5070.53
262_F278_F0.5060.53
422_L447_R0.5060.53
187_S438_Q0.5060.53
728_Y741_Q0.5060.53
181_L328_G0.5060.53
276_C279_D0.5050.53
243_G325_T0.5050.53
723_A727_V0.5050.53
222_L263_V0.5050.53
542_D546_R0.5040.52
335_I339_K0.5040.52
808_D878_I0.5040.52
831_K879_A0.5040.52
750_A786_T0.5040.52
707_I751_L0.5030.52
371_K378_D0.5030.52
595_M603_V0.5030.52
178_Y414_S0.5030.52
813_L828_A0.5030.52
392_S395_H0.5020.52
820_K823_G0.5020.52
357_E362_E0.5020.52
763_A766_L0.5020.52
217_D222_L0.5010.52
417_D420_S0.5010.52
709_N712_T0.5010.52
294_N341_G0.5010.52
91_V152_P0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ffyA 1 0.9913 100 0.136 Contact Map
1gaxA 1 0.8893 100 0.324 Contact Map
1ileA 1 0.8643 100 0.332 Contact Map
1wz2A 1 0.9088 100 0.348 Contact Map
1wkbA 1 0.7731 100 0.415 Contact Map
2v0cA 1 0.7264 100 0.464 Contact Map
4arcA 1 0.7503 100 0.483 Contact Map
3ziuA 1 0.6265 100 0.589 Contact Map
1rqgA 2 0.5798 100 0.675 Contact Map
4qreA 1 0.5418 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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